Exploration isocinétique de la pathologie fémoro patellaire

in Actes de la 2ème Journée lilloise de Pathologie du Genou (1998, December 18)

La prise en charge en Centre de Jour de patients Alzheimer au stade débutant

Conference (1998, December 17)

In vivo and in vitro effect of new glibenclamide isosteres

Conference (1998, December 12)

Equine Neutrophil Myeloperoxidase in Plasma: Design of a Radio-Immunoassay and First Results in Septic Pathologies

in Veterinary Immunology and Immunopathology (1998), 66(3-4), 257-71

The strangulated intestinal pathologies of horses are accompanied by a local activation of the neutrophils, that can be revealed by measuring the tissular enzymatic activity of the granulocytic enzyme ... [more ▼]

The strangulated intestinal pathologies of horses are accompanied by a local activation of the neutrophils, that can be revealed by measuring the tissular enzymatic activity of the granulocytic enzyme myeloperoxidase (MPO). To estimate the possible spreading of this neutrophil activation to the systemic circulation, we designed a radioimmunoassay (RIA) for equine neutrophil myeloperoxidase (MPO) (EC 1.11.1.7) using a specific rabbit antiserum. MPO was labeled with 1 mCi 125I by a technique of self-labeling in the presence of 10(-4) M hydrogen peroxide. The RIA was performed by incubation of 100 microl diluted antiserum, 100 microl labeled MPO (+/-30,000 cpm) and 100 microl of the reference molecule (unlabeled MPO) solution or the unknown sample, at room temperature for 18 h. The antibody-antigen complexes were isolated by double antibody precipitation. The sensitivity of the RIA was 2 ng/ml. The RIA showed good precision and accuracy with intra- and inter-assay coefficients of variation 6% and 8%, respectively, for MPO concentrations ranging from 2 ng/ml to 60 ng/ml. The best sampling technique for MPO measurement in plasma was to collect blood into EDTA, which allowed us to get a plasmatic value stable with time. The mean MPO value in normal horses was 69.5 +/- 19.4 ng/ml in EDTA anticoagulated plasma (n = 48). The stress of transport and anaesthesia did not modify the mean plasmatic value of MPO. No significant increase of plasma MPO was observed in 17 horses submitted to surgery for pathologies without systemic impact. But, in 25 horses with obstructive intestinal pathologies, persistent abnormal MPO concentrations were measured (until 740 ng/ml). [less ▲]

Profils langagiers dans le syndrome de l'X-fragile et le syndrome de Down

Conference (1998, December 10)

The analysis of language difficulties in SLI children (Specific Language Impairment children) with normal cognitive abilities and in mentally retarded children (with genetic pathologies) gives us the ... [more ▼]

The analysis of language difficulties in SLI children (Specific Language Impairment children) with normal cognitive abilities and in mentally retarded children (with genetic pathologies) gives us the opportunity to test these different hypotheses. The language specificities of these different syndromes allow us to analyse the reciprociqual and sequential effects of the different language components. This procedure has a theorical and fundamental interest but also a practical interest. Effectively, it leads to numerous applications in speech and language pathology (concerning the pathologies definition as well as the hierarchisation of the therapeutical goals and the construction of the therapeutical programs). [less ▲]

La résistance bactérienne aux antibiotiques, un modèle exemplaire d'évolution moléculaire dirigée

in Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie (1998), 60(4), 287-294

The simplest conceivable event that can occur at the gene level can result in the development of efficacious resistance tot antibiotics. The bacterial world behaves as an enormous organism whose cells can ... [more ▼]

The simplest conceivable event that can occur at the gene level can result in the development of efficacious resistance tot antibiotics. The bacterial world behaves as an enormous organism whose cells can exchange their genes very easily. Accordingly, oppotunities for the exhcange of genetic material in nature are probably unlimited. This knowledge cannot be ignored. It leads to the important conclusion that the antibiotics are societal drugs. A resistance gene which has appeared somewhere in the world can travel far and fast. [less ▲]

Phase behavior of diblock copolymers between styrene and n-alkyl methacrylates

in Macromolecules (1998), 31(24), 8509-8516

In contrast to most diblock copolymers which exhibit the classical upper critical ordering transition (UCOT), polystyrene-b-poly n-butyl methacrylatePS-b-PBMAhas been shown to undergo ordering upon ... [more ▼]

In contrast to most diblock copolymers which exhibit the classical upper critical ordering transition (UCOT), polystyrene-b-poly n-butyl methacrylatePS-b-PBMAhas been shown to undergo ordering upon heating through a lower critical ordering transition (LCOT). Here we report the phase behavior of a family of diblock copolymers formed from styrene and a homologous series of n-alkyl methacrylates, as determined by combined dynamic rheological testing and small-angle neutron scattering (SANS). It is shown that the shortest side chain methacrylates, with the exception of methyl methacrylate, exhibit the LCOT, while for side chains longer than n-butyl, the copolymers exhibit the classical UCOT behavior. Combined group contribution/lattice fluid model calculations of the solubility parameter and specific volume of the corresponding homopolymers qualitatively support these observations. The same calculations were further employed to molecularly design LCOT behavior into a new diblock material consisting of styrene and a random copolymer of methyl and lauryl methacrylate, denoted PS-b-P(MMA-r-LMA). The success of this approach suggests a simple semiquantitative method for predicting and designing the phase behavior of weakly interacting polymer pairs. [less ▲]

WFPC2 PSF Subtractions

in Bulletin of the American Astronomical Society (1998, December 01)

Subtraction of scaled PSFs from direct CCD images of quasars (or stars) offers not only the possibility of detecting the presence of host or foreground galaxies (or companions like brown dwarfs or planets ... [more ▼]

Subtraction of scaled PSFs from direct CCD images of quasars (or stars) offers not only the possibility of detecting the presence of host or foreground galaxies (or companions like brown dwarfs or planets) but also provides a means of deriving accurate photometry of the primary objects. A series of PSF subtraction tests have been performed, using observed PSFs from the WFPC2 PSF Library as well as TinyTim PSFs; preliminary results indicate that appropriate synthetic TinyTim PSFs perform as well as observed PSFs. Specifically, using an optimally selected observed PSF, near the target on the chip ( < 10arcsec ), close in focus (within 1-2 microns), similar in spectral type, and with good S/N, yielded single photometric values with an RMS of ~ 0.01-0.02 mag. Using a carefully constructed synthetic PSF, close in focus and jitter to the target image, and as close as possible to the center of the target, resulted in photometric results with an RMS similar to that achieved with the observed PSF (0.01-0.02 mag). [less ▲]

Polarization properties of a sample of broad absorption line and gravitationally lensed quasars

in Astronomy and Astrophysics (1998), 340

New broad-band linear polarization measurements have been obtained for a sample of 42 optically selected QSOs including 29 broad absorption line (BAL) QSOs. The polarization properties of different sub ... [more ▼]

New broad-band linear polarization measurements have been obtained for a sample of 42 optically selected QSOs including 29 broad absorption line (BAL) QSOs. The polarization properties of different sub-classes have been compared, and possible correlations with various spectral indices searched for. The main results of our study are: (1) Nearly all highly polarized QSOs of our sample belong to the sub-class of BAL QSOs with low-ionization absorption features (LIBAL QSOs). (2) The range of polarization is significantly larger for LIBAL QSOs than for high-ionization (HI) BAL QSOs and non-BAL QSOs. (3) There is some indication that HIBAL QSOs as a class may be more polarized than non-BAL QSOs and therefore intermediate between LIBAL and non-BAL QSOs, but the statistics are not compelling from the sample surveyed thus far. (4) For LIBAL QSOs, the continuum polarization appears significantly correlated with the line profile detachment index, in the sense that LIBAL QSOs with P Cygni-type profiles are more polarized. No correlation was found with the strength of the low- or the high-ionization absorption features, nor with the strength or the width of the emission lines. These results are consistent with a scenario in which LIBAL QSOs constitute a different class of radio-quiet QSOs with more absorbing material and more dust. Higher maximum polarization can therefore be reached, while the actually measured polarization depends on the geometry and orientation of the system as do the line profiles. The observed correlation is interpreted within the framework of recent ``wind-from-disk'' models. Tables~2 and 3 are also available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html}\fnmsep\thanks{Based on observations collected at the European Southern Observatory (ESO, La Silla) [less ▲]

Transport of arginine and ornithine into isolated mitochondria of Saccharomyces cerevisiae.

in European Journal of Biochemistry (1998), 258(2), 702-9