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See detailEffets du complexe cis-dichlorodiammino-platine(II) - acide désoxyribonucléique sur des cellules normales ou cancéreuses
Heinen, Ernst ULg; Desaive, Claude ULg; Houssier, Claude ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1976), 170(4), 919-921

The effects of cis-dichloro-diammino-platinum(II) (cis-Pt) bound to DNA have been compared to those of free cis-Pt in mouse Ehrlich tumor cells, in peritoneal macrophages and in chick embryo fibroblasts ... [more ▼]

The effects of cis-dichloro-diammino-platinum(II) (cis-Pt) bound to DNA have been compared to those of free cis-Pt in mouse Ehrlich tumor cells, in peritoneal macrophages and in chick embryo fibroblasts cultivated in vitro.Cis-Pt has no antimitotic activity anymore when linked tp DNA. This would be due to the fact that free cis-Pt is not released from cis-Pt-DNA complex inside lysosomes. [less ▲]

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