References of "Nguyen Khac, Minh-Tuan"
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See detailPost-traumatic thoracic outlet syndrome
DUBUISSON, Annie ULg; lamotte, Catherine; FOIDART, Marguerite ULg et al

in Acta Neurochirurgica (2012)

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See detailIs paralysing lumbar disc herniation a surgical emergency ?
DUBUISSON, Annie ULg; BORLON, Sarah ULg; NGUYEN KHAC, Minh-Tuan ULg et al

Conference (2011, March 26)

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See detailLa main de Gilliatt-Sumner ou le syndrome de défilé cervicothoracique neurogène vrai. A propos de sept cas opérés.
DUBUISSON, Annie ULg; NGUYEN KHAC, Minh-Tuan ULg; SCHOLTES, Félix ULg et al

in Neuro-Chirurgie (2011), 57(1), 9-14

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they ... [more ▼]

BACKGROUND AND PURPOSE: The clinical picture of hand atrophy related to a cervical rib or elongated C7 transverse process was well described in the modern literature by Gilliatt and Sumner; in 1970, they reported a series of nine patients whose motor status was stabilized following brachial plexus decompression. We report here seven patients suffering from thoracic outlet syndrome (TOS), who developed hand atrophy, sometimes because of diagnostic delay. METHODS: The patient's charts were analysed retrospectively. RESULTS: The seven patients were all female; the mean age was 43 years. The first complaints were arm pain and paresthesias lasting six months to 5 years. Three patients were treated with C56/C67 discectomy plus disc prosthesis (one patient), ulnar neurolysis at the elbow (the same patient), carpal tunnel release (one patient), and intravenous immunoglobulins (one patient) before TOS diagnosis. Hand atrophy, severe in five patients, was present at presentation. All patients underwent brachial plexus decompression by the anterior (four), posterior (two), or transaxillary (one) approach. This last approach was completed 18 months later by brachial plexus neurolysis via the anterior approach. Postoperatively, motor deficit was improved in two patients and stabilized in five patients. CONCLUSIONS: Physicians' unfamiliarity with TOS diagnosis or their reluctance to accept the diagnosis without electrical confirmation can lead to hand atrophy. Brachial plexus decompression at this stage usually stabilizes the deficit. [less ▲]

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See detailEncéphalocèle orbitaire post-traumatique bilatéral
Racaru, Tudor ULg; Nguyen Khac, Minh-Tuan ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2010), 65

L'encéphalocèle orbitaire aigu traumatique est une entité rare. Selon Pubmed moins de 25 cas ont été raportés. Nous présentons le premier cas d'encéphalocèle post-traumatique bilatéral provoqué par une ... [more ▼]

L'encéphalocèle orbitaire aigu traumatique est une entité rare. Selon Pubmed moins de 25 cas ont été raportés. Nous présentons le premier cas d'encéphalocèle post-traumatique bilatéral provoqué par une fracture enfoncement du toit de l'orbite. Un traitement rapide est nécessaire pour éviter l'hypertension intra-orbitaire qui peut être responsable de lésions dégénératives du nerf optique. La réparation du toit de l'orbite nécessite une reconstruction rigide pour éviter la transmission de variations de la pression intra-crânienne. Dans le cas rapporté, la reconstruction du toit de l'orbite a été effectuée par voie crânienne sous-frontale à l'aide d'un mélange de poudre d'os à la colle biologique soutenu par un treillis en titane fixé avec des vis [less ▲]

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See detailDoes radiation treatment delay affect survival in glioblastoma ?
Robe, Pierre ULg; Nguyen Khac, Minh-Tuan ULg; Lenelle, Jacques ULg et al

Conference (2009, March 21)

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See detailThe Gilliatt-Sumner hand: an ill-known clinical picture from cervical ribs. Report of 5 operated cases.
Dubuisson, Annie ULg; Figiel, S.; Laungani, A. et al

Conference (2009, March 21)

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See detailThe Gilliatt-Summer hand: an ill-know clinical picture from cervical ribs. Report of 5 operated cases
Dubuisson, Annie ULg; Figiel, S.; Laungani, A. et al

Conference (2009, March)

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See detailIRM interventionnelle : vers une neuronavigation en temps réel.
Martin, Didier ULg; Nguyen Khac, Minh-Tuan ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2008), 63

La neuronavigation est un outil neurochirurgical qui peut être comparé au GPS. Elle sert à guider la procédure neurochirurgicale en visualisant les déplacements des instruments chirurgicaux sur les images ... [more ▼]

La neuronavigation est un outil neurochirurgical qui peut être comparé au GPS. Elle sert à guider la procédure neurochirurgicale en visualisant les déplacements des instruments chirurgicaux sur les images préopératoires. En augmentant la précision du geste, elle permet d’atteindre des lésions parfois très petites ou difficiles d’accès tout en réduisant la morbidité et en augmentant l’efficacité. Elle présente cependant un écueil majeur. L’image utilisée par le système de navigation est obtenue avant l’intervention et ne peut être corrigée durant celle-ci. En raison des modifications anatomiques inhérentes à l’opération (modification du volume du liquide céphalo-rachidien, résection de la tumeur,…), il apparaît progressivement une discordance entre la réalité chirurgicale et l’imagerie. Les informations pertinentes se périment ainsi peu à peu et la précision se perd. L’IRM interventionnelle est le moyen de réactualiser la neuronavigation par des images de haute définition. De plus, elle permet de réaliser des contrôles intra-opératoires de la qualité du geste chirurgical. [less ▲]

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See detailChromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas.
Turkheimer, Federico E; Roncaroli, Federico; Hennuy, Benoît ULg et al

in BMC Bioinformatics (2006), 7

BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that ... [more ▼]

BACKGROUND: Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that their coordinated expression depends on their position on chromosomes has highlighted the need for mathematical approaches to exploit this dependency for the analysis of expression data-sets. RESULTS: We have devised a novel mathematical technique (CHROMOWAVE) based on the Haar wavelet transform and applied it to a dataset obtained with the Affymetrix HG-U133_Plus_2 array in 27 gliomas. CHROMOWAVE generated multi-chromosomal pattern featuring low expression in chromosomes 1p, 4, 9q, 13, 18, and 19q. This pattern was not only statistically robust but also clinically relevant as it was predictive of favourable outcome. This finding was replicated on a data-set independently acquired by another laboratory. FISH analysis indicated that monosomy 1p and 19q was a frequent feature of tumours displaying the CHROMOWAVE pattern but that allelic loss on chromosomes 4, 9q, 13 and 18 was much less common. CONCLUSION: The ability to detect expression changes of spatially related genes and to map their position on chromosomes makes CHROMOWAVE a valuable screening method for the identification and display of regional gene expression changes of clinical relevance. In this study, FISH data showed that monosomy was frequently associated with diffuse low gene expression on chromosome 1p and 19q but not on chromosomes 4, 9q, 13 and 18. Comparative genomic hybridisation, allelic polymorphism analysis and methylation studies are in progress in order to identify the various mechanisms involved in this multi-chromosomal expression pattern. [less ▲]

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See detailModulation of the HSV-TK/ganciclovir bystander effect by n-butyrate in glioblastoma: correlation with gap-junction intercellular communication.
Robe, Pierre ULg; Jolois, Olivier ULg; Nguyen Khac, Minh-Tuan ULg et al

in International Journal of Oncology (2004), 25(1), 187-92

The efficacy of HSV-TK/ganciclovir gene therapy largely relies on the bystander effect, i.e. the ability of transfected cells to kill the adjacent, untrasfected cells. This mechanism itself depends ... [more ▼]

The efficacy of HSV-TK/ganciclovir gene therapy largely relies on the bystander effect, i.e. the ability of transfected cells to kill the adjacent, untrasfected cells. This mechanism itself depends chiefly on the transfer via gap junctions of phosphorylated ganciclovir between cells, and is often deficient in glioblastomas. In this report, we demonstrate that n-butyrate markedly enhances the gap junction intercellular communication of GJIC-deficient glioma cells, and significantly increases the bystander effect in such cells. This effect of n-butyrate appears to be independent from its HDAC inhibitory effect, since trichostatin A does not reproduce it. [less ▲]

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