References of "Ansseau, Marc"
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See detailImplication de la neurohypophyse dans le stress psychique
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Legros, Jean-Jacques ULg

in Encéphale (L') (2001), 27(3, May-Jun), 245-59

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various ... [more ▼]

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various psychiatric diseases such an anorexia nervosa, bipolar disorder, schizophrenia and obsessive-compulsive disorder. AVP and OT are secreted into the hypophyseal portal circulation by neurons which project from the paraventricular nucleus to the external zone of the median eminence. AVP and OT-containing neurons in the suprachiasmatic and paraventricular nuclei project to limbic areas, including the hippocampus, the subiculum, the ventral nucleus of the amygdala and the nucleus of the diagonal band. Specific AVP receptors which are pharmacologically different from the pressor and antidiuretic AVP receptors have been found in the anterior pituitary. OT receptors have been identified in a variety of forebrain sites. The neurohypophyseal secretion is regulated by the cholinergic muscarinic, histaminergic and beta-adrenergic systems. Stress alters the secretion of one or more of the hypothalamic factors which interact at the pituitary to increase the secretion of ACTH. AVP and OT have been shown to modulate the effect of Corticotropin-Releasing Factor (CRF) on ACTH secretion and appear to play a key role in mediating the ACTH response to stress. Although AVP is a relatively weak secretagogue for ACTH, it markedly potentiates the activity of CRF both in vitro and in vivo. The role of OT is more complex. In vitro, OT stimulates ACTH release at high doses whereas in human it inhibits ACTH secretion at low doses. The type of stressor appear to determine the relative importance of these secretatogues in ACTH response. Several recent studies indicate that psychological stressors display a similar degree of variety of secretagogue release patterns as was found earlier for physical stressors. A bewildering array of technique produces a bewildering array of conclusions. In rats, OT may be an important secretagogue during a novel stimulus, whereas the role for AVP is less clear. Indeed two studies out of ten suggest a stimulating role for AVP. In response to frustration and submission, OT and AVP are secreted. Regarding social isolation, results are difficult to interpret and the role of AVP could be species-dependent. In contrast plasma OT levels do not change. After restraint, ACTH release is primarily mediated by the active increase of OT and AVP does not appear to play a role. When restraint is associated with moderate levels of physical components and during immobilisation, all two secretagogs are involved in the ACTH response. With fear, ACTH response appears to be driven by OT. In humans, one study indicates that high emotionality women increase plasma OT in response to uncontrollable noise. Various neuroendocrine dysregulations have been observed in psychiatric disease. Either an increase or a decrease of the hypothalamic-pituitary-adrenal (HPA) function have been described in several illnesses. Effects of OT appear to be reciprocal to the effects of AVP. OT has been called the "amnestic" neuropeptide due to its capacity to attenuate memory consolidation and retrieval. AVP exhibits a central activating action on mood, memory and selective attention. Underweight patients with anorexia nervosa have abnormally high levels of centrally directed AVP and reduced OT levels. These modifications could enhance the retention of cognitive distortions of aversive consequences of eating. Patients with bipolar disorder show a biphasic secretion of AVP. Depressive episodes are associated with decreased vasopressinergic activity whereas manic episodes involve an increased release. AVP might be responsible for an increased catecholamine activity. In addition, lithium could act as an antagonist to AVP. In schizophrenic patients, studies using the apomorphine stimulation suggest increased oxytoninergic and decreased vasopressinergic functions. These findings are consistent with the beneficial role of AVP on schizophrenic symptoms noted in several trials. The increased OT could be responsible for "positive" symptomatology such as delusions and hallucinations. Obsessive compulsive disorder (OCD) includes a range of cognitive and behavioral disturbances that could be influenced by OT. In animals, several studies have emphasized the role of AVP in promoting repetitive grooming behaviors and maintaining conditioned response to aversive stimuli. In OCD patients, one study have reported that AVP/OT ratio was negatively correlated with symptom severity. However, an independent report found similar AVP concentrations in OC patients without a personal or family history of tic disorder and in normal subjects. Whether these modifications are only a consequence of the central disturbances or whether those peptides could participate in the pathogenesis of these affections remains to be elucidated. [less ▲]

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See detailBelgian normative data of the temperament and character inventory
Hansenne, Michel ULg; Le Bon, O.; Gauthier, Audrey ULg et al

in European Journal of Psychological Assessment (2001), 17(1), 56-62

The Temperament and Character Inventory (TCI) is a 226-item self-questionnaire developed to assess the seven dimensions of personality described by Cloninger and his colleagues. Normative data from 322 ... [more ▼]

The Temperament and Character Inventory (TCI) is a 226-item self-questionnaire developed to assess the seven dimensions of personality described by Cloninger and his colleagues. Normative data from 322 representative French-speaking subjects from Belgium are presented and the psychometric properties are discussed. Mean scores of temperament dimensions were appreciably different from those published by Cloninger. In our sample, novelty seeking and self-transcendence scores were lower and harm avoidance scores were higher compared to US norms. The other dimensions were almost identical. The factorial analysis showed that the hypothesized factor structure of temperament and character dimensions was almost confirmed. The present study also confirmed that the TCI scales were weakly related among themselves. The relationships were consistent with those reported by previous reports. Gender differences were also found for different dimensions. [less ▲]

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See detailRelationship between Clinical Effects, Serum Drug Concentration, and Concurrent Drug Interactions in Depressed Patients Treated with Citalopram, Fluoxetine, Clomipramine, Paroxetine or Venlafaxine
Charlier, Corinne ULg; Pinto, Emmanuel ULg; Ansseau, Marc ULg et al

in Human Psychopharmacology (2000), 15(6), 453-459

The relationship between clinical effects and plasma concentrations of citalopram, fluoxetine, clomipramine, paroxetine and venlafaxine was studied in 119 cases of major depression. Clinical effects were ... [more ▼]

The relationship between clinical effects and plasma concentrations of citalopram, fluoxetine, clomipramine, paroxetine and venlafaxine was studied in 119 cases of major depression. Clinical effects were evaluated using the Clinical Global Impression (CGI) improvement scale. Antidepressants were quantified by a separative chromatographic methodology. Plasma concentrations in responder patients were compared with the plasma concentrations proposed in literature as effective values. We found that the usual therapeutic window is convenient for citalopram and clomipramine, but could be reduced for fluoxetine and increased for venlafaxine and paroxetine. Concurrent drug interactions were also evaluated and clomipramine or citalopram plasma levels were found to be influenced by the presence of associated drugs. A larger study is needed, taking into account not only plasma concentrations and clinical effects, but also some pharmacokinetic data, especially the metabolic activity characterising the patient, and the presence or not of associated drugs. Copyright 2000 John Wiley [less ▲]

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See detailRelationship between CNV topography and irritability in depression
Papart, Patrick ULg; WEERTS, Pascale ULg; Pinto, Emmanuel ULg et al

in Journal of Psychophysiology (2000), 14(Suppl 1),

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See detailP300 event-related brain potential and personality in depression.
Hansenne, Michel ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in European Psychiatry (2000), 15(6), 370-7

P300 is an event-related brain potential (ERP) particularly interesting to the study of cognitive processes in normal subjects and in psychopathology. P300 has been applied in depression with ... [more ▼]

P300 is an event-related brain potential (ERP) particularly interesting to the study of cognitive processes in normal subjects and in psychopathology. P300 has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect, suicidal behavior and psychotic features significantly influence P300 amplitude. However, no data are available on the possible influences of the personality of depressed patients on P300. Since personality is related to P300 in normal subjects, the aim of the present study is to investigate the relationship between ERPs (P200, N200, and P300) and the Temperament and Character Inventory (TCI) in 54 depressed patients. The main results of the study concern the absence of major correlations between personality dimensions as assessed by the TCI and ERP parameters among depressed patients. Only weak partial positive correlations relate N200 latency with harm avoidance, and P300 amplitude (Pz) with the self-directedness dimension. N200 amplitude is also negatively correlated to persistence. However, the preliminary nature of the presented results with respect to the weak statistical significance should be underlined. [less ▲]

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See detailSerotonergic-1a activity and contingent negative variation.
Hansenne, Michel ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in Biological Psychology (2000), 52(3), 259-65

While cholinergic, dopaminergic, noradrenergic, and gabaergic effects on contingent negative variation (CNV) have been largely described, little is known about serotonergic influence. Therefore, the ... [more ▼]

While cholinergic, dopaminergic, noradrenergic, and gabaergic effects on contingent negative variation (CNV) have been largely described, little is known about serotonergic influence. Therefore, the relationship between CNV and serotonergic activity as reflected by prolactin (PRL) response to flesinoxan, a 5-HT(1A) full agonist, has been investigated in 28 healthy volunteers. To investigate the clinical implications of the relationship between CNV and serotonergic-1a activity, a group of 43 depressed patients was included in the study. Results among healthy volunteers showed a significant negative relationship between PRL response to flesinoxan and CNV amplitude at Fz, but no relationship for the other electrodes (Cz and Pz). In depressed patients, the relationships were not significant. Overall, this study does not support serotonergic effects on CNV. However, this information is indirect (correlations) and is limited to 5-HT(1A) activity. [less ▲]

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See detailEffects on nicotine administered via a transdermal delivery system on vigilance : a repeated measure study
Mancuso, Giovanna; Andrès Bénito, Pilar; Ansseau, Marc ULg et al

in Psychopharmacology (1999), 142(1), 18-23

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing ... [more ▼]

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing test 1.3, 3 and 6.3 hrs after patch application, to verify the involvement of the dose of nicotine on the performance. The results confirm and extend the knowledge on the increasing effects of nicotine on vigilance previously found with orally and transdermally administered nicotine. Moreover, results show that such performance was independent of the time of nicotine absorption, which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time. ((c) 1999 APA/PsycINFO, all rights reserved) [less ▲]

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See detailDepressive vulnerability is not an independent risk factor for osteoporosis in postmenopausal women.
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Paul, I. et al

in Maturitas (1999), 33(2), 133-7

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy ... [more ▼]

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy postmenopausal women, whether depressive symptomatology, assessed by the General Health Questionnaire (GHQ), was associated to a significant decrease in BMD, hence supporting the hypothesis of an independent pathogenetic link between the two disorders. We investigated 121 postmenopausal women, aged 48-77 years, spontaneously attending a screening visit for osteoporosis in an outpatient facility. BMD of the spine and the non-dominant hip (total and neck areas) were measured by Dual Energy X-Ray absorptiometry. All subjects completed to the 'General Health Questionnaire' translated and validated in French. No significant correlations were observed between the GHQ score and BMD of the spine (P = 0.54), the total hip area (P = 0.65), or the femoral neck area (P = 0.65). No differences in terms of spinal or femoral BMD were observed between women with GHQ score < 5 or > or = 5. When comparing values of BMD between women within the upper and the lower quartiles for GHQ score, no difference was observed for spine (P = 0.69), total hip (P = 0.80), or femoral neck (P = 0.93). Similarly, GHQ scores were not significantly different when comparing women in the upper and lower quartiles of BMD distribution at the spine or the hip. In conclusion, notwithstanding the clinical pattern of postmenopausal osteoporosis can lead to depression and, on the other hand, hormonal and behavioral disturbances reported in depression might be enhancing factors for accelerated bone loss, our present results do not support the hypothesis that otherwise healthy postmenopausal women with increased depressive complaints are also more prone to exhibit osteoporotic fractures. [less ▲]

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See detailP300 event-related potential and serotonin-1A activity in depression.
Hansenne, Michel ULg; Ansseau, Marc ULg

in European Psychiatry (1999), 14(3), 143-7

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem ... [more ▼]

The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.40, P = 0.007 at Cz; r = -0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude. [less ▲]

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See detailHarm avoidance and serotonin.
Hansenne, Michel ULg; Ansseau, Marc ULg

in Biological Psychology (1999), 51(1), 77-81

The relationships between the Tridimensional Personality Questionnaire (TPQ) and serotonergic activity has been described in some studies with controversial results. These studies have focused on specific ... [more ▼]

The relationships between the Tridimensional Personality Questionnaire (TPQ) and serotonergic activity has been described in some studies with controversial results. These studies have focused on specific patient populations rather than normal controls. Therefore, the aim of the present study is to examine the relationships between the TPQ and serotonergic activity in a group of non-patient subjects. Twenty-three normal subjects answered the TPQ, and the serotonergic activity was assessed by the prolactin response to a highly potent and selective 5-HT1a agonist (flesinoxan). A positive relationship between harm avoidance and PRL response to flesinoxan was found. This study is consistent with the hypothesized link between serotonergic activity and the harm avoidance dimension of the biosocial model of Cloninger. [less ▲]

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See detailTemperament and character inventory (TCI) and depression.
Hansenne, Michel ULg; Reggers, J.; Pinto, Emmanuel ULg et al

in Journal of Psychiatric Research (1999), 33(1), 31-6

Although several studies have assessed the relationships between the temperament dimensions of the Cloninger model of personality and depression, little is known about the role played by the character ... [more ▼]

Although several studies have assessed the relationships between the temperament dimensions of the Cloninger model of personality and depression, little is known about the role played by the character dimensions proposed by the seven-factor model of Cloninger in depression. In this study, the relationships between the Temperament and Character Inventory (TCI) and depression were examined in a sample of 40 major depressive patients and 40 healthy controls. Depressed patients exhibit higher harm avoidance and self-transcendence scores as well as lower self-directedness and cooperativeness scores as compared to healthy controls. However, the three other dimensions do not differ between depressive patients and controls. Among the depressive group, harm avoidance, self-directedness and cooperativeness dimensions are related to the severity of depression as assessed by the Hamilton scale. This study confirms the state dependence of the harm avoidance dimension and suggests a relationship between the character dimensions of the Cloninger model and depression. [less ▲]

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See detailLe controle thérapeutique des médicaments antidépresseurs
Charlier, Corinne ULg; Ansseau, Marc ULg; Pinto, Emmanuel ULg et al

in Annales de Biologie Clinique (1999), 57(4, Jul-Aug), 463-8

Depression is a pathology frequently observed in general medicine (10%). Treatment of depression makes great use of drugs from different pharmacological classes. The optimal posology is difficult to ... [more ▼]

Depression is a pathology frequently observed in general medicine (10%). Treatment of depression makes great use of drugs from different pharmacological classes. The optimal posology is difficult to establish, and clinicians prefer to avoid side effects by prescribing low regimen. This study is related to an evaluation of seric antidepressant concentrations in comparison with the daily doses in a large psychiatric population. Side effects of drugs are appreciated by enzymatic determinations. [less ▲]

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See detailDépression et suicide : Aspects biologiques
ANSSEAU, Marc ULg; PITCHOT, William ULg

in Neuro-psy (1998)

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See detailThe tridimensional personality questionnaire (TPQ) and depression.
Hansenne, Michel ULg; Pitchot, William ULg; Gonzalez Moreno, A. et al

in European Psychiatry (1998), 13(2), 101-3

The relationships between the Tridimensional Personality Questionnaire (TPQ) and depression were examined in a sample of 53 major depressive patients and 33 healthy controls. Depressed patients exhibit ... [more ▼]

The relationships between the Tridimensional Personality Questionnaire (TPQ) and depression were examined in a sample of 53 major depressive patients and 33 healthy controls. Depressed patients exhibit higher harm avoidance scores as well as lower novelty seeking sub-scale exploratory excitability (NS1) scores as compared to healthy controls. However, the other dimensions and their sub-scales do not differ between depressive patients and controls. In the depressive group, the harm avoidance dimension is related to the severity of depression as assessed by the Hamilton scale. This study confirms the state dependence of the harm avoidance dimension and suggests a relationship between the novelty seeking sub-scale NS1 and depression. [less ▲]

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See detailCatecholaminergic function and temperament in major depressive disorder: a negative report.
Hansenne, Michel ULg; Ansseau, Marc ULg

in Psychoneuroendocrinology (1998), 23(5), 477-83

In the biosocial model of Cloninger, the three personality dimensions are related to different central neurotransmission systems. In agreement with this model, a recent study (Wiesbeck et al., 1995 ... [more ▼]

In the biosocial model of Cloninger, the three personality dimensions are related to different central neurotransmission systems. In agreement with this model, a recent study (Wiesbeck et al., 1995) showed an association between growth hormone response to apomorphine, an indirect assessment of the dopaminergic system, and novelty seeking score in alcohol-dependent men. In the present study we investigated the same methodology in a sample of major depressive patients. In addition, we assessed the relationship between noradrenergic function and Cloninger's dimensions using the clonidine test, an indirect assessment of the noradrenergic system. Growth hormone responses to apomorphine and clonidine were not associated with novelty seeking, reward dependence or harm avoidance dimension scores. This study therefore does not confirm the results of Wiesbeck et al. (1995), and does not support an association between noradrenergic activity and reward dependence dimension. However, given the complexity of central neurotransmission systems and the limitations of neuroendocrine challenges for the assessment of those processes, this study could not be considered as definitive evidence against the association between personality dimensions and their hypothesized central substrates. [less ▲]

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See detailLe cas clinique du mois. Un cas de syndrome de Munchausen (trouble factice).
Kjiri, K.; Ajamieh, A.; Hansenne, Michel ULg et al

in Revue Médicale de Liège (1998), 53(7), 390-2

Factitious disorders are characterized by physical or psychological symptoms that are intentionally produced or feigned in order to assume the sick role. In the particularly severe type presented by ... [more ▼]

Factitious disorders are characterized by physical or psychological symptoms that are intentionally produced or feigned in order to assume the sick role. In the particularly severe type presented by Munchausen syndrome, the person's entire life may consist of either trying to get admitted to or staying in hospitals. From the case of a 47 year old patient exhibiting symptoms of neurological aspect associated with psychological complaints, the issue of differential diagnosis of a factitious disorder is addressed. The integration of the reported symptomatology to the subject's personal history seems indispensable to the understanding and the global therapy of the patient. [less ▲]

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See detailLe monitoring thérapeutique des antidépresseurs
Charlier, Corinne ULg; Ansseau, Marc ULg; Gougnard, Thierry et al

in Revue Médicale de Liège (1997), 52(5), 336-44

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See detailInfluence of Diazepam on Contingent Negative Variation
Papart, Patrick ULg; Ansseau, Marc ULg; Timsit-Berthier, M.

in Human Psychopharmacology (1997), 12

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See detailHarm avoidance dimension of the Tridimensional Personality Questionnaire and serotonin-1A activity in depressed patients.
Hansenne, Michel ULg; Pitchot, William ULg; Moreno, A. G. et al

in Biological Psychiatry (1997), 42(10), 959-61

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