References of "Frederich, Michel"
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See detailNutritional Composition and Rearing Potential of the Meadow Grasshopper (Chorthippus parallelus Zetterstedt)
Paul, Aman ULiege; Frederich, Michel ULiege; Uyttenbroeck, Roel ULiege et al

in Journal of Asia-Pacific Entomology (2016), 19(4), 1111-1116

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are ... [more ▼]

Insects, particularly those belonging to the family Acrididae (grasshoppers), are commonly consumed as human food in many parts of the world. Grasshoppers of the species Chorthippus parallelus are abundantly found throughout Europe. However, these insects were not consumed by Europeans till now, but could possibly be used as human food, which is why we investigated their chemical composition. We found that they contain high level of proteins (69%), with an excellent amino acid profile and protein digestibility (97%). Furthermore, specimens of C. parallelus have an interesting fatty acids profile and minerals composition. Preliminary toxicity assessment indicates that these insects do not exhibit toxicity towards neutrophil cells (white blood cells). These data suggest that C. parallelus could be considered for human consumption. Rearing trials done during the study show that commercial rearing could be developed to produce sufficient biomass for sustaining human consumption. [less ▲]

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See detailPotential Antimalarials from Tropical Plants and Natural Products
Frederich, Michel ULiege; Ledoux, Allison ULiege

Scientific conference (2016, November 16)

Malaria is caused by Plasmodium, a protozoan parasite transmitted by anopheles mosquitoes, and was responsible for 438 000 deaths worldwide in 2015 according to the last World Malaria report.1 The ... [more ▼]

Malaria is caused by Plasmodium, a protozoan parasite transmitted by anopheles mosquitoes, and was responsible for 438 000 deaths worldwide in 2015 according to the last World Malaria report.1 The resistance of parasites to available and affordable medicines has become a widespread problem in exposed countries, making the search of new antimalarial compounds still necessary. As the immeasurable therapeutic potential of plants is well established2, natural products could be an interesting source of new antimalarial drugs. Indeed, according Newmann and Cragg, more than 60% of the antiparasitic drugs discovered between 1981 and 2014 were unaltered naturals products (12.5%), natural products derivatives (31.3%) and synthetic drugs with a natural product pharmacophore (18.8%).3 Then, the pharmacological and phytochemical study of plants, especially from traditional pharmacopoeias can be of first interest to discovered new antimalarial compound and also to valorize the traditional knowledge. The first part of the talk will concern some examples of results obtained in the lab : the in vivo activity of strychnogucine B, which was isolated from strychnos icaja and semi-synthetized, the optimization of ellagic acid as a lead in the treatment of malaria and the validation of MIT from Mezoneuron benthamianum. In the second part of the talk, the work about Poupartia borbonica, an endemic plant from Reunion Island studied in the framework of a collaboration with the University of Reunion Island will be presented. [less ▲]

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See detailValorization of Seeds from Some Field Border Flowering Seeds
Paul, Aman ULiege; Danthine, Sabine ULiege; Mutwale Kapepula, Paulin ULiege et al

Poster (2016, September 20)

Flowering strips are now being increasingly cultivated along the fields to improve biodiversity. However after serving for the desired function, these plants have no utilization besides animal feed. It ... [more ▼]

Flowering strips are now being increasingly cultivated along the fields to improve biodiversity. However after serving for the desired function, these plants have no utilization besides animal feed. It could be really interesting to valorize some commonly grown plant in these strips to render food or health promoting compounds. With this objective in mind the seeds of Achillea millefolium, Anthriscus sylvestris and Prunella vulgaris were investigated for lipids, proteins and phenolic content. Further the lipids were analyzed for fatty acid profile using gas chromatography and the phenolic compounds in the methanolic extract of defatted seeds were identified using HPLC-DAD. The antiradical activity of the methanolic extracts obtained from defatted seeds was investigated using DPPH and ABTS assays. The anti-inflammatory potential of these seed extracts was evaluated on the reactive oxygen species (ROS) production by stimulated neutrophils and on the specific activity of myeloperoxidase (MPO), a pro-oxidant enzyme marker of inflammation. Seeds from all three plants were analyzed with interesting levels of lipids, proteins and phenolic content. Linoleic acid, oleic acid and alpha-linolenic acid were the major fatty acids analyzed in A. millefolium, A. sylvestris and P. vulgaris respectively. On the other hand different phenolic acid formed the major phenolic constituents. Seed extracts displayed high ABTS and DPPH radical-scavenging activities in a dose dependent manner. Also a strong dose dependent anti-inflammatory activity of all three extracts was observed against ROS production by neutrophils and MPO activity. Results indicate that these seed show a great potential to render lipids which could be utilized as human food, further the defatted seeds could be directly included in human diet due to interesting levels of proteins and anti-inflammation ability. [less ▲]

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See detailNew antimalarial compounds isolated from Poupartia borbonica, a Mascarene Islands endemic plant
Ledoux, Allison ULiege; Jansen, Olivia ULiege; St-Gelais, Alexis et al

in Planta Medica (2016, July), 82(S01), 1-381

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See detailStudy of Mezoneuron benthamianum, a plant traditionally used against malaria in Guinea
Tchinda Tiabou, Alembert ULiege; Loua, Jean; Esters, Virginie ULiege et al

Poster (2016, July)

Despite some improvements in malaria control, this parasitic disease remains a major public health problem in many African countries, causing about 400 000 deaths/year through the continent, mainly by ... [more ▼]

Despite some improvements in malaria control, this parasitic disease remains a major public health problem in many African countries, causing about 400 000 deaths/year through the continent, mainly by children under the age of five (WHO, 2015). In Guinea, the leaves of Mezoneuron benthamianum Baill. are traditionally used to treat malaria (Traore et al., 2013) and showed a good antiplasmodial activity in an antiprotozoal in vitro screening (Traore et al., 2014), as well as promising results in a preliminary small-scale ethnomedical study (unpublished data), encouraging us to continue the study of this plant. The aim of this work was to evaluate the activity of M. benthamianum leaves extracts against P. falciparum using an in vitro test model (p-LDH assay) and to undertake a bio-guided fractionation to identify the compounds responsible for the activity. Hydroethanolic extracts (70% v/v) of M. benthamianum leaves showed a moderate in vitro activity against P. falciparum 3D7, with IC50 = 22.5 – 32.6 µg/ml, depending on the batch; while a dark precipitate formed during ethanol evaporation showed higher activity (IC50 = 6,5µg/ml). The bioguided fractionation was performed on this most active fraction and allowed the isolation of three diterpens, two flavonoids, resveratrol, gallic acid and its ethylester, β-sitosterol glucoside and pheophorbide derivatives. The active compounds belong to several phytochemical classes, including flavonoids, pheophorbide and gallic acid derivatives, contributing together to the global antiplasmodial activity of the hydroalcoholic extract against P. falciparum parasite. This study gives some concrete evidence to support the ethnopharmacological use of Mezoneuron benthamianum leaves extract in the management of malaria. The active compounds can be further studied for their antiplasmodial potential, as well as their suitability to be used as quality markers for the standardization of this herbal drug from the Guinean traditional pharmacopeia. [less ▲]

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See detailIsolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum
Mskhiladze, Lasha; Chincharadze, David; St-Gelais, Alexis et al

in International Journal of Pharmaceutical Sciences and Drug Research (2016), 8(4), 240-243

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers ... [more ▼]

The isolation and identification of β-sitosterol 3-O-β-glucopyranoside, quercetin 3-O-β-glucopyranoside, isorhamnetin 3,4'-di-O-β-glucopyranosideand isorhamnetin 3,7-di-O-β-glucopyranosidefrom the flowers of Allium gramineumthat growsin Georgia.The structures of isolated compounds havebeen determined by 1H and 13C nuclear magnetic resonance (NMR) Isolation and Identification of Steroid and Flavonoid Glycosides from the Flowers of Allium gramineum. Available from: https://www.researchgate.net/publication/305851744_Isolation_and_Identification_of_Steroid_and_Flavonoid_Glycosides_from_the_Flowers_of_Allium_gramineum [accessed Aug 5, 2016]. [less ▲]

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See detailFingerprinting and validation of a LC-DAD method for the analysis of biflavanones in Garcinia kola-based antimalarial improved traditional medicines
Tshisekedi Tshibangu, Pascal ULiege; Mutwale Kapepula, Paulin ULiege; Kabongo Kapinga, Marie Josée et al

in Journal of Pharmaceutical & Biomedical Analysis (2016), 128(2016), 382-390

African populations use traditional medicines in their initial attempt to treat a range of diseases. Nevertheless, accurate knowledge of the composition of these drugs remains a challenge in terms of ... [more ▼]

African populations use traditional medicines in their initial attempt to treat a range of diseases. Nevertheless, accurate knowledge of the composition of these drugs remains a challenge in terms of ensuring the health of population and in order to advance towards improved traditional medicines (ITMs). In this paper chromatographic methods were developed for qualitative and quantitative analyses of a per os antimalarial ITM containing Garcinia kola. The identified analytical markers were used to establish TLC and HPLC fingerprints. G. kola seeds were analysed by HPLC to confirm the identity of the extract used by the Congolese manufacturer in the ITM. The main compounds (GB1, GB2, GB-1a and Kolaflavanone) were isolated by preparative TLC and identified by UPLC–MS and NMR. For the quantification of the major compound GB1, a simple and rapid experimental design was applied to develop an LC method, and then its validation was demonstrated using the total error strategy with the accuracy profile as a decision tool. The accurate results were observed within 0.14–0.45 mg/mL range of GB1 expressed as naringenin. The extracts used in several batches of the analysed oral solutions contained GB1 (expressed as naringenin) within 2.04–2.43%. Both the fingerprints and the validated LC-DAD were found suitable for the quality control of G. kolabased raw material and finished products, respectively. [less ▲]

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See detailScreening of mahoran plants for cosmetic applications.
Saive, Matthew ULiege; Frederich, Michel ULiege; Fauconnier, Marie-Laure ULiege

Poster (2016, June 01)

This study’s main aim is to identify plant species showing anti-oxidant, anti-inflammatory and skin whitening properties. A selection of 89 samples from previous infield studies on the traditional uses of ... [more ▼]

This study’s main aim is to identify plant species showing anti-oxidant, anti-inflammatory and skin whitening properties. A selection of 89 samples from previous infield studies on the traditional uses of plants in Mayotte were analyzed. The anti-oxidant activity was assessed using the α, α-diphenyl-β-picrylhydrazyl (DPPH) method developed by Blois [1]. The anti-inflammatory activity and the skin whitening activity were both assessed through the study of inhibition kinetics from specific enzymes: respectively, lipoxygenase (EC 1.13.11.12) due to its important role in the leukotriene pathway and tyrosinase (EC. 1.14.18.1) as it takes part in the melanogenesis pathway. The IC 50 value for each sample and for each activity was obtained using UV/Vis spectrophotometric technics. These IC 50 were then compared with the ones obtained from known molecules found in the literature: namely, (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (IC50 = 4,388 µM) for the anti-oxidant activity, nordihydroguaiaretic acid (IC50 = 3,5µM) for the anti-inflammatory activity and kojic acid (IC50 = 722 µM) for the anti-tyrosinase activity. The most effective anti-oxidant activity was observed in fresh leaves from Acalypha wilkesiana Müll.Arg. (IC50 = 0,381 g/L) and Leea guineensis G. Don. (IC50 = 0,225 g/L) as well as in dried roots from Litchi chinensis Sonn. (IC50 = 0,346 g/L). All results are expressed in grams of fresh matter. According to the preliminary tests for the-anti-inflammatory and skin whitening activities, the crude extracts from Kalanchoe pinnata Lam. Pers., Litchi chinensis Sonn., Zingiber zerumbet (L.) Sm., Leea guineensis G. Don. and Paullinia pinnata L. are likely to show promising activities. [less ▲]

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See detailTerpenoids from Phaulopsis imbricata (Acanthaceae)
Kengne, A.B.O.; Tene, M.; Tchinda Tiabou, Alembert ULiege et al

in Journal of Medicinal Plants Research (2016), 10(10), 122-129

The whole plant of Phaulopsis imbricata (Forssk.) Sweet (Acanthaceae) was collected at Bansoa, Cameroon, shade dried and extracted by maceration in methanol. This study was carried out to isolate ... [more ▼]

The whole plant of Phaulopsis imbricata (Forssk.) Sweet (Acanthaceae) was collected at Bansoa, Cameroon, shade dried and extracted by maceration in methanol. This study was carried out to isolate secondary metabolites from this plant species that has not been investigated so far. Two lupane-type triterpenoids, one β-type carotenoid, one eudesmane-type sesquiterpenoid, and one sterol glycoside were isolated from the dried methanol extract using solvent partitioning, column chromatography and re-crystallization. They were identified as lupeol, betulin, (all-E)-lutein, cryptomeridiol, and sitosterol 3- O-β-D-glucopyranoside, respectively. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods including 1D- and 2D- nuclear magnetic resonance (NMR), infrared (IR) and mass spectrometry (MS). This is the first report of these compounds from the genus Phaulopsis. To the best of our knowledge, P. imbricata is also the first species of the genus to be phytochemically studied. [less ▲]

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See detailFrom Valeriana officinalis to cancer therapy: the success of a bio-sourced compound
Hamaïdia, Malik ULiege; Barez, Pierre-Yves ULiege; Carpentier, Alexandre ULiege et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20

Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have been a potent source of drugs for the treatment of human diseases. In this review, we recapitulate the story ... [more ▼]

Over the centuries, bio-sourced compounds isolated from plants, insects and microorganisms have been a potent source of drugs for the treatment of human diseases. In this review, we recapitulate the story of one of these compounds, 2-propylpentanoic acid, derived from the Valeriana officinalis flowering plant and its path to validation as a cancer treatment. [less ▲]

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See detailSubstituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities
Marquise, Nada; Chevallier, Floris; Nassar, Ekhlas et al

in Tetrahedron (2016), 72(6), 825-836

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions ... [more ▼]

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions. Different dihalogenated diaryl ketones, prepared by sequential deprotocupration-aroylation, were identified as suitable substrates to this purpose. Conditions were identified to allow successful syntheses of several 6-/7-arylated 4-azafluorenones, 1-substituted 4-azafluorenones, 2-phenyl-3-azafluorenone, and 4-phenyl-3-azafluorenone from 3-(bromobenzoyl)-2-chloropyridines, 3-benzoyl-4-bromo-2-chloropyridines, 4-benzoyl-2,5-dichloropyridine, and 4-benzoyl-2,3-dichloropyridine, respectively. Some of the synthesized compounds exhibit interesting biological properties [less ▲]

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See detailBRYONIA ALBA L. AND ECBALLIUM ELATERIUM (L.) A. RICH. - TWO RELATED SPECIES OF THE CUCURBITACEAE FAMILY WITH IMPORTANT PHARMACEUTICAL POTENTIAL
Ielciu, Irina-Ioana ULiege; Frederich, Michel ULiege; Tits, Monique ULiege et al

in Farmacia (2016), 64(3), 323-332

The importance of the Cucurbitaceae family consists not only in the species that are widely known for various economically important human uses, but also in the species that have proven an important and ... [more ▼]

The importance of the Cucurbitaceae family consists not only in the species that are widely known for various economically important human uses, but also in the species that have proven an important and promising potential concerning their biological activities. Bryonia alba L. and Ecballium elaterium (L.) A. Rich. are two species belonging to this family, that are known since ancient times for their homeopathic or traditional use in the treatment of numerous disorders. There is clear evidence that links between the two species are not only related to family morphological characters, but also to a certain degree to the sexual system and, most importantly, to the active principle content or to potential medicinal uses. All these elements helped to include both species in the same tribe and may result in important reasons for heading future studies towards the elucidation of their complete phytochemical composition and mechanisms of the biological activities. The present study aims to review the existing scientific literature on the two species and to offer sufficient evidence in order to justify a most detailed study of their pharmaceutical potential. [less ▲]

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See detailChemical Fingerprint and Anti-Sickling Activity of Rosmarinic Acid and Methanolic Extracts from Three Species of Ocimum from DR Congo
Tshilanda, Dorothée D.; Mutwale Kapepula, Paulin ULiege; Onyamboko, Damase V. N. et al

in Journal of biosciences and Medicines (2016), 04(January), 59--68

The aim of this study was to characterize the polyphenolic composition by determination of chemical fingerprints of Methanolic extracts of Ocimum canum Sims, Ocimum basilicum L. and Ocimum gratissimum L ... [more ▼]

The aim of this study was to characterize the polyphenolic composition by determination of chemical fingerprints of Methanolic extracts of Ocimum canum Sims, Ocimum basilicum L. and Ocimum gratissimum L. from Democratic Republic of Congo and to compare their antisickling activity of that of rosmarinic acid, the major compound to those of methanolic extracts. Phytochemical analysis performed by TLC and HPLC analysis, showed that rosmarinic acid is the most abundant phenolic acid in these Ocimum species according to the following order O. basilicum L., O. gratissimum L. and O. canum Sims. Methanolic extracts of these three species and pure rosmarinic acid showed significant antisickling activities with minimal concentration of normalization values of 0.18 ± 0.03, 0.23 ± 0.04, 0.26 ± 0.04 and 0.31 ± 0.05 mg/mL for rosmarinic acid, O. basilicum L., O. gratissimum L. and O. canum Sims methanolic extracts respectively. The antisickling activity order is the same as that of the rosmarinic acid content, indicating that this polyphenolic acid would be among the main active molecules in these extracts. [less ▲]

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See detailGrasshoppers as a food source? A review
Paul, Aman ULiege; Frederich, Michel ULiege; Uyttenbroeck, Roel ULiege et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(AgricultureIsLife), 337-352

Description of the subject. Current trends suggest an increasing future demand for conventional meats, which indicates a strong need to shift this dependency to other alternative protein sources such as ... [more ▼]

Description of the subject. Current trends suggest an increasing future demand for conventional meats, which indicates a strong need to shift this dependency to other alternative protein sources such as insects. Literature. From a nutritional point of view, of all the insects consumed globally, grasshoppers are particularly important as a human food. Data from the literature regarding the nutrient composition, amino acid profile, fatty acid profile, mineral composition and vitamin content of grasshoppers as reviewed in this paper, suggest that a number of grasshopper species are a good source of nutrients. It also highlights some of the health related aspects that might arise from the consumption of grasshoppers, mostly linked to agricultural practices and the allergic response of sensitive individuals. The paper also summarizes some religious, social and economic factors that are associated with grasshopper consumption. Conclusions. The success of introducing grasshoppers as a novel food in western countries depends on changes in consumer attitudes. It would be interesting to develop food products derived from grasshoppers in a form acceptable to consumers. Furthermore, it is important to explore the food potential of some grasshopper species native to western countries and to develop their rearing methodologies to enhance availability. [less ▲]

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See detailPros and cons of flowers strips for farmers. A review
Uyttenbroeck, Roel ULiege; Hatt, Séverin ULiege; Paul, Aman ULiege et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(s1), 225-235

Description of the subject. To counteract environmental problems due to agricultural intensification, European farmers can apply agri-environmental schemes in their fields. Flower strips are one example ... [more ▼]

Description of the subject. To counteract environmental problems due to agricultural intensification, European farmers can apply agri-environmental schemes in their fields. Flower strips are one example of these schemes, with the aim of supporting biodiversity, leading to an increase in “useful” species groups such as pollinators for crop pollination and natural enemies for pest control. However, to our knowledge, a complete appraisal of the pros and cons of flower strips, from a farmer’s point of view, does not yet exist. It is proposed that better and more complete information could increase the adoption and implementation of such agri-environmental schemes. Objectives. This study aims 1) to assess the pros and cons of flower strips, from a farmer’s point of view, and 2) to highlight the knowledge gaps that exist in the scientific literature, for the different types of pros and cons. Method. We listed the different components of the appraisal of pros and cons and conducted a systematic screening of the scientific literature on flower strips and these components. Results. The largest part of the 31 selected studies was concerning agronomical and ecological processes, such as pollination and animal pest control. Most of them indicated positive effects of flower strips. For many components of the appraisal, mostly economic and social ones, few or no studies were found. Conclusions. While a positive balance of pros and cons, from a farmer’s point of view, came from our literature screening, large research gaps still remain and more research is required, especially in the economic and social components of the evaluation. [less ▲]

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See detailAntioxidant potentiality of three herbal teas consumed in Bandundu rural areas of Congo.
Mutwale Kapepula, Paulin ULiege; Mbombo Mungitshi, Patricia; Franck, Thierry ULiege et al

in Natural Product Research (2016)

The aim of this study was to evaluate and compare the cellular antioxidant activities of Lantana montevidensis, Lippia multiflora, and Ocimum gratissimum leaves often consumed as herbal teas in a rural ... [more ▼]

The aim of this study was to evaluate and compare the cellular antioxidant activities of Lantana montevidensis, Lippia multiflora, and Ocimum gratissimum leaves often consumed as herbal teas in a rural area of Bandundu severely affected by konzo, which is related to oxidative damage. Consequently, dietary supplements with proven antioxidant potentialities could be of real interest to promote in this area. Phytochemical screening by TLC and HPLC-DAD of extracts revealed the presence of verbascoside as a major phenolic compound. Verbascoside in L. montevidensis and O. gratissimum is reported here for the first time. All extracts displayed high ABTS and DPPH radical-scavenging activities at the concentration range of 1-40 mug mL-1 according to order: L. multiflora > O. gratissimum > L. montevidensis. L. multiflora showed the best cellular antioxidant activity using DCFH-DA on HL-60 monocytes assay at 1-20 mug mL-1. These herbal teas may be used as nutraceuticals for their potent antioxidant activity. [less ▲]

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See detailMetabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.
Frederich, Michel ULiege; Pirotte, Bernard ULiege; Fillet, Marianne ULiege et al

in Journal of Medicinal Chemistry (2016), 59(19), 86498666

"Omics" sciences have been developed to provide a holistic point of view of biology and to better understand the complexity of an organism as a whole. These systems biology approaches can be examined at ... [more ▼]

"Omics" sciences have been developed to provide a holistic point of view of biology and to better understand the complexity of an organism as a whole. These systems biology approaches can be examined at different levels, starting from the most fundamental, i.e., the genome, and finishing with the most functional, i.e., the metabolome. Similar to how genomics is applied to the exploration of DNA, metabolomics is the qualitative and quantitative study of metabolites. This emerging field is clearly linked to genomics, transcriptomics, and proteomics. In addition, metabolomics provides a unique and direct vision of the functional outcome of an organism's activities that are required for it to survive, grow, and respond to internal and external stimuli or stress, e.g., pathologies and drugs. The links between metabolic changes, patient phenotype, physiological and/or pathological status, and treatment are now well established and have opened a new area for the application of metabolomics in the drug discovery process and in personalized medicine. [less ▲]

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See detailPhenolic compounds from the roots of Ochna schweinfurthiana and their antioxidant and antiplasmodial activities
Messi, A. N.; Ngo Mbing, J.; Ndongo, J. T. et al

in Phytochemistry Letters (2016), 17

An investigation of compounds extracted from Ochna schweinfurthiana roots with ethyl acetate led to the isolation of three new compounds 4‴-methoxylophirone A (1), 4,4′,4‴–trimethoxylophirone A (2) and ... [more ▼]

An investigation of compounds extracted from Ochna schweinfurthiana roots with ethyl acetate led to the isolation of three new compounds 4‴-methoxylophirone A (1), 4,4′,4‴–trimethoxylophirone A (2) and (4E;7Z)-3,8-dicarboxy-1-(O-β-D-glucopyranosyl-(1 → 6)-O-β-D-glucopyranosyl-2,9-dihydroxyhexeicosa-4,7-diene (3). Six known compounds were also identified, including Calodenone (4), Calodenine B (5), Lophirone A (6), Gerontoisoflavone A(7), 16α,17-dihydroxy-ent-kauran-19-oic acid (8) and 3β-O-D-glucopyranosyl-β-sitosterol (9). This report describes the first time that compounds 4-8 have been isolated from this plant, while 8 has never been identified in the genus Ochna. Some of the isolated compounds were evaluated for their antiplasmodial activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7 and antioxidant activity using DPPH radical scavenging and Ferric reducing-antioxidant power (FRAP) assays. Compound 5 exhibited prominent radical scavenging and FRAP activities, while 7 had weak activity. Compound 1 showed good in vitro anti-plasmodial activity. The structures of the isolated compounds were elucidated by spectroscopic methods and comparisons with prior data in the literature. © 2016 Phytochemical Society of Europe [less ▲]

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See detailSphingolipids: promising lipid-class molecules with potential applications for industry. A review
Miazek, Krystian ULiege; Lebecque, Simon ULiege; Hamaïdia, Malik ULiege et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), (20(S1)), 321-336

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