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See detailDo general practitioners and psychiatrists agree about defining cure from depression? The DEsCRIBE (TM) survey
Demyttenaere, Koen; Ansseau, Marc ULg; Constant, Eric et al

in BMC Psychiatry (2011), 11

BACKGROUND: This study aimed to document the outcome dimensions that physicians see as important in defining cure from depression. The study also aimed to analyse physicians' attitudes about depression ... [more ▼]

BACKGROUND: This study aimed to document the outcome dimensions that physicians see as important in defining cure from depression. The study also aimed to analyse physicians' attitudes about depression and to find out whether they affect their prescribing practices and/or the outcome dimensions that they view as important in defining cure. METHODS: A 51-item questionnaire based on six validated scales was used to rate the importance of several depression outcome dimensions. Physicians' attitudes about depression were also assessed using the Depression Attitude Scale. Overall, 369 Belgian physicians (264 general practitioners [GPs]; 105 psychiatrists) participated in the DEsCRIBE survey. RESULTS: GPs and psychiatrists strongly agreed that functioning and depressive symptomatology were most important in defining cure; anxious and somatic symptomatology was least important. GPs and psychiatrists differed in their attitudes about depression (p <0.001). Logistic regression revealed that the attitudes of GPs - but not psychiatrists - were significantly associated with their rates of antidepressant prescription (p < 0.001) and that certain attitudes predicted which outcome dimensions were seen as important in defining cure. CONCLUSIONS: Belgian GPs and psychiatrists strongly agreed on which criteria were important in defining cure from depression but differed in their attitudes about depression. The outcome dimensions that were considered important in defining cure were influenced by physicians' attitudes - this was more pronounced in GPs than in psychiatrists. [less ▲]

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See detailEpidemiology of the metabolic syndrome in Luxembourg findings from ORISCAV-LUX study
Alkerwi, A; Sauvageot, N; Donneau, Anne-Françoise ULg et al

Conference (2011)

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See detailPrevalence of the metabolic syndrome in Luxembourg according to the Joint Interim Statement definition estimated from the ORISCAV-LUX study.
Alkerwi, Ala'a; Donneau, Anne-Françoise ULg; Sauvageot, Nicolas et al

in BMC Public Health (2011), 11(1), 4

ABSTRACT: BACKGROUND: The prevalence of the metabolic syndrome (MS) has been determined in many countries worldwide but never in Luxembourg. This research aimed to 1) establish the gender- and age ... [more ▼]

ABSTRACT: BACKGROUND: The prevalence of the metabolic syndrome (MS) has been determined in many countries worldwide but never in Luxembourg. This research aimed to 1) establish the gender- and age-specific prevalence of MS and its components in the general adult population of Luxembourg, according to the most recent Joint Interim Statement (JIS) definition, by using both the high and low cut-off points to define abdominal obesity, and 2) compare and assess the degree of agreement with the Revised National Cholesterol Education Programme-Adult Treatment Panel III (R-ATPIII) and the International Diabetes Federation (IDF) definitions. METHODS: A representative stratified random sample of 1349 European subjects, aged 18-69 years, participated to ORISCAV-LUX survey. Logistic regression and odds ratios (OR) were used to study MS prevalence with respect to gender and age. The Framingham risk score (FRS) to predict the 10-year coronary heart disease (CHD) risk was calculated to compare the proportion of MS cases below or above 20%, according to both high and low waist circumference (WC) thresholds. Cohen's kappa coefficient (kappa) was utilized to measure the degree of agreement between MS definitions. RESULTS: The prevalence of the MS defined by the JIS was 28.0% and 24.7% when using the low (94/80) and the high (102/88) WC cut-off points, respectively. The prevalence was significantly higher in men than in women (OR = 2.6 and 2.3 for the low and high WC thresholds), as were all components of the MS except abdominal obesity measured by both thresholds. It also increased with age (OR values in age categories ranging from 2.7 to 28 when compared to the younger subjects for low WC and from 3.3 to 31 for the high WC cut-offs). The 10-year predicted risk of CHD by FRS did not depend on the threshold used. Globally, excellent agreement was observed between the three definitions of MS (kappa= 0.89), in particular between JIS and IDF (kappa = 0.93). Agreement was significantly higher in women than in men, and differed between age groups. CONCLUSION: Regardless of the definition used, the adult population of Luxembourg reveals a high MS prevalence. Our findings contribute to build evidence regarding the definitive construct of the MS, to help selecting the waist circumference thresholds for Europid populations, and to support the need to revise the guidelines for abdominal obesity levels. [less ▲]

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See detailCardiometabolic Syndrome
Alkerwi, A; Albert, Adelin ULg; Guillaume, Michèle ULg

in Gasparyan, AY (Ed.) Cardiovascular Risk Factors (2011)

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See detailEtude Belge HelpED :Effet de la revalidation érectile par iPDE 5 sur l’évolution psychosociale de l’homme pour dysfonction érectile
Andrianne, Robert ULg; Claes, Hubert; Opsomer, Reinier et al

in Belgian Journal of sexual health (2011)

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See detailSCREENIN G AND PREDICTING MALNUTRITION IN lUNG CANCER PATIENTS: DEVELOPING NEW TOOLS.
BARTHELEMY, Nicole ULg; Donneau, Anne-Françoise ULg; Haterte, Stéphanie ULg et al

in Radiotherapy & Oncology (2010, September), 96(supp 1), 378

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See detailDéveloppement d’un modèle de hiérarchisation des maladies émergentes en Région Wallonne
Vandeputte, Sébastien ULg; Humblet, Marie-France ULg; Fecher-Bourgeois, Fabienne ULg et al

in Epidémiologie et Santé Animale (2010), 58

Au niveau mondial, on observe depuis quelques décennies une augmentation de l’émergence ou de la réémergence de maladies animales dont la plupart sont zoonotiques. L’émergence récente de la fièvre ... [more ▼]

Au niveau mondial, on observe depuis quelques décennies une augmentation de l’émergence ou de la réémergence de maladies animales dont la plupart sont zoonotiques. L’émergence récente de la fièvre catarrhale ovine en Belgique ne fait que confirmer ce phénomène. L’objectif du projet est de développer un modèle conceptuel de hiérarchisation des maladies émergentes en Région Wallonne ayant pour but de quantifier les pertes économiques directes et indirectes subies par les éleveurs et la société civile en cas d’émergence d’une maladie animale. La première étape du projet consiste à construire une liste de maladies émergentes ou potentiellement émergentes en recourant à une revue de la littérature de référence récente et à des réunions de consensus entre experts. La liste finalisée sera hiérarchisée sur base de différents critères tels que, par exemple, des critères socio-économiques ou zootechniques. Plusieurs maladies modèles, figurant à des rangs différents dans la liste, seront ensuite étudiées en profondeur. L’étude de ces maladies modèles nous permettra d’estimer les pertes socio-économiques résultant des maladies animales et des maladies humaines si la maladie possède un potentiel zoonotique. Cette estimation se fera grâce à différentes techniques usuelles d’analyse socio-économique et le résultat de cette estimation nous permettra de paramétrer l’échelle des pertes socio-économiques. Finalement, l’ensemble des résultats obtenus seront synthétisés et, en tenant compte de la typologie de chaque maladie (basée sur divers éléments quantitatifs), une estimation des pertes socio-économiques de chaque maladie listée pourra être établie. [less ▲]

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See detailA new statistical method for evaluating long-term analytical performance of laboratories applied to an external quality assessment scheme for flow cytometry.
Coucke, Wim; Van Blerk, Marjan; Libeer, Jean*-Claude et al

in Clinical Chemistry & Laboratory Medicine (2010), 48(5), 645-50

BACKGROUND: The Belgian External Quality Assessment Scheme for Flow Cytometry evaluates the long-term analytical performance of participating laboratories by calculating a regression line between the ... [more ▼]

BACKGROUND: The Belgian External Quality Assessment Scheme for Flow Cytometry evaluates the long-term analytical performance of participating laboratories by calculating a regression line between the target and reported values of each parameter for each laboratory during the past 3 years. This study aims to develop a method to find laboratories with aberrant variability or bias using robust techniques and to obtain robust estimates of the variability. METHODS: A method is proposed to find outliers with respect to the individual regression line, followed by a step to find regression lines with excessive variability and finally a step to find regression lines with high bias. RESULTS: The model was applied to the results obtained by 52 laboratories for CD4%. From the 1340 data points, 35 were determined to be regression outliers. The second step revealed one regression line with excessive variability; the third step detected three regression lines with exceeding bias. CONCLUSIONS: The methodology allows assessment of the long-term performance of laboratories, taking into account samples with different target values. Outliers in the first step indicate accidental mistakes, outliers in the second and third step point to high analytical variability or bias. [less ▲]

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See detailFirst nationwide survey on cardiovascular risk factors in Grand-Duchy of Luxembourg (ORISCAV-LUX)
Alkerwi, A; Sauvageot, N; Donneau, Anne-Françoise ULg et al

Poster (2010)

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See detailFirst nationwide survey on cardiovascular risk factors in Grand-Duchy of Luxembourg (ORISCAV-LUX).
Alkerwi, Ala'a; Sauvageot, Nicolas; Donneau, Anne-Françoise ULg et al

in BMC Public Health (2010), 10

BACKGROUND: The ORISCAV-LUX study is the first baseline survey of an on-going cardiovascular health monitoring programme in Grand-Duchy of Luxembourg. The main objectives of the present manuscript were 1 ... [more ▼]

BACKGROUND: The ORISCAV-LUX study is the first baseline survey of an on-going cardiovascular health monitoring programme in Grand-Duchy of Luxembourg. The main objectives of the present manuscript were 1) to describe the study design and conduct, and 2) to present the salient outcomes of the study, in particular the prevalence of the potentially modifiable and treatable cardiovascular disease risk factors in the adult population residing in Luxembourg. METHOD: ORISCAV-LUX is a cross-sectional study based on a random sample of 4496 subjects, stratified by gender, age categories and district, drawn from the national insurance registry of 18-69 years aged Luxembourg residents, assuming a response rate of 30% and a proportion of 5% of institutionalized subjects in each stratum. The cardiovascular health status was assessed by means of a self-administered questionnaire, clinical and anthropometric measures, as well as by blood, urine and hair examinations. The potentially modifiable and treatable risk factors studied included smoking, hypertension, dyslipidemia, diabetes mellitus, and obesity. Both univariate and multivariate statistical analyses used weighted methods to account for the stratified sampling scheme. RESULTS: A total of 1432 subjects took part in the survey, yielding a participation rate of 32.2%. This figure is higher than the minimal sample size of 1285 subjects as estimated by power calculation. The most predominant cardiovascular risk factors were dyslipidemia (69.9%), hypertension (34.5%), smoking (22.3%), and obesity (20.9%), while diabetes amounted 4.4%. All prevalence rates increased with age (except smoking) with marked gender differences (except diabetes). There was a significant difference in the prevalence of hypertension and of lipid disorders by geographic region of birth. The proportion of subjects cumulating two or more cardiovascular risk factors increased remarkably with age and was more predominant in men than in women (P<0.0001). Only 14.7% of men and 23.1% of women were free of any cardiovascular risk factor. High prevalence of non-treated CVRF, notably for hypertension and dyslipidemia, were observed in the study population. CONCLUSION: The population-based ORISCAV-LUX survey revealed a high prevalence of potentially modifiable and treatable cardiovascular risk factors among apparently healthy subjects; significant gender and age-specific differences were seen not only for single but also for combined risk factors. From a public health perspective, these preliminary findings stress the urgent need for early routine health examinations, preventive interventions and lifestyle behavioural changes, even in young asymptomatic adults, to decrease cardiovascular morbidity and mortality in Luxembourg. [less ▲]

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See detailComparison of participants and non-participants to the ORISCAV-LUX population-based study on cardiovascular risk factors in Luxembourg.
Alkerwi, Ala'a; Sauvageot, Nicolas; Couffignal, Sophie et al

in BMC Medical Research Methodology (2010), 10

BACKGROUND: Poor response is a major concern in public health surveys. In a population-based ORISCAV-LUX study carried out in Grand-Duchy of Luxembourg to assess the cardiovascular risk factors, the non ... [more ▼]

BACKGROUND: Poor response is a major concern in public health surveys. In a population-based ORISCAV-LUX study carried out in Grand-Duchy of Luxembourg to assess the cardiovascular risk factors, the non-response rate was not negligible. The aims of the present work were: 1) to investigate the representativeness of study sample to the general population, and 2) to compare the known demographic and cardiovascular health-related profiles of participants and non-participants. METHODS: For sample representativeness, the participants were compared to the source population according to stratification criteria (age, sex and district of residence). Based on complementary information from the "medical administrative database", further analysis was carried out to assess whether the health status affected the response rate. Several demographic and morbidity indicators were used in the univariate comparison between participants and non-participants. RESULTS: Among the 4452 potentially eligible subjects contacted for the study, there were finally 1432 (32.2%) participants. Compared to the source population, no differences were found for gender and district distribution. By contrast, the youngest age group was under-represented while adults and elderly were over-represented in the sample, for both genders. Globally, the investigated clinical profile of the non-participants was similar to that of participants. Hospital admission and cardiovascular health-related medical measures were comparable in both groups even after controlling for age. The participation rate was lower in Portuguese residents as compared to Luxembourgish (OR = 0.58, 95% CI: 0.48-0.69). It was also significantly associated with the professional status (P < 0.0001). Subjects from the working class were less receptive to the study than those from other professional categories. CONCLUSION: The 32.2% participation rate obtained in the ORISCAV-LUX survey represents the realistic achievable rate for this type of multiple-stage, nationwide, population-based surveys. It corresponds to the expected rate upon which the sample size was calculated. Given the absence of discriminating health profiles between participants and non-participants, it can be concluded that the response rate does not invalidate the results and allows generalizing the findings for the population. [less ▲]

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See detailA novel definition of the multivariate coefficient of variation
Albert, Adelin ULg; Zhang, Lixin ULg

in Biometrical Journal = Biometrische Zeitschrift (2010), 52(5), 667-675

The coefficient of variation CV (%) is widely used to measure the relative variation of a random variable to its mean or to assess and compare the performance of analytical techniques/equipments. A review ... [more ▼]

The coefficient of variation CV (%) is widely used to measure the relative variation of a random variable to its mean or to assess and compare the performance of analytical techniques/equipments. A review is made of the existing multivariate extensions of the univariate CV where, instead of a random variable, a random vector is considered, and a novel definition is proposed. The multivariate CV obtained only requires the calculation of the mean vector, the covariance matrix and simple quadratic forms. No matrix inversion is needed which makes the new approach equally attractive inhigh dimensional as in very small sample size problems. As an illustration, the method is applied to electrophoresis data from external quality assessment in laboratory medicine, to phenotypic characteristics of pocket gophers and to a microarray data set. [less ▲]

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See detailEpidemiology of major depression in Belgian parkinsonian patients
Vanderheyden, Jean-Emile; GONCE, Michel ULg; BOURGEOIS, Philip et al

in Acta Neurologica Belgica (2010), 110

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See detailMicroleakage after thermocycling of three self-etch adhesives under resin-modified glass-ionomer cement restorations
Geerts, Sabine ULg; Seidel, Laurence ULg; Albert, Adelin ULg et al

in International Journal of Dentistry [=IJD] (2010), ID 728453

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See detailThe multivariate coefficient of variation for comparing serum protein electrophoresis techniques in External Quality Assessment schemes
Zhang, Lixin ULg; Albarède, Stéphanie; Dumont, Gilles et al

in Accreditation and Quality Assurance (2010)

External Quality Assessment (EQA) schemes are national or transnational programmes designed to control the analytical performance of clinical laboratories and to maintain inter-laboratory variability ... [more ▼]

External Quality Assessment (EQA) schemes are national or transnational programmes designed to control the analytical performance of clinical laboratories and to maintain inter-laboratory variability within acceptable limits. In such EQA programmes, participants are usually grouped by the type of assay technique/equipment they use. The coefficient of variation (CV) is a simple tool for comparing the inter-laboratory reproducibility of such techniques: the lower the CV, the better the analytical performance. Serum protein electrophoresis, a laboratory test profile consisting of five fractions (albumin, α1, α2, β and γ globulins) summing up to 100% of total proteins, can also be assayed in different ways depending on the media or the analytical principle. We propose a multivariate coefficient of variation for comparing the performance of electrophoretic techniques in EQA, thus extending the univariate CV concept. First, the compositional nature of electrophoretic data requires a one-to-one transformation from the 5-dimensional to the 4-dimensional space. Next, robust estimations of the mean and the covariance matrix are needed to avoid the effect of outliers. The new approach is illustrated on electrophoretic datasets from the French and Belgian national EQA programmes. [less ▲]

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See detailPenetration of enrofloxacin into the nasal secretions and relationship between nasal secretions and plasma enrofloxacin concentrations after intramuscular administration in healthy pigs
Bimazubute, M.; Cambier, Carole ULg; Baert, K. et al

in Journal of Veterinary Pharmacology & Therapeutics (2010), 33(2), 183-188

The pharmacokinetic behaviour of enrofloxacin (ENRO) in plasma and nasal secretions of healthy pigs was investigated, after a single-dose intramuscular administration of 2.5 mg/kg body weight of the drug ... [more ▼]

The pharmacokinetic behaviour of enrofloxacin (ENRO) in plasma and nasal secretions of healthy pigs was investigated, after a single-dose intramuscular administration of 2.5 mg/kg body weight of the drug. Blood samples and nasal secretions were collected at predetermined times after drug administration. Concentrations of ENRO and its active metabolite ciprofloxacin (CIPRO) were determined in plasma and nasal secretions by high-performance liquid chromatography (HPLC). CIPRO was not detected probably because we investigated young weaned pigs. The data collected in 12 pigs for ENRO were subjected to noncompartmental analysis. In plasma, the maximum concentration of drug (C-max), the time at which this maximum concentration of drug (T-max) was reached, the elimination half-life (t(beta)(1/2)) and the area under the concentration vs. time curve (AUC) were, respectively, 694.7 ng/mL, 1.0 h, 9.3 h and 8903.2 ng h/mL. In nasal secretions, Cmax, Tmax, t(beta)(1/2) and AUC were, respectively, 871.4 ng/mL, 2.0 h, 12.5 h and 11 198.5 ng.h/mL. In a second experiment conducted in 10 piglets, the relationship between concentrations of ENRO measured in the plasma and the nasal secretions has been determined following single-dose intramuscular administration of 2.5, 10 or 20 mg/kg body weight of the drug. It has been demonstrated that, among several variables, i.e., (1) the dose administered, (2) the time between intramuscular injection and blood sampling, (3) the age, (4) the sex, (5) the animal body weight and (6) the plasma concentration of the drug, only the latter influenced significantly the ENRO concentration in nasal secretions. Practically, using a generalized linear mixed model, ENRO concentrations in the nasal secretions (mu g/mL) can be predicted taking into account the ENRO concentrations in plasma (mu g/mL), according to the following equation: ENROnasal secretion 1.94 ENROplasma - 0.24. [less ▲]

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See detailRevisiting the multivariate coefficient of variation for comparing electrophoretic techniques in External Quality Assessment (EQA) schemes
Zhang, Lixin ULg; Albert, Adelin ULg

Conference (2009, October 15)

External Quality Assessment (EQA) schemes are national programmes designed to control the analytical performance of clinical laboratories and to maintain inter-laboratory variability within acceptable ... [more ▼]

External Quality Assessment (EQA) schemes are national programmes designed to control the analytical performance of clinical laboratories and to maintain inter-laboratory variability within acceptable limits. In this context, the type of assay technique or equipment used by the participants is an important factor to take into account. The coefficient of variation (CV) is widely used in EQA to compare the reproducibility of techniques and equipments: the lower the CV, the better the analytical performance. The recent introduction of protein electrophoresis, a laboratory test profile consisting of five fractions (albumin, α1, α2, β and γ globulins) summing up to 100%, in the EQA programme (Zhang et. al. 2008) prompted us to revisit an old problem (Reyment 1960), namely the multivariate extension of the univariate CV concept, and to suggest some amendments to existing solutions. Further, the application of the multivariate CV to techniques and methods used in the assay of protein electrophoresis raises concomitant statistical problems. First, the compositional nature of electrophoretic data requires a log-ratio one-to-one transformation from the simplex to the real space (Aitchison 1982). Next, robust estimations of the mean and the covariance matrix (Rousseeuw and Van Driessen 1999) are needed to avoid the effect of outliers. The resulting robust multivariate CVs are illustrated on electrophoretic EQA material from the Belgian and French national EQA programmes to assess the analytical variability of the electrophoretic techniques used. [less ▲]

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See detailComparaison de 5 techniques de prération du PRP (Platelet-Rich Plasma ou plasma)
Kaux, Jean-François ULg; Le Goff, Caroline ULg; Seidel, Laurence ULg et al

in Annales de Réadaptation et de Médecine Physique (2009, October), 52(Sup. 1), 109

Introduction : Depuis une vingtaine d’années, le développement des activités sportives s’accompagne d’une incidence accrue de diverses tendinopathies, souvent rebelles aux traitements conservateurs ... [more ▼]

Introduction : Depuis une vingtaine d’années, le développement des activités sportives s’accompagne d’une incidence accrue de diverses tendinopathies, souvent rebelles aux traitements conservateurs classiques (anti-inflammatoires non stéroïdiens, orthèses, kinésithérapie, infiltrations…). De nouvelles thérapeutiques, dont l’injection de concentrés plaquettaires (plasma riche en plaquettes ou PRP), sont actuellement en cours d’évaluation clinique. Objectifs : L’injection de PRP fait actuellement l’objet de recherche comme thérapeutique des tendinopathies chroniques. L’injection intra-tendineuse nécessite idéalement un volume minimal afin de diminuer la pression lors de l’injection et minimiser les douleurs, mais il doit également présenter une concentration plaquettaire élevée ; par ailleurs, la quantité de facteurs de croissance libérés pourrait être liée au système de préparation. Méthodes : Après avoir prélevés divers échantillons de sang veineux chez 5 patients, nous avons comparé 5 techniques de préparation du PRP : celle du Service d’Hématologie Biologique du CHU de Liège, le PRP Kit de Curasan®, les techniques Plateltex®, GPS®II et RegenLab®. Résultats : Les différentes techniques permettent d’obtenir des concentrations plaquettaires plus importantes que dans le sang avec des volumes variables (de 0,3 mL à 6 mL) et un nombre de globules rouges et globules blancs limité (sauf pour GPS® II). Le nombre de plaquettes/µL apparaît plus élevé avec la technique Plateltex® et obtient le plus petit volume à injecter. Les autres techniques permettent également d’obtenir de petits volumes sauf avec le GPS®II. Le nombre de plaquettes collectées dans le PRP apparaît donc plus élevé avec cette technique mais avec une concentration faible. Discussion – Conclusion : La technique décrite par Plateltex® permet de recueillir le PRP le plus concentré dans le volume le plus faible. [less ▲]

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