References of "Poncin, Jacques"
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See detailSomatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis.
Poncin, Jacques ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in European Journal of Endocrinology (1999), 140(6), 573-6

Pituitary adenomas are a common manifestation of multiple endocrine neoplasia type 1 (MEN1) but most of them occur sporadically. There are only a few well defined genetic abnormalities known to occur in ... [more ▼]

Pituitary adenomas are a common manifestation of multiple endocrine neoplasia type 1 (MEN1) but most of them occur sporadically. There are only a few well defined genetic abnormalities known to occur in these sporadic tumours. The MEN1 gene located on 11q13 has recently been cloned and allelic deletion and mutation analysis studies have implicated the MEN1 gene in a significant fraction of the sporadic counterparts of typical MEN1 neoplasms (parathyroid tumours, insulinomas and gastrinomas). To determine if MEN1 gene inactivation is also involved in the development of sporadic pituitary adenomas, allelic deletions of chromosome 11q13 and MEN1 gene mutations and polymorphisms were assessed in 35 sporadic tumours of the anterior pituitary (9 prolactin-secreting, 8 GH-secreting, 3 TSH-secreting, 2 TSH/GH-secreting, 4 Cushing, 9 silent). Thirty-one tumours were found to be heterozygous for at least one MEN1 intragenic polymorphism (25 cases) or for a flanking gene polymorphism (6 cases). The remaining tumours were not informative. No mutations were found in any tumour except in one prolactinoma which was homozygous or hemizygous for a mutation (1-117 C-->T) in a region close to the promoter. Unfortunately, blood or normal tissue was not available in this case. Our data show that somatic MEN1 mutations do not contribute significantly to tumorigenesis of sporadic pituitary adenomas and suggest that mutation of other genes are likely to contribute to the pathogenesis of these tumours. [less ▲]

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See detailCharacterization of menin from normal individuals and MEN1 patients
Poncin, Jacques ULg; Closset, J.; Legros, J. J. et al

in 6th International Pituitary Congress - Abstract book (1999)

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See detailCharacterization of menin from leucocytes of normal and men-1 affected individuals
Poncin, Jacques ULg; Closset, Jean ULg; Legros, Jean-Jacques ULg et al

in 81st Annual Meeting of the Endocrine society - Abstract book (1999)

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See detailMutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases.
Poncin, Jacques ULg; Abs, R.; Velkeniers, B. et al

in Human Mutation (1999), 13(1), 54-60

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in parathyroids, enteropancreatic endocrine tissues, anterior pituitary, and other tissues. The gene ... [more ▼]

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in parathyroids, enteropancreatic endocrine tissues, anterior pituitary, and other tissues. The gene for MEN1 has recently been cloned and shown to code for a 610-amino acid protein of enigmatic function which probably acts as a tumor suppressor. Several mutations causing the MEN1 phenotype have been recently identified. In order to determine the spectrum of MEN1 gene mutations in a sample of 25 Belgian patients, we have systematically screened the 10 exons and adjacent sequences of the MEN1 gene by means of an automatic sequencing protocol. Twelve different mutations were identified including nonsense, frameshift, splicing, and missense mutations. Two of these mutations (D172Y and 357del4) occurred more than once. A missense mutation was also found in a kindred with familial hyperparathyroidism. We observed no significant correlation between the nature or position of mutation and the clinical status. We have also detected 6 intragenic polymorphisms and DNA sequence variants and have analyzed their frequencies in our population. [less ▲]

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See detailMutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type I and related diseases
Poncin, Jacques ULg; Abs, R.; Velkeniers, B. et al

in IV european Congress of Endocrinology - Abstract book (1998)

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See detailMutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type I and related diseases
Poncin, Jacques ULg; Abs, R.; Velkeniers, B. et al

in 5th Euroregional Oncology meeting - abstract book (1998)

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See detailThe spectrum of MEN1 gene mutations in Belgian patients with MEN1 and related diseases
Poncin, Jacques ULg; Abs, R.; Velkeniers, B. et al

in The 5th International Pituitary congress - Abstract book (1998)

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See detailThe spectrum of MEN1 gene mutations in Belgian patients with MEN1 and related diseases
Poncin, Jacques ULg; Abs, R.; Velkeniers, B. et al

in 80th Annual Meeting of the Endocrine society - Abstract book (1998)

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See detailAtheromasie et lipides
Chapelle, Jean-Paul ULg; Delwaide, Paul ULg; Gielen, Jacques et al

Conference (1988, February 25)

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