Densitometric Determination of Salicin in Willow Stem Bark

in Journal of Planar Chromatography (1993), 6(november-december), 434-437

Most of the salicin present in willow stem bark occurs as labile glycosides (e.g. salicin, salicortin, 2-O'-acetylsalicortin, 3-O'-acetylsalicortin, tremulacin and fragilin). On alkaline hydrolysis, these ... [more ▼]

Most of the salicin present in willow stem bark occurs as labile glycosides (e.g. salicin, salicortin, 2-O'-acetylsalicortin, 3-O'-acetylsalicortin, tremulacin and fragilin). On alkaline hydrolysis, these acylated derivatives decompose to salicin; in this way, the total amount of salicin can be determined. A HPTLC method has been developed for the quantitative determination of salicin in stem bark before and after alkaline hydrolysis. The mobile phase used for the separation is a modification of one described in the literature. a double or triple migration is necessary to separate salicin from other components of the extract. The results have been compared with those obtained after bidimensional chromatography using two phases described for the quantitative evaluation of salicin. to check that separation was complete, the spectrum of salicin obtained from willow extracts was superimposed on that of a salicin standard.Quantification was performed at lambda = 270nm, the wavelenght of maximum absorption in the IV spectrum of salicin. [less ▲]

Utilisation en thérapeutique de pycnogenols pour la préparation de médicaments à activité anti-inflammatoire

Patent (1992)

The use of pycnogenols (including mainly prodelphinidins) being contained in plant extracts (e.g. Ribes nigrum or Black Currant leaves) in a proportion of at least 2% by weight or isolated and purified ... [more ▼]

The use of pycnogenols (including mainly prodelphinidins) being contained in plant extracts (e.g. Ribes nigrum or Black Currant leaves) in a proportion of at least 2% by weight or isolated and purified form, dor the preparation of antiinflammatory medicaments. A novel therapeutic use of pycnogenols extracted from Ribes nigrum leaves is particularly described . [less ▲]

Proanthocyanidins from Ribes nigrum leaves - Isolation and structure determination

in Bulletin de Liaison Groupe Polyphenols (1992)

In summary, the antiinflammatory activity of Ribes nigrum leaves is mainly due to proanthocyanidins which are the major oligomers in the proanthocyanidins fraction

Densitometric Evaluation of Spiraeoside after Derivatization in Flowers of Filipendula Ulmaria (L.) Maxim

in Journal of Pharmaceutical & Biomedical Analysis (1992), 10(10-12, Oct-Dec), 1085-8

Spiraeoside (quercetin-4'-glucoside) is the major and most caharacteristic flavonoid of Filipendula ulmaria flowers and is not found in the leaves and stems. This paper describes a quantification of ... [more ▼]

Spiraeoside (quercetin-4'-glucoside) is the major and most caharacteristic flavonoid of Filipendula ulmaria flowers and is not found in the leaves and stems. This paper describes a quantification of spiraeoside by HPTLC densitometry after derivatization with diphenylboric acid -2-aminoester. The fluorescence of this flavonoid was measured at 330 nm. the spiraeoside content in batches of Filipendula ulmaria flowers ranged from 3 to 4.3 %. It is of note that these results are similar to those published elsewhere after HPLC analysis of other batches. [less ▲]

Alkaloids of Strychnos Usambarensis Stem Bark

in Planta Medica (1991), 57(5), 501

From ethnobotanical uses of Strychnos henningsii to antiinflammatories, analgesics and antispasmodics

in Journal of Ethnopharmacology (1991), 34

Strychnos henningsii GILG is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints, malaria and snake bites. Different preliminary ... [more ▼]

Strychnos henningsii GILG is used in African traditional medicine for the treatment of various ailments, including rheumatism, gastrointestinal complaints, malaria and snake bites. Different preliminary pharmacological experiments are described. The results show that some of the reported folk medicinal applications of S. henningsii can be at least partially explained by the presence of retuline-like alkaloids, whose use could lead to new antinociceptive (antiinflammatory and analgesic) and antispasmodic drugs. [less ▲]

Utilisation de composés de la série de la rétuline et de l'isorétuline à titre de composés à activité pharmaceutique, en particulier de médicaments analgésiques, antispasmodiques et antiinflammatoires

Patent (1989)

Compounds of retuline series and isoretuline series are described. These alkaloids can be prepared by hemisynthesis from strychnine or strychnobiline that are the main alkaloids of Strychnos nux-vomica ... [more ▼]

Compounds of retuline series and isoretuline series are described. These alkaloids can be prepared by hemisynthesis from strychnine or strychnobiline that are the main alkaloids of Strychnos nux-vomica (strychnine) or Strychnos variabilis (strychnobiline). The compounds of both series (retuline and isoretuline) display antiinflammatory, analgesic and antispasmodic effects that could lead to new medicaments. [less ▲]

Strychnozairine, an indole alkaloid from Strychnos variabilis

in Phytochemistry (1985), 34(1), 205-207

Through a combination of spectroscopic techniques (UV,CD,IR,MS and NMR) it has been possible to show that strychnozairine, an alkaloid isolated from the root bark of Strychnos variabilis, is N&-acetyl-16 ... [more ▼]

Through a combination of spectroscopic techniques (UV,CD,IR,MS and NMR) it has been possible to show that strychnozairine, an alkaloid isolated from the root bark of Strychnos variabilis, is N&-acetyl-16-R-formyl-19-oxo-20,21-didehydrostrychnane. [less ▲]

Antimitotic activity of strychnopentamine, a bisindolic alkaloid

in Journal of Ethnopharmacology (1984), 12

Strychnopentamine has been tested for its cytotoxicity and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine ... [more ▼]

Strychnopentamine has been tested for its cytotoxicity and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids. [less ▲]

12'-Hydroxystrychnobiline, nouvel alcaloïde bisindolinique du Strychnos variabilis

in Journal of Natural Products (1983), 46(5), 638-645

12'-hydroxystrychnobiline, a new unsymmetrical bisindole alkaloid, was isolated from the root barks of Strychnos variabilis. Its structure was established by acid hydrolysis and by spectral analysis ... [more ▼]

12'-hydroxystrychnobiline, a new unsymmetrical bisindole alkaloid, was isolated from the root barks of Strychnos variabilis. Its structure was established by acid hydrolysis and by spectral analysis, especially by 1H-nmr at 360MHz. We compare its absolute stereochemistry with that of other alkaloids that contain an oxazine ring. [less ▲]