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See detailIncreased IL-6 and TGF-beta(1) concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy
Barthelemy-Brichant, Nicole ULg; Bosquee, Lionel; Cataldo, Didier ULg et al

in International Journal of Radiation, Oncology, Biology, Physics (2004), 58(3), 758-767

PURPOSE: To assess, in lung cancer patients, the effects of thoracic radiotherapy (RT) on the concentrations of transforming growth factor-beta(1) (TGF-beta(1)) and interleukin-6 (IL-6) in the ... [more ▼]

PURPOSE: To assess, in lung cancer patients, the effects of thoracic radiotherapy (RT) on the concentrations of transforming growth factor-beta(1) (TGF-beta(1)) and interleukin-6 (IL-6) in the bronchoalveolar lavage (BAL) fluid. METHODS AND MATERIALS: Eleven patients with lung cancer requiring RT as part of their treatment were studied. BAL was performed bilaterally before, during, and 1, 3, and 6 months after RT. Before each BAL session, the patient's status was assessed clinically using pulmonary function tests and an adapted late effects on normal tissue-subjective, objective, management, analytic (LENT-SOMA) scale, including subjective and objective alterations. The National Cancer Institute Common Toxicity Criteria were used to grade pneumonitis. The TGF-beta(1) and IL-6 levels in the BAL fluid were determined using the Easia kit. RESULTS: The TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated areas were significantly increased by thoracic RT. The increase in TGF-beta(1) levels tended to be greater in the group of patients who developed severe pneumonitis. In the BAL fluid from the nonirradiated areas, the TGF-beta(1) and IL-6 concentrations remained unchanged. CONCLUSION: The observed increase in TGF-beta(1) and IL-6 concentrations in the BAL fluid recovered from the irradiated lung areas demonstrated that these cytokines may contribute to the process leading to a radiation response in human lung tissue. [less ▲]

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See detailCatastrophic thinking about pain increases discomfort during internal atrial cardioversion
Vlaeyen, Johan W S; Timmernans, Carl; Rodriguez, Luz-Maria et al

in Journal of Psychosomatic Research (2004), 56(1), 139-144

Objectives: This study investigated whether pain catastrophizing is associated with distress and perceived disability in patients with atrial fibrillation, whether pain catastrophizing predicts pain and ... [more ▼]

Objectives: This study investigated whether pain catastrophizing is associated with distress and perceived disability in patients with atrial fibrillation, whether pain catastrophizing predicts pain and fear during a medical procedure of atrial cardioversion, and whether pain catastrophizing influences the effects of an opioid analgesic during internal cardioversion. Methods: A secondary analysis is performed upon data from a double-blind placebo-controlled trial during which the effect of intranasal butorphanol tartrate (INB) was evaluated in patients with atrial fibrillation using a step-up internal atrial cardioversion protocol. Before the procedure, patients completed measures of pain catastrophizing, mood, distress and perceived disability. After each shock, patients completed measures of pain and fear. Results: We found that pain catastrophizing predicted the affective pain rating of the first shock, and the fear increase during subsequent shocks. There was no effect of INB. However, when controlling for the differences in pain catastrophizing, INB significantly reduced fear as compared to placebo. This suggests that the effects of INB during atrial cardioversion were overshadowed by the effects of pain catastrophizing. Conclusions: It is recommended that in future atrial cardioversion trials, stratification based on pain catastrophizing be performed. Reducing catastrophizing thinking about pain through cognitive-behavioral techniques are likely to reduce levels of fear during internal atrial cardioversion and may increase the effectiveness of concomitant analgesics. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailFurther evidence of association between periodontal conditions and coronary artery disease
Geerts, Sabine ULg; Legrand, Victor; Charpentier, Joseph et al

in Journal of Periodontology (2004), 75(9), 1274-1280

There is increasing evidence that chronic infections, such as periodontal diseases, could play a role in the initiation and development of coronary artery disease. The present study was intented to test ... [more ▼]

There is increasing evidence that chronic infections, such as periodontal diseases, could play a role in the initiation and development of coronary artery disease. The present study was intented to test for a possible association between presence and severityof periodontitis and coronary artery disease in a belgian population. [less ▲]

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See detailpolychlorinated biphenyls contamination in women with breast cancer
Charlier, Corinne ULg; Albert, Adelin ULg; Zhang, Lixin ULg et al

in Clinica Chimica Acta (2004), 347

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See detailCrural artery bypass with the autogenous greater saphenous vein
Van Damme, Hendrik ULg; Zhang, Lihong ULg; Baguet, E. et al

in European Journal of Vascular and Endovascular Surgery : The Official Journal of the European Society for Vascular Surgery (2003), 26(6), 635-642

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating ... [more ▼]

Objective. To evaluate the long-term outcome of greater saphenous vein (GSV) infrapopliteal revascularisation in a single centre over a 10 year period. Material and methods. Fourty-one variables relating to a consecutive series of 90 crural artery GSV(76% in situ) bypasses in 81 patients (1990-2000) were analysed. The mean age of the 47 men and 34 women was 70 years. Limb-threatening ischaemia was present in 96% of cases, claudication in four patients. In 18 patients, surgery was 'redo'. Results. The perioperative mortality was 3% (n = 3). Patient survival was 54% at 4 years. Independent risk factors affecting survival were chronic renal insufficiency (p = 0.04), hypertension (p = 0.02), and ischaemic heart disease (p = 0.01). Four bypasses thrombosed within 30 days. Three of them could be successfully reopened. Mean follow-up was 39 months. The primary patency rate at 4 years was 80%. Chronic renal insufficiency revealed to be the single independent risk factor for graft thrombosis (p = 0.03, RR = 12.4). The 4-year limb salvage rate was 88%. No independent risk factor affecting the limb salvage could be identified. Conclusion. Crural artery revascularisation is a valuable option for the management of limb threatening infrapopliteal arterial occlusive disease. [less ▲]

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See detailFactors predictive of nephropathy in DCCT Type 1 diabetic patients with good or poor metabolic control
Zhang, Liying; Krzentowski, Georges; Albert, Adelin ULg et al

in Diabetic Medicine : A Journal of the British Diabetic Association (2003), 20(7), 580-585

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic ... [more ▼]

Aims The study aim was to assess the time-related risk of developing diabetic nephropathy [albumin excretion rate (AER) greater than or equal to 40 mg/24 h] from baseline covariates in Type 1 diabetic patients with either good or poor metabolic control (MC). Methods Based on material from the Diabetes Control and Complications Trial study (n = 1441), patients were considered as under good or poor MC if their HbA(1c) mean level up to last visit fell in the lowest (less than or equal to 6.9%) or highest (greater than or equal to 9.5%) quintile of the overall HbA(1c) distribution, respectively. Prevalence cases of nephropathy were excluded from the study. Survival analysis and Cox regression were applied to the data. Results Among patients with good MC (n = 277), 15% had developed nephropathy at the end of the study. Conversely, among patients with poor MC (n = 268), the proportion without the complication was 52%. When adjusting for MC, time to diabetic nephropathy was related to age (P < 0.0001), AER (P < 0.001), duration of diabetes (P < 0.005), body mass index (BMI) (P < 0.005), all at baseline, and to gender (P < 0.01). Patients with upper normal range AER levels, longer duration of diabetes and lower BMI were at higher risk, regardless of MC. The adverse effect of younger age on diabetic nephropathy was more marked in good than in poor MC. Although women tended to develop the complication more often under good MC, they appeared to be better protected under poor MC. Conclusions This study confirms occurrence of diabetic nephropathy under good MC and non-occurrence of the complication despite poor MC. It also demonstrates that some baseline covariates can affect, in a differential manner, time to diabetic nephropathy depending on MC. [less ▲]

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See detailPrevention of malnutrition in older people during and after hospitalisation: results from a randomised controlled clinical trial
Gazzotti, C.; Arnaud-Battandier, F.; Parello, M. et al

in Age & Ageing (2003), 32(3), 321-325

Objective: to prevent the occurrence of weight loss during hospitalisation and following discharge by daily oral supplementation. Design: in a prospective, randomised, controlled study of 80 patients aged ... [more ▼]

Objective: to prevent the occurrence of weight loss during hospitalisation and following discharge by daily oral supplementation. Design: in a prospective, randomised, controlled study of 80 patients aged 75 or more, and at risk of undernutrition based on their initial Mini Nutritional Assessment score, patients were randomised into a control group or one receiving oral supplementation. The intervention was a prescription of 200 ml sweet or salty sip feed twice daily (500 kcal, 21 g protein per day) throughout hospitalisation and convalescence. Nutritional status was assessed at baseline and after 2 months using Mini Nutritional Assessment and body weight record. Results: compliance with oral supplementation was good and daily extra energy intake was 407+/-184 kcal. On day 60, significant weight loss from upon admission was observed in the control group (-1.23+/-2.5 kg; P=0.01), but not in the supplemented group (0.28+/-3.8 kg; NS). At the end of the study, Mini Nutritional Assessment scores were higher in the supplemented group than in the control group (23.5+/-3.9 versus 20.8+/-3.6; P<0.01). Conclusion: use of daily oral supplementation during and after hospitalisation maintains body weight and increases Mini Nutritional Assessment score in patients at risk of undernutrition. [less ▲]

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See detailBreast cancer and serum organochlorine residues
Charlier, Corinne ULg; Albert, Adelin ULg; Herman, Philippe ULg et al

in Occupational and Environmental Medicine (2003), 60(5), 348-351

Background: Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations. Aims: To compare the blood levels ... [more ▼]

Background: Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations. Aims: To compare the blood levels of total dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB) in samples collected at the time of breast cancer discovery, in order to avoid the potential consequences of body weight change ( after chemotherapy or radiotherapy) on the pesticide residue levels. Methods: Blood levels of HCB and total DDT (we calculated total DDT concentrations by adding all DDT and DDE isomers) were compared in 159 women with breast cancer and 250 presumably healthy controls. Risk of breast cancer associated with organochlorine concentration was evaluated. Results: Mean levels of total DDT and HCB were significantly higher for breast cancer patients than for controls. No differences in serum levels of total DDT or HCB were found between oestrogen receptor positive and oestrogen receptor negative patients with breast cancer. Conclusions: These results add to the growing evidence that certain persistent pollutants may occur in higher concentrations in blood samples from breast cancer patients than controls. [less ▲]

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See detailJoint Mobility in Adult Patients with Groin Hernias
Pans, Alain ULg; Albert, Adelin ULg

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (2003), 7(1), 21-4

The basic mechanisms of hernia formation remain mostly unknown, but several studies suggest that a connective-tissue pathology, affecting mainly the collagen metabolism, could play a role in the genesis ... [more ▼]

The basic mechanisms of hernia formation remain mostly unknown, but several studies suggest that a connective-tissue pathology, affecting mainly the collagen metabolism, could play a role in the genesis of groin hernias. It would be interesting to know if this pathology can express some clinical signs other than the hernia. Our study focused on the joint mobility and the diagnostic criteria for benign joint hypermobility syndrome. Sixty male adult patients with inguinal hernias and 62 control subjects without hernias, age-matched, were compared, taking into account anamnestic criteria (family history of groin hernia, joint sprain, joint dislocation, skin striae, major arthralgia) and joint mobility. This was assessed by using Beighton criteria and measuring the range of movement of five joints (extension of the fifth finger, thumb, wrist, elbow, and knee). The frequency of the positive anamnestic criteria was not statistically different between the two groups. Nevertheless, a family history of groin hernia was observed in 25% of the hernia patients, against 16% in the control subjects ( P=0.23). The mean Beighton score was 0.30 in the hernia patients and 0.29 in the control population. The movement range of the five examined joints was similar in the two groups. In conclusion, patients with a groin hernia presented neither joint hypermobility nor clinical evidence of a benign joint hypermobility syndrome. Although abnormal collagen metabolism is likely implicated in hernia formation, this pathology does not seem to have clinical repercussion on joint mobility. [less ▲]

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See detailDifference in risk factors for postoperative nausea and vomiting.
Stadler, Michaela; Bardiau, Françoise ULg; Seidel, Laurence ULg et al

in Anesthesiology (2003), 98(1), 46-52

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for ... [more ▼]

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for postoperative nausea and vomiting in various surgical populations in a clinical audit setting. METHODS: The study included 671 consecutive surgical inpatients, aged 15 yr or more, undergoing various procedures. The study focused on postoperative nausea visual analog scale scores every 4 h and vomiting episodes within 72 h. Both vomiting and retching were considered as emetic events. Patient-, anesthesia-, and surgery-related variables that were considered to have a possible effect on the proportion of patients experiencing postoperative nausea and/or vomiting were examined. The bivariate Dale model for binary correlated outcomes was used to identify selectively the potential risk factors of postoperative nausea and vomiting. RESULTS: Among the 671 patients in the study, 126 (19%) reported one or more episodes of nausea, and 66 patients (10%) suffered one or more emetic episodes during the studied period. There was a highly significant association between the two outcomes. Some risk factors were predictive of both nausea and vomiting (female gender, nonsmoking status, and general anesthesia). History of migraine and type of surgery were mainly responsible for nausea but not for vomiting. The predictive effect of risk factors was controlled for postoperative pain and analgesic drugs. CONCLUSION: This study shows that differences exist in risk factors of postoperative nausea and vomiting. These could be explained by differences in the physiopathology of the two symptoms. [less ▲]

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See detailAn intervention study to enhance postoperative pain management.
Bardiau, Françoise ULg; Taviaux, Nicole F; Albert, Adelin ULg et al

in Anesthesia and Analgesia (2003), 96(1), 179-85

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery ... [more ▼]

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery departments were involved. In this study we sought to evaluate the results of a continuous quality improvement program by defining quality indicators and using quality tools. A quality program in accordance with current standards of acute pain treatment (multimodal) was worked out to enhance pain relief for all surgical inpatients. A survey of nurses' knowledge with regard to postoperative pain was conducted, and a visual analog scale (VAS) was introduced to assess pain intensity. Both nurses and physicians became familiar with evidence-based guidelines concerning postoperative pain. The entire process was monitored in three consecutive surveys and enrolled 2383 surgical inpatients. Pain indicators based on VAS and analgesic consumption were recorded during the first 72 postoperative hours. After a baseline survey about current practices of pain treatment, a nurse-based, anesthesiologist-supervised APS was implemented. The improvement in pain relief, expressed as VAS scores, was assessed in two further surveys. A quality manual was written and implemented. A major improvement in pain scores was observed after the APS inception (P < 0.001). IMPLICATIONS: The implementation of an acute pain service, including pain assessment by a visual analog scale, standard multimodal pain treatment, and continuous quality evaluation, improved postoperative pain relief. Establishing teams of surgeons, anesthesiologists, and nurses is the prerequisite for this improvement. [less ▲]

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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULg; Balsat, Alain; Dujardin, Marco et al

Scientific journal (2003)

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See detailExperimental comparison of cavity sealing ability of five dental adhesive systems after thermocycling
Cao, L.; Geerts, Sabine ULg; Gueders, Audrey ULg et al

in Journal of Adhesive Dentistry (2003), 5(2, Summer), 139-144

Purpose: To evaluate the cavity sealing obtained after thermocycling with five adhesive systems in which one all-in-one adhesive was compared to three one-bottle adhesives, and to observe the effect of a ... [more ▼]

Purpose: To evaluate the cavity sealing obtained after thermocycling with five adhesive systems in which one all-in-one adhesive was compared to three one-bottle adhesives, and to observe the effect of a low-charged resin layer added to a one-bottle adhesive. Materials and Methods: Twenty-five recently extracted teeth were randomly allocated to five experimental adhesive systems (n = 5 each): Optibond Solo (OS), Scotchbond 1 (SB1), PQ 1, Prompt-L-Pop (PLP), SB1+Revolution (R). On each tooth, two rectangular cavities at the cementoenamel junction were filled with a microhybrid composite (Z100) and the tested adhesives. Teeth were thermocycled and stained with AgNO3 + vitamin C. Leakage was evaluated on a 6-point (0-5) severity scale and the highest score was selected for each restoration. Results were treated by ordinal logistic regression and considered to be significant at p < 0.05. Results: No significant difference was found between leakage values for enamel and dentin interfaces. Leakage scores never exceeded 2 for OS, SB1 and SB1+R, while they reached a maximum of 5 in 20% of PLP cases. OS was significantly better than the other adhesive systems, which were statistically equivalent. The addition of a flowable composite layer on SB1 did not yield a significant difference, but tended to give better results mainly at the dentin interface. Conclusion: The all-in-one adhesive PLP because of quite variable results, seems less reliable than the one-bottle adhesives, of which OS provides significantly the best results. Addition of a flowable composite on SB1 appears to yield slightly better results. [less ▲]

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See detailRandom Response Model for estimating illicit drug prevalence among youth. A feasibility study.
Mauer, M.; Donneau, Anne-Françoise ULg; Pasquasy, N. et al

Report (2003)

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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULg; Balsat, Alain; Dujardin, Marc ULg et al

in Strasser, H.; Kluth, K.; Rausch, H. (Eds.) et al Quality of work and products in enterprises of the future (2003)

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See detailPeriodontal condition in Belgian patients with acute or chronic heart disease
Geerts, Sabine ULg; Charpentier, Joseph ULg; Albert, Adelin ULg et al

in Journal of Dental Research (2002, December), 81(Sp. Iss. B), 240-240

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See detailSystemic release of endotoxins induced by gentle mastication: Association with periodontitis severity
Geerts, Sabine ULg; Nys, Monique ULg; De Mol, Patrick ULg et al

in Journal of Dental Research (2002, December), 81(Sp. Iss. B), 235-235

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