References of "Valdes Socin, Hernan Gonzalo"
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See detailMaladie de Cushing et adénome corticotrope: fonctions antéhypophysaires avant et après microchirurgie transsphénoidale
Martin, Didier ULg; Valdes Socin, Hernan Gonzalo ULg; Beckers, Albert ULg et al

in Neuro-Chirurgie (2002), 48(2-3, Pt 2), 226-233

Background and purpose. - Cushing's disease is characterized by an overproduction of ACTH inducing an hypersecretion of corticosteroids. We assessed the non-corticotrophic pituitary functions before and ... [more ▼]

Background and purpose. - Cushing's disease is characterized by an overproduction of ACTH inducing an hypersecretion of corticosteroids. We assessed the non-corticotrophic pituitary functions before and after microsurgical resection of the corticotrophic adenoma. Methods. - We reviewed retrospectively a series of 98 patients (19 males, 79 females) undergoing transsphenoidal surgery between 1974 and 2001. Prolactin levels, somatrotrophic, gonadotrophic and thyroidotrophic functions were assessed and compared before and after resection of the adenoma. Results. - Before surgery, we observed an elevation of prolactin and a reduction of the GH, TSH, LH and FSH levels. These modifications were not linked to the volume of the adenoma but depended on the systemic effect of the hypercorticism or on local paracrine mechanisms. Selective adenomectomy usually restored altered corticotrophic and also, unlike (partial or total) hypophysectomy, the non-corticotrophic functions. Conclusions. - Non-corticotrophic functions are often altered in Cushing's disease but can be restored after selective adenomectomy. [less ▲]

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See detailDiagnostic differentiel et traitement medical dans la maladie de Cushing.
Beckers, Albert ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Neuro-Chirurgie (2002), 48(2-3 Pt 2), 163-172

Cushing's disease remains a difficult diagnosis in spite of new technical procedures such as pituitary MRI, selective bilateral petrosal or cavernous sampling, (111)In pentreotide scan and 18 ... [more ▼]

Cushing's disease remains a difficult diagnosis in spite of new technical procedures such as pituitary MRI, selective bilateral petrosal or cavernous sampling, (111)In pentreotide scan and 18 Flurodeoxyglucose pituitary PET scan. In this article, we review biological diagnostic procedures of Cushing's disease and corticotroph adenomas. According to our experience and the literature, we summarize the approach in medical treatment of Cushing's disease. [less ▲]

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See detailLe cathétérisme bilatérale des sinus pétreux avec dosages multihormonaux dans la maladie de Cushing
Valdes Socin, Hernan Gonzalo ULg; Bataille, Yoann ULg; Meurisse, Nicolas ULg et al

in Annales d'Endocrinologie (2002), 63(1), 23-30

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI ... [more ▼]

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI, surgical findings and multihormonal BPSS. Seven patients (6F/1M) with Cushing's disease, mean age at diagnosis of 35 years (range 24-55) were prospectively studied to compare radiological and multihormonal BPSS data with surgical and pathological findings. In untreated patients, simultaneous measures of ACTH, TSH and prolactine (PRL) were done at time 0, 7, 15, 22 minutes after CRH (500 mg) and TRH (200 mg) stimulation. An intersinus gradient of 1.4 was considered as a lateralisation. All microadenomas were identified during surgery, diameters ranged from 2 to 7 mm. All patients were in long-term surgical remission. Pathological studies confirmed a tumoral tissue with ACTH immunostaining in 6/7 cases and PRL in 3/7 cases. Pituitary MRI correctly identified tumors in 4 cases, the remaining tumors were not seen. Basal and stimulated intersinus gradients of ACTH, TSH and PRL were homolateral in 6/7 cases and were coincident with surgical findings in 4/7 cases. The other three cases were contralateral to MRI and surgical data. In conclusion, simultaneous gradient of ACTH, PRL and TSH did not improve lateralisation prediction in this series. Hormonal hypersecretion was homolateral in six cases whereas pathological studies demonstrated a mixed secretion in only three cases. A preferential pituitary draining could explain these discordances. Data from our series and from others (done with CRH stimulation and ACTH-PRL measures) strongly suggest a paracrine interaction between tumoral and normal pituitary tissue. [less ▲]

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See detailHyperthyroïdie sur Amiodarone : études complémentaires, traitement et suivi de 32 cas
Valdes Socin, Hernan Gonzalo ULg; Leisteidt, S.; Betea, Daniela ULg et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailAcromégalie : Diabète, intolérance au glucose et sensibilité à l'insuline
Valdes Socin, Hernan Gonzalo ULg; Vroonen, Laurent ULg; Betea, Daniela ULg et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailSevere Growth hormone deficiency in non diabetic patients with corticotroph microadenomas : effects of pituitary surgery and implications for GH replacement
Valdes Socin, Hernan Gonzalo ULg; Laret, V.; de Fays, C. et al

in 10th Meeting of the European Neuroendocrine Association - Abstract book (2002)

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See detailPinéalomes familiaux : Etudes biologiques et génétiques préliminaires
Allouch, A.; Valdes Socin, Hernan Gonzalo ULg; Hendrick, J. C. et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailDéficience sévère en hormone de croissance chez les patients non diabétiques avec un microadénome corticotrope : Effets de la chirurgie hypophysaire et implications thérapeutiques
Valdes Socin, Hernan Gonzalo ULg; Laret, V.; de Fays, C. et al

in XXème Congrès de la Société Française d'Endocrinologie - Abstract book (2002)

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See detailClinical and genom-wide linkage studies of a multigénérational family with acromegaly and the exclusion of requiem gene
Khoo, S. K.; Chan, S.; Pendek, R. et al

in The Endocrine Society's 84th Annual Meeting - Abstract book (2002)

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See detailFamilial isolated pituitary tumors : clinical and molecular studies in 80 patients
Valdes Socin, Hernan Gonzalo ULg; Jaffrain-Réa, M. L.; Tamburrano, G. et al

in The Endocrine Society's 84th Annual Meeting - Abstract book (2002)

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See detailFamilial secreting-pinealomas : biological and preliminary genetic studies
Allouch, A.; Valdes Socin, Hernan Gonzalo ULg; Hendrick, J. C. et al

in 10th Meeting of the European Neuroendocrine Association - Abstract book (2002)

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See detailManagement of hypercalcemia from Parathyroid Carcinoma by immunisation
Betea, Daniela ULg; Bradwell, A. R.; Valdes Socin, Hernan Gonzalo ULg et al

in The Endocrine Society's 84th Annual Meeting - Abstract book (2002)

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See detailFamilial Pituitary tumors
Valdes Socin, Hernan Gonzalo ULg; Poncin, J.; Vanbellinghen, Jean-François ULg et al

in Neuroendocrinologica : Dalla Riserca di base alla Clinica (2002)

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See detailCarcinome parathyroïdien : Contrôle de l'hypercalcémie par immunothérapie
Betea, Daniela ULg; Bradwel, A.; Valdes Socin, Hernan Gonzalo ULg et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailMétamorphose d'une acromégalie en un adénome hypophysaire non-fonctionnel : Etudes clinique et génétiques
Valdes Socin, Hernan Gonzalo ULg; Stevenaert, Achille ULg; Legros, Jean-Jacques ULg et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailLes tumeurs à calcitronine extrathyroïdiennes
Valdes Socin, Hernan Gonzalo ULg; Corhay, Jean-Louis ULg; de Leval, Laurence ULg et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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See detailMetamorphosis of acromegaly to a non-functioning pituitary adenoma
Valdes Socin, Hernan Gonzalo ULg; Stevenaert, Achille ULg; Legros, Jean-Jacques ULg et al

in 5th European Congress of Endocrinology - Abstract book (2001)

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See detailStruma Ovarii toxique : Etudes Génétiques
Valdes Socin, Hernan Gonzalo ULg; Parma, J.; Vassart, G. et al

in Annales d'Endocrinologie : XIXe Congrès de la Société Française d'Endocrinologie - Abstract book (2001)

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