References of "Quertemont, Etienne"
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See detailLes biais attentionnels envers l’alcool chez les « petits consommateurs » vs « gros consommateurs » dans un environnement virtuel
Pollet, Hélène; Quertemont, Etienne ULiege; Bouchard, Stéphane et al

Poster (2017, November 18)

Introduction : Les personnes dépendantes à l'alcool montrent des biais attentionnels quand elles sont confrontées à des indices liés à l’alcool (Kreusch, Vilenne, & Quertemont, 2013). D’après le modèle de ... [more ▼]

Introduction : Les personnes dépendantes à l'alcool montrent des biais attentionnels quand elles sont confrontées à des indices liés à l’alcool (Kreusch, Vilenne, & Quertemont, 2013). D’après le modèle de Wiers et al. (2007), les biais attentionnels favoriseraient la consommation répétée de substances. Objectif : Cette étude exploratoire évalue dans quelle mesure la réalité virtuelle fournit un environnement permettant de tester ces biais attentionnels. Hypothèse : Les gros consommateurs d'alcool présentent des biais attentionnels plus fréquents et plus intenses que les petits consommateurs. Méthode : Un questionnaire en ligne permettant de recruter 24 petits et 24 gros consommateurs d’alcool a d’abord été administré afin de présélectionner les sujets. Les participants ont ensuite réalisé une tâche d’immersion dans un environnement virtuel de « bar ». Le nombre de zooms effectués sur les stimuli « bières » et le nombre de commentaires rapportés en lien avec l’alcool étaient mesurés. Directement après l’immersion, la Visual Analogue Craving Scale (VAS) leur était administrée afin d’évaluer leur envie de boire. Résultats : Les « gros consommateurs » présentent davantage de zooms sur les stimuli « bières » que les «petits consommateurs». De plus, les « gros consommateurs » présentent un score plus élevé à la VAS que les «petits consommateurs », ce qui témoignerait d’une envie de consommer plus élevée après l’immersion par rapport aux « petits consommateurs ». Cependant, aucune corrélation significative n’a été mise en avant entre le nombre de zooms effectués et le score à la VAS chez les « gros consommateurs ». Conclusion : En accord avec nos hypothèses, nos résultats ont montré que les gros consommateurs présentent davantage de biais attentionnels envers les stimuli liés à l’alcool que les petits consommateurs ». Cependant, de futures recherches sont nécessaires afin de pouvoir confirmer que la réalité virtuelle fournit un environnement qui permet de tester les biais attentionnels. [less ▲]

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See detailLa réalité virtuelle, un outil issu de la recherche et dédié aux traitements des peurs !
Etienne, Anne-Marie ULiege; Stassart, Céline ULiege; Leclercq, Anne-Lise ULiege et al

Speech/Talk (2017)

Une série de projets scientifiques sont en cours dans le domaine des soins de santé globale au sein de la Faculté de Psychologie, Logopédie et Science de l’Education prenant appui sur la technologie de la ... [more ▼]

Une série de projets scientifiques sont en cours dans le domaine des soins de santé globale au sein de la Faculté de Psychologie, Logopédie et Science de l’Education prenant appui sur la technologie de la réalité virtuelle. L’équipe travaille notamment sur la dépendance à l’alcool, la douleur, l’obésité, le bégaiement, etc… Pour ces recherches, elle utilise des environnements virtuels en 3D en temps réel. Ces environnements virtuels permettent de naviguer librement dans des scénarios, d’incorporer progressivement des sensations physiques et émotionnelles et de graduer les interactions au rythme des utilisateurs. [less ▲]

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See detailTraiter l’alexithymie en Hôpital de Jour Psychiatrique : Identification des modulateurs favorisant une meilleure prise en charge
Nasello, Julian ULiege; Servais, Catherine; Close, Mireille et al

Poster (2017, May 19)

L’alexithymie (i.e., incapacité à exprimer ses émotions par des mots) serait-elle sensible aux traitements psychothérapeutiques dispensés en Hôpital de Jour (HPJ) ? Quelles en seraient les variables ... [more ▼]

L’alexithymie (i.e., incapacité à exprimer ses émotions par des mots) serait-elle sensible aux traitements psychothérapeutiques dispensés en Hôpital de Jour (HPJ) ? Quelles en seraient les variables prédictives ? Notre recherche a porté sur 73 participants sélectionnés en HPJ et présentant des troubles de l’humeur. En comparant les scores d’entrée et de sortie, des réductions significatives ont été observées sur tous les aspects d’alexithymie. De plus, certaines variables impactant significativement sur l’alexithymie ont été mises en avant : variables démographiques (i.e., genre ; âge ; durée de séjour) ; médication ; variables du MMPI-2 ; support social perçu (PSS). Il apparait que le PSS ainsi que cinq variables mesurées par le MMPI-2 (e.g., les pratiques antisociales ou les attitudes négatives face au traitement) tendaient à réduire ou augmenter les niveaux d’alexithymie. Dès lors, ces résultats tendent à favoriser une conception plus flexible des traits de personnalité, à mettre en évidence le rôle fondamental de la régulation exogène des émotions et à fournir aux thérapeutes les variables à prendre en considération pour optimiser la prise en charge de l’alexithymie. [less ▲]

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See detailDealing with Alexithymia in a Day Psychiatric Hospital - A study identifying significant modulators to promote recovery
Nasello, Julian ULiege; Servais, Catherine; Close, Mireille et al

Conference (2017, April 21)

Objective: in this research, we studied changings and modulations of alexithymia [defined by Difficulties in Identifying Feelings (DIF); in Discussing Feelings (DDF) and by an Externally-Oriented Thinking ... [more ▼]

Objective: in this research, we studied changings and modulations of alexithymia [defined by Difficulties in Identifying Feelings (DIF); in Discussing Feelings (DDF) and by an Externally-Oriented Thinking (EOT)]. The purpose was to investigate if Day Psychiatric Hospitalization (DPH) could promote significant improvements on difficulties linked to alexithymia in a population of mood disorders patients (N = 73). Methods & results: a first study showed significant reductions of alexithymia scores. Considered as a personality trait, alexithymia’s changings lead us to promote the relative stability hypothesis, by displaying that moderate to high correlational levels were achieved. A second study revealed the variables impacting significantly on alexithymia. The selected variables were: demographic (i.e. gender; age; number of days of treatment); MMPI-2 variables; and perceived social support (assessed with the MSPSS scale). We found notably a positive effect of perceived social support (PSS) that reduced difficulties associated to alexithymia and other variables that increased alexithymia levels (e.g. antisocial practices, negative attitude to treatment). Conclusion: positive effects of PSS are well known and two main hypotheses were already proposed to explain its effect: PSS acting directly or as a buffer on stressful events. In conclusion, at the one hand, we showed that it is possible to significantly decrease at a certain level a phenomenon such as alexithymia. At the other hand, we enlightened significant modulators of alexithymia that might help therapists to promote or avoid specific aspects for patients involved in a recovery process. [less ▲]

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See detailAccurate Control of 17beta-Estradiol Long-Term Release Increases Reliability and Reproducibility of Preclinical Animal Studies.
Gérard, Céline ULiege; Gallez, Anne ULiege; Dubois, Charline ULiege et al

in Journal of Mammary Gland Biology & Neoplasia (2017), 22(1), 1-11

Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to ... [more ▼]

Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to-use slow releasing devices to administer steroids, especially estrogens, to small experimental animals remains the method of choice in terms of animal well-being and of safety for both the researcher and the animal. In this study, we evaluated and compared, in vitro and in vivo, the release kinetic of estradiol (E2) over sixty days from two different slow-releasing systems: the matrix pellet (MP) and the reservoir implant (RI). We compared the impact of these systems in three E2-sensitive mouse models : mammary gland development, human MCF7 adenocarcinoma xenograft and mouse melanoma progression. The real amount of E2 that is released from both types of devices could differ from manufacturer specifications due to inadequate release for MP and initial burst effect for RI. Compared to MP, the interindividual variability was reduced with RI thanks to a superior control of the E2 release. Depending on the dose-dependent sensitivity of the physiological or pathological readout studied, this could lead to an improvement of the statistical power of in vivo experiments and thus to a reduction of the required animal number. Altogether, our data draw attention on the importance to adequately select the slow-releasing device that is the most appropriated to a specific experiment to better fulfill the 3Rs rule (Replacement, Reduction, Refinement) related to animal welfare and protection. [less ▲]

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See detailAnalyses des prédicteurs significatifs de l’alexithymie après une prise en charge en hôpital de jour
Nasello, Julian ULiege; Quertemont, Etienne ULiege; Blavier, Adelaïde ULiege et al

Poster (2017, January 18)

L’alexithymie, souvent considérée comme un trait de personnalité, serait-elle sensible aux traitements psychothérapeutiques dispensés en hôpital de jour ? Quelles en seraient les variables prédictives ... [more ▼]

L’alexithymie, souvent considérée comme un trait de personnalité, serait-elle sensible aux traitements psychothérapeutiques dispensés en hôpital de jour ? Quelles en seraient les variables prédictives ? Notre recherche a porté sur un échantillon de 192 participants hospitalisés, majoritairement représenté par des patients présentant des troubles de l’humeur (64,6%). Plusieurs variables ont été prises en considération : le sexe, l’âge, la durée d’hospitalisation (M séjour = 6 semaines), la médication, les dix échelles cliniques de base du « Minnesota Multiphasic Personality Inventory-2 » (MMPI-2), l’indice de négativité au traitement du MMPI-2 (échelle TRT) et le support social perçu (PSS) mesuré par la « Multidimensional Scale of Perceived Social Support » (MSPSS). Les impacts positifs du support social perçu et les impacts négatifs de la non-adhésion au traitement se sont révélés être des prédicteurs particulièrement significatifs de l’alexithymie. [less ▲]

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See detailAlexithymie et Ouverture Émotionnelle : effets positifs de la psychothérapie de groupe en hôpital de jour
Triffaux, Jean-Marc ULiege; Nasello, Julian ULiege; Servais, Catherine et al

Poster (2017, January 18)

À partir d’un échantillon de 192 patients, nous avons évalué l’effet de l’hospitalisation de jour sur l’alexithymie et l’ouverture émotionnelle. Ces deux variables ont été mesurées à travers deux échelles ... [more ▼]

À partir d’un échantillon de 192 patients, nous avons évalué l’effet de l’hospitalisation de jour sur l’alexithymie et l’ouverture émotionnelle. Ces deux variables ont été mesurées à travers deux échelles : la TAS-20 [1] et la DOE-36 [2]. A l’époque de l’« evidence based medicine », ces résultats permettent d’améliorer nos interventions thérapeutiques et d’envisager, de manière clinique et scientifique, la durée de séjour optimale de nos patients. [less ▲]

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See detailAlcohol-cue exposure decreases response inhibition towards alcohol-related stimuli in detoxified alcohol-dependent patients
Kreusch, Fanny; Billieux, Joël; Quertemont, Etienne ULiege

in Psychiatry Research (2017), 249

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol ... [more ▼]

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol relapse. The aim of the present study is to investigate whether the induction of a craving state, using an alcohol cue exposure paradigm, influences response inhibition towards both neutral stimuli and alcohol-related stimuli in alcohol-dependent patients. Thirty-one detoxified alcohol-dependent patients were exposed to either their preferred alcoholic beverage or to a glass of water. They then performed a modified stop signal task, which used alcohol-related words, neutral words and non-words, and a lexical decision as the Go response. The alcohol-cue exposure group reported significantly higher alcohol craving and showed higher percentages of commission errors towards alcohol-related words than the control group. All participants, but especially those of the alcohol-cue exposure group, showed also shorter reaction times when alcohol words were used as targets in go trials. The induction of alcohol craving in detoxified alcohol-dependent patients increases the motivational salience value of alcohol stimuli, leading them to automatically approach alcohol-related cues and therefore impairing response inhibition towards those stimuli. [less ▲]

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See detailLoss of treatment benefit when heroin-assisted treatment is stopped after 12 month
Demaret, Isabelle ULiege; Quertemont, Etienne ULiege; Litran, Géraldine et al

in Journal of Substance Abuse Treatment (2016), 69

Purpose: In 2013, during a recent heroin-assisted treatment trial, participants in heroinassisted treatment (HAT) decreased significantly more their street heroin use than participants in oral methadone ... [more ▼]

Purpose: In 2013, during a recent heroin-assisted treatment trial, participants in heroinassisted treatment (HAT) decreased significantly more their street heroin use than participants in oral methadone treatment. After the trial, HAT was discontinued. To examine whether the treatment benefits were sustained three months after the trial, the use of street heroin by the participants was analysed in a follow-up study. Results: At the follow-up assessment, street heroin use increased in the experimental group. The two groups no longer showed a significant difference (p=0.55) in the level of street heroin use. Conclusion: A predetermined and forced end of HAT was followed by a significant increase in the level of street level use. [less ▲]

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See detailLa psychothérapie institutionnelle : un processus thérapeutique au service de la régulation émotionnelle et de l'empathie
Triffaux, Jean-Marc ULiege; Gernay, Delphine; Servais, Catherine et al

in Encéphale (L') (2016)

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See detailDifferential effects of context on psychomotor sensitization to ethanol and cocaine
Didone, Vincent ULiege; Quoilin, Caroline; Dieupart, Julie et al

in Behavioural Pharmacology (2016), 27(2 & 3), 173-181

Repeated drug injections lead to sensitization of their stimulant effects in mice, a phenomenon sometimes referred to as drug psychomotor sensitization. Previous studies showed that sensitization to ... [more ▼]

Repeated drug injections lead to sensitization of their stimulant effects in mice, a phenomenon sometimes referred to as drug psychomotor sensitization. Previous studies showed that sensitization to cocaine is context dependent as its expression is reduced in an environment that was not paired with cocaine administration. In contrast, the effects of the test context on ethanol sensitization remain unclear. In the present study, female OF1 mice were repeatedly injected with 1.5 g/kg ethanol to test for both the effects of context novelty/familiarity and association on ethanol sensitization. A first group of mice was extensively pre-exposed to the test context before ethanol sensitization and ethanol injections were paired with the test context (familiar and paired group). A second group was not pre-exposed to the test context, but ethanol injections were paired with the test context (nonfamiliar and paired group). Finally, a third group of mice was not pre-exposed to the test context and ethanol was repeatedly injected in the home cage (unpaired group). Control groups were similarly exposed to the test context, but were injected with saline. In a second experiment, cocaine was used as a positive control. The same behavioral procedure was used, except that mice were injected with 10 mg/kg cocaine instead of ethanol. The results show a differential involvement of the test context in the sensitization to ethanol and cocaine. Cocaine sensitization is strongly context dependent and is not expressed in the unpaired group. In contrast, the expression of ethanol sensitization is independent of the context in which it was administered, but is strongly affected by the relative novelty/familiarity of the environment. Extensive pre-exposure to the test context prevented the expression of ethanol sensitization. One possible explanation is that expression of ethanol sensitization requires an arousing environment. [less ▲]

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See detailCorrelation between ethanol behavioral sensitization and midbrain dopamine neuron reactivity to ethanol
Didone, Vincent ULiege; Masson, Sébastien; Quoilin, Caroline et al

in Addiction Biology (2016), 21(2), 387-396

Repeated ethanol injections lead to a sensitization of its stimulant effects in mice. Some recent results argue against a role for ventral tegmental area (VTA) dopamine neurons in ethanol behavioral ... [more ▼]

Repeated ethanol injections lead to a sensitization of its stimulant effects in mice. Some recent results argue against a role for ventral tegmental area (VTA) dopamine neurons in ethanol behavioral sensitization. The aim of the present study was to test whether in vivo ethanol locomotor sensitization correlates with changes in either basal- or ethanol evoked firing rates of dopamine neurons in vitro. Female Swiss mice were daily injected with 2.5 g/kg ethanol (or saline in the control group) for 7 days and their locomotor activity was recorded. At the end of the sensitization procedure, extracellular recordings were made from dopaminergic neurons in midbrain slices from these mice. Significantly higher spontaneous basal firing rates of dopamine neurons were recorded in ethanol-sensitized mice relative to control mice, but without correlations with the behavioral effects. The superfusion of sulpiride, a dopamine D2 antagonist, induced a stronger increase of dopamine neuron firing rates in ethanol-sensitized mice. This shows that the D2 feedback in dopamine neurons is preserved after chronic ethanol administration and argues against a reduced D2 feedback as an explanation for the increased dopamine neuron basal firing rates in ethanol-sensitized mice. Finally, ethanol superfusion (10–100 mM) significantly increased the firing rates of dopamine neurons and this effect was of higher magnitude in ethanol-sensitized mice. Furthermore, there were significant correlations between such a sensitization of dopamine neuron activity and ethanol behavioral sensitization. These results support the hypothesis that changes in brain dopamine neuron activity contribute to the behavioral sensitization of the stimulant effects of ethanol. [less ▲]

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See detailResponse to novely and cocaine stimulant effects: lack of stability across environments in female Swiss mice
Nyssen, Laura ULiege; Brabant, Christian ULiege; Didone, Vincent ULiege et al

in Psychopharmacology (2016), 233

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model ... [more ▼]

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model novelty seeking is the "response to novelty," i.e., the levels of locomotor activity in a new environment. In rodents, a positive correlation was demonstrated between the response to novelty and several effects of drugs, especially the locomotor stimulant effects of cocaine. Objectives: The present study was designed to test in mice whether the response to novelty is stable across environments and whether its relationship with the stimulant effects of cocaine is altered by environmental changes. Experiment 1 assessed the responses to novelty of the same mice in two different novel environments. Experiment 2 tested the correlation between response to novelty and acute stimulant effects of cocaine recorded in two distinct environments. Results: The results show a weak correlation only during the first 5 min of the session between the responses to novelty measured in two distinct environments. Experiment 2 demonstrates that novelty responses and stimulant effects of cocaine are positively correlated only when both behavioral responses are measured in the same environment. In contrast, the relationship between response to novelty and acute stimulant effects of cocaine is completely lost when the behavioral responses are recorded in two different environments. Conclusions: The present results question the usual interpretation of the correlation between the response to novelty and the stimulant effects of cocaine as reflecting a relationship between two underlying individual stable characteristics. [less ▲]

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See detailCannabis use in adolescence: potential interventions on effect expectancies.
Schmits, Emilie ULiege; Quertemont, Etienne ULiege

Conference (2015, September 03)

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