References of "Klimek, Monique"
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See detailAnalysis of PEG 400 and 4000 in urine for gut permeability assessment using solid phase extraction and gel permeation chromatography with refractometric detection
Loret, S.; Nollevaux, G.; Remacle, R. et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2004), 805(2), 195-202

We developed a treatment of urine samples allowing the analysis of two intestinal permeability markers: polyethylene glycol (PEG) 400 (highly diffusible; basal permeability indicator) and PEG 4000 (poorly ... [more ▼]

We developed a treatment of urine samples allowing the analysis of two intestinal permeability markers: polyethylene glycol (PEG) 400 (highly diffusible; basal permeability indicator) and PEG 4000 (poorly diffusible; indicator of an abnormal increase of permeability) by a unique gel permeation chromatography (GPC) with refractometric detection. Urinary PEG were extracted using a mixed-bed resin composed of C2 and C 18 layers. Permeability mean values determined in 11 human healthy subjects were 24.20 +/- 9.30% and 0.12 +/- 0.08% for, respectively, PEG 400 and 4000. The percentage of the PEG 4000 permeability value to the one of PEG 400 corresponded to an intestinal permeability index (IPI) of 0.52 +/- 0.35 expressing a low diffusion of this poorly permeability marker. (C) 2004 Published by Elsevier B.V. [less ▲]

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See detailThe concentration of polyamines in human blood : a reinvestigation
Collienne, p; Grandfils, Christian ULg; Klimek, Monique ULg et al

Poster (2000, April 13)

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See detailComparison between the Natural Postnatal Maturation and the Spermine-Induced Maturation of the Rat Intestine
Peulen, Olivier ULg; Pirlet, Christine; Klimek, Monique ULg et al

in Archives of Physiology & Biochemistry (1998), 106(1), 46-55

In the suckling rats, orally provided spermine induced structural and biochemical changes in the intestine, which are characteristics of the postnatal maturation. This induced maturation was compared to ... [more ▼]

In the suckling rats, orally provided spermine induced structural and biochemical changes in the intestine, which are characteristics of the postnatal maturation. This induced maturation was compared to that occurring spontaneously. Eight mumol spermine were administered orally once a day, for one or three days, to suckling rats which were 11 days old at the beginning of the experiment. The animals were killed 0, 2, 4, 6, 8, 10 hours or 3 days after the first treatment. Control rats from the same litter were treated in the same way but received only the vehicle. In order to complete the study of the naturally occurring maturation, another group of rats was killed when they were 12, 13, 15, 16, 17, 18, 19, 20, 21 or 30 days old. Animal and intestine weights were measured. Disaccharidase specific activity, and protein, DNA and RNA contents were estimated in the small intestine. Histological and ultrastructural aspects of the intestinal mucosa were examined. For all these parameters, the maturation induced by spermine ingestion appeared close to that occurring naturally at weaning. Consequently, dietary spermine induces all the morphological and biochemical modifications characterizing the intestinal postnatal maturation in the suckling rat suggesting a role of the polyamines in the naturally occurring processes. [less ▲]

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See detailEffects of a long-term low-polyamine diet on biochemical parameters and polyamine content in different organs of the germ-free rat
Deloyer, Patricia; Peulen, Olivier ULg; Klimek, Monique ULg et al

in Bardocz, S.; White, A.; Hajos, G. (Eds.) COST 917 Biogenically active amines in food. Volume II : Metabolic effects of biologically active amines in food (1998)

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