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See detailStatistical analysis of electrophoresis results in External Quality Assessment schemes
Zhang, Lixin ULg; Libeer, Jean-Claude; Hamers, Nicole et al

Poster (2006, July)

The goal of External Quality Assessment (EQA) schemes is to ensure that results obtained on a particular specimen in a given clinical laboratory do not differ significantly from those obtained by other ... [more ▼]

The goal of External Quality Assessment (EQA) schemes is to ensure that results obtained on a particular specimen in a given clinical laboratory do not differ significantly from those obtained by other laboratories on the same specimen. Hence, EQA aims at improving inter-laboratory agreement. Classically, the same blind control specimen is sent to all laboratories and test results are returned to the EQA organizer and analyzed statistically. Robust methods are used to estimate the mean (target value) and standard deviation (SD, inter-laboratory variability) because of the frequent presence of outliers. Laboratories are considered as “poor performers” if their results depart from the target value by a given threshold (e.g., 3×SD). Serum protein electrophoresis is a laboratory test which yields five fractions (albumin, α1, α2, β and γ) which sum up to 100%. So far, EQA schemes have analyzed the five fractions separately as for ordinary tests. Thus, a laboratory is qualified as a poor performer if at least one fraction is out of range. This approach does not take into account the other fractions and the linear relationship between them. A novel statistical approach has been developed to analyze EQA electrophoresis results from a global standpoint by using multivariate standard and robust methods to eliminate the effect of outlying profiles. When applied to electrophoresis data from the Belgian EQA scheme (n = 189 laboratories), the approach has shown that other laboratories should be considered as poor performers than by the classical univariate method. It has also highlighted the need for taking into account the type of electrophoresis assay in judging the laboratory performance. The method will be implemented routinely in the Belgian EQA scheme. [less ▲]

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See detailPrognostic value of PSA nadir < or =4 ng/ml within 4 months of high-dose radiotherapy for locally advanced prostate cancer
Nickers, Philippe ULg; Albert, Adelin ULg; Waltregny, David ULg et al

in International Journal of Radiation, Oncology, Biology, Physics (2006), 65(1), 73-77

PURPOSE: To investigate early prostate-specific antigen (PSA) kinetics after high radiation doses of 85 Gy on locally advanced prostate cancer. METHODS AND MATERIALS: A total of 201 patients were ... [more ▼]

PURPOSE: To investigate early prostate-specific antigen (PSA) kinetics after high radiation doses of 85 Gy on locally advanced prostate cancer. METHODS AND MATERIALS: A total of 201 patients were prospectively and consecutively treated with external beam radiotherapy and a brachytherapy boost. Of the 201 patients, 104 received concomitant hormonal therapy on the decision of the referring urologist and were excluded, yielding a study population of 97 patients. The first posttreatment PSA analysis was performed not earlier than 1 month after treatment completion but within the first 4 months, and then every 4 months. Analysis of PSA kinetics included the PSA nadir (nPSA) at values of < or =4 ng/mL to < or =0.5 ng/mL. The nPSA at < or =4 ng/mL within 4 months (nPSA < or =4/4m) was the variable of interest. RESULTS: We established highly significant associations between an nPSA of < or =1 and < or =0.5 ng/mL and the nPSA < or =4/4m (p <0.0001). A hazard ratio of 0.33 (95% Confidence Interval (CI), 0.12-0.91) underlined the lower risk of recurrence related to nPSA < or =4/4m achievement (p = 0.033). Using time-dependent covariate models for patients who did not reach an nPSA < or =4/4m, an nPSA of < or =1 ng/mL remained without prognostic significance (p = 0.06). However, for patients who reached an nPSA < or =4/4m, an nPSA of < or =1 ng/mL did significantly improve the prognosis (p <0.001), but much later after treatment. The same analysis was repeated for nPSA < or =0.5 ng/mL with similar conclusions as when nPSA < or =4/4m was obtained (p <0.01). CONCLUSION: The nPSA < or =4/4m has been demonstrated to be a significant predictor of biochemical no evidence of disease after high radiation doses of 85 Gy. Its major advantage is that it was available earlier than the other nadirs. [less ▲]

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See detailComparison of inflammatory responses after off-pump and on-pump coronary surgery using surface modifying additives circuit
Quaniers, Janine ULg; Leruth, Julie ULg; Albert, Adelin ULg et al

in Annals of Thoracic Surgery (2006), 81(5), 1683-1690

Background. Cardiac surgery is followed by various degrees of inflammation, which have harmful consequences. Because of the central role of extracorporeal circulation ( EC), off- pump coronary bypass ... [more ▼]

Background. Cardiac surgery is followed by various degrees of inflammation, which have harmful consequences. Because of the central role of extracorporeal circulation ( EC), off- pump coronary bypass surgery is deemed preferable. Do different modalities of EC challenge this view? Methods. Four groups of similar patients underwent coronary surgery: ( group 1) on- pump, EC with closed surface modifying additives ( SMA) circuit and no pump suckers ( n = 20); ( group 2) on- pump, EC with open SMA circuit and pump suckers ( n = 20); ( group 3) off- pump ( beating heart) and heparin 3 mg/ kg ( n = 20); ( group 4) off- pump ( beating heart) and heparin 1 mg/ kg ( n = 20). Interleukins ( IL)- 6, IL- 8, IL- 10, myeloperoxidase, elastase, and terminal complex of the complement ( TCC) were analyzed at various times: at induction ( time I); after heparin ( time II); after complete revascularization ( time III); after protamine ( time IV); and 24 hours later ( time V). Results. The TCC was significantly higher in groups 1 and 2 at time III. The pattern of IL- 6 was the same for the four groups. No significant difference in myeloperoxydase content was noted; however, elastase was significantly higher in the two EC ( on- pump) groups. Conclusions. Except for the complement system and elastase, on- pump surgery with SMA- coated circuits did not elicit any greater inflammatory response than off-pump surgery. [less ▲]

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See detailA phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668].
Robe, Pierre ULg; Martin, Didier ULg; Albert, Adelin ULg et al

in BMC Cancer (2006), 6

BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median ... [more ▼]

BACKGROUND: The prognosis of patients suffering from WHO grade 3 and 4 astrocytic glioma remains poor despite surgery, radiation therapy and the use of current chemotherapy regimen. Indeed, the median survival of glioblastoma multiforme (WHO grade 4) patients is at best 14.6 month with only 26.5 percent of the patients still alive after 2 years and the median survival of anaplastic astrocytomas (WHO grade 3) is 19.2 month. Recent evidence suggests that the transcription factor NF-kappaB is constitutively expressed in malignant gliomas and that its inhibition by drugs like Sulfasalazine may block the growth of astrocytic tumors in vitro and in experimental models of malignant gliomas. DESIGN: ULg_GBM_04/1 is a prospective, randomized, double blind single-center phase 1-2 study. A total of twenty patients with progressive malignant glioma despite surgery, radiation therapy and a first line of chemotherapy will be recruited and assigned to four dosage regimen of Sulfasalazine. This medication will be taken orally t.i.d. at a daily dose of 1.5-3-4 or 6 g, continuously until complete remission, evidence of progression or drug intolerance. Primary endpoints are drug safety in the setting of malignant gliomas and tumor response as measured according to MacDonald's criteria. An interim analysis of drug safety will be conducted after the inclusion of ten patients. The complete evaluation of primary endpoints will be conducted two years after the enrollment of the last patient or after the death of the last patient should this occur prematurely. DISCUSSION: The aim of this study is to evaluate the safety and efficacy of Sulfasalazine as a treatment for recurring malignant gliomas. The safety and efficacy of this drug are analyzed as primary endpoints. Overall survival and progression-free survival are secondary endpoint. [less ▲]

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See detailEffect of nutritional status on oxidative stress in an ex vivo perfused rat liver
Stadler, M.; Nuyens, V.; Seidel, Laurence ULg et al

in Anesthesiology (2005), 103(5), 978-986

Background: Normothermic ischemia-reperfusion is a determinant in liver injury occurring during surgical procedures, ischemic state, and multiple organ failure. The preexisting nutritional status of the ... [more ▼]

Background: Normothermic ischemia-reperfusion is a determinant in liver injury occurring during surgical procedures, ischemic state, and multiple organ failure. The preexisting nutritional status of the liver might contribute to the extent of tissue injury and primary nonfunction. The aim of this study was to determine the role of starvation on hepatic ischemia-raperfusion injury in normal rat livers. Methods: Rats were randomly divided into two groups: one had free access to food, the other was fasted for 16 h. The portal vein was cannulated, and the liver was removed and perfused in a closed ex vivo system. Two modes of perfusion were applied in each series of rats, fed and fasting. In the ischemia-reperfusion mode, the experiment consisted of perfusion for 15 min, warm ischemia for 60 min, and reperfusion during 60 min. In the nonischemia mode, perfusion was maintained during the 135-min study period. Five rats were included in each experimental condition, yielding a total of 20 rats. Liver enzymes, potassium, glucose, lactate, free radicals, ie., dienes and trienes, and cytochrome c were analyzed in perfusate samples. The proportion of glycogen in hepatocytes was determined in tissue biopsies. Results: Transaminases, lactate dehydrogenase, potassium, and free radical concentrations were systematically higher in fasting rats in both conditions, with and without ischemia. Cytochrome c was higher after reperfusion in the fasting rats. Glucose and lactate concentrations were greater in the fed group. The glycogen content decreased in both groups during the experiment but was markedly lower in the fasting rats. Conclusions: In fed rats, liver injury was moderate, whereas hepatocytes integrity was notably impaired both after continuous perfusion and warm ischemia in fasting animals. Reduced glycogen store in hepatocytes may explain reduced tolerance. [less ▲]

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See detailWhat happens with adverse events during 6 months of treatment with selective serotonin reuptake inhibitors?
Demyttenaere, K.; Albert, Adelin ULg; Mesters, P. et al

in Journal of Clinical Psychiatry (2005), 66(7), 859-863

Objective: Although adverse events are a key factor in compliance, their evolution during treatment with antidepressants is poorly documented. Therefore, the time course of adverse events during 6 months ... [more ▼]

Objective: Although adverse events are a key factor in compliance, their evolution during treatment with antidepressants is poorly documented. Therefore, the time course of adverse events during 6 months of antidepressant treatment was investigated. Method: 85 psychiatric outpatients with a DSM-IV diagnosis of major depressive disorder (with the exclusion of other DSM-IV Axis I disorders) were enrolled between September 2002 and March 2003 in a multicenter, randomized, double-blind trial with selective serotonin reuptake inhibitors (fluoxetine [N = 421 and paroxetine [N = 43]). At each visit, the presence and severity of treatment-emergent adverse events were assessed systematically using the UKU Side Effect Rating Scale (UKU). General linear mixed modeling was used to investigate the predictors of the time course of adverse events. Results: Overall, the number of at least moderately severe adverse events decreased with time. More severely depressed patients reported overall more (at least moderately severe) adverse events than less severely depressed patients (p =.0002), but the decrease in reported adverse events was comparable over time. Men (N = 30) and women (N = 55) reported initially the same number of at least moderately severe adverse events, but the habituation was more rapid in men (p <.0001). Completers (N = 58) and dropouts (N = 27) did not differ initially, but completers' habituation was more rapid (p =.014). The habituation of adverse events was also more rapid in recurrent than in first-episode patients but only in men (p =.0025). Conclusion: The time course of adverse events varies with the severity of depression, sex, completer or dropout status, and recurrent versus first-episode depression. [less ▲]

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See detailAnalisi delle caratteristiche antropometriche e delle capacità di salto di giovani pallavolisti d'alto livello
Ciccarone, Guido; Fontani, Giuliano; Albert, Adelin ULg et al

in Medicina Dello Sport (2005), 58(1), 1-15

Aim. The volleyball is a situational sport classified among activities laying on alternative aerobe and anaerobe processes, with an important participation of the muscular mass and an accentuated ... [more ▼]

Aim. The volleyball is a situational sport classified among activities laying on alternative aerobe and anaerobe processes, with an important participation of the muscular mass and an accentuated prevalence of the alactacid anaerobe process. Within a population of young top volleyball athletes, the goal of the study was to compare several anthropometrical and functional variables according to the role of the player during the game. Methods. Data were collected by 42 volleyball players which trained with the Italian national junior team, divided into four groups: 1) side spikers (n=14; age=18.5 +/- 1.4 y.); 2) centre spikers (n=15; age 18.1 +/- 11.1 y.); (3) setters (n=7; age=18.4 +/- 1.3 y), and; 4) universal spikers (n=6; age=17.5 +/- 0.8 y.). Morphological data were height, weight, body mass index (BMI), indirect ratio of body fat determined by the method of Katch (%BF), reach with 1 (R1) or 2 (R2) hands. The explosive force was measured with the method of Bosco [1] : squat jump (SJ), counter movement jump (CMJ), CMJ with arms (CMJas) and repeated jumps during 15 seconds (RJ15). The ability to jump was measured with the Vertec test in two conditions: spike (Vertec attack, VA) and block (Vertec block, VB). Jumping performance was determined through the difference between VA and R1 (running spring, RS) and VB and R2 (standing spring, SS). Results. Significant differences were pointed out for the height (F=4,75; p < 0,006), R1 (F=3,6; p < 0,02) and R2 (F=3,66; p < 0,02). For the three anthropological variables, centre spikers (C) were significantly higher than setters (S). Comparing players' performance at the Bosco test, no significant differences appeared between groups. Results of Vertec test showed significant differences in VA (F = 7.29; p < 0.001) where group C performed better than groups S and U (universal spikers), and in VB (F = 3.95; p < 0.05) where group C achieved significantly better then setters. Analysis of the correlation matrix showed that height and weight were strongly correlated between them and with R1 and R2. Performances at Bosco test and at Vertec test were respectively correlated between them but no correlation was observed between results of Bosco and Vertec test. With Bosco test gathered information provide an assessment of the jumping ability without connection to the specific skills while Vertec test provide more specific information about the athlete's ability to use spring in specific conditions. A high correlation was identified between anthropometrics variables and the results of the Vertec test. Multiple regression analysis confirmed that, excepted %BF which is only (inversely) correlated to Vertec performances, all groups of variables were correlated between them. Conclusion. Results pointed out that in junior top level volleyball, the anthropometrical profile of the players is directly related to specific variables which must be used to select talented athletes and to plan training in connection with specific role of the player in the game. Because of the reduced duration of the game episodes and to the increasing intensity of the game rhythm, the modern volleyball involve increasingly the alactacid anaerobe component. It is for all above reasons that top level volleyball needs always more muscular powerful athletes who are also fast and able to use high jumping abilities. For that reason, assessment, training and follow up of the jumping abilities become some of the most determinant aspects of the player's effectiveness. Data underline the interest of the use of specific tests to identify the jumping ability of volleyball athletes. The protocol developed in that study can provide determinant information during the first phase of athletes' selection. [less ▲]

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See detailThe Effect of Cyclodextrins on the Aqueous Solubility of a New Mmp Inhibitor: Phase Solubility, 1 H-Nmr Spectroscopy and Molecular Modeling Studies, Preparation and Stability Study of Nebulizable Solutions
Bertholet, Pascal; Guéders, Maud ULg; Dive, Georges ULg et al

in Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society for Pharmaceutical Sciences (2005), 8(2), 164-175

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous ... [more ▼]

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous solubility, different cyclodextrins (CDs) have been tested to increase its solubility. The aim of this study was to prepare and to characterize inclusion complexes between RO and CDs, in order to develop nebulizable solutions. METHODS: The complex formation was investigated by phase solubility studies. (1)H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between RO and dimethyl-beta-CD (DIMEB). Nebulizable solutions of RO were developed with CDs and a stability study was performed over 9 months. RESULTS: The phase solubility studies showed that beta-CD and its derivatives form a 1:2 complex with RO, whereas gamma-CD includes RO with a 1:1 stoichiometry and a weak stability constant. T-ROESY spectra showed that DIMEB is able to complex two RO substituents (nitrophenyl and biphenyl groups) with preferential orientations, while molecular modeling demonstrated that the configurations observed with (1)H-NMR are energetically favorable, especially owing to H-bond formation between RO and DIMEB. Two CDs were selected to develop nebulizable solutions of RO and the stability study demonstrated that RO degradation in solution is strongly dependent on the concentration of the 1:2 inclusion complex. CONCLUSIONS: CDs are able to include RO and to improve its aqueous solubility. The beta-CD derivatives can be used to formulate nebulizable solutions of RO, the stability of which depends on the concentration of the 1:2 complex. [less ▲]

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See detailDevelopment of an antidepressant compliance questionnaire
Demyttenaere, K.; Bruffaerts, R.; Albert, Adelin ULg et al

in Acta Psychiatrica Scandinavica (2004), 110(3), 201-207

Objective: The development of the Antidepressant Compliance Questionnaire (ADCQ), assessing patients' attitudes and beliefs on depression and antidepressants. Method: A 51-item questionnaire was applied ... [more ▼]

Objective: The development of the Antidepressant Compliance Questionnaire (ADCQ), assessing patients' attitudes and beliefs on depression and antidepressants. Method: A 51-item questionnaire was applied to 85 psychiatric out-patients with a DSM-IV diagnosis of major depressive disorder (MDD). This data set was used to assess psychometric properties of the ADCQ. The questionnaire was also applied to 272 primary care out-patients with MDD. Results: A principal component analysis revealed four dimensions with good internal consistency and acceptable test-retest reliability: 'perceived doctor-patient relationship', 'preserved autonomy', 'positive beliefs on antidepressants' and 'partner agreement', resulting in a final questionnaire comprising 33-items. Responses were independent from depression severity and patient age. The response patterns of both psychiatric and primary care patients are provided and illustrate the many erroneous beliefs on antidepressants. Conclusion: The ADCQ has good psychometric properties; further investigation should investigate whether this questionnaire is predictive of patient compliance. [less ▲]

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See detailAnalysis of anthropometric caracteristics and jumping ability in junior top level volleyball athletes. Comparison by role
Ciccarone, G.; Fontani, G.; Albert, Adelin ULg et al

Poster (2004, August)

This study is focused on the comparison of the players characteristics in youth Italian top level volleyball athletes according to the role on the game.

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See detailWithin-patient variability of F-18-FDG: Standardized uptake values in normal tissues
Paquet, Nancy; Albert, Adelin ULg; Willems, Jacqueline ULg et al

in Journal of Nuclear Medicine (2004), 45(5), 784-788

The aim of this study was to evaluate the test-retest variability of standardized uptake values (SUVs) in normal tissues and the impact of various methods for measuring the SUV. Methods: SUVs were ... [more ▼]

The aim of this study was to evaluate the test-retest variability of standardized uptake values (SUVs) in normal tissues and the impact of various methods for measuring the SUV. Methods: SUVs were determined in 70 cancer-free patients (40 female and 30 male) on 2 occasions an average of 271 d apart. Mean values for body weight and height, blood glucose level, injected dose, and uptake period did not change between the 2 groups of studies. Four regions of interest (ROIs) were placed-on the liver, lung, mediastinum, and trapezius muscle. Mean and maximum SUVs normalized for body weight were obtained, and normalizations were then applied for lean body mass (LBM), LBM and blood glucose level, body surface area (BSA), and BSA and blood glucose level. Results: In the lungs and muscle, metabolic activity within the ROIs was significantly different in the 2 studies, no matter which method was used for the SUVs. The differences ranged from 0.02 to 0.1 for SUV normalized for body weight and SUV normalized for LBM and from 0.001 to 0.002 for SUV normalized for BSA. In the liver, results were similar for all SUVs, except for maximum SUV corrected for LBM and maximum SUV corrected for LBM and blood glucose level. The metabolic activity measured in the mediastinum was also comparable in the 2 studies, regardless of the type of SUV. When investigating whether any normalization method for SUVs reduces variability and improves test-retest concordance, we found no significant superiority for any. The best intraclass correlation coefficients were obtained with the SUV normalized for body weight, in both the liver and the mediastinum, but the coefficients of variation were similar for all 3 mean SUVs that were not corrected for glucose level (range, 10.8%-13.4%). However, normalizing for blood glucose level increased the variability and decreased the level of concordance between studies. Conclusion: The SUVs measured in normal liver and mediastinum in cancer-free patients are stable over time, no matter which normalization is used. Correcting for blood glucose level increases the variability of the values and should therefore be avoided. Normalizing for BSA or LBM does not improve the reproducibility of the measurements. [less ▲]

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See detailIncreased IL-6 and TGF-beta(1) concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy
Barthelemy-Brichant, Nicole ULg; Bosquee, Lionel; Cataldo, Didier ULg et al

in International Journal of Radiation, Oncology, Biology, Physics (2004), 58(3), 758-767

PURPOSE: To assess, in lung cancer patients, the effects of thoracic radiotherapy (RT) on the concentrations of transforming growth factor-beta(1) (TGF-beta(1)) and interleukin-6 (IL-6) in the ... [more ▼]

PURPOSE: To assess, in lung cancer patients, the effects of thoracic radiotherapy (RT) on the concentrations of transforming growth factor-beta(1) (TGF-beta(1)) and interleukin-6 (IL-6) in the bronchoalveolar lavage (BAL) fluid. METHODS AND MATERIALS: Eleven patients with lung cancer requiring RT as part of their treatment were studied. BAL was performed bilaterally before, during, and 1, 3, and 6 months after RT. Before each BAL session, the patient's status was assessed clinically using pulmonary function tests and an adapted late effects on normal tissue-subjective, objective, management, analytic (LENT-SOMA) scale, including subjective and objective alterations. The National Cancer Institute Common Toxicity Criteria were used to grade pneumonitis. The TGF-beta(1) and IL-6 levels in the BAL fluid were determined using the Easia kit. RESULTS: The TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated areas were significantly increased by thoracic RT. The increase in TGF-beta(1) levels tended to be greater in the group of patients who developed severe pneumonitis. In the BAL fluid from the nonirradiated areas, the TGF-beta(1) and IL-6 concentrations remained unchanged. CONCLUSION: The observed increase in TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated lung areas demonstrated that these cytokines may contribute to the process leading to a radiation response in human lung tissue. [less ▲]

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See detailCatastrophic thinking about pain increases discomfort during internal atrial cardioversion
Vlaeyen, Johan W S; Timmernans, Carl; Rodriguez, Luz-Maria et al

in Journal of Psychosomatic Research (2004), 56(1), 139-144

Objectives: This study investigated whether pain catastrophizing is associated with distress and perceived disability in patients with atrial fibrillation, whether pain catastrophizing predicts pain and ... [more ▼]

Objectives: This study investigated whether pain catastrophizing is associated with distress and perceived disability in patients with atrial fibrillation, whether pain catastrophizing predicts pain and fear during a medical procedure of atrial cardioversion, and whether pain catastrophizing influences the effects of an opioid analgesic during internal cardioversion. Methods: A secondary analysis is performed upon data from a double-blind placebo-controlled trial during which the effect of intranasal butorphanol tartrate (INB) was evaluated in patients with atrial fibrillation using a step-up internal atrial cardioversion protocol. Before the procedure, patients completed measures of pain catastrophizing, mood, distress and perceived disability. After each shock, patients completed measures of pain and fear. Results: We found that pain catastrophizing predicted the affective pain rating of the first shock, and the fear increase during subsequent shocks. There was no effect of INB. However, when controlling for the differences in pain catastrophizing, INB significantly reduced fear as compared to placebo. This suggests that the effects of INB during atrial cardioversion were overshadowed by the effects of pain catastrophizing. Conclusions: It is recommended that in future atrial cardioversion trials, stratification based on pain catastrophizing be performed. Reducing catastrophizing thinking about pain through cognitive-behavioral techniques are likely to reduce levels of fear during internal atrial cardioversion and may increase the effectiveness of concomitant analgesics. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailFurther evidence of association between periodontal conditions and coronary artery disease
Geerts, Sabine ULg; Legrand, Victor; Charpentier, Joseph et al

in Journal of Periodontology (2004), 75(9), 1274-1280

There is increasing evidence that chronic infections, such as periodontal diseases, could play a role in the initiation and development of coronary artery disease. The present study was intented to test ... [more ▼]

There is increasing evidence that chronic infections, such as periodontal diseases, could play a role in the initiation and development of coronary artery disease. The present study was intented to test for a possible association between presence and severityof periodontitis and coronary artery disease in a belgian population. [less ▲]

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See detailpolychlorinated biphenyls contamination in women with breast cancer
Charlier, Corinne ULg; Albert, Adelin ULg; Zhang, Lixin ULg et al

in Clinica Chimica Acta (2004), 347

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See detailCrural artery bypass with the autogenous greater saphenous vein
Van Damme, Hendrik ULg; Zhang, Lihong ULg; Baguet, E. et al

in European Journal of Vascular and Endovascular Surgery : The Official Journal of the European Society for Vascular Surgery (2003), 26(6), 635-642

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating ... [more ▼]

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating to a consecutive series of 90 crural artery GSV(76% in situ) bypasses in 81 patients (1990-2000) were analysed. The mean age of the 47 men and 34 women was 70 years. Limb-threatening ischaemia was present in 96% of cases, claudication in four patients. In 18 patients, surgery was 'redo'. Results. The perioperative mortality was 3% (n = 3). Patient survival was 54% at 4 years. Independent risk factors affecting survival were chronic renal insufficiency (p = 0.04), hypertension (p = 0.02), and ischaemic heart disease (p = 0.01). Four bypasses thrombosed within 30 days. Three of them could be successfully reopened. Mean follow-up was 39 months. The primary patency rate at 4 years was 80%. Chronic renal insufficiency revealed to be the single independent risk factor for graft thrombosis (p = 0.03, RR = 12.4). The 4-year limb salvage rate was 88%. No independent risk factor affecting the limb salvage could be identified. Conclusion. Crural artery revascularisation is a valuable option for the management of limb threatening infrapopliteal arterial occlusive disease. [less ▲]

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See detailFactors predictive of nephropathy in DCCT Type 1 diabetic patients with good or poor metabolic control
Zhang, Liying; Krzentowski, Georges; Albert, Adelin ULg et al

in Diabetic Medicine : A Journal of the British Diabetic Association (2003), 20(7), 580-585

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic ... [more ▼]

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic patients with either good or poor metabolic control (MC). Methods Based on material from the Diabetes Control and Complications Trial study (n = 1441), patients were considered as under good or poor MC if their HbA(1c) mean level up to last visit fell in the lowest (less than or equal to 6.9%) or highest (greater than or equal to 9.5%) quintile of the overall HbA(1c) distribution, respectively. Prevalence cases of nephropathy were excluded from the study. Survival analysis and Cox regression were applied to the data. Results Among patients with good MC (n = 277), 15% had developed nephropathy at the end of the study. Conversely, among patients with poor MC (n = 268), the proportion without the complication was 52%. When adjusting for MC, time to diabetic nephropathy was related to age (P < 0.0001), AER (P < 0.001), duration of diabetes (P < 0.005), body mass index (BMI) (P < 0.005), all at baseline, and to gender (P < 0.01). Patients with upper normal range AER levels, longer duration of diabetes and lower BMI were at higher risk, regardless of MC. The adverse effect of younger age on diabetic nephropathy was more marked in good than in poor MC. Although women tended to develop the complication more often under good MC, they appeared to be better protected under poor MC. Conclusions This study confirms occurrence of diabetic nephropathy under good MC and non-occurrence of the complication despite poor MC. It also demonstrates that some baseline covariates can affect, in a differential manner, time to diabetic nephropathy depending on MC. [less ▲]

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