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See detailEvaluation de la régénération tendineuse suite à l'injection de concentré plaquettaire dans les tendons lésés de rats
Remy, Hélène ULg

Master's dissertation (2009)

Tendinopathies are frequent pathologies affecting both professional and occasional athletes as well as the general public. Nowadays, various treatments are described in the literature but there is little ... [more ▼]

Tendinopathies are frequent pathologies affecting both professional and occasional athletes as well as the general public. Nowadays, various treatments are described in the literature but there is little evidence to support their effectiveness. Moreover, unless cured with an adequate treatment which needs careful attention, tendinopathies tend to get chronic. It is for these reasons that a new way of treating chronic tendinopathies with injections of platelet-rich plasma (PRP) is actually being the subject of a few studies. This treatment has already been evaluated in various studies both in vitro and in vivo and its effects seem efficient with the tissues repairing processes, as well as the general management of tendinopathies. However, these studies are not numerous: one of them demonstrated the efficiency of PRP in the treatment of epicondylitis while another was successful in curing patellar tendinopathies. In an effort to strengthen the results of the studies realised on this topic, we have evaluated the regeneration of tendinitis after an injection of PRP in hurt tendons. These experiments have been realised on rats. The results, obtained after biomechanics, biochemical and histological analyses were conducted, revealed a higher tissue recovery for tendons treated with PRP. Results are even better when VEGF111 was added to the PRP treatment. Hence, we can make the assumption that, in clinical conditions, recovery from ruptured Achilles tendons could be ameliorated with the injections of platelet-rich plasma. This therapy could even be efficient in treating cases such as chronic tendinopathies that are immune to classic therapies and it could be tried before surgical treatment. However, randomized studies to be realised in a longer term perspective and on a greater number of patients would be necessary and useful in order to confirm PRP’s efficiency. [less ▲]

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