References of "1997"
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See detail1,2,4-Benzothiadiazine derivatives, their preparation and use
Pirotte, Bernard ULg; Lebrun, P.; De Tullio, Pascal ULg et al

Patent (1997)

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See detailVersatile and controlled synthesis of star and branched macromolecules by dentritic initiation
Trollsas, Michaël; Hedrick, James L.; Mecerreyes, David et al

in Macromolecules (1997), 30(26), 8508-8511

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See detailPrésentation du plan particulier d'intervention de Liège-Airport
Burette, Philippe ULg

Conference (1997, December 18)

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See detailVers un multiculturalisme citoyen de l'Union Européenne?
Martiniello, Marco ULg

Scientific conference (1997, December 16)

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See detailHybrid wheat - a different wheat crop?
Bodson, Bernard ULg; Franc, Jean; Destain, Jean-Pierre ULg et al

in Aspects of Applied Biology (1997, December 15), (50), 23-30

From 1994 to 1996, trials have been carried out in Gembloux (Belgium) to evaluate the agronomical value of hybrid wheat varieties and to determine the best adapted growing conditions for these new wheats ... [more ▼]

From 1994 to 1996, trials have been carried out in Gembloux (Belgium) to evaluate the agronomical value of hybrid wheat varieties and to determine the best adapted growing conditions for these new wheats. These experiments show that the best hybrids have a yield potential hyghly superior to classical varieties. In order to improve the cost-effectiveness of hybrid wheat crops, a reduction in seed rate may be possible together with changes in nitrogen fertilisation, if the results of preliminary studies are confirmed. [less ▲]

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See detailAlteration of Interendothelial Adherens Junctions Following Tumor Cell-Endothelial Cell Interaction in Vitro
Lewalle, J. M.; Bajou, Khalid ULg; Desreux, Joëlle ULg et al

in Experimental Cell Research (1997), 237(2), 347-56

The integrity of the vascular endothelium is mainly dependent upon the organization of interendothelial adherens junctions (AJ). These junctions are formed by the homotypic interaction of a transmembrane ... [more ▼]

The integrity of the vascular endothelium is mainly dependent upon the organization of interendothelial adherens junctions (AJ). These junctions are formed by the homotypic interaction of a transmembrane protein, vascular endothelial cadherin (VE-cadherin), which is complexed to an intracellular protein network including alpha-, beta-, and gamma-catenin. Additional proteins such as vinculin and alpha-actinin have been suggested to link the VE-cadherin/catenin complex to the actin-based cytoskeleton. During the process of hematogenous metastasis, circulating tumor cells must disrupt these intercellular junctions in order to extravasate. In the present study, we have investigated the influence of tumor cell-endothelial cell interaction upon interendothelial AJ. We show that human breast adenocarcinoma cells (MCF-7), but not normal human mammary epithelial cells, induce a rapid endothelial cell (EC) dissociation which correlates with the loss of VE-cadherin expression at the site of tumor cell-EC contact and with profound changes in vinculin distribution and organization. This process could not be inhibited by metalloproteinase nor serine protease inhibitors. Immunoprecipitations and Western blot analysis demonstrate that the overall expression of VE-cadherin and vinculin as well as the composition of the VE-cadherin/catenins complex are not affected by tumor cells while the tyrosine phosphorylation status of proteins within the complex is significantly altered. Our data suggest that tumor cells modulate AJ protein distribution and phosphorylation in EC and may, thereby, facilitate EC dissociation. [less ▲]

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See detailSynergism for the improvement of tensile strength in block copolymers of polystyrene and poly(n-butyl methacrylate)
Weidisch, R.; Michler, G. H.; Arnold, M. et al

in Macromolecules (1997), 30(25), 8078-8080

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See detailAngiogenesis by Fibroblast Growth Factor 4 Is Mediated through an Autocrine Up-regulation of Vascular Endothelial Growth Factor Expression
Deroanne, Christophe ULg; Hajitou, Amin; Calberg-Bacq, Claire-M. et al

in Cancer Research (1997), 57

The infection of normal mouse mammary EF43 cells by a retroviral vector carrying either Fgf-3 (EF43.Fgf-3) or Fgf-4 (EF43.Fgf-4) cDNA resulted in the transformation of cells displaying different ... [more ▼]

The infection of normal mouse mammary EF43 cells by a retroviral vector carrying either Fgf-3 (EF43.Fgf-3) or Fgf-4 (EF43.Fgf-4) cDNA resulted in the transformation of cells displaying different tumorigenic potentials in nude mice (A. Hajitou and C-M. Calberg-Bacq, Int. J. Cancer, 63: 702-709, 1995). EF43.Fgf-4 produced rapidly developing tumors at all sites of inoculation, whereas EF43.Fgf-3 produced slowly growing tumors only in the mammary fat pad. Cells infected with the vector carrying the selection gene alone (EF43.C) were not tumorigenic. The angiogenic properties of these cells were tested in an in vitro angiogenesis model using human umbilical vein endothelial cells (HUVECs) cultured at the surface of a type I collagen gel and their capacity to form tube-like structures on invasion of the gel. Only the conditioned medium (CM) of EF43.Fgf-4 induced an angiogenic morphotype in HUVECs. In parallel, the mRNA expression of matrix metalloproteinase 1 and c-ETS-1 was increased in the HUVECs displaying a differentiated phenotype, whereas the tissue inhibitor of matrix metalloproteinase 1 mRNA level was decreased. Recombinant human fibroblast growth factor 4 (FGF-4) did not induce an angiogenic phenotype in HUVECs by itself. By Western blot analysis, a high expression of vascular endothelial growth factor (VEGF) was detected in the EF43.Fgf-4 CM. This result was confirmed by Northern blot analysis of total RNA extracted from the three cell types; the steady-state level of VEGF mRNA was low and equivalent in EF43.C and EF43.Fgf-3, whereas it was strongly increased in EF43.Fgf-4. Culturing EF43 cells carrying only the selection gene with increasing concentrations of recombinant human FGF-4 resulted in a dose-dependent stimulation of VEGF. The induction of the angiogenic morphotype and the parallel modulations of the biosynthetic phenotype in HUVECs were completely suppressed by adding a neutralizing antibody directed against VEGF to EF43.Fgf-4 CM. Furthermore, inhibition of protein kinase C by bisindoylmaleimide suppressed the angiogenic phenotype induced by the CM of EF43.Fgf-4. Our results point to an indirect angiogenic activity of FGF-4 through the autocrine induction of VEGF secretion by EF43.Fgf-4 cells, an original signaling pathway that might be significant in tumor progression and metastasis. [less ▲]

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See detailPrivate Multiple Congenital Anomaly Syndromes May Result from Unbalanced Subtle Translocations: T(2q;4p) Explains the Lambotte Syndrome
Herens, Christian ULg; Jamar, Mauricette ULg; Alvarez Gonzalez, Maria-Luz ULg et al

in American Journal of Medical Genetics (1997), 73(2), 127-31

In 1990, Lambotte syndrome was reported as an apparently autosomal recessive multiple congenital anomaly/mental retardation (MCA/MR) syndrome observed in 4 of 12 sibs from a probably consanguineous mating ... [more ▼]

In 1990, Lambotte syndrome was reported as an apparently autosomal recessive multiple congenital anomaly/mental retardation (MCA/MR) syndrome observed in 4 of 12 sibs from a probably consanguineous mating [Verloes et al., Am J Med Genet 1990; 37:119-123]. Major manifestations included intrauterine growth retardation (IUGR), microcephaly, large soft pinnae, hypertelorism, beaked nose, and extremely severe neurologic impairment, with holoprosencephaly in one instance. After the observation of a further affected child born of one unaffected sister, in situ hybridization analysis and chromosome painting techniques demonstrated a subtle t(2;4)(q37.1; p16.2) translocation in the mother, suggesting a combination of 2q/4p trisomy/monosomy in all of the affected children of the family. Many private sporadic or recurrent MCA/MR syndromes maybe due to similar symmetric translocations, undetectable by conventional banding techniques. [less ▲]

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See detailLe Démon du journalisme. Émergence et légitimation du reportage au XIXe siècle
Durand, Pascal ULg

Scientific conference (1997, December 12)

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See detailLes agences dans la fonction administrative et le modèle Augias : une analyse critique
Fecher-Bourgeois, Fabienne ULg

Conference given outside the academic context (1997)

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See detailLaboratory Diagnosis of Neonatal Bacterial Infections
Melin, Pierrette ULg

Conference (1997, December 11)

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See detailIntroduction à la sociologie des champs symboliques de Pierre Bourdieu
Durand, Pascal ULg

Scientific conference (1997, December 10)

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See detailL'infection vaginale: le diagnostic microbiologique
Melin, Pierrette ULg

Conference (1997, December 06)

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See detailAnimateur de l'atelier Intégration sociale et citoyenneté
Martiniello, Marco ULg

Scientific conference (1997, December 05)

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