Prevalence of naturally occuring cartilage defects in the ovine stifle

Poster (2012)

Characterization of BoHV-5 field strains circulation and report of transient specific subtype of bovine herpesvirus 5 in Argentina

in BMC Veterinary Research (2011), 7

Comparative study of the in vitro and in vivo properties of two bovine herpesvirus-5 reference strains

in Acta Veterinaria Scandinavica (2011), 53

Ruminant herpesviruses

in Lefèvre, P. C.; Blancou, J.; Chermette, R. (Eds.) et al Infectious and Parasitic Diseases of Livestock (2010)

Characterization of interspecific recombinants generated from closely related bovine herpesviruses 1 and 5 through multiple PCR sequencing assays

in Journal of Virological Methods (2009)

Co-infection with two closely related alphaherpesviruses results in a highly diversified recombination mosaic displaying negative genetic interference

in Journal of Virology (2009), 83(7), 3127-3137

Phylogenetic studies of the emergence and spread of natural recombinants in herpesviruses infecting humans and animals have been reported recently. However, despite an ever-increasing amount of evidence ... [more ▼]

Phylogenetic studies of the emergence and spread of natural recombinants in herpesviruses infecting humans and animals have been reported recently. However, despite an ever-increasing amount of evidence of recombination in herpesvirus history, the recombination process and the consequences on the genetic diversity of the progeny remain poorly characterized. We addressed this issue by using multiple single-nucleotide polymorphisms (SNPs) differentiating the two subtypes of an alphaherpesvirus, bovine herpesvirus 1 (BoHV-1). Analysis of a large sample of progeny virions obtained in a single growth cycle of coinfected BoHV-1 strains provided a prospective investigation of the recombination dynamics by using SNPs as recombination markers. We found that the simultaneous infection with two closely related herpesviruses results in a highly diversified recombination mosaic. From the analysis of multiple recombinants arising in the progeny, we provide the first evidence of genetic interference influencing the recombination process in herpesviruses. In addition, we report striking differences in the levels of recombination frequency observed along the BoHV-1 genome. With particular emphasis on the genetic structure of a progeny virus population rising in vitro, our data show to which extent recombination participates to the genetic diversification of herpesviruses [less ▲]

Les mécanismes et les conséquences sur l'organisme des infections virales chez les équidés

in Nouveau Praticien Vétérinaire Equine (2008), 5

Ruminant herpesviruses

in Lefèvre, P. C.; Blancou, Jean; Chermette, R. (Eds.) Infectious and parasitic diseases of Livestock (2008)

Marker vaccines and the impact of their use on diagnosis and prophylactic measures

in Revue Scientifique et Technique-Office International des Epizooties (2007), 26(2), 351-372

Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of ... [more ▼]

Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of their use on the diagnosis and prevention of major infectious diseases. Gene-deleted vaccines, DIVA strategies (differentiating infected from vaccinated animals) and similar methods have been successfully applied in the control and eradication of Aujeszky's disease, infectious bovine rhinotracheitis, classical swine fever, foot and mouth disease and, recently, avian influenza. The efficacy and performance of existing marker vaccines and their companion diagnostic tools (which should be assesed by an independent body) are discussed, as are the ways in which these tools are deployed by competent authorities. The limits and the advantages of the use of marker vaccines are carefully analysed in the light of practical experiences. Although these vaccines can limit the speed and the extent of virus dissemination and thus reduce the number of animals slaughtered, marker vaccines are no substitute for sanitary measures. Early detection and warning systems and the quick implementation of sanitary measures, including stamping out, remain key issues in the control of highly contagious diseases. [less ▲]

Malattia di Aujeszky. Il virus, patogenesi ed epidemiologia

in Suinicoltura (2007), 9