References of "Tits, Monique"
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See detailPalicoside: précurseur naturel de l'akagérine
Brandt, Viviane; Tits, Monique ULg; Penelle, Jacques et al

Poster (2000, July)

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See detailInhibition of Croton Oil-Induced Oedema in Mice Ear Skin by Capsular Polysaccharides from Cyanobacteria
Garbacki, Nancy ULg; Gloaguen, Vincent; Damas, Jacques ULg et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (2000), 361(4), 460-4

The anti-inflammatory properties of hydrophilic extracts of the capsular polymers of twelve cyanobacterial strains belonging to the genera Phormidium and Nostoc from marine and terrestrial habitats were ... [more ▼]

The anti-inflammatory properties of hydrophilic extracts of the capsular polymers of twelve cyanobacterial strains belonging to the genera Phormidium and Nostoc from marine and terrestrial habitats were tested topically on croton oil-induced oedema in mice ear skin. The screening program identified several strains as producers of anti-inflammatory products (up to 56% inhibition of the oedema). The inhibition response was dose-dependent. The application of trichloroacetic acid-treated extracts reduced the oedema by about 60%. On the other hand, one of the strains enhanced the inflammatory response. Analysis of five of the extracts showed the presence of neutral sugars (from 34.3% to 47.1%, w/w), uronic acids (from 7.1% to 26.7%, w/w) and proteins (from 30.1% to 57.0%, w/w) in the crude polymer. Rhamnose, fucose, arabinose, xylose, mannose, glucose, galactose, galacturonic acid and glucuronic acid were detected as well as sulphate groups (from 9.6% to 21.5%, w/w of sugars). The main components found were glucose and mannose. [less ▲]

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See detailQuaternary Indole Alkaloids from the Stem Bark of Strychnos Guianensis
Penelle, Jacques; Tits, Monique ULg; Christen, Philippe et al

in Phytochemistry (2000), 53(8), 1057-66

Two new quaternary alkaloids, 9-methoxy-Nb-methylgeissoschizol and guiachrysine together with the known compounds C-alkaloid O, fluorocurine, mavacurine, macusine B and C-profluorocurine, were isolated ... [more ▼]

Two new quaternary alkaloids, 9-methoxy-Nb-methylgeissoschizol and guiachrysine together with the known compounds C-alkaloid O, fluorocurine, mavacurine, macusine B and C-profluorocurine, were isolated from Strychnos guianensis stembark. The structures of the compounds were elucidated on the basis of spectroscopic studies. [less ▲]

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See detailNew Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos Icaja Roots
Frederich, Michel ULg; De Pauw-Gillet, Marie-Claire ULg; Llabres, Gabriel ULg et al

in Planta Medica (2000), 66(3), 262-9

Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy ... [more ▼]

Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38). [less ▲]

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See detailNew strictosidine beta-glucosidase from Strychnos mellodora
Brandt, Viviane; Geerlings, Arjan; Tits, Monique ULg et al

in Plant Physiology & Biochemistry (2000), 38(3), 187-192

A stable strictosidine glucosidase was isolated from dried powdered material of Strychnos mellodora. The kinetic parameters Km and Vmax of the purified glucosidases from catharanthus roseus and S ... [more ▼]

A stable strictosidine glucosidase was isolated from dried powdered material of Strychnos mellodora. The kinetic parameters Km and Vmax of the purified glucosidases from catharanthus roseus and S. mellodora towards strictosidine, dolichantoside and palicoside were determined and compared. [less ▲]

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See detailAnti-inflammatory and chondroprotective activity of prodelphinidins isolated from Ribes nigrum leaves.
Tits, Monique ULg; de Leval, Xavier; Diercksens, Yves et al

Poster (2000)

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See detailAnti-Inflammatory and Immunological Effects of Centaurea Cyanus Flower-Heads
Garbacki, Nancy ULg; Gloaguen, Vincent; Damas, Jacques ULg et al

in Journal of Ethnopharmacology (1999), 68(1-3), 235-41

Centaurea cyanus flower-heads are used in European phytotherapy for the treatment of minor ocular inflammations. Different pharmacological experiments (inhibition of carrageenan, zymosan and croton oil ... [more ▼]

Centaurea cyanus flower-heads are used in European phytotherapy for the treatment of minor ocular inflammations. Different pharmacological experiments (inhibition of carrageenan, zymosan and croton oil-induced oedemas, inhibition of plasma haemolytic activity, induction of anaphylatoxin activity) showed that polysaccharides extracted from C. cyanus flower-heads had anti-inflammatory properties and interfered with complement. Moreover, these polysaccharides were found to be mainly composed of galacturonic acid, arabinose, glucose, rhamnose and galactose. [less ▲]

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See detailIn Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium Falciparum
Frederich, Michel ULg; Hayette, Marie-Pierre ULg; Tits, Monique ULg et al

in Antimicrobial Agents and Chemotherapy (1999), 43(9), 2328-31

The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium ... [more ▼]

The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC(50) = 0.03 microM) than it did against the chloroquine-sensitive strain. [less ▲]

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See detailGuiaflavine, a new bisindole quaternary alkaloid from the stem bark of Strychnos guianensis
Penelle, Jacques; Tits, Monique ULg; Christen, P. et al

Poster (1999, July)

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See detailGuiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark of Strychnos Guianensis
Penelle, J.; Tits, Monique ULg; Christen, P. et al

in Journal of Natural Products (1999), 62(6), 898-900

A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by ... [more ▼]

A reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by detailed spectroscopic methods and comparison with model compounds. [less ▲]

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See detailGuiaflavine, un nouvel alcaloïde quaternaire bisindolique isolé à partir de l'écorce de tige du Strychnos guianensis
Penelle, Jacques; Tits, Monique ULg; Christen, Philippe et al

Poster (1999, May)

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See detailQuatre alcaloïdes à noyau bèta-carboline isolés des écorces de tronc du Strychnos mellodora
Brandt, Viviane; Tits, Monique ULg; Geerlings, A et al

Poster (1999, May)

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See detailGuiaflavine, a new bisindole quaternary alkaloid from the stem bark of Strychnos guianensis
Penelle, Jacques; Tits, Monique ULg; Christen, Philippe et al

Conference (1999, May)

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