Use of tamoxifen in a German Sheperd dog with sclerosing encapsulating peritonitis

in Journal of Small Animal Practice (2010), 51(12), 649-653

Barometric whole-body plethysmographic measurements in dogs suffering from brachycephalic airway obstruction syndrome

in Veterinary Journal (2010)

The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n=11) and after (n=6) surgery using ... [more ▼]

The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n=11) and after (n=6) surgery using barometric whole-body plethysmography (BWBP), with the relationship between BWBP variables and the severity of the clinical signs assessed by the use of a respiratory score based on clinical, radiographic and endoscopic findings. Partial collapse of the left main bronchus was a common finding not previously described as part of the brachycephalic airway obstructive disease syndrome. Epiglottic cysts, laryngeal granulomas and nasopharyngeal turbinates in English Bulldogs were other previously unreported findings. No significant correlation between the respiratory score and any of the BWBP variables was detected. Compared to healthy dogs, brachycephalic dogs had a significantly lower Te/Ti ratio (expiratory time over inspiratory time), peak inspiratory flow (PIF) per kg bodyweight (BW), significantly higher peak expiratory flow (PEF) per kgBW, PEF/PIF, and enhanced pause. These variations are compatible with upper airway obstructions primarily in the extrathoracic airways. Following surgery, a significant decrease in PEF/PIF was detected. The study showed that BWBP could be used to characterise the respiratory strategy in brachycephalic dogs before and after surgery [less ▲]

Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs

in Veterinary Journal (2010)

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h ... [more ▼]

This study investigated the differences in pharmacokinetic, urodynamic and haemodynamic parameters in female Beagle dogs in which blood sampling and urethral pressure profiles were performed over 24 h periods, after single or three times daily (T0-T6h-T12h) administration of phenylpropanolamine (PPA). Maximal concentration (Cmax) was reached 2 h after PPA administration (Tmax). The half-life lasted 4 h and, because of bioaccumulation, three times daily administration induced an increase in Cmax. Compared to the control group, a significant increase in urethral resistance was observed at Tmax after 1 week of once daily administrations. After one week of administering PPA every 6 h during the daytime, but not during the night, and despite higher plasma concentrations, the urethral resistance did not increase at any time, compared to the control group. The increase in mean arterial pressure values was compensated by a decreased heart rate. The clinical efficacy of the temporary increase in urethral resistance following single daily administration of PPA in dogs suffering from urethral sphincter mechanism incompetence (USMI) needs to be further investigated in a randomised clinical trial. [less ▲]

Linear foreign bodies in cats

in Proceedings du 15th congrès FECAVA (2009, November)

Telemetric investigation of the vesico-urethral function in the bitch: preliminary results

Poster (2009, September)

Surgery of urinary bladder tumors

in Proceedings du 18th Annula Scientific Meeting de l'ECVS (2009, July)

The gastric dilatation-volvulus syndrome: the specialist's point of view

in Proceedings du congrès Canifelis Emergency et Critical Care (2009, January)

Penile aneurysmal bone cyst causing urethral obstruction in a dog

Poster (2008, July)

Exophthalmos and strabismus associated with a frontal mucocele in a 6-month-old puppy

Poster (2008, May)

A technique for resection of invasive tumors involving the trigone area of the bladder in dogs: preliminary results in two dogs.

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (2008), 37(5), 427-37

OBJECTIVE: To describe a surgical technique for resection of the entire bladder neck, including the trigone and proximal urethra in dogs with invasive tumors causing life-threatening urinary tract ... [more ▼]

OBJECTIVE: To describe a surgical technique for resection of the entire bladder neck, including the trigone and proximal urethra in dogs with invasive tumors causing life-threatening urinary tract obstruction. STUDY DESIGN: Clinical case reports. ANIMALS: Dogs (n=2) with bladder tumors. METHODS: Circumferential excision of the bladder neck and proximal urethra with preservation of the neurovascular pedicles was performed to remove a rhabdomyosarcoma (dog 1) and a transitional cell carcinoma (dog 2) involving the trigone and bladder neck that were causing urinary tract obstruction. Reconstruction of the bladder and proximal urethra included bilateral ureteroneocystostomy. Adjuvant chemotherapy was administered postoperatively to both dogs. RESULTS: Postoperatively, dogs 1 and 2 were continent after 7 and 17 days, respectively, and regained normal urinary function after resolution of a transient pollakiuria. Dog 1 had no evidence of local or regional recurrence; however, a large solitary pulmonary metastatic lesion was diagnosed 8 months later. The dog was euthanatized despite a lack of clinical signs. Dog 2 had at least 1 metastatic lesion in the abdominal wall 6 months later and was euthanatized at 580 days because of renal failure. CONCLUSION: En-bloc removal of the bladder neck and proximal urethra with preservation of the dorsal vascular and nervous pedicles, although a technically challenging procedure, can be performed without associated urinary incontinence or bladder wall necrosis. CLINICAL RELEVANCE: In dogs with invasive bladder tumors causing life-threatening urinary tract obstruction, resection of the bladder neck and proximal urethra should be considered as a promising surgical alternative to urinary diversion. [less ▲]