References of "Ansseau, Marc"
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See detailAripiprazole, hypertension, and confusion.
Pitchot, William ULg; Ansseau, Marc ULg

in Journal of Neuropsychiatry and Clinical Neurosciences (The) (2010), 22(1), 12333

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See detailFibromyalgia and related conditions: Electromyogram profile during isometric muscle contraction
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Dupont, Catherine ULg et al

in Joint Bone Spine (2010), 77

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 ... [more ▼]

Objectives: To evaluate electromyogram (EMG) profiles in patients with three related conditions: fibromyalgia, chronic fatigue syndrome, and depression. Methods: We studied 44 healthy volunteers, 22 patients with fibromyalgia, 11 patients with chronic fatigue syndrome, and 10 patients admitted for depression. The trapezius electromyogram was recorded during maximally sustained, bilateral, 90◦ abduction of the shoulders. EMG signal frequency and amplitude were measured throughout the test. Results: In the fibromyalgia group, isometric contraction duration was significantly shorter than in the other two patient groups (P < 0.001) and the EMG frequency and amplitude pattern indicated premature discontinuation of the muscle contraction. Findings in the chronic fatigue patients were similar to those in the healthy controls. The patients with depression had a distinctive EMG profile characterized by excessive initial motor-unit recruitment with a shift in the frequency spectrum. Conclusions: Fibromyalgia was associated with a specific EMG pattern indicating premature discontinuation of the muscle contraction. Therefore, maximal voluntary muscle contraction tests may be of limited value for assessing function in fibromyalgia patients. Chronic fatigue syndrome patients had similar EMG findings to those in the healthy controls. The EMG alterations in the patients with depression were consistent with manifestations of psychomotor retardation. [less ▲]

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See detailEffets du cannabis sur la santé psychologique
Quertemont, Etienne ULg; Blairy, Sylvie ULg; Ansseau, Marc ULg

in Seutin, Vincent; Scuvée, Jacqueline; Quertemont, Etienne (Eds.) Regards croisés sur le cannabis (2010)

Les individus intoxiqués au cannabis rapportent généralement des effets subjectifs plaisants, même si des symptômes désagréables ne sont pas à exclure chez certaines personnes ou à certaines occasions ... [more ▼]

Les individus intoxiqués au cannabis rapportent généralement des effets subjectifs plaisants, même si des symptômes désagréables ne sont pas à exclure chez certaines personnes ou à certaines occasions. L’intoxication cannabique aiguë perturbe différents processus cognitifs plus ou moins intensément. Les effets les plus nets sont probablement les altérations de la mémoire qui surviennent lors de l’intoxication cannabique, et en particulier la perturbation de la consolidation de nouveaux souvenirs. Toutefois, on observe également lors de l’intoxication cannabique une altération de la flexibilité mentale et comportementale rendant les comportements plus rigides et plus impulsifs. Enfin, le cannabis perturbe clairement l’estimation subjective de l’écoulement du temps, donnant ainsi l’impression d’un ralentissement du temps. Ces derniers effets expliquent d’ailleurs en partie l’accroissement lors d’une intoxication cannabique des risques d’accidents de conduite automobile. En conclusion, et compte tenu des difficultés méthodologiques mentionnées précédemment, on peut affirmer que les gros consommateurs de cannabis, surtout ceux qui ont fumé du cannabis quotidiennement pendant de longues périodes couvrant parfois des années, présentent un fonctionnement cognitif légèrement altéré. Les déficits cognitifs identifiés sont plutôt de faible magnitude, touchent généralement la mémoire et disparaissent le plus souvent après quelques semaines d’abstinence. Il semble donc que le cannabis produit des altérations cognitives essentiellement durant les périodes de consommation. Les effets observés dans les semaines qui suivent l’arrêt de la consommation chez les gros consommateurs sont vraisemblablement liés au syndrome de sevrage cannabique ou à la présence résiduelle de cannabis dans l’organisme. Le fait que les déficits cognitifs identifiés chez les consommateurs chroniques de cannabis abstinents ressemblent fortement aux effets de l’intoxication cannabique (légers troubles de la mémoire, réduction de la flexibilité mentale et impulsivité), renforce l’idée qu’il pourrait s’agir d’effets résiduels du cannabis qui mettent plus longtemps à se résorber chez les très gros consommateurs. A ce jour, les études scientifiques n’ont donc pas encore démontré de manière incontestable l’existence de troubles cognitifs persistants, voire permanents, chez les consommateurs réguliers de cannabis devenus abstinents depuis plusieurs mois, mais ils ne les ont pas exclus non plus. Une conclusion prudente serait dès lors que les déficits cognitifs persistants induits par la consommation régulière de grosses quantités de cannabis sont relativement limités et transitoires. Ceci n’exclut pas la survenue d’autres problèmes à long terme, comme par exemple le développement d’une addiction au cannabis, des difficultés sociales ou relationnelles ou d’autres effets sur la santé. D’autres études, méthodologiquement mieux contrôlées, seront cependant nécessaires pour conclure définitivement sur la question de l’existence d’altérations cognitives persistantes suite à la consommation chronique de cannabis. Compte tenu des résultats parfois contradictoires de la littérature scientifique, il n’est pas aisé de tirer des conclusions fermes à propos des effets du cannabis sur la santé psychologique et particulièrement sur les effets persistants susceptibles de se perpétuer au-delà des périodes d’intoxication. Alors que le tableau de l’intoxication/ivresse cannabique est relativement clair, les effets persistants d’une consommation abusive de cannabis sont l’objet d’âpres débats. On peut néanmoins tirer les conclusions suivantes. Les études les plus récentes concordent pour affirmer que l’abus de cannabis, surtout durant l’adolescence, est susceptible de provoquer des troubles psychotiques ou, de manière encore plus évidente, de les précipiter chez des individus fragiles. L’abus chronique de cannabis semble aussi favoriser les troubles de l’humeur, tels que dépression et trouble bipolaire. L’existence d’un syndrome amotivationnel qui serait induit par l’abus chronique de cannabis est plus controversée, même s’il est observé dans certaines études. Ce syndrome amotivationnel supposé est en partie lié à différents troubles cognitifs induits par le cannabis. S’il est avéré que la consommation chronique de cannabis provoque effectivement des altérations du fonctionnement cognitif et tout particulièrement de la mémoire, il reste à déterminer si ces déficits cognitifs persistent au-delà des périodes d’intoxications ou s’ils s’estompent progressivement après l’arrêt de l’abus de cannabis. [less ▲]

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See detailElectroconvulsive therapy for depression in a patient with an intracranial arachnoid cyst.
Desseilles, Martin ULg; Thiry, Jean-Christophe; Monville, Jean-Francois et al

in Journal of ECT (2009), 25(1), 64-6

Electroconvulsive therapy (ECT) has been frequently considered relatively contraindicated in patients with space-occupying lesions in the brain. After the 7 cases available in the literature, we describe ... [more ▼]

Electroconvulsive therapy (ECT) has been frequently considered relatively contraindicated in patients with space-occupying lesions in the brain. After the 7 cases available in the literature, we describe the safe use of ECT in a depressive patient with arachnoid cyst. We provide a comprehensive review on this clinical association, and we conclude that even if the few data available are reassuring, careful neurological evaluation before the ECT treatment is indicated. [less ▲]

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See detailFacteurs genetiques de l'alcoolo-dependance Revue des principales donnees de la litterature.
Pinto, Emmanuel ULg; Ansseau, Marc ULg

in Encéphale (L') (2009), 35(5), 461-9

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric ... [more ▼]

INTRODUCTION: Alcohol dependence is a complex and multifactorial disease resulting both from neurobiological mechanisms and environmental factors. It is frequently associated with comorbid psychiatric disorders or with specific personality or behavioral features. Although action can be taken on the environment in order to decrease the risk of the illness, current methods used to prevent or to treat this pathology show moderate efficacy: problematic consumption of ethanol in the general population as well as relapse rates under treatment in dependent patients remain indeed very high. LITERATURE FINDINGS: It is therefore of major importance to broaden our knowledge of alcohol dependence and its comorbidities so as to improve both their prevention and treatment. In this perspective, recent progress in the field of neurosciences may contribute to achieve this goal. Precisely, genetics is a promising way benefiting from many advances in genetic epidemiology, cellular and molecular biology, neuroimaging and pharmacology. In parallel with a better understanding of the neurobiology of addictions and associated behaviors, these techniques led to the identification of brain mechanisms in which a genetic variation may influence the individual vulnerability towards alcohol dependence. Moreover, there is growing evidence that alcoholism results from the interaction of genetic and environmental factors influencing both its expression and its course. Given the fact that alcohol-dependence seems highly heritable (50 to 60% of the variance in both men and women), this review assesses the role of some of the genomic regions linked with the disease, as well as the principal variants of candidate genes identified as specifically involved in the predisposition. Polymorphisms of genes influencing alcohol metabolism, GABAergic, dopaminergic and serotonergic neurotransmission seem, indeed, at stake in the development of alcohol-dependence and its related features such as personality, behavior, impulse control or craving. In the future, a better characterization of the links between genotypes and phenotypes will probably increase our ability to treat alcoholic patients. [less ▲]

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See detailNeurobiological bases of suicidality in major depression
Desseilles, Martin ULg; Scwartz, Sophie; Dang Vu, Thanh et al

in World Journal of Biological Psychiatry (2009), 9(Suppl. 1),

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See detailAbnormal neural filtering of irrelevant visual information in depression
Desseilles, Martin ULg; Balteau, Evelyne ULg; Sterpenich, Virginie et al

in NeuroImage (2009), 45(Suppl. 1),

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See detailObjective: remission of depression in primary care The Oreon Study.
Ansseau, Marc ULg; Demyttenaere, Koen; Heyrman, Jan et al

in European Neuropsychopharmacology (2009), 19(3), 169-76

OBJECTIVE: Treatment of depression should result in the absence of symptoms, i.e. remission, in order to restore the functional status of the patient and reduce the risk for relapse. The study assessed ... [more ▼]

OBJECTIVE: Treatment of depression should result in the absence of symptoms, i.e. remission, in order to restore the functional status of the patient and reduce the risk for relapse. The study assessed the current remission rates in primary care and determined the influencing factors. METHODS: 10 consecutive depressive patients treated by antidepressants for at least 3 months and not more than 12 months were screened by each investigator. Remission rates were defined using the Hamilton-Depression scale 7 items (score of 3 or less) as well as the Carroll self rating scale (score of 7 or less). In addition, patients completed the Sheehan Disability Scale (SDS). Initial severity of depression, type of treatment and socio-economic factors were collected. RESULTS: 292 general practitioners screened a total of 2630 patients. Results indicated low remission rates: 28.3% according to the clinician and 17.1% according to the patient. Absence of remission was associated with higher impairment in work, social and family life. The most frequently reported residual symptoms in nonremitters were general somatic symptoms (92%), depressed mood (92%), psychic anxiety (91%) and impaired work and activities (89%). No differences were observed in remission rates between men and women. Remission rates were significantly lower in patients living alone as compared to those living in couple or family (25.1% vs 30.2%, p=0.03), in patients with lower education (21.3% vs 32.3%, p<0.001), in patients speaking French as compared to Dutch (24.0% vs 34.0% p<0.001), and unemployed patients compared to patients having an occupation (17.1% vs 39.0%, p<0.001). Higher initial severity and number of previous episodes decreased remission rates (p<0.001). CONCLUSION: This study shows low remission rates in depressed patients treated in general practice. The absence of remission is associated with impairment in work, social and family life. Special attention should be given to identify patients who do not reach remission. [less ▲]

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See detailOxytocin: From milk ejection to maladaptation in stress response and psychiatric disorders. A psychoneuroendocrine perspective.
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Geenen, Vincent ULg et al

in Annales d'Endocrinologie (2009), 70(6), 449-54

Oxytocin (OT) is implicated in stress reduction as well as in social behavior. It inhibits the stress-induced activity of the hypothalamic-pituitary adrenal axis responsiveness. OT is involved in social ... [more ▼]

Oxytocin (OT) is implicated in stress reduction as well as in social behavior. It inhibits the stress-induced activity of the hypothalamic-pituitary adrenal axis responsiveness. OT is involved in social affiliation, sexual and maternal-infant binding, anxiety, mood, feeding control and memory. Several lines of evidence suggest a role of OT in psychiatric disorders. Various psychiatric disorders are strongly influenced by social variables, such as panic attacks, depression and early childhood autism, and seem to exhibit a particularly close connection with the brain dynamics that underlie social emotions. This paper proposes an overview of OT in psychiatric disorders through the links with the stress response and prosocial behavior. [less ▲]

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See detailL'hypnose dans la prise en charge des douleurs chroniques
Zelinka, V.; Faymonville, Marie-Elisabeth ULg; Pitchot, William ULg et al

in Acta Psychiatrica Belgica (2009), 109(3), 21-28

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING ... [more ▼]

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING, CLINICAL STUDIES AND EMPIRICAL OBSERVATIONS. THESE DATA SHOWTHAT THROUGH THE DIVERSITY OF ITS EFFECTS, HYPNOSIS CAN MODULATE THE BIO-PSYCHO-SOCIAL DIMENSIONS OF CHRONIC PAIN. THE CHOICE OF THIS THERAPEUTIC TECHNIQUE SHOULD BE GUIDED BY THE ESTIMATE OF ITS USEFULNESS. THE EFFICACY IS ASSESSED ON AN INDIVIDUAL BASIS, TAKING INTO ACCOUNT THE BENEFITS AND LIMITATIONS OF HYPNOSIS FOR EACH PATIENT. [less ▲]

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See detailDependance au zolpidem et crise d'epilepsie.
Pitchot, William ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (2009), 64(7-8), 407-8

Zolpidem is an imidazopiridine with hypnotic properties. Compared to benzodiazepines, zolpidem has a mechanism of action that is thought to reduce the risk of dependence or abuse. However, in the past 10 ... [more ▼]

Zolpidem is an imidazopiridine with hypnotic properties. Compared to benzodiazepines, zolpidem has a mechanism of action that is thought to reduce the risk of dependence or abuse. However, in the past 10 years, several cases of zolpidem abuse, dependence and withdrawal reactions have been described in the litterature. Here, we describe a case of dependence and withdrawal seizure. [less ▲]

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See detailThe TaqI A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease?
Pinto, Emmanuel ULg; Reggers, Jean ULg; Gorwood, Philip et al

in Alcohol (2009), 43(4), 271-5

Cloninger's type II is a severe, early-onset, male-limited, and genetically influenced, impulsive form of alcoholism. Significant association has been reported between the A1 allele of the D2 dopamine ... [more ▼]

Cloninger's type II is a severe, early-onset, male-limited, and genetically influenced, impulsive form of alcoholism. Significant association has been reported between the A1 allele of the D2 dopamine receptor (DRD2) gene, substance misuse and personality traits of impulsivity and novelty seeking. We assessed the association between the TaqI A DRD2 gene polymorphism with Cloninger's typology and family history of alcohol abuse, which is thought to be more frequent in type II alcoholics. Fifty-one male alcohol-dependent patients were discriminated between type I and type II according to age at onset of alcohol-related problems and interviewed about family history of alcoholism. The associations between DRD2 (A1 or A2 alleles), family history, and typology were assessed by Pearson's chi-square test. Although typology was not associated with the studied polymorphism, a higher rate of general family history of alcohol abuse was still observed in type II patients (chi(2)(1)=4.53; P=.033). Furthermore, the A1 allele of the DRD2 was significantly associated with paternal history of alcoholism (chi(2)(1)=4.66; P=.031) and male, first-degree, collateral history of alcoholism (chi(2)(1)=4.40; P=.036). Age at onset of alcohol-related problems as main discriminator between type I and type II alcohol dependence does not seem to be associated by the TaqI A DRD2 polymorphism. However, the A1 allele of the DRD2 may be a marker of male familial alcoholism, which has been associated with type II alcohol dependence. [less ▲]

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See detailLe cerveau dans tous ses etats.
Moonen, Gustave ULg; Ansseau, Marc ULg; Scheen, André ULg

in Revue Médicale de Liège (2008), 63(5-6), 229-30

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See detailContingent negative variation abnormalities in posttraumatic stress disorder
Papart, Patrick ULg; Ansseau, Marc ULg; Bartholomé, F.

in European Neuropsychopharmacology (2008), 18(Suppl 4), 481-482

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See detailL'électroconvulsivothérapie en 2008.
Servais, Sophie ULg; Ansseau, Marc ULg; Mikolajczak, Gladys ULg et al

in Revue Médicale de Liège (2008), 63

L’électroconvulsivothérapie (anciennement dénommée sismothérapie, électronarcose ou électrochoc) est une technique thérapeutique utilisée dans certaines affections psychiatriques. Elle consiste en la ... [more ▼]

L’électroconvulsivothérapie (anciennement dénommée sismothérapie, électronarcose ou électrochoc) est une technique thérapeutique utilisée dans certaines affections psychiatriques. Elle consiste en la réalisation d’une crise convulsive généralisée induite par le passage d’un courant électrique transcrânien. S’il est vrai que cette méthode continue de stigmatiser l’imaginaire collectif en suscitant effroi et méfiance (modèle de barbarie thérapeutique pour certains, traitement obsolète pour d’autres), elle se révèle, au contraire, être un traitement souvent très efficace, dans certains cas irremplaçable, et dans l’ensemble très bien toléré. Ainsi, ces dernières années ont vu un regain d’intérêt pour l’ECT. Elle constitue, aujourd’hui, la plus ancienne des somathérapies psychiatriques toujours en vigueur. [less ▲]

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See detailDépression et neuroplasticité.
Pitchot, William ULg; Polis, Marie-Hélène ULg; Belachew, Shibeshih ULg et al

in Revue Médicale de Liège (2008), 63

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See detailEditorial. Le cerveau dans tous ses états.
Moonen, Gustave ULg; Ansseau, Marc ULg; Scheen, André ULg

in Revue Médicale de Liège (2008), 63

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See detailShock-like sensations associated with duloxetine discontinuation.
Pitchot, William ULg; Ansseau, Marc ULg

in Annals of Clinical psychiatry : Official Journal of the American Academy of Clinical Psychiatrists (2008), 20(3), 175

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