References of "Vandenput, Sandrina"
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See detailScintigraphical Evaluation of Alveolar Clearance in Horses
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, D. H. et al

in Veterinary Journal (1998), 156(1), 51-58

This study proposed a standardized method for measuring alveolar epithelium membrane permeability in the horse. The normal rate of clearance (%.min-1) from lung into blood of nebulized 99mTc-DTPA has been ... [more ▼]

This study proposed a standardized method for measuring alveolar epithelium membrane permeability in the horse. The normal rate of clearance (%.min-1) from lung into blood of nebulized 99mTc-DTPA has been established for healthy horses (Group A) compared with values obtained with horses suffering from chronic obstructive pulmonary disease (COPD; Group B). The 99mTc-DTPA clearance was measured in the caudoventral (R1) and in the half caudal (R2) parts of the left lung during different time intervals. The two regions aimed to define the influence of the airways on measured clearance (R2 contained proportionally more conducting airways than R1). It was concluded that a comparison of groups of subjects may be performed in R2 and on data collected during a 20 min period. The normal clearance rate in R2 was 1.80 +/- 0.46%.min-1 (T1/2R2 = 40.99 +/- 12.45 min) in Group A. In Group B, a significantly faster 99mTc-DTPA transfer rate was found (4.17 +/- 0.83%.min-1 or T1/2R2 = 17.17 +/- 3.38min). Bronchoalveolar lavage (BAL) suggested that the increased permeability measured in Group B could be the result of lung inflammatory responses. Our results have demonstrated the ability of the 99mTc-DTPA clearance test to detect alveolar epithelial damage in horses. Furthermore, we were able to show that a regional analysis of the alveolar-capillary barrier integrity may be performed satisfactorily in the equine patient. [less ▲]

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See detailEffect of a set stabled environmental control on pulmonary function and airway reactivity of COPD affected horses
Vandenput, Sandrina ULg; Votion, Dominique ULg; Duvivier, D. H. et al

in Veterinary Journal (1998), 155(2), 189-195

The aim of this study was to evaluate the respiratory function of horses affected with chronic obstructive pulmonary disease (COPD) when maintained in a barn on wood shavings and fed grass silage for a ... [more ▼]

The aim of this study was to evaluate the respiratory function of horses affected with chronic obstructive pulmonary disease (COPD) when maintained in a barn on wood shavings and fed grass silage for a period of 6 weeks. The mechanics of breathing, blood gas analysis and bronchial reactivity were examined on five horses with COPD at the end of the environment-controlled period (Period B) and the results compared with values obtained after 2 months at pasture (Period A) and after the onset of clinical signs of acute crisis (Period C). The results showed that clinical and functional parameters were similar in healthy horses and in COPD horses placed on pasture or stabled and fed grass silage. Moreover, the bronchial reactivity of COPD horses at pasture was similar to the bronchial reactivity of healthy horses. COPD horses fed grass silage however presented a bronchial reactivity intermediate between those measured after Period A and Period C which suggested they would be more susceptible to develop bronchoconstriction when in contact with inhaled irritants. [less ▲]

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See detailAirway response of horses with COPD to dry powder inhalation of ipratropium bromide
Duvivier, Dominique Hannia; Votion, Dominique ULg; Vandenput, Sandrina ULg et al

in Veterinary Journal (1997), 154(2), 149-53

To determine the effects of the dry powder inhalation (DPI) of ipratropium bromide (ipratropium) on the airways of health horses and the dose-response curve in horses suffering from chronic obstructive ... [more ▼]

To determine the effects of the dry powder inhalation (DPI) of ipratropium bromide (ipratropium) on the airways of health horses and the dose-response curve in horses suffering from chronic obstructive pulmonary disease (COPD) by means of pulmonary function tests, five healthy horses were first studied. Ipratropium (2400 micrograms ipratropium horse-1) was contained in gelatine capsules and administered using a dry powder device connected to an adapted face mask. Pulmonary function tests were recorded before inhalation and 15 and 60 min after inhalation. No modification of pulmonary function was observed. The airway response to ipratropium DPI was then determined in six horses suffering from COPD. To induce airway obstruction, the horses were bedded on straw and fed hay. When the maximal change in pleural pressure during tidal breathing exceeded 1.96 kPa, pulmonary function tests were recorded before DPI, and 15 and 60 min post-inhalation. Placebo (six capsules horse-1) or ipratropium (600, 1200 and 2400 micrograms horse-1) was administered in a randomized order to each horse using the dry powder device and the adapted face mask. Neither ipratropium nor placebo DPI affected respiratory frequency (f) or tidal volume (VT). Inhalation of 600 micrograms ipratropium horse-1 resulted in a delayed decrease of total pulmonary resistance (RL) whereas dynamic compliance (Cdyn) was improved (although not significantly) at both times of measurement when compared with values following placebo inhalation. Simultaneous decreased RL and increased Cdyn, was observed within 15 min after DPI of 1200 micrograms ipratropium horse-1 and persisted for the 1 h duration of the experiment. Doubling the dose also improved pulmonary function but not significantly more than following inhalation of 1200 micrograms ipratropium. No systemic side effects were observed in either group of horses. [less ▲]

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See detailAnalysis of Equine Scintigraphical Lung Images
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, H. et al

in Veterinary Journal (1997), 153(1), 49-61

A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to ... [more ▼]

A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to establish reference ranges of I/Q distribution pattern. Computed I/Q images were divided in three regions based on the activity due to the inhalation (I) versus perfusion (Q) procedure. For each region a regional mismatching factor (Iri), i.e. the I/Q of the region, and an intraregional mismatching factor (Lri), which expresses the variability of pixels' I/Q within the region, were calculated. The Per(Ri) and Cen(Ri), which are the percentage of pixels in the parenchymal and in the central parts of the lung belonging to the region, were also computed. Results of this analysis showed a good match between I and Q distribution pattern. [less ▲]

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See detailPemphigus foliacé dans l'espèce équine : synthèse et description de 2 cas.
Amory, Hélène ULg; Beco, Luc; Desmecht, Daniel ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailTreatment of COPD horses by dry powder inhalation of ipratropium bromide
Duvivier, D. H.; Votion, Dominique ULg; Vandenput, Sandrina ULg et al

in Proceedings of the 36th British Equine Veterinary Association Congress (1997)

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See detailAlveolar clearance in COPD horses
Votion, Dominique ULg; Duvivier, D. H.; Vandenput, Sandrina ULg et al

in Proceedings of the 36th British Equine Veterinary Association Congress (1997)

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See detailAerosol therapy in the equine species
Duvivier, Dominique Hannia; Votion, Dominique ULg; Vandenput, Sandrina ULg et al

in Veterinary Journal (1997), 154(3), 189-202

Inhalation therapy plays an increasing role in the management of equine respiratory disorders. This alternative to systematic treatment permits a high concentration of medication to act locally while ... [more ▼]

Inhalation therapy plays an increasing role in the management of equine respiratory disorders. This alternative to systematic treatment permits a high concentration of medication to act locally while minimizing side effects and residues. In human medicine, literature in this field is prolific and continuously renewed, whereas in veterinary medicine, applications of aerosol therapy are less extensive. This review considers the principles of action of the different types of devices used for inhalation, i.e., nebulization, metered-dose inhalation and dry powder inhalation, describes the technical and practical requirements for their use in the equine species and considers the advantages and disadvantages of each inhalation device. The pharmacological agents currently administered to horses by inhalation are also discussed. Perspectives of aerosol therapy in the equine species, including aerosols already used in human medicine and their potential applications for horses are described [less ▲]

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See detailTechnical validation of a face mask adapted for dry powder inhalation in the equine species
Duvivier, Dominique Hannia; Votion, Dominique ULg; Vandenput, Sandrina ULg et al

in Equine Veterinary Journal (1997), 29(6), 471-476

Development of dry powder inhalation (DPI) for horses requires the use of an adapted face mask. In experiment I, 4 masks (A, B, C and D) were tested and factors influencing the delivery of the dry powder ... [more ▼]

Development of dry powder inhalation (DPI) for horses requires the use of an adapted face mask. In experiment I, 4 masks (A, B, C and D) were tested and factors influencing the delivery of the dry powder were determined. Mask A was one which is commercially available for metered-dose inhalation. Mask B had the same shape as Mask A but an airtight rubber seal was added for the connection between the mask and horse's head. Mask C was a prototype adapted for DPI with connection for the DPI device between the nostrils, airtight expiratory valves in front of each nostril and airtight rubber seal to attach the mask on the horse's head. Mask D was the same as Mask C but the airtight expiratory valve was situated in front of one nostril and the connection for the DPI device was placed in front of the other nostril. Inhalet emptying and peak inspiratory pressure were measured on 5 healthy horses with each face mask. Both Masks A and B gave a low rate of inhalet emptying. Inspiratory pressures created in Masks C and D were negative enough to ensure inhalet emptying rates of mean +/- s.d. 98.28 +/- 1.79% and 100% respectively. In experiment 2, the face masks giving the greatest inhalet emptying were used to test the therapeutic efficacy of ipratropium bromide DPI. This was tested on 6 horses suffering from acute exacerbation of chronic obstructive pulmonary disease (COPD). At a dose of 200 micrograms/100 kg bwt, ipratropium administered with Mask D improved significantly pulmonary function measurements compared to baseline values and placebo inhalation. With Mask C, a double dose of ipratropium (400 micrograms/100 kg bwt) was necessary to improve these parameters compared to baseline values. This indicated the importance of locating the DPI device in front of one nostril. It was concluded that inhalet emptying is correlated to inspiratory pressures measured in the face masks. Secondly, these pressures are in turn dependent on the air-tightness of the mask, i.e. air-tightness of the expiratory valve and close connection between the horse's head and the mask. Thirdly, position of the DPI device in front of a nostril allows bronchodilation at a dose half that required when the device is placed between the nostrils. Finally DPI using Mask D (EquiPoudre) is a rapid, effective and well tolerated inhalation treatment for COPD horses. [less ▲]

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See detailAirborne dust and aeroallergen concentrations in different sources of feed and bedding for horses
Vandenput, Sandrina ULg; Istasse, Louis ULg; Nicks, Baudouin ULg et al

in Veterinary Quarterly (The) (1997), 19(4), 154-158

Standardized methods were used to make quantitative and qualitative assessments of respirable dust and aeroallergens in feed and bedding for horses. Concentrations of airborne dust were measured by using ... [more ▼]

Standardized methods were used to make quantitative and qualitative assessments of respirable dust and aeroallergens in feed and bedding for horses. Concentrations of airborne dust were measured by using a Rion particle counter, and levels of major aeroallergens implicated in chronic obstructive pulmonary disease were measured by using an Andersen sampler. Laboratory conditions allowed comparison of the different sources of forage, supplements, and bedding without external influences such as ventilation, external temperature and horse activity affecting the result. Grass silages of approximately 50% dry matter and alfalfa pellets appeared to be very good sources of forage with low levels of dust and aeroallergens. The studied good quality straw was significantly less dusty with fewer allergens than the wood shavings. Supplements, such as whole grains and molassed concentrates, contained many respirable particles and aeroallergens. Rolled grains were significantly more dusty than good hay. [less ▲]

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See detailEffects of romifidine on pulmonary function in horses with chronic obstructive pulmonary disease in clinical remission
Votion, Dominique ULg; Ghafir, Yasmine; Vandenput, Sandrina ULg et al

in Pflügers Archiv : European Journal of Physiology (1996), 431(6), 324

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See detailImprovement of pulmonary function in COPD horses due to environmental management
Vandenput, Sandrina ULg; Votion, Dominique ULg; Duvivier, D. H. et al

in Pflügers Archiv : European Journal of Physiology (1996), 432(4), 143

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See detailEffect of serotonergic blockade on calf pulmonary function after the intravenous administration of 3-methylindole
Linden, Annick ULg; Desmecht, Daniel ULg; Vandenput, Sandrina ULg et al

in Journal of Comparative Pathology (1996), 114(4), 361-371

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked ... [more ▼]

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked increase of respiratory rate, decrease of tidal volume and increase in minute ventilation. Pulmonary mechanics values were also profoundly affected, lung dynamic compliance being reduced to approximately one-third of its baseline value and total pulmonary resistance being increased two-fold. Arterial oxygen partial pressure was dramatically reduced. Successive challenges with 3-Mi after physiological saline pretreatment resulted in quantitatively identical alterations of pulmonary function values. Conversely, all these ventilatory, mechanical and gas exchange changes were abolished by pretreatment with serotonergic antagonists. It was concluded that intravenous administration of 3-Mi to healthy calves induced immediate and reversible bronchoconstriction which affected both central and peripheral airways. Because the effect was abolished by pretreatment with antiserotonin drugs, it is suggested that 3-Mi acts either directly by stimulating serotonergic receptors or indirectly through the release of serotonin from platelets. Current concepts of the physiopathological cascade underlying the toxicity of 3-Mi should, therefore, be re-evaluated in the light of this pharmacological mechanism. [less ▲]

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See detailDermatophylose équine: revue à partir d'un cas clinique
Vandenput, Sandrina ULg; Manteca, C.; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1996), 140(2), 125-129

From a clinical case of equine dermatophilosis, a short review of literature is proposed. The aetiology, causal factors, symptoms and lesions are brievely reviewed. Therapeutics and prophylaxis are ... [more ▼]

From a clinical case of equine dermatophilosis, a short review of literature is proposed. The aetiology, causal factors, symptoms and lesions are brievely reviewed. Therapeutics and prophylaxis are outlined. [less ▲]

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See detailCardio-respiratory adjustments and arterial blood gases in exercising horses in crisis and in clinical remission
Art, Tatiana ULg; Anciaux, N.; Duvivier, H. et al

in Pferdeheilkunde (1996), 12(4), 717-718

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See detailNonspecific airway responsiveness of COPD horses : effects of environmental control
Vandenput, Sandrina ULg; Votion, Dominique ULg; Anciaux, N. et al

in Pflügers Archiv : European Journal of Physiology (1996), 431(6), 324

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See detailMaladie pulmonaire obstructive chronique dans l'espèce équine
Vandenput, Sandrina ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Equine chronic obstructive pulmonary disease (COPD), also known as <<heaves>>, is a respiratory syndrome associated with stabling or exposure to hay or conditions in which molds or dust prevail. This ... [more ▼]

Equine chronic obstructive pulmonary disease (COPD), also known as <<heaves>>, is a respiratory syndrome associated with stabling or exposure to hay or conditions in which molds or dust prevail. This paper reviews the different aspects of the equine COPD. Etiology, potential evolutions, treatment and prevention of this disease are evolved. [less ▲]

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See detailLa traction : un effort impressionnant
Art, Tatiana ULg; Crigel, M. H.; Vandenput, Sandrina ULg et al

in Pastoret, Paul-Pierre; Laurant, P.; Courtois, R. (Eds.) et al Le Cheval Ardennais (1996)

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See detailTherapeutic efficacy of ipratropium bromide inhaled from a dry powder inhaler in COPD horses
Duvivier, D. H.; Art, Tatiana ULg; Vandenput, Sandrina ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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