References of "Pierard, Claudine"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailRisquer sa peau pour quelques "joints".
Hermanns-Lê, Trinh ULg; DELVENNE, Philippe ULg; PIERARD, Gérald ULg et al

in Revue Médicale de Liège (2013), 68(5-6), 311-314

Detailed reference viewed: 15 (6 ULg)
Full Text
See detailTraitement par anti-TNF-alpha et cancers de la peau
Pierard, Claudine ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg et al

in ONCO-HEMATO (2011), 5

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailDysidrose palmo-plantaire sous sous le kaleidoscope.
Devillers, C.; Pierard, Claudine ULg; Hermanns-Lê, Trinh ULg et al

in Revue Médicale de Liège (2010), 65(1), 18-22

A pruritic vesicular, pustular or squamous eruption confined to the lateral aspect of fingers or toes corresponds to the overall pattern of dysidrosis. Such a clinical pattern is defined by its peculiar ... [more ▼]

A pruritic vesicular, pustular or squamous eruption confined to the lateral aspect of fingers or toes corresponds to the overall pattern of dysidrosis. Such a clinical pattern is defined by its peculiar topography. It is encountered in diseases resulting from various etiologies. Thus, conceptually, dysidrosis is a common clinical aspect shared by diverse disorders related to different etiologies and pathomechanisms. The dermatopathological assessment and the patch test procedure shed some light on this nosological diversity. Allergic contact dermatitis, irritation dermatitis, mycids, alterations of acrosyringia, and drug or food reactions are eventually involved in this process. However, most cases of dysidrotic dermatoses do not disclose their origins and they remain idiopathic. [less ▲]

Detailed reference viewed: 76 (3 ULg)
Full Text
Peer Reviewed
See detailEchec a l'echec diagnostique et therapeutique dans les pertes de cheveux.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2010), 65(5-6), 413-9

Hair loss, also called hair effluvium is often considered as an ancillary complaint. However, this situation is quite common in both genders. It is part of numerous clinical presentations in internal ... [more ▼]

Hair loss, also called hair effluvium is often considered as an ancillary complaint. However, this situation is quite common in both genders. It is part of numerous clinical presentations in internal medicine and dermatology. Obviously, any correlation between a biologic abnormality and hair loss does not prove a relationship of causality. In absence of pathogenic diagnosis and causality criteria, chances are low to control adequately hair effluvium by a treatment given by the whims of fate. In addition, the risk and frequency of therapeutic inertia are increased. When the hair loss is not controlled and/or compensated by growth of new hairs, several types of alopecia inexorably develop. [less ▲]

Detailed reference viewed: 58 (5 ULg)
Full Text
Peer Reviewed
See detailIndaguer le "ugly duckling" mais eviter le "telly belly". Algorithme exploratoire de la frontiere diagnostique du melanome.
Quatresooz, Pascale ULg; Pierard, Gérald ULg; Pierard, Claudine ULg

in Revue Médicale de Liège (2010), 65(4), 180-5

In a manichean ideal, one expects unreservedly a clear-cut distinction between benign melanocytic neoplasms and the malignant ones. Such a distinction is commonly established by a clinico-pathologic ... [more ▼]

In a manichean ideal, one expects unreservedly a clear-cut distinction between benign melanocytic neoplasms and the malignant ones. Such a distinction is commonly established by a clinico-pathologic confrontation for the majority of neoplasms. However, the boundaries may be blurred and uncertain for some lesions. We present an exploratory clinicopathologic algorithm of the border area between seemingly benign and seemingly malignant melanocytic neoplasms. The concept of a group of neoplasms called skin melanocytomas shed some light on such quandaries where the risk of misdiagnosis is quite high. [less ▲]

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailFaire un faux pas face a des syphilides "de deuxieme floraison".
El Hayderi, L.; Pierard, Gérald ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 420-2

In a recent past, the incidence of syphilis has increased in various geographical regions, particularly in urban areas. In addition, the disease is particularly associated with HIV infection. In secondary ... [more ▼]

In a recent past, the incidence of syphilis has increased in various geographical regions, particularly in urban areas. In addition, the disease is particularly associated with HIV infection. In secondary syphilis, the diagnosis may prove to be particularly difficult to reach because the clinico-pathological resemblance with other skin disorders is commonly high. The risk of diagnostic roaming is associated with therapeutic inertia which is highly prejudiciable to the patient. [less ▲]

Detailed reference viewed: 60 (3 ULg)
Full Text
Peer Reviewed
See detailFacing towards epidermal stem cells (Review).
Schreder, Anelaure; Pierard, Gérald ULg; Paquet, Philippe ULg et al

in International Journal of Molecular Medicine (2010), 26(2), 171-4

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation ... [more ▼]

Skin contains somatic stem cells that generate keratinocyte, melanocyte and mesenchymal cell lineages. These somatic stem cells have traditionally been thought to be restricted in their differentiation and regeneration potential to the tissues in which they reside. This review focused on epidermal stem cells (ESCs). These cells are distinguished from transitory amplifier cells and post-mitotic cells. ESC are found in the interadnexal epidermis and in the bulge region of hair follicles. A series of ESCs markers are available, but increased sensitivity and specificity require further development. [less ▲]

Detailed reference viewed: 54 (4 ULg)
Full Text
Peer Reviewed
See detailThe therapeutic potential of TNF-alpha antagonists for skin psoriasis comorbidities.
Pierard, Gérald ULg; Pierard, Claudine ULg; Szepetiuk, Grégory ULg et al

in Expert Opinion on Biological Therapy (2010), 10(8), 1197-208

IMPORTANCE OF THE FIELD: Alopecia, psoriatic arthritis, the metabolic syndrome, inflammatory bowel diseases and cardiovascular diseases may occur as skin psoriatic comorbidities. TNF-alpha antagonists are ... [more ▼]

IMPORTANCE OF THE FIELD: Alopecia, psoriatic arthritis, the metabolic syndrome, inflammatory bowel diseases and cardiovascular diseases may occur as skin psoriatic comorbidities. TNF-alpha antagonists are used to treat psoriasis. Adalimumab is one of the recognized active agents for this indication. AREAS COVERED IN THIS REVIEW: The current peer-reviewed publications and presentation of original findings. WHAT THE READER WILL GAIN: Adalimumab is active on recalcitrant psoriasis and some of its comorbidities, particularly arthropathies and Crohn's disease. However, the progression of the radiological alterations is limited with regression of the bony erosions. Psoriatic enthesopathy also regresses. Mortality associated with psoriasis arthropathy is on the decline. Crohn's disease, the most frequent inflammatory bowel comorbidity of psoriasis, is responsive to adalimumab. The effect of adalimumab on the metabolic syndrome and cardiovascular involvement is more erratic. The spectacular effects of adalimumab may be associated with some adverse effects. In particular, despite a marked reduction in the psoriasis area-and-severity index (PASI) score some new acute lesions of cutaneous psoriasis may develop corresponding to paradoxical psoriasis. Other potential adverse effects include infections, granulomas, rapid growth of cancers and occurrence of lymphomas. TAKE HOME MESSAGE: Adalimumab frequently controls moderate-to-severe forms of cutaneous psoriasis and some of its comorbidities. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detailL'image du mois. Langue villeuse noire.
Szepetiuk, Grégory ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2010), 65(4), 169-70

Detailed reference viewed: 67 (2 ULg)
Full Text
Peer Reviewed
See detailComment j'explore... une dermatose hypochromique ou achromique.
Devillers, C.; Szepetiuk, Grégory ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2010), 65(2), 109-12

Some skin disorders typically share in common a hypochromic or achromic aspect. The diagnostic approach relies on a directed evaluation of the medical history and a careful clinical examination. In ... [more ▼]

Some skin disorders typically share in common a hypochromic or achromic aspect. The diagnostic approach relies on a directed evaluation of the medical history and a careful clinical examination. In addition, the cyanoacrylate skin surface biopsy helps establish the diagnosis. [less ▲]

Detailed reference viewed: 82 (4 ULg)
Full Text
Peer Reviewed
See detailL'image du mois. Une papule episodiquement turgescente sur la cuisse.
Devillers, C.; Letot, Bernard ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2010), 65(1), 4-5

Detailed reference viewed: 23 (4 ULg)
Full Text
Peer Reviewed
See detailHigh resolution skin colorimetry, strain mapping and mechanobiology.
Devillers, C.; Pierard, Claudine ULg; Schreder, A. et al

in International Journal of Cosmetic Science (2010), 32(4), 241-5

SYNOPSIS: Skin colours are notoriously different between individuals. They are governed by ethnicities and phototypes, and further influenced by a variety of factors including photoexposures and sustained ... [more ▼]

SYNOPSIS: Skin colours are notoriously different between individuals. They are governed by ethnicities and phototypes, and further influenced by a variety of factors including photoexposures and sustained mechanical stress. Indeed, mechanobiology is a feature affecting the epidermal melanization. High-resolution epiluminescence colorimetry helps in deciphering the effects of forces generated by Langer's lines or relaxed skin tension lines on the melanocyte activity. The same procedure shows a prominent laddering pattern of melanization in striae distensae contrasting with the regular honeycomb pattern in the surrounding skin. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detailWeathering of the hairless scalp: a study using skin capacitance imaging and ultraviolet light-enhanced visualization.
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg et al

in Clinical & Experimental Dermatology (2010), 35(1), 83-5

The balding scalp is particularly exposed to sunlight, hence, the overall ageing process modulated by ultraviolet and near-infrared light may be increased at this location. The induced changes are better ... [more ▼]

The balding scalp is particularly exposed to sunlight, hence, the overall ageing process modulated by ultraviolet and near-infrared light may be increased at this location. The induced changes are better revealed under ultraviolet light examination. Any alteration in the epidermal maturation is potentially reflected by stratum corneum changes observed as disturbances on skin-capacitance imaging. [less ▲]

Detailed reference viewed: 37 (1 ULg)
Full Text
Peer Reviewed
See detailAngiogenic fast-growing melanomas and their micrometastases.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Paquet, Philippe ULg et al

in European Journal of Dermatology (2010), 20(3), 302-7

Malignant melanoma (MM), particularly its fast-growing type, is prone to interstitial, intravascular and extravascular migratory metastases. There is no information linking their growth fraction, the ... [more ▼]

Malignant melanoma (MM), particularly its fast-growing type, is prone to interstitial, intravascular and extravascular migratory metastases. There is no information linking their growth fraction, the configuration of the MM advancing edge, the extent in vascularity and the propensity to metastatic progression. The objective of this study was to determine the growth fraction, the size of vascularity and the contours of the progression border of 32 fast-growing MM with regard to the presence or absence of a micrometastatic spread inside the skin and overt metastases in the sentinel lymph nodes. In vivo high resolution colorimetry was performed as a clinical estimate of MM vascularity. Euclidean geometry and fractal analysis were used on immunohistochemical sections. The relative microvasculature profile area beneath MM, and the fractal dimension D of the MM frontline were assessed. The MIB/Ki-67 index was determined in MM cells. Value a* of colorimetry was similarly increased in the presence or absence of micro-metastases. No difference in growth fraction was revealed between these neoplasms. Correlations were found between vascularity and angiotropism, and between the micrometastatic process and the sentinel lymph node involvement. By contrast, no correlation was shown between vascularity and the fractal D dimension of the MM advancing edge. In sum, this study establishes a link between the extent of MM growth fraction, vascularity and the presence of dermal and nodal micrometastases in fast-growing MM. [less ▲]

Detailed reference viewed: 26 (5 ULg)
Full Text
Peer Reviewed
See detailImpact de l'infection par le VIH sur les cancers cutanes.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64(1), 37-40

A series of skin cancers are more frequent or show a worsened course and outcome in HIV-treated patients. The leading neoplasms correspond to basal and squamous cell carcinomas, some primary cutaneous ... [more ▼]

A series of skin cancers are more frequent or show a worsened course and outcome in HIV-treated patients. The leading neoplasms correspond to basal and squamous cell carcinomas, some primary cutaneous lymphomas and malignant melanomas. In theses patients, early diagnosis and radical treatment on sight should be considered. [less ▲]

Detailed reference viewed: 31 (2 ULg)
Full Text
Peer Reviewed
See detailPanoplies des therapies ciblees par anticorps monoclonaux en dermatologie. Actualite et prospectives.
Pierard, Claudine ULg; Quatresooz, Pascale ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2009), 64(5-6), 334-8

Targeted therapies are focused on one or a few molecules particularly involved in specific diseases. Some inflammatory dermatoses and cutaneous neoplasia potentially benefit from these approaches. Nine ... [more ▼]

Targeted therapies are focused on one or a few molecules particularly involved in specific diseases. Some inflammatory dermatoses and cutaneous neoplasia potentially benefit from these approaches. Nine monoclonal antibodies of interest in dermatology are presented according to the disorders where they have proven their efficacy. Biotherapies extend beyond monoclonal antibodies. A given effect, such as TNF-alpha antagonism, is indeed obtained by distinct drug classes. The interindividual differences in the therapeutic responses remain unpredictable, and there is no criteria of selection of patients who could benefit the most from these targeted medications. [less ▲]

Detailed reference viewed: 70 (10 ULg)
Full Text
Peer Reviewed
See detailLe paradoxe des effets cutanes indesirables, mais predictifs de l'efficacite des therapies ciblees anticancereuses.
Quatresooz, Pascale ULg; Rorive, Andrée ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2009), 64(5-6), 347-50

A series of medical disciplines benefit from the emergence of diverse targeted therapies using monoclonal antibodies. Skin is affected by adverse events of such therapies primarily targeting internal ... [more ▼]

A series of medical disciplines benefit from the emergence of diverse targeted therapies using monoclonal antibodies. Skin is affected by adverse events of such therapies primarily targeting internal cancers. As a unique event in medicine, some of the skin adverse effects are predictive markers of the therapeutic antineoplastic activity. This fact concerns the paroxismal acneiform eruption and the inflammatory flare-up of actinic keratoses. Such a situation is linked to the fact that these specific "unwanted" effects are not really side effects but rather represent the direct pharmacological consequence of the activity directed to the EGF receptors which are particularly abundant in the follicular ostium and in precursor lesions to skin carcinomas. [less ▲]

Detailed reference viewed: 37 (2 ULg)
Full Text
Peer Reviewed
See detailElectrometric assessment of the effect of a zinc oxide paste in diaper dermatitis.
Xhauflaire, Emmanuelle ULg; Henry, Frédérique ULg; Pierard, Claudine ULg et al

in International Journal of Cosmetic Science (2009), 31(5), 369-74

Diaper dermatitis affects nearly 50% of infants as well as some bed-ridden adults particularly in the elderly people. This condition is induced by irritation and maceration, and may be further exacerbated ... [more ▼]

Diaper dermatitis affects nearly 50% of infants as well as some bed-ridden adults particularly in the elderly people. This condition is induced by irritation and maceration, and may be further exacerbated by Candida sp. colonization and infection. A key factor in the pathogenesis is the alteration in both the barrier function and the water-holding capacity of the stratum corneum. The purpose of this study was to assess the effects of an unmedicated zinc oxide-petrolatum paste and to observe for possible shielding and restoring effects on the water-holding capacity of the stratum corneum altered by diaper dermatitis. The paste appeared to load the hollow skin microrelief. It was inferred that this effect was responsible for a reticulated shielding effect. Compared with healthy skin and untreated diaper dermatitis, the application of the anhydrous paste resulted in a trend to normalize electrometric properties of skin reflecting the combination of transepidermal water loss and the water-holding capacity of the stratum corneum. [less ▲]

Detailed reference viewed: 34 (0 ULg)
Full Text
Peer Reviewed
See detailReactions cutanees indesirables des traitements par anticorps monoclonaux.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2009), 64(5-6), 339-46

A number of adverse skin reactions can occur during some treatments using monoclonal antibodies. Some of the reactions are specifically linked to the pharmacological effect of the drug. Others are the ... [more ▼]

A number of adverse skin reactions can occur during some treatments using monoclonal antibodies. Some of the reactions are specifically linked to the pharmacological effect of the drug. Others are the expression of more common drug reactions. Their early recognition and their adequate management are important to consider in order to avoid a morbidity severely altering the quality of life and even the life prognosis. [less ▲]

Detailed reference viewed: 94 (1 ULg)