References of "Winkler, Rose"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailCharacterization of the IGF system and analysis of the possible molecular mechanisms leading to IGF-II overexpression in a mesothelioma.
Hodzic, D.; Delacroix, Laurence ULg; Willemsen, P. et al

in Hormone & Metabolic Research (1997), 29(11), 549-55

The expression of members of the IGF system in a mesothelioma from a patient suffering from hypoglycemia, in term placenta and HT29 colon adenocarcinoma cells were compared. Very high levels of IGF-II ... [more ▼]

The expression of members of the IGF system in a mesothelioma from a patient suffering from hypoglycemia, in term placenta and HT29 colon adenocarcinoma cells were compared. Very high levels of IGF-II mRNA and protein were detected in the mesothelioma. Moreover, half of the IGF-II protein took the high-molecular-weight form. We also analyzed the parental imprinting status and the promoter usage of the IGF-II gene. Our results showed loss of imprinting (LOI) in the mesothelioma while the imprinting was maintained in HT29 cells, expressing moderate levels of the transcript. Promoter P4 was active in the three tissues we analyzed, whereas IGF-II mRNA transcription from promoter P3 was only detected in the mesothelioma and the placenta, expressing comparably high levels of the transcript. IGF-II gene structure was identical in the analyzed tissues and cells. The type-I receptor mRNA expression was very low in the tumor. IGFBP-2, -4 and -5 mRNAs were detected in the mesothelioma, while IGFBP-2, -3 and -5 transcripts were detected in the placenta. IGFBP-1 and -6 transcripts were not detected. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailMolecular dissection of the insulin-like growth factor axis in the human thymus
Geenen, Vincent ULg; Kecha, Ouafae; Achour, Imane et al

in Diabetologia (1997), 40

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailCharacterization of the insulin-like growth (IGF) axis in the human thymus
Kecha, Ouafae; Achour, Imane; Martens, Henri ULg et al

in The Endocrine Society (Ed.) Proceedings of the 77th Annual Meeting of the Endocrine Society (1997)

Detailed reference viewed: 6 (0 ULg)
Peer Reviewed
See detailLoss of one Ha-rasl allele in some human colorectal tumours
Lambert, S. A.; Martial, Joseph ULg; Winkler, Rose ULg

in Leukemia Research (1986), 10

Detailed reference viewed: 6 (0 ULg)