References of "Art, Tatiana"
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See detailPart 1: Physiopathology of obstructive respiratory disorders
Art, Tatiana ULg; Lekeux, Pierre ULg

in Dunlop, Robert H; Malbert, Charles-Henri (Eds.) Veterinary Pathophysiology (2004)

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See detailPart 2: Functional effects of restrictive pulmonary diseases
Art, Tatiana ULg; Lekeux, Pierre ULg

in Dunlop, Robert H; Malbert, Charles-Henri (Eds.) Veterinary Pathophysiology (2004)

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See detailPart 3: Physiopathology of vascular pulmonary diseases
Art, Tatiana ULg; Lekeux, Pierre ULg

in Dunlop, Robert H; Malbert, Charles-Henri (Eds.) Veterinary Pathophysiology (2004)

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See detailMyeloperoxydase concentration in bronchoalveolar lavage from healthy and heavy horses
Art, Tatiana ULg; Desmet, Christophe ULg; Lekeux, Pierre ULg et al

in Proceedings : 22nd Symposium of the Veterinary and Comparative Respiratory Society (2004)

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See detailDéficience du système glutathion chez le cheval de course
De Moffarts, Brieuc; Kirschvink, N.; Art, Tatiana ULg et al

in 30ème Journée de la Recherche Equine, Les Haras Nationaux (2004)

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See detailEffet de l’entraînement et de l’intensité de l’exercice sur les marqueurs sanguins du stress oxydant chez le trotteur
De Moffarts, Brieuc; Kirschvink, Nathalie; Art, Tatiana ULg et al

in Proceedings: Congrès de l'Association Vétérinaire Equine Française (AVEF) (2004)

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See detailEffect of exercise on blood glutathione in healthy race horses
De Moffarts, Brieuc; Kirschvink, Nathalie; Art, Tatiana ULg et al

in Pflügers Archiv : European Journal of Physiology (2004), 447

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See detailActivator protein-1 activity in bronchial brushing samples from horses with recurrent airway obstruction
Couëtil, L.; Art, Tatiana ULg; Bureau, Fabrice ULg et al

in Proceedings of the 22nd Symposium of the Veterinary and Comparative Respiratory Society (2004)

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See detailChronic cough in horses : environmental management and aerosol therapy
Art, Tatiana ULg

in Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere (2004), 32 (G)

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See detailEffects of glycopyrrolate inhalation on pulmonary function in heaves-affected horses in crisis
Art, Tatiana ULg; De Moffarts, Brieuc; Van Erck, Emmanuelle ULg et al

in Pflügers Archiv : European Journal of Physiology (2004), 447

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See detailAspects pratiques de la thérapie par aérosol chez le cheval
Art, Tatiana ULg; Van Erck-Westergren, E.; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2004), 36

Although the classical treatment for respiratory disease include systemic administration of drugs, aerosol therapy is nowadays another way of administration available in horses. It has the advantage to ... [more ▼]

Although the classical treatment for respiratory disease include systemic administration of drugs, aerosol therapy is nowadays another way of administration available in horses. It has the advantage to allow to minimise the dosage of drug and has a better efficacy/toxicity ratio. This paper summarises the advantages and drawbacks of this technique, the different equipment nowadays available as well as the main drugs that may be use for aerosol therapy in horses [less ▲]

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See detailImpact of training and exercise intensity on blood antioxidant markers in healthy Standardbred horses
De Moffarts, Brieuc; Kirschvink, Nathalie; Art, Tatiana ULg et al

in Equine & Comparative Exercise Physiology (2004), 1(3), 211-220

This study investigated the effect of training and exercise intensity on blood antioxidant markers in six healthy Standardbred horses. Markers studied were uric acid (UA), ascorbic acid (AA), α-tocopherol ... [more ▼]

This study investigated the effect of training and exercise intensity on blood antioxidant markers in six healthy Standardbred horses. Markers studied were uric acid (UA), ascorbic acid (AA), α-tocopherol, vitamin A (Vit A), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione – reduced (GSH) and oxidized (GSSG), glutathione redox ratio (GRR), copper (Cu), zinc (Zn) and selenium (Se). The horses performed a standardized exercise test (SET) when they were untrained (T0), after 4 weeks of light training (T4) and after 8 weeks of interval training (T12). Forty-eight hours after SET T4 and SET T12, a SET with run up to fatigue (TTF4 and TTF12) was performed. Maximal oxygen consumption (V˙O2max) was determined within 3–5 days after TTF4 and TTF12. At each test (SET T(i) and TTF(i)), venous blood was sampled at rest (R), peak-exercise (Emax), 15 (E15) and 60 (E60) min after the test. UA, AA and GRR were increased significantly by the exercise, whereas GSH and Vit A were decreased significantly (P<0.05). Training-related increases (T0 vs. T4 vs. T12) were observed for UA, SOD, GPx and Se, whereas GSH, α-tocopherol and Zn decreased (P<0.05). Exercise intensity (TTF(i) vs. T(i)) increased UA and AA significantly and decreased GSH significantly (P<0.05). A significant correlation between ΔSOD and ΔV˙O2max (r=0.86, p<0.05) determined at SET T4 and SET T12 was found. Taken together, these results indicate that training and exercise intensity significantly influence blood antioxidant markers in healthy Standardbred horses [less ▲]

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See detailInfluence of breathing pattern and lung inflation on impulse oscillometry measurements in horses.
Van Erck, Emmanuelle; Votion, Dominique ULg; Kirschvink, Nathalie et al

in Veterinary Journal (2004), 168(3), 259-69

The objective of this paper was to determine if changes in ventilation patterns could influence the outcome of respiratory function measurements performed with our impulse oscillometry system (IOS) in ... [more ▼]

The objective of this paper was to determine if changes in ventilation patterns could influence the outcome of respiratory function measurements performed with our impulse oscillometry system (IOS) in horses. In a first study, IOS tests were performed in vitro on six isolated equine lungs. Lung inflation levels were controlled by modifying depressurisation inside an artificial thorax and different ventilation patterns were imposed. In a second in vivo study, transient variations in breathing pattern were evaluated both with the IOS and a current reference technique (CRT) in five healthy mature horses after an intravenous (i.v.) injection of lobeline hydrochloride. In both studies, respiratory rate (RR, range: 7-42 breaths/min.) and tidal volume (V(T), range: 0.4-25 L) had minor or no influence on IOS parameters. The influence of lung inflation, most marked for resistance at 5 Hz (R(5 Hz)), was limited for the considered physiological range. In vivo, statistical models indicated that maximal changes in pleural pressure (Max Delta Ppl) and peak flows were the main determinants of the variability of the resistance (R(rs)) and the reactance (X(rs)) of the respiratory system. The fourfold increase in baseline Max Delta Ppl and peak flows obtained during hyperpnoea caused a significant increase in R(rs) at 5 and 10 Hz and a decrease in X(rs) at all frequencies. We conclude that IOS parameters are not influenced by tachypnoea, but will reflect alterations in respiratory mechanics caused by hyperpnoeic breathing [less ▲]

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See detailFunctional effects of restrictive pulmonary diseases
Art, Tatiana ULg; Lekeux, Pierre ULg

in Dunlop, R. H.; Malbert, C. H. (Eds.) Veterinary Pathophysiology (2004)

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See detailMeasurement of respiratory function by impulse oscillometry in horses
Van Erck, Emmanuelle; Votion, Dominique ULg; Art, Tatiana ULg et al

in Equine Veterinary Journal (2004), 36(1), 21-28

Reasons for performing study: Due to technical implementations and lack of sensitivity, pulmonary function tests are seldom used in clinical practice. Impulse oscillometry (IOS) could represent an ... [more ▼]

Reasons for performing study: Due to technical implementations and lack of sensitivity, pulmonary function tests are seldom used in clinical practice. Impulse oscillometry (IOS) could represent an alternative method. Objectives: To define feasibility, methodology and repeatability of IOS, a forced oscillation technique that measures respiratory resistance (R-rs) and reactance (X-rs) from 5 to 35 Hz during spontaneous breathing, in horses. Methods: Using 38 healthy horses, R-rs and X-rs reference values were defined and influence of individual biometrical parameters was investigated. In addition, IOS measurements of 6 horses showing clinical signs of heaves were compared to those of 6 healthy horses. Results: Airtightness and minimal dead space in the facemask were prerequisites to IOS testing and standardisation of head position was necessary to avoid variations in R-rs due to modified upper airway geometry. In both healthy and diseased animals, measurements were repeatable. In standard-type breeds, the influence of the horse's size on IOS parameters was negligible. An increase in R-5Hz greater than 0.10 kPa/l/sec and R-5Hz>R-10Hz, combined with negative values of X-rs between 5 and 20 Hz, was indicative of heaves crisis. Conclusions: IOS is a quick, minimally invasive and informative method for pulmonary function testing in healthy and diseased horses. Potential relevance: IOS is a promising method for routine and/or field respiratory clinical testing in the equine species. [less ▲]

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See detailSpécificités cardiorespiratoires des ânes
Delvaux, Véronique ULg; Kirschvink, N.; Amory, Hélène ULg et al

in Proceedings: Congrès de l'Association Vétérinaire Equine Française (AVEF) (2004)

A group of 22 donkeys underwent a series of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For ... [more ▼]

A group of 22 donkeys underwent a series of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For particular tests (haematology, measurement of arterial blood gases, electrocardiogram width phonocardiogram, thoracic radiographs, cardiac echocardiography), no major différences were found. However, the mechanical ventilation parameters differed from those for horses and were similar to those for food-producing animals (cattle). The conformation of the pharynx and larynx is slightly différent to that of horses making it more difficult to pass an endoscope through this area. The differencial leukocyte count from tracheal lavage includes a number of epithelial cells, and a higher percentage of eosinophils and neutrophils for donkeys compared to horses. These similarities and différences between donkeys and horses should be taken into account when performing ancillary tests. [less ▲]

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See detailÉtude rétrospective des causes médicales d’intolérance à l’effort chez le cheval.
Ponthier, Jérôme ULg; van Ercke, Emmanuelle; Art, Tatiana ULg et al

Poster (2003, November)

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See detailUse of the impulse oscillometry system for testing pulmonary function during methacholine bronchoprovocation in horses.
Van Erck, Emmanuelle ULg; Votion, Dominique ULg; Kirschvink, Nathalie et al

in American Journal of Veterinary Research (2003), 64(11), 1414-1420

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses ... [more ▼]

OBJECTIVE: To compare sensitivity of the impulse oscillometry system (IOS) with that of the conventional reference technique (CRT; ie, esophageal balloon method) for pulmonary function testing in horses. ANIMALS: 10 horses (4 healthy; 6 with recurrent airway obstruction [heaves] in remission). PROCEDURE: Healthy horses (group-A horses) and heaves-affected horses (group-B horses) were housed in a controlled environment. At each step of a methacholine bronchoprovocation test, threshold concentration (TC(2SD); results in a 2-fold increase in SD of a value) and sensitivity index (SI) were determined for respiratory tract system resistance (R(rs)) and respiratory tract system reactance (X(rs)) at 5 to 20 Hz by use of IOS and for total pulmonary resistance (RL) and dynamic lung compliance (C(dyn)), by use of CRT. RESULTS: Bronchoconstriction resulted in an increase in R(rs) at 5 Hz (R(5Hz)) and a decrease in X(rs) at all frequencies. Most sensitive parameters were X(rs) at 5 Hz (X(5Hz)), R(5Hz), and R(5Hz):R(10Hz) ratio; RL and the provocation concentration of methacholine resulting in a 35% decrease in dynamic compliance (PC(35)C(dyn)) were significantly less sensitive than these IOS parameters. The TC(2SD) for X(rs) at 5 and 10 Hz was significantly lower in group-B horses, compared with group-A horses. The lowest TC(2SD) was obtained for X(5Hz) in group-B horses and R(5Hz) in group-A horses. CONCLUSIONS AND CLINICAL RELEVANCE: In contrast to CRT parameters, IOS parameters were significantly more sensitive for testing pulmonary function.The IOS provides a practical and noninvasive pulmonary function test that may be useful in assessing subclinical changes in horses. [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULg; De Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Pratique Vétérinaire Equine (2003), 35(139), 23-29

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ... [more ▼]

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ipratropium bromide have been tested. This study is to evaluate the efficacy of the synthetic antimuscarinic compound glycopyrrolate as a bronchodilator in horses. Respiratory crisis was induced in seven allergic horses by exposure to natural allergens. Prior to the study, it was established that the attack could be stopped using intravenous atropine sulphate. Pulmonary function tests (ventilation and arterial blood gas analysis) were performed on the horses before and then after aerosol administration of 1500 µg of glycopyrrolate (Robinul®). The attack was characterised by an increase in total pulmonary resis¬tance and maximum pleural pressure variation and by decreased compliance. This study demonstrates that glycopyrrolate exhibits affects that are just as rapid and effective as intravenous atropine or aerosol administration of 1200 µg dry powder Ipratropium. In addi¬tion the treatment was well tolerated and no side-effects were observed in contrast to those seen with intravenous administration of atro¬pine. Therefore this drug has an important role to play among the therapeutics available to practitioners for acute respiratory attacks in horses [less ▲]

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