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See detailEvidence for a Second Receptor Binding Site on Human Prolactin
Goffin, Vincent; Struman, Ingrid ULg; Mainfroid, V. et al

in Journal of Biological Chemistry (1994), 269(51), 32598-606

The existence of a second receptor binding site on human prolactin (hPRL) was investigated by site-directed mutagenesis. First, 12 residues of helices 1 and 3 were mutated to alanine. Since none of the ... [more ▼]

The existence of a second receptor binding site on human prolactin (hPRL) was investigated by site-directed mutagenesis. First, 12 residues of helices 1 and 3 were mutated to alanine. Since none of the resulting mutants exhibit reduced bioactivity in the Nb2 cell proliferation bioassay, the mutated residues do not appear to be functionally necessary. Next, small residues surrounding the helix 1-helix 3 interface were replaced with Arg and/or Trp, the aim being to sterically hinder the second binding site. Several of these mutants exhibit only weak agonistic properties, supporting our hypothesis that the channel between helices 1 and 3 is involved in a second receptor binding site. We then analyzed the antagonistic and self-antagonistic properties of native hPRL and of several hPRLs analogs altered at binding site 1 or 2. Even at high concentrations (approximately 10 microM), no self-inhibition was observed with native hPRL; site 2 hPRL mutants self-antagonized while site 1 mutants did not. From these data, we propose a model of hPRL-PRL receptor interaction which slightly differs from that proposed earlier for the homologous human growth hormone (hGH) (Fuh, G., Cunningham, B. C., Fukunaga, R., Nagata, S., and Goeddel, D. V., and Well, J. A. (1992) Science 256, 1677-1680). Like hGH, hPRL would bind sequentially to two receptor molecules, first through site 1, then through site 2, but we would expect the two sites of hPRL to display, unlike the two binding sites of hGH, about the same binding affinity, thus preventing self-antagonism at high concentrations. [less ▲]

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See detailSpecific transcription factors of the tumor BT-474 mammary cells regulate the c-erbB2 gene expression.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Gol-Winkler, Rose

Conference (1994, December 22)

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See detailA conserved 5' to 3' exonuclease activity in yeast and human nucleotide excision repair protein RAD2 and XPG
Habraken, Yvette ULg; Sung, Patrick; Prakash, Louise et al

in Journal of Biological Chemistry (1994), 269(50), 31342-5

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See detailLe théâtre religieux médiéval en langue d'oc
Henrard, Nadine ULg

Doctoral thesis (1994)

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See detailTraitement de l'ostéoporose: données actuelles et perspectives
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Franchimont, P.

in Revue du Rhumatisme (1994), 61(10, Pt 2), 155-164

Postmenopausal osteoporosis is characterized not only by a reduction in bone mass but also by bone microarchitecture alterations, which result in greater bone frailty and in an increased fracture risk ... [more ▼]

Postmenopausal osteoporosis is characterized not only by a reduction in bone mass but also by bone microarchitecture alterations, which result in greater bone frailty and in an increased fracture risk. Many drugs have been studied to determine whether they prevent bone loss or reduce the incidence of additional fractures in patients with established osteoporosis. Primary prevention of osteoporosis rests on regular exercising and adequate intake of dietary calcium. For secondary prevention in women undergoing menopause, replacement estrogen therapy given for at least ten years is associated with substantial reductions in fractures of the radius, hip, and spine. Other drugs capable of arresting postmenopausal bone loss include parenteral, nasal or rectal calcitonin and diphosphonates. However, the long-term safety of the latter requires further evaluation. Current studies are evaluating new molecules with potential preventive efficacy, such as ipriflavone. There is no general consensus about the efficacy of treatments for established osteoporosis with fractures. To date, no controlled studies have demonstrated a reduction in the incidence of further fractures in patients given calcium alone. Studies of hydroxylated vitamin D derivatives have been disappointing, although daily administration of vitamin D3 in combination with calcium significantly reduced the incidence of nonvertebral fractures in a population of elderly institutionalized subjects. Plausible explanations for this effect include increased vitamin D levels and reduced parathyroid levels in the bloodstream. Parenteral or nasal calcitonin stabilizes or increases bone mineral content in both cancellous and cortical bone. This effect is especially marked in high-turn-over patients. Several lines of evidence suggest that calcitonin therapy has a protective effect against vertebral and hip fractures. In patients with osteoporosis, oral or intravenous diphosphonates are associated with a significant increase in cancellous bone mass with no loss of cortical bone. Etidronate may be especially beneficial in severe osteoporosis with marked loss of bone and multiple vertebral crush fractures. Fluoride stimulates the growth and synthetic activity of osteoblasts. Accurate information is needed on the optimal dosage of fluoride, on the effects of fluoride on the appendicular skeleton, and, above all, on the biomechanical properties of the bone produced under fluoride therapy. In addition to these commercially available drugs, several other agents are at various stages of the development process.(ABSTRACT TRUNCATED AT 400 WORDS) [less ▲]

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See detailPyridothiadiazines inhibit glucose-induced insulin release by activating ATP-sensitive K+ channels
Lebrun, P.; Antoine, M. H.; Ouedraogo, R. et al

Conference (1994, December 10)

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See detailModélisation de l'impact du tunnel de Kinkempois sur la nappe alluviale de la Meuse
Dassargues, Alain ULg; Monjoie, Albéric

Report (1994)

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See detailFumure azotée et protection fongicide des céréales d'hiver en Belgique
Bodson, Bernard ULg; Meeus, Patrick; Falisse, André

in Quatrième conférence internationale sur les maladies des plantes (1994, December 06)

The determination and the splitting of winter cereals nitrogen fertilisation as proposed and used in Belgium include three applications (tillering, beginning of stem elongation, flag leaf). While ... [more ▼]

The determination and the splitting of winter cereals nitrogen fertilisation as proposed and used in Belgium include three applications (tillering, beginning of stem elongation, flag leaf). While permitting to improve yield and haven quality, this largely contribute to limit croptogamic diseases development and thus the number of fungicide treatments needed to achieve an economic optimum. [less ▲]

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See detailMaladie de Kaposi chez une patiente souffrant d'une immunodéficience acquise VIH négative
Nikkels, Arjen ULg; Collignon, Jacques ULg; Moutschen, M. P. et al

in Presse Médicale (1994), 23(38), 1760-1761

A 79-year-old woman of Mediterranean ascent suffered from corticosteroid-dependent chronic obstructive lung disease, hypogammaglobulinemia (IgG 1 and 2), decreased CD16 natural killer cell function and ... [more ▼]

A 79-year-old woman of Mediterranean ascent suffered from corticosteroid-dependent chronic obstructive lung disease, hypogammaglobulinemia (IgG 1 and 2), decreased CD16 natural killer cell function and non-HIV related CD4 and CD8 lymphopenia. Such immunodeficiency could be either a variant of common variable immunodeficiency or an early stage of the idiopathic CD4 + T lymphocytopenia syndrome. She developed bilateral lesions of Kaposi's sarcoma on the lower extremities resembling the classic European type of the disease. The tumors contained both CD34 + and Factor XIIIa + cells. The HLA-DR5 haplotype was not found. Weekly low intravenous dosages of vinblastine improved the lesions but the patient died from pontic infarction. [less ▲]

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See detailEpithelial-to-Mesenchymal Transition in Hpv-33-Transfected Cervical Keratinocytes Is Associated with Increased Invasiveness and Expression of Gelatinase A
Gilles, Christine ULg; Polette, M.; Piette, Jacques ULg et al

in International Journal of Cancer = Journal International du Cancer (1994), 59(5), 661-6

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on ... [more ▼]

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on collagen rafts. Cell lines from the first group reconstituted CINIII-like lesions, whereas cell lines from the second group reconstituted epithelia comparable to micro-invasive carcinomas. They were thus postulated to represent distinct stages of cervical carcinogenesis. The present results have shown that lines from group I, which have conserved an epithelial morphology in monolayer, (i) could not invade matrigel when tested in a modified Boyden chamber assay, (ii) produced solely gelatinase B and (iii) were unable to activate exogenous gelatinase A. On the other hand, lines from group II associated epithelial-to-mesenchymal transition (acquisition of elongated morphology, vimentin positivity) with high in vitro invasive potential and with the ability both to produce and to activate gelatinase A. These results strongly support the hypothesis that the epithelial-to-mesenchymal transition and the associated events might be implicated in the progression to the metastatic phenotype. [less ▲]

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See detailVHRS: the Very High Resolution Spectrograph for the VLT.
Magain, Pierre ULg; Dekker, H.; Delabre, B.

in Future VLT Instruments: Scientific Drivers and Concept Definitions (1994, December 01)

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See detailA kinetic model of the formation of the hot oxygen geocorona. 1: Quiet geomagnetic conditions
Shematovich, V. I.; Bisikalo, D. V.; Gérard, Jean-Claude ULg

in Journal of Geophysical Research (1994), 99

A model of the hot oxygen geocorona in the transition region near the exobase is described. It is based on a Monte Carlo solution of the nonlinear Boltzmann equation for hot oxygen atoms produced by ... [more ▼]

A model of the hot oxygen geocorona in the transition region near the exobase is described. It is based on a Monte Carlo solution of the nonlinear Boltzmann equation for hot oxygen atoms produced by chemical processes usually considered as a source of hot oxygen (photodissociation of O2 and dissociative recombination of O2(+) and NO(+) ions). The evolution of the system is described stochastically as a series of random Markovian processes. The energy distribution function of the thermal and non-thermal O(3P) atoms and of the nonthermal O(1D) atoms is calculated from the thermospheric collision-dominated region to the exosphere where the gas flow is virtually collisionless. The model is applied to equatorial latitudes for conditions of low solar and geomagnetic activity. Numerical simulations show that the distribution function of thermal oxygen is increasingly perturbed by collisions with the hot oxygen population at high altitudes and departs significantly from a Maxwellian distribution at all altitudues. The number density and temperature of the nonthermal oxygen atoms are derived from their microscopic distribution function and found tobe in qualitative agreement with previous theoretical and experimental estimates. [less ▲]

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See detail(Erratum) Further observational evidence that MG J0414+0534 is a gravitational mirage.
Angonin-Willaime, M.-C.; Vanderriest, C.; Hammer, F. et al

in Astronomy and Astrophysics (1994), 292

In Sect. 3.3, the identifications of components A1 and A2 for the optical data were inadvertently inverted. This does not change substantially the discussion; just read A1 for A2 and vice versa. In ... [more ▼]

In Sect. 3.3, the identifications of components A1 and A2 for the optical data were inadvertently inverted. This does not change substantially the discussion; just read A1 for A2 and vice versa. In particular, the ratio A2/A1 = 0.3 cannot be made compatible with the radio value without one or several of the mechanisms we suggested. We apologize for the error and thank Dr S. Mao for bringing it to our attention. Erratum to Astron. Astrophys. 281, 388-394 (1994) [less ▲]

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See detailA flare event on HR2517
Sterken, C.; Manfroid, Jean ULg

in Information Bulletin on Variable Stars (1994), 4120

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See detailNomenclature stellaire et catalogues astronomiques - II.
Manfroid, Jean ULg; Renson, Pierre ULg

Article for general public (1994)

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