Showing results 21 to 34 of 34
 Mammosomatotropes in Human Pituitary Adenomas as Revealed by Electron Microscopic Double Gold Immunostaining MethodBeckers, Albert  ; ; Stevenaert, Achille et alin Acta Endocrinologica (1988), 118(4), 503-12 Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to ... [more ▼] Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to moderate hyperprolactinemia. Immunohistochemistry revealed PRL-containing cells without any close relationship with high PRL serum level in 6 patients. Double immunogold staining revealed mammosomatotrope cells characterized by simultaneous presence of GH and PRL in the same granules in 2 patients. Since mammosomatotropes have never been demonstrated in the normal pituitary, our results probably signify gene dysregulation in pituitary cells of those acromegalic patients. [less ▲] Detailed reference viewed: 11 (0 ULg) Clinical and Radiological Aspects of Dysplastic Gangliocytoma (Lhermitte-Duclos Disease): A Report of Two Cases with Review of the Literature; ; Martin, Didier et alin Neurosurgery (1988), 22(1, Pt 1), 124-8 Two cases of Lhermitte-Duclos disease confirmed by biopsy are reported. Review of the 58 published cases shows that the disease can manifest itself only by signs of increased intracranial pressure ... [more ▼] Two cases of Lhermitte-Duclos disease confirmed by biopsy are reported. Review of the 58 published cases shows that the disease can manifest itself only by signs of increased intracranial pressure. Cerebellar symptoms are not constant. Computed tomographic (CT) scans suggest the diagnosis by showing a posterior fossa lesion, iso- and hypodense, partially calcified, and not enhanced by contrast medium. Magnetic resonance imaging (MRI) seems to define limits of the lesion better than CT scanning and could improve the surgical approach. Surgical excision of the lesion is the only satisfactory treatment. The postoperative prognosis is usually favorable. [less ▲] Detailed reference viewed: 23 (5 ULg)Les adenomes hypophysaires a TSH.Beckers, Albert ; Hennen, Georges ; Reznik, Michel et alin Revue Médicale de Liège (1988), 43(10), 396-402 Detailed reference viewed: 4 (1 ULg)Le traitement de l'acromégalie par SMS 201-995 : résultats obtenus chez 38 patients.Beckers, Albert ; ; et alin Annales d'Endocrinologie (1988) Detailed reference viewed: 11 (1 ULg)Myélinolyse centrale du pont, son cadre nosographique parmi les lésions neuropathologiques dues à l'alcoolismeReznik, Michel ; LIFRANGE, Eric ; et alin Revue Médicale de Liège (1987), 42 Detailed reference viewed: 1 (0 ULg) Tumeur neuroendocrine de la cavite nasale (esthesioneuroblastome). A propos d'un cas avec syndrome de Cushing paraneoplasique.Reznik, Michel ; ; et alin Annales de Pathologie (1987), 7(2), 137-42 Presentation of a 48-y old woman who developed a neuroendocrine tumor of the nasal cavities. This lesion progressed rapidly despite an extensive resection and repeated chemotherapy. The patient refused ... [more ▼] Presentation of a 48-y old woman who developed a neuroendocrine tumor of the nasal cavities. This lesion progressed rapidly despite an extensive resection and repeated chemotherapy. The patient refused radiotherapy. Before her death, 28 months later, she exhibited a paraneoplastic Cushing-like syndrome. At autopsy, restricted to the brain, there was a 5 cm diameter tumor invading the frontal area without alteration of the hypothalamus or the pituitary gland. Routine histology and electron microscopy confirmed the neuroendocrine nature of the tumor. Immunohistochemistry revealed the tumor to be positive only for neurone specific enolase, negative for S-100 protein, neurofilament and ACTH. The pituitary gland was positive for most usual hormones (GH, PRL, TSH, LH, FSH) but only few cells were slightly positive for ACTH. Many Crooke cells were observed. These findings suggest that the tumor secreted an ACTH-like substance (not detected actually by immunochemistry) that stimulated the activity of the adrenal cortex but inhibited normal production of ACTH at the pituitary gland level. [less ▲] Detailed reference viewed: 82 (1 ULg)Encéphalopathie limbique paranéoplasique, secrétion inappropriée d'ADH et crises épileptiques subintrantes infracliniques: Corrélations cliniques, anatomo-pathologiques et métaboliques par tomographie à émission de positonsFranck, Georges ; Sadzot, Bernard ; Salmon, Eric et alin Revue Neurologique (1987), 143(10), 657-669 We report a case of limbic encephalopathy clinically characterized by a progressive amnestic syndrome and many EEG seizures mainly localized on the left temporal area. Biological investigations revealed ... [more ▼] We report a case of limbic encephalopathy clinically characterized by a progressive amnestic syndrome and many EEG seizures mainly localized on the left temporal area. Biological investigations revealed diabetes mellitus and a syndrome of inappropriate antidiuretic hormone secretion (IADH). Haemodynamic and metabolic studies by positron-emission tomography showed an important increase in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen on the left anterior temporal region precisely where the electrical seizures were recorded. Nine months later, severe disorders of memory and a dramatic decrease in CBF and CMRO2 on the same area region were present. At autopsy, a small size oat cell bronchial carcinoma was found with metastases in two small adjacent lymph nodes. Neuropathological examination showed atrophy (neuronal loss, protoplasmic gliosis) in the amygdala; where there was in addition an area of nodular gliosis. The hippocampus and parahippocampal gyrus lesions were severe on the left and moderate on the right side. The authors discuss the nosology of their case in the paraneoplastic syndromes and, with a review of the literature, the role of ADH and cellular hyperactivity in the pathogenesis of specifically localized neuronal alterations. [less ▲] Detailed reference viewed: 135 (0 ULg)Gangliocytome dysplasique du cervelet ou maladie de LhermitteDuclos (A propos de 2 cas opérés); Martin, Didier ; et alConference (1986, December) Detailed reference viewed: 41 (0 ULg)Immunocytochemical demontration of hormones in cell granules of several human pituitary adenomasBeckers, Albert ; ; Stevenaert, Achille et alin Histochemical Journal (The) (1986), 18(1), 55 Immunocytochemical demonstration of hormones in cells granules of several human pituitary adenomasBeckers, Albert ; Stevenaert, Achille ; et alin Histochemical Journal (The) (1986) Detailed reference viewed: 2 (0 ULg)Localisation ultrastructurale d'hormones hypophysaires par reaction immunocytochimique sur coupes fines d'adenomes.Beckers, Albert ; ; Reznik, Michel et alin Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (1985), 179(3), 397-402 Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti ... [more ▼] Human pituitary adenomas were fixed in glutaraldehyde and embedded in epon. Ultrathin sections were incubated either with anti-hGH, anti-hPRL or anti-hLH. They were incubated with second step goat anti-rabbit immunoglobulins linked to gold particles. Two PRL secreting adenomas, one GH and PRL secreting adenoma, one ACTH secreting adenoma and two non secreting adenomas were studied. The specificity and the limits of the method were discussed in relation with the results obtained in light microscopy with the PAP method. [less ▲] Detailed reference viewed: 20 (0 ULg)Immunogold staining of pituitary hormones in human adenoma biopsies; Beckers, Albert ; Stevenaert, Achille et alin Biology of the Cell (1985) Detailed reference viewed: 2 (0 ULg)Ultrastructural immunocytochemical localization of hormones in human pituitary adenomasBeckers, Albert ; ; Stevenaert, Achille et alin Neuroendocrinology letters (1985) Detailed reference viewed: 2 (0 ULg)Immunogold staining of pituitary hormones in human adenoma biopsies.Beckers, Albert ; ; Reznik, Michel et alin Biology of the Cell (1985) Detailed reference viewed: 3 (0 ULg)
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