References of "Radermecker, Régis"
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See detailDoes Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review
Bacevic, Miljana ULiege; Brkovic, Bozidar; Albert, Adelin ULiege et al

in Calcified Tissue International (2017)

Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms ... [more ▼]

Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration. [less ▲]

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See detailMerci à vous!
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2017), 60(3),

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See detailMens sana in corpore sano
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2017), 60(2),

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See detailInnovations Thérapeutiques appliquées au diabète
RADERMECKER, Régis ULiege

Conference (2017, January)

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See detailVous êtes formidables
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2017), 60

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See detailL’IMAGE DU MOIS.Une tumeur cardiaque indéterminée
RADERMECKER, Régis ULiege; RENSON, Virginie ULiege; Delvenne, Philippe ULiege et al

in Revue Médicale de Liège (2017), 72(1), 4-5

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See detailLes essais cliniques en Belgique
RADERMECKER, Régis ULiege

Conference given outside the academic context (2016)

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See detailTempus fugit
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2016), 59

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See detailJournée mondiale du Diabète: ne jamais baisser les bras
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2016), 59

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See detailUpdate des traitements en diabétologie en 2016
RADERMECKER, Régis ULiege

Conference given outside the academic context (2016)

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See detailLes nouvelles technologies au servivce du patient diabétique
RADERMECKER, Régis ULiege

Conference given outside the academic context (2016)

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See detailSoyons optimistes
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2016), 59(4), 3

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See detailLes mustères de la "Viege noire" ou comment se passe la demande d'allocation de handicap
Marquet, Françoise; RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2016), 59(4), 9-13

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See detailLes PCSK9 : la mort des statines ?
RADERMECKER, Régis ULiege

Conference (2016, March 19)

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See detailDes nouvelles de votre revue
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2016), 59

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See detailNos différences, une richesse
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2016), 59

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