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See detailThe penicillin Target in Bacteria
Ghuysen, Jean-Marie ULg; Leyh-Bouille, Mélina; Frère, Jean-Marie ULg et al

in Spencer, B. (Ed.) Industrial Aspects of Biochemistry (FEBS Proceedings) (1974)

The bacterial target of beta-lactam antibiotics consists of a set of multiple, membrane-bound receptors. Some of them have been characterized as DD-carboxypeptidases. The DD-carboxypeptidases catalyse the ... [more ▼]

The bacterial target of beta-lactam antibiotics consists of a set of multiple, membrane-bound receptors. Some of them have been characterized as DD-carboxypeptidases. The DD-carboxypeptidases catalyse the opening of amide bonds and transfer the carbonyl carbon to an exogenous nucleophile, and are specifically designed to operate on the D-Ala-D-Ala linkageof L-R-D-Ala-D-Ala terminated peptides (where R is most often a diamino acid residue). The R61, R39 and several Bacilli DD-carboxypeptidases are known to be serine-enzymes and the G DD-carboxypeptidase has been characterized as a metallo (Zn ions) enzyme. Both the R61 and the G enzymes have been crystallized. In turn, the S. faecalis 43,000-Mr DD-carboxypeptidase, which is inhibited by low dose levels of pCMB, might be a thiol-enzyme. The goal pursued is the understanding of the mechanistic properties and functioning of the active centers of the DD-carboxypeptidases at the molecular and atomic levels. The research program involves 1) further characterization of the S. faecalis enzyme (which can be obtained in a water-soluble form); 2) isolation of various Streptomyces membrane-bound enzymes in a truly water-soluble form; 3) sequencing of the G and R61 enzymes; 4) the 2.8 A structure analysis of the G enzyme. (A similar study is conducted by Dr. J.R. Knox at the University of Connecticut, on the R61 enzyme, which enzyme is prepared and purified in this laboratory and then sent to Storrs); 5) conformational studies and quantitative structure activity relationships (QSAR). Source du résumé : http://www.researchcrossroads.org/index.php?view=article&id=50%3Agrant-details&option=com_content&Itemid=64&grant_id=4296130 [less ▲]

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See detailAnorthosites and their environment
de Ward, Dirk; Duchesne, Jean-Clair ULg; Michot, Jean

in Bellière, Jacques; Duchesne, Jean-Clair (Eds.) Géologie des Domaines cristallins (1974)

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See detailLa pratique des groupes en éducation
de Landsheere, Gilbert ULg

in Orientation Scolaire et Professionnelle (L') [=OSP] (1974), 3

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See detailEvaluation continue et examens : précis de docimologie.
de Landsheere, Gilbert ULg

Book published by Labor - 3e édition revue et corrigée (1974)

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See detailCinq années d'automatisation à la Bibliothèque Générale de l'Université de Liège (1969-1973)
Krins, Alfred ULg

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in België (1974), 45(1/2), 64-105

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See detailElementi di docimologia : valutazione continua ed esami
de Landsheere, Gilbert ULg

Book published by La Nuova Italia (1974)

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See detailLa crise mondiale de l'éducation
de Landsheere, Gilbert ULg

in Toison d'Or (La) (1974), 6

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See detailClinicopathological study of ninety cases of clinical stage I cutaneous malignant melanoma
Castermans, A.; Castermans-Elias, S.; Lapière, M. et al

in Chir. Plastica (1974), 2

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See detailComparative study of the effects of ethidium bromide and DNA-ethidium bromide complex on normal and cancer cells.
Heinen, Ernst ULg; Bassleer, R.; Calberg-Bacq, C. M. et al

in Biochemical Pharmacology (1974), 23(10), 1549-51

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See detailBanque de questions et indices de certitude. Options docimologiques adaptées à l'enseignement secondaire
Leclercq, Dieudonné ULg

in Education : tribune libre (1974), (n° 149 décembre 1974 et 150 janvioer 1975), 49-5871-79

Dans cet article réparti en deux numéros de la revue, l'auteur décrit les options docimologiques prises dans la conception et la gestion de deux banques de questions qu'il a contribué à concevoir et ... [more ▼]

Dans cet article réparti en deux numéros de la revue, l'auteur décrit les options docimologiques prises dans la conception et la gestion de deux banques de questions qu'il a contribué à concevoir et réaliser : celle de l'Ecole Technique de la Force Aérienne à Saffraanberg et celle de l'Enseignement provincial liégeois. Il présente pour la première fois (p. 57) la distribution spectrale des qualités de réponses. NB : les consignes et barèmes de tarifs ne sont plus ceux que l'auteur recommande actuellement d'utiliser. [less ▲]

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See detailComment les maîtres enseignent : analyse des interactions verbales en classe
de Landsheere, Gilbert ULg; Bayer, Edouard

Book published by Ministère de l’Education nationale et de la Culture française. Direction générale de l’Organisation des études - 3ème édition (1974)

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See detailNiveau protéique des régimes à base de maïs deshydraté pour les jeunes bovins en croissance engraissement
Cordiez, Emile ULg; Bienfait, Jean-Marie ULg; Lambot, Olivier et al

in Annales de Médecine Vétérinaire (1974), 118

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See detailAction of a new psychotropic drug (sulpiride) on avoidance behavior in rats
Fontaine, Ovide ULg; Libon, P.; Richelle, Marc ULg

in Psychopharmacologia (1974), 39

Sulpiride, a new psychotropic drug with neuroleptic activity, was administered to rats in a sidman avoidance schedule. Doses ranging from 1 to 80mg/kg resulted on the animal recieving fever shocks. This ... [more ▼]

Sulpiride, a new psychotropic drug with neuroleptic activity, was administered to rats in a sidman avoidance schedule. Doses ranging from 1 to 80mg/kg resulted on the animal recieving fever shocks. This effect was not correlated with an increase of responding and seemed unrelated to the suppressing action abruptly observed at high doses (i.e. 150 to 200 mg/kg). These results differ from those classicaly obtained with other neuroleptics. [less ▲]

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See detailSpectroscopic observation of Venus
Monfils, A.; Gérard, Jean-Claude ULg

in Exploration of the planetary system; Proceedings of the Symposium (1974)

The interest of a spectroscopic investigation of the upper atmosphere of Venus in the ultraviolet is briefly shown. The conditions for the observations to be made are defined and the main properties of ... [more ▼]

The interest of a spectroscopic investigation of the upper atmosphere of Venus in the ultraviolet is briefly shown. The conditions for the observations to be made are defined and the main properties of the necessary instrument are deduced and described. The proposed package is a quadruple miniature spectrometer covering the entire spectral range extending from 1200 A to 8000 A with a resolving power of 500. [less ▲]

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See detailAnalyse statistique de résultats d'essais à blanc
Claustriaux, Jean-Jacques ULg; Rousseaux, G.

in Biométrie-Praximétrie (1974), 14(1-2), 57-79

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See detailDosage radioimmunologique de l'hormone folliculo-stimulante (FSH) hypophysaire de canard a l'aide d'un systeme de mammiferes
Croix, D.; Hendrick, J. C.; Balthazart, Jacques ULg et al

in Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1974), 168(1), 136-40

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See detailNon-stationnarite et aspects fonctionnels du comportement agonistique chez Tilapia macrochir (Boulenger 1912) (Piscer: Cichlidae)
Balthazart, Jacques ULg

in Acta Zoologica et Pathologica Antverpiensia (1974), 58(0), 29-40

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