References of "Ansseau, Marc"
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See detailNeurophysins response to apomorphine and clonidine in major depression
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Legros, Jean-Jacques ULg

in European Neuropsychopharmacology (2005, March), 15(Suppl. 1), 77-78

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See detail5-Hydroxytryptamine 1A receptors, major depression, and suicidal behavior.
Pitchot, William ULg; Hansenne, Michel ULg; Pinto, Emmanuel ULg et al

in Biological Psychiatry (2005), 58(11), 854-8

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are ... [more ▼]

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are available, however, regarding the possible specific role of 5-HT1A receptors in the biology of suicidality. Therefore, the aim of our study was to use a neuroendocrine strategy to test the hypothesis of a role for 5-HT1A receptors in the biology of suicidal behavior. METHODS: Hormonal (adrenocorticotropic hormone [ACTH], cortisol, prolactin [PRL]) and temperature responses after administration of flesinoxan, a highly potent and selective 5-HT1A receptor full agonist, were assessed in 40 inpatients with major depression, divided into two subgroups (20 suicide attempters and 20 nonattempters), compared with 20 normal control subjects matched for gender and age. RESULTS: Compared with nonattempters, suicide attempters exhibited significantly lower PRL (p = .01), cortisol (p = .014), and temperature (p = .0002) responses. Prolactin (p = .007), cortisol (p = .04), and temperature (p = .00003) responses were also decreased in suicide attempters compared with normal control subjects. In contrast, we did not observe any significant differences in hormonal or temperature responses to flesinoxan between depressed patients without a history of suicide attempt and normal control subjects. CONCLUSIONS: The present study tends to confirm the role of 5-HT and more specifically 5-HT1A receptors in the biology of suicidal behavior in major depression. [less ▲]

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See detailLa dépression : au cœur du mal (2/3).
Ansseau, Marc ULg

in Tempo Médical (2005), 272

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See detailLa dépression : la réponse thérapeutique (3/3)
Ansseau, Marc ULg

in Tempo Médical (2005), 274

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See detailDHCo Délivrance d'héroïne sous contrôle médical
Ansseau, Marc ULg; Gustin, Frédéric; Hodiaumont, Fabienne et al

Book published by Academia Press (2005)

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See detailObsessive-compulsive personality disorder: Response to pharmacological treatment.
Ansseau, Marc ULg

in Maj, M.; Akiskal, H. S.; Mezzich, J. E. (Eds.) et al Personality Disorders (2005)

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See detailTherapeutic application of right prefrontal low repetitive transcranial magnetic stimulation on depressed patients
Fuchs, S.; Reggers, Jean ULg; Pinto, Emmanuel ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 226

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See detailNeurohypophyseal response to apomorphine and clonidine stimulation in major depression
Scantamburlo, Gabrielle ULg; Fuchs, Sonia; Pitchot, William ULg et al

in European Neuropsychopharmacology (2004, October), 14(Suppl. 3), 291-292

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See detailL'attaque de panique
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (2004), 59(5), 293-6

Panic attacks can occur unexpectedly and in almost any situation. The present article discusses the main features of anxiety states, the approach, the management and the practice guidelines for the ... [more ▼]

Panic attacks can occur unexpectedly and in almost any situation. The present article discusses the main features of anxiety states, the approach, the management and the practice guidelines for the treatment of panic disorder. [less ▲]

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See detailHormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study
Pitchot, William ULg; Wauthy, Jacques ULg; Legros, Jean-Jacques ULg et al

in European Neuropsychopharmacology (2004), 14(2), 151-155

RATIONALE: Flesinoxan is a highly potent and selective 5-HT1A agonist. In a recent study, in normal volunteers, flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone ... [more ▼]

RATIONALE: Flesinoxan is a highly potent and selective 5-HT1A agonist. In a recent study, in normal volunteers, flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. OBJECTIVES: In order to better define the role of 5-HT receptor subtypes in response to flesinoxan, we assessed the influence of 5-HT1A and 5-HT2 antagonists on hormonal and temperature responses to flesinoxan. METHODS: Hormonal and temperature responses were studied in 6 volunteers with or without pretreatment with pindolol (30 mg p.o.), a 5-HT1A antagonist, or ritanserin (10 mg p.o.), a selective 5-HT2 antagonist, using a double-blind crossover design. RESULTS: Pindolol significantly antagonized ACTH, PRL, GH and temperature responses to flesinoxan and ritanserin exhibited similar activity on PRL and ACTH responses. CONCLUSIONS: These results show the role of 5-HT1A mechanisms in the PRL, ACTH, GH, and temperature responses to flesinoxan, and the role of 5-HT2 mechanisms in PRL and ACTH responses. Therefore, they confirm the interest of flesinoxan as a 5-HT neuroendocrine probe. [less ▲]

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See detailPersonality profile and drug of choice; a multivariate analysis using Cloninger's TCI on heroin addicts, alcoholics, and a random population group.
Le Bon, O.; Basiaux, P.; Streel, E. et al

in Drug and Alcohol Dependence (2004), 73(2), 175-82

As personality may predispose, precipitate or perpetuate substance abuse and/or dependence, and as it is considered to remain stable across the years in a given subject, potential links with the drug of ... [more ▼]

As personality may predispose, precipitate or perpetuate substance abuse and/or dependence, and as it is considered to remain stable across the years in a given subject, potential links with the drug of choice may help screen future patients before drug consumption. The present study compared three groups: 42 patients with heroin dependence (mean age: 31.2; standard deviation (SD): 5.5; 10 females), 37 patients with alcohol dependence (mean age 44.2; SD: 9.1; 9 females) and 83 subjects from a random population sample (mean age: 38.8; SD: 6.9; 20 females). Personality was measured by Cloninger's Temperament and Character Inventory (TCI). Pillai's MANCOVA with age as a covariate and gender as a cofactor was highly significant. Univariate ANOVA analyses using TCI dimensions as dependent variable showed most variables to vary in parallel for the two patient groups in comparison with controls. Post-hoc tests showed heroin patients to score higher in Novelty-Seeking and Self-Directedness than alcohol patients. Sub-dimensions Exploratory Excitability, Fear of the Uncertain, Responsibility, Congruent Second Nature and Transpersonal Identification were also significantly different in the two patient samples. Logistic regression showed Exploratory Excitability to segregate up to 76% of heroin patients from alcohol patients. In conclusion, personality profiles were linked to some preferential choice of drug and personality screening might be tested in preventive strategies. [less ▲]

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See detailImpact of low frequency transcranial magnetic stimulation on event-related brain potentials.
Hansenne, Michel ULg; Laloyaux, Olivier ULg; Mardaga, Solange et al

in Biological Psychology (2004), 67(3), 331-41

Contradictory findings exist concerning the inhibitory function of low frequency repetitive transcranial magnetic stimulation (rTMS). Therefore, the study examines the impact of different duration of low ... [more ▼]

Contradictory findings exist concerning the inhibitory function of low frequency repetitive transcranial magnetic stimulation (rTMS). Therefore, the study examines the impact of different duration of low frequency rTMS on ERPs. In 17 subjects, auditory ERPs were measured before and after 1 Hz rTMS delivered over the left prefrontal cortex during 10 min (600 pulses) and 15 min (900 pulses). Results showed that 15 min of 1 Hz rTMS induced a significant increase of P300 latency. There was no effect for early ERP components (N100, P200 and N200). This study confirms and extends that 1 Hz rTMS produces a real inhibitory effect only when the duration of the stimulation is about 15 min. The data suggest that rTMS modifies the speed of cognitive processing rather than the energetical aspect of information processing, and that cortical inhibition induced by the magnetic stimulation affects principally the controlled cognitive processes and not the automatic ones. [less ▲]

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See detailSerum melatonin and urinary 6-sulfatoxymelatonin in major depression.
Crasson, Marion ULg; Kjiri, Selwa; Colin, Anne et al

in Psychoneuroendocrinology (2004), 29

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See detailPolymorphisms in the CYP 2D6 gene: Association with plasma concentrations of fluoxetine and paroxetine
Charlier, Corinne ULg; Broly, Franck; Pinto, Emmanuel ULg et al

in Therapeutic Drug Monitoring (2003), 25(6), 738-742

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of ... [more ▼]

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of whites are poor metabolisers (PM), and, on the contrary, about 5% are ultrarapid metabolizers (UM), inducing very different rates in the transformation of antidepressants extensively metabolized by CYP 2D6. CYP 2D6 polymorphism can be a potential risk factor for the development of side effects or a reason for the poor efficacy of the treatment. Various probe drugs may be used for phenotyping CYP 2D6, but genotyping is now available using leukocyte DNA and is independent of concomitant drug use. in this study, we used PCR-based methods for the identification of CYP 2D6 genotypes in 49 patients receiving standard doses of fluoxetine or paroxetine and found that plasma concentration of the antidepressant drugs was significantly correlated with genetic status. In one patient who displayed CYP 2D6 gene duplication (UM), paroxetine plasma concentration was extremely low. in PM fluoxetine-treated patients, drug plasma concentration was significantly higher than that seen in extensive metabolizers. [less ▲]

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See detailExposition hormonale precoce et repercussions comportementales dans l'hyperplasie congenitale des surrenales: a propos d'un cas
Tortolani, Isabelle ULg; Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg et al

in Revue Médicale de Liège (2003), 58(10), 631-4

Congenital adrenal hyperplasia is a recessive autosomal transmission endocrine pathology that exposes people who suffer from it to an abnormally high concentration of adrenal androgens during the prenatal ... [more ▼]

Congenital adrenal hyperplasia is a recessive autosomal transmission endocrine pathology that exposes people who suffer from it to an abnormally high concentration of adrenal androgens during the prenatal and early postnatal periods. This disease induces female's virilism of variable degree. The case of a 29 year-old patient, who suffers from this affection and also presents a psychiatric disorder, raises questions about the possible consequences of an early exposure to androgens on the adult behaviour. [less ▲]

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See detailCognitive topography imbalance in alcoholism
Papart, Patrick ULg; Liota, F.; Bartholomé, F. et al

in Journal of Psychophysiology (2003), 17(Suppl 1), 7-8

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See detailRelationships between DRD2 and DAT polymorphisms and personality traits in healthy subjects
Pinto, Emmanuel ULg; Reggers, Jean ULg; Adam, Martine ULg et al

in European Neuropsychopharmacology (2003, September), 13(Suppl. 4), 427-428

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See detailMismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects.
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Scantamburlo, Gabrielle ULg et al

in Human Psychopharmacology (2003), 18(3), 201-5

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of the mismatch negativity (MMN) may contribute to a clearer understanding of its functional significance, and may have clinical implications. In this context, some findings suggest that the scalp-recorded MMN reflects activity from multiple neuronal ensembles within or in the immediate vicinity of the primary auditory cortex and with possible contribution from the frontal cortex. However, few data are available concerning the influence of neurotransmitter systems on the MMN. In this study, the relationship between both noradrenergic and dopaminergic systems and the MMN were investigated in 34 healthy volunteers. Noradrenergic and dopaminergic activities were assessed with the apomorphine and clonidine challenge tests. The results showed no significant relationship between either growth hormone (GH) responses to apomorphine or clonidine and the MMN amplitude or latency. Therefore, this study does not demonstrate the implication of dopaminergic and noradrenergic activities as assessed by GH response to apomorphine and clonidine for the generation and/or the modulation of the MMN. However, given the complexity of the central neurotransmitter systems, these results cannot be considered as definitive evidence against a relationship between dopaminergic and noradrenergic activity and the MMN. [less ▲]

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See detailHarm avoidance is related to mismatch negativity (MMN) amplitude in healthy subjects
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Scantamburlo, Gabrielle ULg et al

in Personality & Individual Differences (2003), 34(6), 1039-1048

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on ... [more ▼]

Event-related potential (ERP) studies evidenced that some personality dimensions induced different controlled cognitive attitudes towards the processing of information. However, few data are available on the possible relationships between personality and automatic attention or early sensory processing. In the present study the relationships between the mismatch negativity (MMN) and personality described by the Cloninger model of personality were investigated. Subjects were 32 healthy volunteers. The MMN was recorded with frequent stimuli tones of 1470 Hz, 70 dB and 40 ms duration, and target (20%) tones of 1470 Hz, 70 dB, 80 ms duration. The subjects completed a French version of the 226-item self-questionnaire TCI within the day following psychophysiological recording. The results showed that the HA dimension was negatively correlated with the MMN amplitude. The association was more present among women than men. No significant relationship existed between the other dimensions of personality and either the MMN amplitude or latency. These findings suggest that the MMN is related to the behavioral inhibition system (BIS), a fact which is consistent with clinical studies conducted on schizophrenia and anxiety disorders. In conclusion, this study suggests that personality dimensions induce different automatic attitudes towards the processing of information. (C) 2002 Published by Elsevier Science Ltd. [less ▲]

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See detailDépression, anxiété, agressivité, impulsivité et comportement suicidaire
PAQUAY, Catherine ULg; PITCHOT, William ULg; Reggers, Jean et al

in Acta Psychiatrica Belgica (2003), 103

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