References of "Garbacki, Nancy"
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See detailInhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats
Garbacki, Nancy ULg; Tits, Monique ULg; Angenot, Luc ULg et al

in BMC Pharmacology (2004), 4(1), 1-9

BACKGROUND: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced ... [more ▼]

BACKGROUND: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats. RESULTS: Pretreatment of the animals with PACs (10, 30, 60 and 100 mg/kg, i.p.) reduced paw oedema induced by carrageenin in a dose and time-dependent manner. PACs also inhibited dose-dependently carrageenin-induced pleurisy in rats. They reduced (A) lung injury, (B) pleural exudate formation, (C) polymorphonuclear cell infiltration, (D) pleural exudate levels of TNF-alpha, IL-1beta and CINC-1 but did not affect IL-6 and IL-10 levels. They reduced (E) pleural exudate levels of nitrite/nitrate (NOx). In indomethacin treated rats, the volume of pleural exudate was low, its content in leukocytes and its contents in TNF-alpha, IL-1beta, IL-6 and IL-10 but not in NOx were reduced. These data suggest that the anti-inflammatory properties of PACs are achieved through a different pattern from those of indomethacin. CONCLUSION: These results suggest that the main mechanism of the anti-inflammatory effect of PACs mainly lies in an interference with the migration of the leukocytes. Moreover, PACs inhibited in vivo nitric oxide release. [less ▲]

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See detailThe kallikrein-kinin system, angiotensin converting enzyme inhibitors and insulin sensitivity
Damas, Jacques ULg; Garbacki, Nancy ULg; Lefèbvre, P. J.

in Diabetes/Metabolism Research & Reviews (2004), 20(4, Jul-Aug), 288-297

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in arterial hypertension has showed that these molecules can exert, beneficial effects on insulin sensitivity and ... [more ▼]

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in arterial hypertension has showed that these molecules can exert, beneficial effects on insulin sensitivity and may reduce the occurrence of type 2 diabetes mellitus. One hypothesis explaining these effects of ACE inhibitors may relate to their capacity to interfere with bradykinin (BK) metabolism and action. BK may participate in the regulation of substrate utilization by, several tissues by improving blood flow and substrate delivery to the tissues and also by promoting translocation of glucose transporters. Moreover, BK has been shown to increase phosphorylation of insulin receptor and its cell substrates. BK also appears to improve the release of insulin. Furthermore, insulin may activate the kallikrein-kinin system, which consequently may increase its metabolic effects. However, in experimental diabetes mellitus, BK can participate to the inflammatory reaction leading to Langerhans islets destruction. In diabetes, whereas tissue kallikrein mRNA levels were reduced in several organs, an overexpression of kinin receptors, an increase in plasma levels of kininogens and kallikrein and an activation of the kinin system have all been reported. Lastly, kinins may be involved in the development of diabetic nephropathy. Reduction of kinin metabolism by ACE inhibitors might be involved in the beneficial effects exerted by these compounds in diabetic kidney functions. Copyright (C) 2004 John Wiley Sons, Ltd. [less ▲]

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See detailSome effects of proanthocyanidins isolated from Ribes nigrum on the cardiovascular system in the rat.
Garbacki, Nancy ULg; Damas, Jacques ULg

in Fundamental & Clinical Pharmacology (2004), 18

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See detailActivation and inactivation of bradykinin in rats.
Damas, Jacques ULg; Garbacki, Nancy ULg

in Pflügers Archiv : European Journal of Physiology (2003), 446

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See detailAnti-inflammatory effect of natural proanthocyanidins: pharmacological evaluation on in vivo models.
Garbacki, Nancy ULg; Tits, Monique ULg; Damas, Jacques ULg

in Pflügers Archiv : European Journal of Physiology (2003), 446

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See detailEffects of prodelphinidins isolated from Ribes nigrum leaves on chondrocyte metabolism and COX activity
Angenot, Luc ULg; Garbacki, Nancy ULg; Damas, Jacques et al

Poster (2002, October 29)

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See detailEffects of prodelphinidins isolated from Ribes nigrum on chondrocyte metabolism and COX activity
Garbacki, Nancy ULg; Angenot, Luc ULg; Bassleer, C. et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (2002), 365(6), 434-441

Articular diseases. such as osteoarthritis, is the clinical expression of the loss of cartilage function. COX inhibitors are widely used in the treatment of such pathologies for their beneficial effects ... [more ▼]

Articular diseases. such as osteoarthritis, is the clinical expression of the loss of cartilage function. COX inhibitors are widely used in the treatment of such pathologies for their beneficial effects on inflammation but often produce a negative activity on cartilage synthesis. In this study, we determined the effect of different prodelphinidins, the major compounds isolated from Ribes nigrum leaves, on the proteoglycans (PGs), type II collagen (coll. II) and prostaglandin E-2 (PGE(2)) production by differentiated human chondrocytes cultivated in long term (12 days) and in clusters as well as their inhibition potential on COX-1 and COX-2 in vitro. Gallocatechin trimer (GC-GC-GC) showed the higher stimulation of PGs and coll. II production (1 mug ml(-1)) and the synthesis of PGE(2) was significantly reduced by gallocatechin dimer (GC-GC), gallocatechin-epigallocatechin (GC-EGC) and GC-GC-GC at 10 and 100 mug ml(-1). The inhibition of PGE(2) synthesis was confirmed by the in vitro test on purified COX enzymes, showing the selectivity of prodelphinidins on COX-2. However, the prodelphinidins had no effects on COX activity in the whole blood assay. Our studies suggest that the prodelphinidins fractions from R. nigrum may be useful as an additive agent in the prevention of osteoarthritis. [less ▲]

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See detailIsolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare
Sahpaz, S.; Garbacki, Nancy ULg; Tits, Monique ULg et al

in Journal of Ethnopharmacology (2002), 79(3), 389-392

The isolation and identification of major phenylpropanoid esters from Marrubium vulgare: (+) (E)-caffeoyl-L-malic acid 1, acteoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, as well as their ... [more ▼]

The isolation and identification of major phenylpropanoid esters from Marrubium vulgare: (+) (E)-caffeoyl-L-malic acid 1, acteoside 2, forsythoside B 3, arenarioside 4, ballotetroside 5, as well as their anti-inflammatory activity are reported for the first time, We evaluated the inhibitory effects of these five compounds on cyclooxygenase (Cox) catalysed prostaglandin biosynthesis activity. Only the glycosidic phenylpropanoid esters showed an inhibitory activity towards the Cox-2 enzyme and three of them: acteoside 2, forsythoside B 3, arenarioside 4, exhibited higher inhibitory potencies on Cox-2 than on Cox-1. These results are of interest, as Cox-2 is mainly associated with inflammation and the Cox-1 inhibition with adverse side effects often observed with non-steroidal anti-inflammatory drugs. The occurence of these phenylpropanoid esters could also explain some other pharmacological properties of M. vulgare. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailLe controle du reseau vasculaire cutane
Damas, Jacques ULg; Garbacki, Nancy ULg; Liégeois, Jean-François ULg et al

in Revue Médicale de Liège (2001), 56(12), 846-9

In man, three kinds of sympathetic neurons reach the skin. Some cholinergic neurons stimulate the sweat glands, they are excited by temperature-regulating centers. Adrenergic neurons release noradrenaline ... [more ▼]

In man, three kinds of sympathetic neurons reach the skin. Some cholinergic neurons stimulate the sweat glands, they are excited by temperature-regulating centers. Adrenergic neurons release noradrenaline and ATP to reduce cutaneous blood flow while cholinergic neurons release acetylcholine and a co-transmitter to dilate skin blood vessels. The excitation of both latter types of nerve cells depends on influences from temperature-regulating centers, baroreceptors and exercise. Moreover, in cutaneous blood vessels, a synthesis of NO is enhanced by an increase of body temperature and overall by direct heating of the skin. Burns are associated with axon reflexes and release of inflammatory mediators. The involvement of these various influences is described. [less ▲]

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See detailCriterii de differentiere a unor specii de Veronica
Crisan, Gianina; Tamas, M.; Garbacki, Nancy ULg et al

in Farmacia (2001), 49(6), 67-73

We have tried to establish some criteria to avoid the substitution of Veronica officinalis L; with anti-ulcer and anti-inflammatory activities with other species of the genus Veronica, especially Veronica ... [more ▼]

We have tried to establish some criteria to avoid the substitution of Veronica officinalis L; with anti-ulcer and anti-inflammatory activities with other species of the genus Veronica, especially Veronica chamaedrys L. widely spread and without therapeutic use. We have studied the different histological, anatomical and phytochemical characters for the two species. A rapid method for the identification of both species is the TLC for flavonoids and phenylpropanic compounds was described. Moreover HPLC is useful to detect the presence of acteoside only in Veronica chamaedrys, while Veronica officinalis contains isoacteoside. [less ▲]

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See detailContribution à l’étude des propriétés anti-inflammatoires de substances naturelles.
Garbacki, Nancy ULg

Master of advanced studies dissertation (2001)

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See detailAnti-inflammatory effects of Centaurea cyanus (Asteraceae) flower-heads.
Garbacki, Nancy ULg; Gloaguen, Vincent; Damas, Jacques ULg et al

Poster (2001)

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See detailVeronica officinalis L. et Veronica chamaedrys L.: étude des différences morphologiques et phytochimiques
Crisan, Gianina; Tamas, Mircea; Garbacki, Nancy ULg et al

Poster (2000, July)

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See detailAntiinflammatory and chonroprotective activity of prodelphinidins isolated from Ribes nigrum leaves
Tits, Monique ULg; de Leval Xavier; Dierckxsens, Yvan et al

Poster (2000, July)

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