References of "Valdes Socin, Hernan Gonzalo"
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See detailMale hypogonadism caused by insolated LH deficiency : From pathology to gene, from gene to physiology
Valdes Socin, Hernan Gonzalo ULg; Salvi, R.; Pralong, F. et al

in The 85th Annual Meeting of the Endocrine Society - Abstract book (2003)

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See detailLong-term prognosis of congestive heart failure in patients with acromegaly
Bihan, H.; Valdes Socin, Hernan Gonzalo ULg; Levasseur, S. et al

in The 85th Annual Meeting of the Endocrine Society - Abstract book (2003)

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See detailThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
Valdes Socin, Hernan Gonzalo ULg; Chanson, Philippe; Delemer, B. et al

in European Journal of Endocrinology (2003), 148(4), 433-442

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 ... [more ▼]

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 male and 20 female) among 4400 pituitary adenomas followed between 1976 and 2001 in six Belgian and French centers. RESULTS: TSH was elevated in 18/43 and alpha subunit in 13/32 patients. In patients with intact thyroid (n=30), mean free tri-iodothyronine was 13.1 pmol/l (range 3.5-23) and mean free thyroxine was 38.4 pmol/l (range 10.2-62.7). Hyperprolactinemia and acromegaly were associated in 9/43 and 8/43 cases. The number of associated hypersecretions was higher in macroadenomas than in microadenomas (Chi square = 11.2, P<0.01). Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome. The proportion of microadenomas versus macroadenomas was 1/11 (period 1974-1986) and 8/32 (period 1987-2001). Bilateral petrosal sinus sampling, (111)In-pentreotide scintigraphy and ((11)C)-l-methionine positron emission tomography scan confirmed diagnosis in four questionable microadenomas. Macroadenomas with extrasellar extension (31 cases) had a tendency to be medially located. Medical treatment with somatostatin analogs was initiated as first-line treatment in 26 patients. TSH levels were reduced by more than 50% in 23/26 cases. A tumoral shrinkage of more than 20% was observed in 5/13 cases. Surgery was performed in 36 patients. After 1 year, 21 of them (58.3%) met the criteria of surgical favorable outcome. Pituitary radiotherapy (n=8) and somatostatin analogs allowed normalization in cases not cured by surgery. CONCLUSION: Ultrasensitive methods for TSH measurement led to an earlier recognition of TSH-secreting pituitary tumors. In this series, we observed that TSH-secreting pituitary tumors are today more frequently found at the stage of microadenomas, medially located, without associated hypersecretions and needing new exploration methods as compared with older series. This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease. [less ▲]

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See detailLe cas clinique du mois. Masse médiastinale antérieure chez une patiente acromégale.
Laret, Vinciane ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Revue Médicale de Liège (2003), 58(12), 724-728

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the ... [more ▼]

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the first diagnostic step consists of finding the etiology of the disease in order to use adequate treatment. This can be complicated by the fact that acromegaly can be associated with other tumors (for instance in MEN-1 disease and Carney Complex) and because chronic GH hypersecretion can stimulate tumor overgrowth and perhaps tumor formation. We describe the case of a 44-year-old acromegalic woman with an anterior mediastinal mass. We present the different diagnoses and a review of the literature. [less ▲]

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See detailNéoplasie endocrinienne multiple de type 1 : De la clinique au gène
Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg; Vanbellinghen, Jean-François ULg et al

in Feuillets de Biologie (2003), 44(250), 39-48

La Néoplasie Endocrinienne Multiple de type 1 (NEM 1), syndrome génétique à transmission autosomique dominante, est caractérisée principalement par l'atteinte des parathyroïdes, du tractus gastro-entéro ... [more ▼]

La Néoplasie Endocrinienne Multiple de type 1 (NEM 1), syndrome génétique à transmission autosomique dominante, est caractérisée principalement par l'atteinte des parathyroïdes, du tractus gastro-entéro-pancréatique et de l'antéhypophyse. Les manifestations cliniques de ce syndrome sont polymorphes. En fonction de l'organe affecté elles peuvent se manifester par l'hypersécrétion hormonale, par un syndrome de masse dû à la taille tumorale, ou parfois par l'apparition d'un cancer. Le gène responsable de la NEM 1 a été identifié sur le chromosome 11, locus 11q13. Il s'agit d'un gène supresseur de tumeur qui code pour une protéine dénommée ménine. Dans cet article nous aborderons les aspects cliniques et génétiques typiques de cette affection. [less ▲]

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See detailThe treatment of sporadic versus MEN1-related pituitary adenomas.
Beckers, Albert ULg; Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Internal Medicine (2003), 253(6), 599-605

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single ... [more ▼]

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single or a combination of three different methods: surgery, medication and radiotherapy. The rationale for deciding the treatment are many but include the aggressiveness of the tumour. The aetiologies of sporadic pituitary adenomas are not fully understood. However, several causes have been identified resulting in specific familial phenotypes like multiple endocrine neoplasia type I (MEN1). MEN1 is related to mutations in the MEN1 gene, a tumour suppressor gene localized on chromosome 11q13 and which encodes menin, a 610 amino acid protein. During the last years, an evidence progressively emerged that MEN1-related adenomas were more aggressive and less responsive to therapy than their sporadic counterparts. In this article, we review the differences between sporadic and MEN1-related adenomas and suggest specific ways of treatment and follow-up for MEN1-related tumours. [less ▲]

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See detailAcromégalie et grossesse
Betea, Daniela ULg; Valdes Socin, Hernan Gonzalo ULg; Hansen, Isabelle ULg et al

in Annales d'Endocrinologie (2002), 63(5), 457-63

Acromegaly usually results from GH hypersecretion by a somatotroph adenoma. The fertility of acromegalic patients is often impaired. Several factors may impact the course of pregnancy in acromegaly ... [more ▼]

Acromegaly usually results from GH hypersecretion by a somatotroph adenoma. The fertility of acromegalic patients is often impaired. Several factors may impact the course of pregnancy in acromegaly. Disturbed pituitary function might lead to infertility or spontaneous abortion. GH is a powerful insulin antagonist, and pregnant acromegalic patients are prone to added glucose intolerance and diabetes. Pregnancy itself might also impact the course of the pituitary tumor. During pregnancy, the normal pituitary increases in size due to estrogens-mediated hyperplasia. Therefore, tumors are at risk for hemorrhage due to enhanced vascularity, and might compress the optic chiasm. In this article we summarize the data on the literature on the reciprocal influences between acromegaly and pregnancy, we discuss therapeutic options and advance diagnostic and surveillance schedules of acromegaly during pregnancy. [less ▲]

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See detailFamilial colloid cyst of the third ventricle: neuroendocrinological follow-up and review of the literature.
Valdes Socin, Hernan Gonzalo ULg; Born, J.; Wallemacq, Caroline et al

in Clinical Neurology & Neurosurgery (2002), 104(4), 367-370

Colloid cysts of the third ventricle are rare, benign cysts of endodermal origin. Between 1989 and 1999, eight patients with this lesion (five females, three males), with a mean age of 40.5 years (range ... [more ▼]

Colloid cysts of the third ventricle are rare, benign cysts of endodermal origin. Between 1989 and 1999, eight patients with this lesion (five females, three males), with a mean age of 40.5 years (range 20-54), were identified out of 1354 operated for tumours of the central nervous system. Among the eight, two were familial. They were half sisters 38 and 28 years-old, who were diagnosed to have colloid cysts of the third ventricle on CT scanning. Transcortical excision yielded 10 and 15 mm sized colloid cysts, respectively. Moreover, both sisters developed a multinodular goiter associated with these congenital tumours. The second sibling developed hyperprolactinemia associated with macroprolactinemia. Pregnancy was only possible after bromocriptine treatment. These cases provide further evidences that colloid cysts probably have an autosomic recessive pattern of inheritance with variable penetrance. [less ▲]

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See detailHirsutisme et hyperthrycose
VALDES SOCIN, Hernan Gonzalo ULg

Scientific conference (2002, June 04)

L'hypertrycose est un ecause fréquente de consultation chez les femmes, et souvent invalidante sur le plan psychologique. L'objet de cette présentation est de différencier l'hirsutisme (de cause ... [more ▼]

L'hypertrycose est un ecause fréquente de consultation chez les femmes, et souvent invalidante sur le plan psychologique. L'objet de cette présentation est de différencier l'hirsutisme (de cause endocrinienne) de l'hypertycose (constitutionnelle). Nous rappelons la sémiologie, la mise au point biologique, la physiopathologie et les différentes explorations de l'hyperandrogénie, qui déterminent ube prise en charge appropriée. [less ▲]

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See detailAnomalies hypophysaires chez le sujet age avec insuffisance renale chronique
Valdes Socin, Hernan Gonzalo ULg; Magis, Delphine ULg; Betea, Daniela ULg et al

in Revue Médicale de Liège (2002), 57(6), 375-381

Chronic renal failure (CRF) in the elderly is a cause of multiple endocrine dysfunctions. The three most common pituitary axes involved are the thyrotrope, lactotrope and gonadotrope axes. Thyroid ... [more ▼]

Chronic renal failure (CRF) in the elderly is a cause of multiple endocrine dysfunctions. The three most common pituitary axes involved are the thyrotrope, lactotrope and gonadotrope axes. Thyroid dysfunction may be the consequence of thyroid or pituitary failure. Hyperprolactinemia results in gonadal failure and is present in 30% of patients. Early presentation of menopause and andropause are common in patients with CRF. Sexual hormonal replacement is controversial and must be individually tailored. We propose a systematic screening in the elderly with CRF: determination of TSH, TPO antibodies and cervical palpation, measures of PRL, LH, FSH and testosterone to explore lactotrope and gonadotrope axis. [less ▲]

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See detailMaladie de Cushing et adénome corticotrope: fonctions antéhypophysaires avant et après microchirurgie transsphénoidale
Martin, Didier ULg; Valdes Socin, Hernan Gonzalo ULg; Beckers, Albert ULg et al

in Neuro-Chirurgie (2002), 48(2-3, Pt 2), 226-233

Background and purpose. - Cushing's disease is characterized by an overproduction of ACTH inducing an hypersecretion of corticosteroids. We assessed the non-corticotrophic pituitary functions before and ... [more ▼]

Background and purpose. - Cushing's disease is characterized by an overproduction of ACTH inducing an hypersecretion of corticosteroids. We assessed the non-corticotrophic pituitary functions before and after microsurgical resection of the corticotrophic adenoma. Methods. - We reviewed retrospectively a series of 98 patients (19 males, 79 females) undergoing transsphenoidal surgery between 1974 and 2001. Prolactin levels, somatrotrophic, gonadotrophic and thyroidotrophic functions were assessed and compared before and after resection of the adenoma. Results. - Before surgery, we observed an elevation of prolactin and a reduction of the GH, TSH, LH and FSH levels. These modifications were not linked to the volume of the adenoma but depended on the systemic effect of the hypercorticism or on local paracrine mechanisms. Selective adenomectomy usually restored altered corticotrophic and also, unlike (partial or total) hypophysectomy, the non-corticotrophic functions. Conclusions. - Non-corticotrophic functions are often altered in Cushing's disease but can be restored after selective adenomectomy. [less ▲]

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See detailDiagnostic differentiel et traitement medical dans la maladie de Cushing.
Beckers, Albert ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Neuro-Chirurgie (2002), 48(2-3 Pt 2), 163-172

Cushing's disease remains a difficult diagnosis in spite of new technical procedures such as pituitary MRI, selective bilateral petrosal or cavernous sampling, (111)In pentreotide scan and 18 ... [more ▼]

Cushing's disease remains a difficult diagnosis in spite of new technical procedures such as pituitary MRI, selective bilateral petrosal or cavernous sampling, (111)In pentreotide scan and 18 Flurodeoxyglucose pituitary PET scan. In this article, we review biological diagnostic procedures of Cushing's disease and corticotroph adenomas. According to our experience and the literature, we summarize the approach in medical treatment of Cushing's disease. [less ▲]

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See detailLe cathétérisme bilatérale des sinus pétreux avec dosages multihormonaux dans la maladie de Cushing
Valdes Socin, Hernan Gonzalo ULg; Bataille, Yoann ULg; Meurisse, Nicolas ULg et al

in Annales d'Endocrinologie (2002), 63(1), 23-30

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI ... [more ▼]

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI, surgical findings and multihormonal BPSS. Seven patients (6F/1M) with Cushing's disease, mean age at diagnosis of 35 years (range 24-55) were prospectively studied to compare radiological and multihormonal BPSS data with surgical and pathological findings. In untreated patients, simultaneous measures of ACTH, TSH and prolactine (PRL) were done at time 0, 7, 15, 22 minutes after CRH (500 mg) and TRH (200 mg) stimulation. An intersinus gradient of 1.4 was considered as a lateralisation. All microadenomas were identified during surgery, diameters ranged from 2 to 7 mm. All patients were in long-term surgical remission. Pathological studies confirmed a tumoral tissue with ACTH immunostaining in 6/7 cases and PRL in 3/7 cases. Pituitary MRI correctly identified tumors in 4 cases, the remaining tumors were not seen. Basal and stimulated intersinus gradients of ACTH, TSH and PRL were homolateral in 6/7 cases and were coincident with surgical findings in 4/7 cases. The other three cases were contralateral to MRI and surgical data. In conclusion, simultaneous gradient of ACTH, PRL and TSH did not improve lateralisation prediction in this series. Hormonal hypersecretion was homolateral in six cases whereas pathological studies demonstrated a mixed secretion in only three cases. A preferential pituitary draining could explain these discordances. Data from our series and from others (done with CRH stimulation and ACTH-PRL measures) strongly suggest a paracrine interaction between tumoral and normal pituitary tissue. [less ▲]

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See detailHyperthyroïdie sur Amiodarone : études complémentaires, traitement et suivi de 32 cas
Valdes Socin, Hernan Gonzalo ULg; Leisteidt, S.; Betea, Daniela ULg et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailAcromégalie : Diabète, intolérance au glucose et sensibilité à l'insuline
Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg; Betea, Daniela ULg et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailSevere Growth hormone deficiency in non diabetic patients with corticotroph microadenomas : effects of pituitary surgery and implications for GH replacement
Valdes Socin, Hernan Gonzalo ULg; Laret, V.; de Fays, C. et al

in 10th Meeting of the European Neuroendocrine Association - Abstract book (2002)

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See detailPinéalomes familiaux : Etudes biologiques et génétiques préliminaires
Allouch, A.; Valdes Socin, Hernan Gonzalo ULg; Hendrick, J. C. et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailDéficience sévère en hormone de croissance chez les patients non diabétiques avec un microadénome corticotrope : Effets de la chirurgie hypophysaire et implications thérapeutiques
Valdes Socin, Hernan Gonzalo ULg; Laret, V.; de Fays, C. et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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