Showing results 1 to 20 of 118
  Treatments for progressing Parkinson's disease: a clinical case scenario study.MAERTENS DE NOORDHOUT, Alain  ; ; et alin Acta Neurologica Belgica (2009), 109(3), 189-99 OBJECTIVE: A 'case scenario' study on clinical decisions in progressing Parkinson's disease (PD) was developed to complement scientific evidence with the collective judgment of a panel of experts. METHODS ... [more ▼] OBJECTIVE: A 'case scenario' study on clinical decisions in progressing Parkinson's disease (PD) was developed to complement scientific evidence with the collective judgment of a panel of experts. METHODS: The opinions of 9 experts in movement disorders on the appropriateness of 9 common pharmacological treatments for 33 hypothetical patient profiles were compared to those of 14 general neurologists. Before rating the case scenarios, all participants received a document integrating European and US guidelines for the treatment of patients with advanced PD. Case scenarios showing disagreement or with inconsistencies in appropriateness ratings were discussed at a feedback meeting. A tool for interactive discussion on the clinical case scenarios included was developed based on the outcome of the study. RESULTS: Current guidelines are often insufficient to adequately guide the management of patients with progressing PD. The case scenario study did not reveal major differences in opinions between experts in movement disorders and general neurologists about the appropriateness of certain drug choices for specific case scenarios. However in about 1 out of 5 treatment decisions where experts stated appropriateness or inappropriateness, the general neurologists panel had no or dispersed opinions. CONCLUSIONS: This study reveals more uncertainty about treatment of advanced PD in general neurologists compared with experts in movement disorders and underlines the need for additional support for guiding treatment decisions in clinical practice. [less ▲] Detailed reference viewed: 9 (0 ULg) Neurological picture. Extreme unilateral widening of Virchow-Robin spacesFumal, Arnaud ; Maertens De Noordhout, Alain ; in Journal of Neurology, Neurosurgery & Psychiatry (2009), 80(1), 64-65 Detailed reference viewed: 35 (8 ULg)Transcranial magnetic stimulation in disorders of consciousness; Gosseries, Olivia ; DELVAUX, Valérie et alin Reviews in the Neurosciences (2009), 20(3-4), 235-250 Detailed reference viewed: 19 (7 ULg)Traitement de la maladie de Parkinson en 2009.MAERTENS DE NOORDHOUT, Alain in Revue Médicale Suisse (2009), 5(214), 1650-5 The cause of Parkinson's disease remains unknown and no cure or prevention exists so far. Levodopa remains by far the most potent symptomatic therapy, but induces side-effects such as motor fluctuations ... [more ▼] The cause of Parkinson's disease remains unknown and no cure or prevention exists so far. Levodopa remains by far the most potent symptomatic therapy, but induces side-effects such as motor fluctuations and abnormal movements, which can somewhat be counterbalanced by optimizing levodopa plasma levels or acting at receptors level with long half-life dopamine agonists. In severe cases, functional surgery with deep brain stimulation can be offered. Some non-dopaminergic symptoms like dementia, freezing, postural instability or dysautonomia do not respond to dopaminergic drugs and need special care. [less ▲] Detailed reference viewed: 14 (1 ULg)Disorders of consciousness: further pathophysiological insights using motor cortex transcranial magnetic stimulation.; ; et al in Progress in Brain Research (2009) Transcranial magnetic stimulation (TMS) is a noninvasive means of investigating the function, plasticity, and excitability of the human brain. TMS induces a brief intracranial electrical current, which ... [more ▼] Transcranial magnetic stimulation (TMS) is a noninvasive means of investigating the function, plasticity, and excitability of the human brain. TMS induces a brief intracranial electrical current, which produces action potentials in excitable cells. Stimulation applied over the motor cortex can be used to measure overall excitability of the corticospinal system, somatotopic representation of muscles, and subsequent plastic changes following injury. The facilitation and inhibition characteristics of the cerebral cortex can also be compared using the modulatory effect of a conditioning stimulus preceding a test stimulus. So called paired-pulse protocols have been used in humans and animals to assess GABA (gamma-amino-butyric acid)-ergic function and may have a future role directing therapeutic interventions. Indeed, repetitive magnetic stimulation, where intracranial currents are induced by repetitive stimulation higher than 1 Hz, has been shown to modulate brain responses to sensory and cognitive stimulation. Here, we summarize information gathered using TMS with patients in coma, vegetative state, and minimally conscious state. Although in the early stages of investigation, there is preliminary evidence that TMS represents a promising tool by which to elucidate the pathophysiological sequelae of impaired consciousness and potentially direct future therapeutic interventions. We will discuss the methodology of work conducted to date, as well as debate the general limitations and pitfalls of TMS studies in patients with altered states of consciousness. [less ▲] Detailed reference viewed: 40 (4 ULg)Motor neuron disorders : novel electrophysiologic approach (MUFDEC protocol)WANG, François-Charles ; ; WANG, Pascale et alin Clinical Neurophysiology (2009), Suppl(Vol 60), 143-152 Detailed reference viewed: 11 (2 ULg)Interprétation de l'index IgG et du diagramme de Reiber par Protis 2 dans les maladies inflammatoires du système nerveux central; FUMAL, Arnaud ; et alin Immuno-Analyse & Biologie Spécialisée [=IBS] (2009), (24), 135-147 Detailed reference viewed: 24 (0 ULg)Repetitive transcranial magnetic stimulation over the primary motor cortex disrupts early boost but not delayed gains in performance in motor sequence learning; Peigneux, Philippe ; MAERTENS DE NOORDHOUT, Alain et alin European Journal of Neuroscience (2008), 28(6), 1216-1221 Detailed reference viewed: 3 (0 ULg)Rtms in Headache Prophylaxis: When Case Reports Hide Our IgnoranceFumal, Arnaud ; MAERTENS DE NOORDHOUT, Alain ; Schoenen, Jean in C N S Spectrums : The International Journal of Neuropsychiatric Medicine (2008), 13(3), 185-7 Detailed reference viewed: 3 (0 ULg)TMS of the occipital cortex induces tactile sensations in the fingers of blind Braille readers; Fumal, Arnaud ; Maertens De Noordhout, Alain et alin Experimental Brain Research (2008), 184(2), 193-200 Various non-visual inputs produce cross-modal responses in the visual cortex of early blind subjects. In order to determine the qualitative experience associated with these occipital activations, we ... [more ▼] Various non-visual inputs produce cross-modal responses in the visual cortex of early blind subjects. In order to determine the qualitative experience associated with these occipital activations, we systematically stimulated the entire occipital cortex using single pulse transcranial magnetic stimulation (TMS) in early blind subjects and in blindfolded seeing controls. Whereas blindfolded seeing controls reported only phosphenes following occipital cortex stimulation, some of the blind subjects reported tactile sensations in the fingers that were somatotopically organized onto the visual cortex. The number of cortical sites inducing tactile sensations appeared to be related to the number of hours of Braille reading per day, Braille reading speed and dexterity. These data, taken in conjunction with previous anatomical, behavioural and functional imaging results, suggest the presence of a polysynaptic cortical pathway between the somatosensory cortex and the visual cortex in early blind subjects. These results also add new evidence that the activity of the occipital lobe in the blind takes its qualitative expression from the character of its new input source, therefore supporting the cortical deference hypothesis. [less ▲] Detailed reference viewed: 21 (0 ULg)L'Image du mois. L'acide 5-Amino-Levulinique (5-ALA) dans le traitement des tumeurs cérébrales malignes; ; et al in Revue Médicale de Liège (2008), 63(1), 4-5 Detailed reference viewed: 3 (0 ULg)TMS in migraineSchoenen, Jean ; ; Maertens De Noordhout, Alain in Wassermann, E. M.; Epstein, C. M.; Ziemann, U. (Eds.) et al The Oxford Handbook of Transcranial Stimulation (2008) Detailed reference viewed: 60 (5 ULg)Therapeutic potential of repetitive transcranial magnetic stimulation in brainFumal, Arnaud ; Schoenen, Jean ; Maertens De Noordhout, Alain et alin Revue Médicale de Liège (2008), 63(5-6), 330-337 Detailed reference viewed: 26 (2 ULg)Diagnostic des neuropathies par compression : utilité des techniques d’imagerie par échotomographie, tomographie axiale computérisée et résonance magnétiqueMAERTENS DE NOORDHOUT, Alain in Revue Neurologique (2007) Detailed reference viewed: 7 (2 ULg)rTMS of the occipital cortex abolishes Braille reading and repetition priming in blind subjects; ; MAERTENS DE NOORDHOUT, Alain et alin Neurology (2007), 68(9), 691-693 To study the functional involvement of the visual cortex in Braille reading, we applied repetitive transcranial magnetic stimulation (rTMS) over midoccipital (MOC) and primary somatosensory (SI) cortex in ... [more ▼] To study the functional involvement of the visual cortex in Braille reading, we applied repetitive transcranial magnetic stimulation (rTMS) over midoccipital (MOC) and primary somatosensory (SI) cortex in blind subjects. After rTMS of MOC, but not SI, subjects made significantly more errors and showed an abolishment of the improvement in reading speed following repetitive presentation of the same word list, suggesting a role of the visual cortex in repetition priming in the blind. [less ▲] Detailed reference viewed: 17 (0 ULg)Le cas clinique du mois. Rhabdomyolyse et hypothyroidie.Jobe, Jérôme ; ; FUMAL, Arnaud et alin Revue Médicale de Liège (2007), 62(7-8), 484-6 We describe the case of a 29 year old patient who presented severe myalgias and asthenia for 3 months. First biological assessment revealed muscular lysis and raised transaminases. The following ... [more ▼] We describe the case of a 29 year old patient who presented severe myalgias and asthenia for 3 months. First biological assessment revealed muscular lysis and raised transaminases. The following complementary screening showed major hypothyroidism with the presence of anti-microsomes antibodies, a carpian canal syndrome and a left ventricular systolic dysfunction. A diagnosis of hypothyroidic rhabdomyolysis consecutive to a Hashimoto disease was then mash. Patient was treated by hormonal thyroid substitution with a progressive improvement of muscular symptoms to complete recovery, and a concomitant normalization of cardiac and thyroid functions. [less ▲] Detailed reference viewed: 66 (5 ULg)Therapeutic use of high-frequency repetitive transcranial magnetic stimulation in stroke.; Peigneux, Philippe ; Moonen, Gustave et alin Stroke (2007), 38(2), 253254 Detailed reference viewed: 6 (1 ULg)Dysphagia as the sole manifestation of myasthenia gravis; Kaux, Jean-François ; Foidart-Dessalle, Marguerite et alin Second Annual Congress (of the new style) of the Royal Belgian Society of Physical and Rehabilitation Medicine (RBSPRM) (2006, December 08) Detailed reference viewed: 55 (16 ULg)Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of actionSchoenen, Jean ; ; et alin Cephalalgia : An International Journal of Headache (2006, November), 26(11), 1352 Detailed reference viewed: 9 (0 ULg)Intravenous immunoglobulins in paraneoplastic brainstem encephalitis with anti-Ri antibodiesFumal, Arnaud ; Jobe, Jérôme ; PEPIN, Jean-Louis et alin Journal of Neurology (2006), 253(10), 1360-1361 Detailed reference viewed: 9 (4 ULg) |
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