Fibroblast growth factor 23 in acute burn patients: Novel insights from an intact-form assay.
ROUSSEAU, Anne-Françoise ; ; DELANAYE, Pierre et al
in Burns : Journal of the International Society for Burn Injuries (in press)
INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress ... [more ▼]
INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress in understanding FGF23 physiology has emphasized the importance of assessing the intact form of FGF23. METHODS: The present cohort study is a complementary analysis of a previously published work. Patients >18 years, admitted within 24h after injury with burn surface area (BSA) >10% were included. C-terminal (c-term) and intact (i) FGF23 assay were performed at admission and every week during 4 weeks of follow-up. Inflammation and iron status were assessed at the same time points. RESULTS: Twenty patients were initially included and 12 were followed until day 28. The c-term FGF23 tended to gradually increase during the 4 weeks of follow-up while iFGF23 was quite stable into normal ranges. Iron status showed a typical inflammatory profile. C-term FGF23 was significantly positively correlated with c-reactive protein (CRP) and negatively correlated with iron levels. iFGF23 was not correlated with CRP or iron. CONCLUSION: FGF23 status following burn is characterized by a dissociation between c-term FGF23 and iFGF23. The hypothesis of an increased cleavage may be raised. Respective role of inflammation and iron levels in such deregulation need to be specified. Both c-term and intact assays should be performed in further studies aiming to increase knowledge on FGF23 regulation and effects in burn patients. [less ▲]Detailed reference viewed: 18 (0 ULg)
The role of biochemical of bone turnover markers in osteoporosis and metabolic bone disease: a consensus paper of the Belgian Bone Club.
Cavalier, Etienne ; ; Bruyère, Olivier et al
in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2016), 27
The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state ... [more ▼]
The exact role of biochemical markers of bone turnover in the management of metabolic bone diseases remains a topic of controversy. In this consensus paper, the Belgian Bone Club aimed to provide a state of the art on the use of these biomarkers in different clinical or physiological situations like in postmenopausal women, osteoporosis in men, in elderly patients, in patients suffering from bone metastasis, in patients with chronic renal failure, in pregnant or lactating women, in intensive care patients, and in diabetics. We also gave our considerations on the analytical issues linked to the use of these biomarkers, on potential new emerging biomarkers, and on the use of bone turnover biomarkers in the follow-up of patients treated with new drugs for osteoporosis. [less ▲]Detailed reference viewed: 26 (2 ULg)
Soins du patient brûlé : une réalité différente chez l'adulte et chez l'enfant ?
Conference (2016, February 26)Detailed reference viewed: 29 (1 ULg)
Bone markers during acute burn care: Relevance to clinical practice?
ROUSSEAU, Anne-Françoise ; Damas, Pierre ; DELANAYE, Pierre et al
in Burns : Journal of the International Society for Burn Injuries (2016)
OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made ... [more ▼]
OBJECTIVE: Bone changes are increasingly described after burn. How bone markers could help to detect early bone changes or to screen burn patients at higher risk of demineralization is still not made clear. We performed an observational study assessing the changes in serum bone markers after moderate burn. METHODS: Adults admitted in the first 24h following burn extended on >10% body surface area were included. Serum levels of collagen type 1 cross-linked C-telopeptide (CTX), tartrate-resistant acid phosphatase 5b (TRAP), type 1 procollagen N-terminal (P1NP) and bone alkaline phosphatase (b-ALP) were measured at admission and every week during the first month. Data are expressed as median [min-max]. RESULTS: Bone markers were measured in 20 patients: 18 men, 2 women (including one post-menopausal). Age was 46 [19-86] years old, burn surface area reached 15 [7-85] %. Twelve patients completed the study. All biomarkers mainly remained into normal ranges during evolution. A huge variability was observed regarding biomarkers evolution. Patient's evolution was not linear and could fluctuate from a decrease to an increase of blood concentrations. There was not necessarily a consistency between the two formation or the two resorption markers. Variations observed between two consecutive measurements were lesser than the accepted critical difference in almost one third of the cases. CONCLUSIONS: Considering available data, role and interest of bone markers in management of burn related bone disease remain unclear. [less ▲]Detailed reference viewed: 13 (3 ULg)
Incidence of bone fractures after critical illness
ROUSSEAU, Anne-Françoise ; Michel, Laure ; Bawin, Maxime et al
in Intensive Care Medicine Experimental (2016), 4(Suppl 1), 1131Detailed reference viewed: 22 (11 ULg)
Phage therapy against antimicrobial resistance, design of the first clinical study Phagoburn.
; ; et al
in Critical Care (2016), 20(Suppl 2), 109Detailed reference viewed: 56 (0 ULg)
Brûlures domestiques enfants et adultes : les gestes qui sauvent.
Conference (2015, December 08)Detailed reference viewed: 17 (1 ULg)
Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects
ROUSSEAU, Anne-Françoise ; DAMAS, Pierre ; LEDOUX, Didier et al
in Burns : Journal of the International Society for Burn Injuries (2015), 41(5), 1028-1034
Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a ... [more ▼]
Background: Burn patients are at risk of vitamin D (VD) deficiency and may benefit from its pleiotropic effects as soon as acute phase. Aim of this observational study was to assess effects of a cholecalciferol (VD3) bolus on VD status in adult burn patients (Group B, GB) after admission, compared to healthy subjects (Group H, GH). Methods: Both groups received an oral dose of 100,000 IU VD3. Blood samples were collected before (D0) and 7 days (D7) after bolus to measure 250H-D, 1,25(OH)2-D, parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23). Albumin (ALB) and VD binding protein (DBP) were measured and used to calculate free 25OH-D level. Data were expressed as median (min–max) or proportions. Results: A total of 49 subjects were included: 29 in GH and 20 in GB. At D0, prevalence of VD deficiency was higher in GB: 25OH-D was 21.5 (10.1–46.3) ng/ml in GH vs 11 (1.8–31.4) ng/ml in GB. DBP and ALB were lower in GB. At D7, DBP was stable in both groups while ALB decreased in GB. 25OH-D increased by 66.6 (13.5–260.3)% in GH. In GB, changes in 25OH-D extended from 36.7% to 333.3% with a median increase of 33.1%. Similar changes were observed in each group for free 25OH-D. High FGF23 levels were observed in GB. Conclusions: This study highlighted the differences in VD status and in response to a high dose VD3 in burn patients when compared to healthy patients. Pitfalls in VD status assessment are numerous during acute burn care: 25OH-D measurement needs cautious interpretation and interest of free 25OH-D is still questionable. They should not prevent burn patients to receive VD supplements during acute care. Higher doses than general recommendations should probably be considered. [less ▲]Detailed reference viewed: 35 (16 ULg)
Serum markers of sepsis in burn patients: it takes more to convince!
ROUSSEAU, Anne-Françoise ; LAYIOS, Nathalie
in Critical Care Medicine (2015), 43(3), 100-1Detailed reference viewed: 19 (2 ULg)
effects of cholecaciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: a one-year pilot randomized controlled trial in adults with severe burns
ROUSSEAU, Anne-Françoise ; FOIDART-DESSALLE, Marguerite ; LEDOUX, Didier et al
in Burns : Journal of the International Society for Burn Injuries (2015), 41(2), 317-325
Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess ... [more ▼]
Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury. Design: Monocentric randomized controlled trial. Methods: Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups. For 12 months, they either received a quarterly IM injection of 200,000 IU VD3 and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers were assessed every 3 months. Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol. Results: Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40 y) were considered osteopenic at inclusion. After one year, calcidiol levels significantly increased in Group D to reach 40 (37–61) ng/ml. No significant change in bone health was observed in both groups while Group D significantly improved quadriceps strength when tested at high velocity. Conclusions: This VD3 supplementation was safe and efficient to correct hypovitaminosis D in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects on muscle health but not on bone health. A high prevalence of hypovitaminosis D and osteopenia in these patients, as well as their wide range of muscle performances, seem to be worrying when considering rehabilitation and quality of life. [less ▲]Detailed reference viewed: 50 (14 ULg)
Vitamin D status in critically ill patients: back to basics!
ROUSSEAU, Anne-Françoise ; CAVALIER, Etienne
in Critical Care (2014), 18(6), 611Detailed reference viewed: 21 (2 ULg)
Critical care and vitamin D status assessment: What about immunoassays and calculated free 25OH-D?
ROUSSEAU, Anne-Françoise ; DAMAS, Pierre ; JANSSENS, Marc et al
in Clinica Chimica Acta (2014), 437Detailed reference viewed: 24 (1 ULg)
Use of a pediatric oxygenator integrated in a veno-venous hemofiltration circuit to remove CO2 : a case report in a severe burn patient with refractory hypercapnia.
ROUSSEAU, Anne-Françoise ; DAMAS, Pierre ; RENWART, Ludovic et al
in Burns : Journal of the International Society for Burn Injuries (2014), 40(7), 57-60Detailed reference viewed: 25 (7 ULg)
Effect of gamma-hydroxybutyrate on keratinocytes proliferation: a preliminary prospective controlled study in severe burn patients.
ROUSSEAU, Anne-Françoise ; ; et al
in International Journal of Critical Illness and Injury Science (2014), 4(2), 108-113Detailed reference viewed: 32 (14 ULg)
Effect of optimized cholecalciferol and calcium intakes on bone mineral density: a randomized controlled trial in adult burns during sequelae stage.
ROUSSEAU, Anne-Françoise ; FOIDART-DESSALLE, Marguerite ; REMY, Christophe et al
in Nutrients (2014), 6Detailed reference viewed: 28 (7 ULg)
Effect of cholecalciferol recommended daily allowances on vitamin D status and fibroblast growth factor-23: an observational study in acute burn patients.
ROUSSEAU, Anne-Françoise ; DAMAS, Pierre ; LEDOUX, Didier et al
in Burns : Journal of the International Society for Burn Injuries (2014), 40(5), 865-70Detailed reference viewed: 18 (6 ULg)