  A Multi‐Scale Computer Model of the Cardiovascular System Can Account for the Three Roles of the Left AtriumPironet, Antoine  ; Dauby, Pierre ; Kosta, Sarah et alin Abstract Book GIGA-Day (2013, January 28) Detailed reference viewed: 35 (7 ULg)A Multi‐Scale Computer Model of the Cardiovascular System Can Account for the Three Roles of the Left AtriumPironet, Antoine ; Dauby, Pierre ; Kosta, Sarah et alPoster (2013, January 28) Detailed reference viewed: 21 (10 ULg)A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship.Pironet, Antoine ; Desaive, Thomas ; Kosta, Sarah et alin BioMedical Engineering OnLine (2013), 12(1), 8 ABSTRACT: BACKGROUND: The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular ... [more ▼] ABSTRACT: BACKGROUND: The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular contractility. However, many criticisms have been expressed against this index and the underlying time-varying elastance theory: first, it does not consider the phenomena underlying contraction and second, the end-systolic pressure volume relationship has been experimentally shown to be load-dependent. METHODS: In place of the time-varying elastance theory, a microscopic model of sarcomere contraction is used to infer the pressure generated by the contraction of the left ventricle, considered as a spherical assembling of sarcomere units. The left ventricle model is inserted into a closed-loop model of the cardiovascular system. Finally, parameters of the modified cardiovascular system model are identified to reproduce the hemodynamics of a normal dog. RESULTS: Experiments that have proven the limitations of the time-varying elastance theory are reproduced with our model: (1) preload reductions, (2) afterload increases, (3) the same experiments with increased ventricular contractility, (4) isovolumic contractions and (5) flow-clamps. All experiments simulated with the model generate different end-systolic pressure-volume relationships, showing that this relationship is actually load-dependent. Furthermore, we show that the results of our simulations are in good agreement with experiments. CONCLUSIONS: We implemented a multi-scale model of the cardiovascular system, in which ventricular contraction is described by a detailed sarcomere model. Using this model, we successfully reproduced a number of experiments that have shown the failing points of the time-varying elastance theory. In particular, the developed multi-scale model of the cardiovascular system can capture the load-dependence of the end-systolic pressure-volume relationship. [less ▲] Detailed reference viewed: 35 (24 ULg)non invasive estimation of left atrial pressure and mitral valve area waveforms during an entire cardiac cyclePaeme, Sabine ; Pironet, Antoine ; Lancellotti, Patrizio et alPoster (2012, December 07) Detailed reference viewed: 11 (2 ULg) non invasive estimation of left atrial pressure and mitral valve area waveforms during an entire cardiac cyclePaeme, Sabine ; Pironet, Antoine ; LANCELLOTTI, Patrizio et alin proceeding of 11th national day of the National Committee on Biomedical Engineering (2012, December 07) Detailed reference viewed: 14 (2 ULg)Direct parameter identification in a model of the cardiovascular systemPironet, Antoine ; Dauby, Pierre ; Desaive, Thomas Poster (2012, December 07) Detailed reference viewed: 4 (1 ULg)Direct parameter identification in a model of the cardiovascular systemPironet, Antoine ; Dauby, Pierre ; Desaive, Thomas in 11th Belgian Day on Biomedical Engineering (2012, December 07) Detailed reference viewed: 8 (1 ULg)The rabbit left ventricle modeling at the cellular scale: application to flow-clamp experimentsKosta, Sarah ; Pironet, Antoine ; Dauby, Pierre in Proceedings of the 11th Belgian National Day on Biomedical Engineering (2012, December) Detailed reference viewed: 8 (4 ULg)The rabbit left ventricle modeling at the cellular scale: application to flow-clamp experimentsKosta, Sarah ; Pironet, Antoine ; Dauby, Pierre Poster (2012, December) Detailed reference viewed: 10 (3 ULg) structural model of the mitral valve included in a cardiovascular closed loop model. Static and dynamic validationPaeme, Sabine ; Pironet, Antoine ; et alConference (2012, August 31) Detailed reference viewed: 7 (3 ULg)Development and Identification of a Closed-Loop Model of the Cardiovascular System Including the AtriaPironet, Antoine ; ; Paeme, Sabine et alConference (2012, August 31) Detailed reference viewed: 31 (1 ULg)Structural model of the mitral valve included in a cardiovascular closed loop model. Static and dynamic validationPaeme, Sabine ; Pironet, Antoine ; et alin proceedings of 8th IFAC Symposium on Biological and Medical Systems, Budapest 29-31 août 2012 (2012, August 31) Detailed reference viewed: 19 (3 ULg)Development and Identification of a Closed-Loop Model of the Cardiovascular System Including the AtriaPironet, Antoine ; ; Paeme, Sabine et alin Proceedings of the 8th IFAC Symposium on Biological and Medical Systems (2012, August) Detailed reference viewed: 19 (4 ULg)Parameter Identification in a Model of the Cardiovascular System Including the AtriaPironet, Antoine ; ; Paeme, Sabine et alin 10th Belgian Day on Biomedical Engineering (2011, December 02) Detailed reference viewed: 13 (4 ULg)Parameter Identification in a Model of the Cardiovascular System Including the AtriaPironet, Antoine ; ; Paeme, Sabine et alPoster (2011, December 02) Detailed reference viewed: 38 (29 ULg)Méthodes d'identification des paramètres dans un modèle du système cardiovasculairePironet, Antoine Master's dissertation (2011) Les dysfonctions du système cardiovasculaire sont une origine majeure des admissions dans les unités de soins intensifs. Dans ces unités, les patients sont très instables et les cliniciens disposent d’un ... [more ▼] Les dysfonctions du système cardiovasculaire sont une origine majeure des admissions dans les unités de soins intensifs. Dans ces unités, les patients sont très instables et les cliniciens disposent d’un nombre limité de mesures pour prendre rapidement les bonnes décisions. L’utilisation de modèles patient-spécifiques pour guider les clini- ciens offre alors des perspectives réelles. Un modèle simple à six compartiments du système cardiovasculaire a été développé par Smith et al. et une méthode d’identification des paramètres de ce modèle a été développée par Revie et al. Ce modèle a été étendu en y ajoutant deux compartiments représentant les oreillettes, dont le comportement est décrit par un modèle inspiré de travaux existants. Une méthode d’identification similaire à celle utilisée par Revie et al. a été développée pour les nouveaux paramètres. Pour ne pas devoir recourir à la pression auriculaire, difficile à mesurer expérimentalement, une méthode permettant de déduire la pression auriculaire à partir de la pression ventriculaire a également été introduite. L’application du modèle étendu et de la méthode d’identification correspondante à des données expérimentales montre que l’introduction des oreillettes dans le modèle ne cause pas de trop grandes erreurs et que la méthode d’estimation de la pression auriculaire est correcte. En conclusion, la valeur ajoutée de la méthode développée dans ce travail est grande, puisqu’elle permet d’obtenir des informations supplémentaires sans introduire de grandes erreurs et sans imposer le besoin de recourir à de nouvelles mesures. [less ▲] Detailed reference viewed: 55 (11 ULg)The Parametrized Diastolic Filling Formalism: Application in the Asklepios Population; ; Pironet, Antoine et alin Conference Program ASME 2011 Summer Bioengineering Conference (2011, June) Detailed reference viewed: 22 (7 ULg) |
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