Multifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms
NCHIMI LONGANG, Alain ; CHERAMY-BIEN, Jean-Paul ; et al
in Circulation. Cardiovascular imaging (2014), 7
BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG ... [more ▼]
BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET). METHODS AND RESULTS: -The study included 53 patients (45 males) with aortic aneurysms, 47 infrarenal (AAA) and 6 thoracic (TAA), who had at least one 18F-FDG PET/computed tomography. Over a 30-month period, more clinical events occurred in patients with increased 18F-FDG uptake on their last examination than in those without (5/18 (28%) vs. 2/35 (6%); P=0.03). Wall stress and stress/strength index computed by FES and 18F-FDG uptake were evaluating a total of 68 examinations. 25 (38%) examinations demonstrated at least one aneurysm wall area of increased 18F-FDG uptake. The mean number of these areas per examination was 1.6 (18/11) in TAAs vs. 0.25 (14/57) in AAAs, while the mean number of increased uptake areas co-localizing with highest wall stress and stress/strength index areas was 0.55 (6/11) and 0.02 (1/57), respectively. Quantitatively, 18F-FDG PET uptake correlated positively with both wall stress and stress/strength index (P<0.05). 18F-FDG uptake was particularly high in subjects with personal history of angina pectoris and familial aneurysm. CONCLUSIONS: -Increased 18F-FDG PET uptake in aortic aneurysms is strongly related to aneurysm location, wall stress as derived by FES and patient's risk factors such as acquired and inherited susceptibilities. [less ▲]Detailed reference viewed: 38 (9 ULg)
2-18F-Fluoro-L-tyrosine in the suspicion of recurrence of previously treated gliomas.
; NAMUR, Gauthier ; et al
in European Journal of Nuclear Medicine and Molecular Imaging (2011), 38(SUPPL), 219Detailed reference viewed: 12 (1 ULg)
Multimodality staging of lung cancer
; NAMUR, Gauthier ; HUSTINX, Roland et al
in PET Clinics (2011), 6
Lung cancer is among the most common and lethal cancers around the world. Most lung cancers are directly attributed to smoking. Common histologic subtypes of lung carcinomas are squamous cell carcinoma ... [more ▼]
Lung cancer is among the most common and lethal cancers around the world. Most lung cancers are directly attributed to smoking. Common histologic subtypes of lung carcinomas are squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. These carcinomas have similar presentations and are primarily treated surgically. Hence, these are usually classified as non-small cell lung carcinoma. Small cell lung carcinoma is an aggressive neuroendocrine tumor with a generally poor prognosis. It usually presents with massive mediastinal lymphadenopathy and widespread metastases at initial diagnosis, and is usually treated with chemotherapy and radiotherapy; surgery has little role.Cough, dyspnea and hemoptysis are the consistent clinical features of most lung cancers. Advances tumors with pleural, chest wall, or mediastinal invasion produce a variety of additional clinical features such as chest pain, brachial plexus neuropathy, Horner syndrome, phrenic or recurrent laryngeal nerve palsy, dysphagia, or superior vena cava syndrome. Sone of the lung cancers are detected as small pulmonary nodules in asymptomatic individuals. [less ▲]Detailed reference viewed: 44 (11 ULg)
Assessment of early therapeutic response in anti-TNFα refractory rheumatoid arthritis with FDG PET/CT.
; KAISER, Marie-Joëlle ; NAMUR, Gauthier et al
in European Journal of Nuclear Medicine and Molecular Imaging (2010), 37(SUPPL), 211Detailed reference viewed: 11 (0 ULg)
Is FDG-PET/CT an early indicator of the clinical response to rituximab in rheumatoid arthritis ?
NAMUR, Gauthier ; KAISER, Marie-Joëlle ; et al
in Journal of Nuclear Medicine (The) (2008), 49(SUPPL), 10Detailed reference viewed: 11 (0 ULg)
FDG PET/CT for diagnostic arterial prosthetic graft infection : preliminary report.
NAMUR, Gauthier ; VAN DAMME, Hendrik ; BECKERS, Catherine et al
in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)Detailed reference viewed: 17 (0 ULg)