References of "Devaux, Floriane"
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Peer Reviewed
See detailMechanochemical Unfolding of Artificial Helical Foldamers by Single-Molecule Force Spectroscopy
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2017, June 15)

Detailed reference viewed: 16 (0 ULiège)
Peer Reviewed
See detailMechanochemical Unfolding of Artificial Helical Foldamers by Single-Molecule Force Spectroscopy
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2017, June 11)

Detailed reference viewed: 17 (0 ULiège)
Peer Reviewed
See detailMechanochemical Unfolding of Artificial Helical Foldamers
Devaux, Floriane ULiege; Li, Xuesong; Ivan, Huc et al

Poster (2017, May 19)

Detailed reference viewed: 28 (0 ULiège)
See detailSynthetic Helical Nanoarhitectures: Mechanochemical study and synthesis
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Conference (2017, March 31)

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Peer Reviewed
See detailSingle-Molecule Force Spectroscopy on helical Foldamers
Devaux, Floriane ULiege

Article for general public (2017)

Detailed reference viewed: 12 (0 ULiège)
See detailSMFS on synthetic helical foldamers
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2016, October 13)

Detailed reference viewed: 21 (0 ULiège)
Peer Reviewed
See detailSingle-Molecule Force Spectroscopy on Synthetic Helical Nanoarchitectures
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2016, September)

Inspired by the many folded conformations of the molecular machineries in nature, chemists have been developing the syntheses of artificial folded molecular architectures, namely foldamers. The ... [more ▼]

Inspired by the many folded conformations of the molecular machineries in nature, chemists have been developing the syntheses of artificial folded molecular architectures, namely foldamers. The investigation of these molecules using AFM-based Single Molecule Force Spectrosocopy (SMFS) allows the elucidation of both mechanochemical properties and conformational dynamics on the unimolecular scale in solution. The stepwise synthesis of aromatic oligoamide-based foldamers was designed to produce well-defined helically-folded molecular architectures. A PEO tether was coupled to one end of the foldamer. SMFS pulling experiments on this system yielded specific and reproducible force-extension patterns characteristic of single foldamers. Those patterns were further analyzed to determine unfolding forces and dynamics as well as to propose mechanistics hypotheses of the unfolding process. Several helical foldamers presenting variable lengths were considered. The force values measured for those foldamers are higher than those previously measured in natural biopolymers showing a high stability under a load and a propensity for the development of emergent properties. In addition, the increased stability of these aromatic oligoamide foldamers was confirmed by the observation of almost instantaneous reversibility of the unfolding under load. [less ▲]

Detailed reference viewed: 19 (2 ULiège)
Peer Reviewed
See detailSingle Molecule force spectroscopy on helical foldamers
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Conference (2016, July 07)

Detailed reference viewed: 11 (3 ULiège)
Peer Reviewed
See detailSingle molecule force spectroscopy on helical foldamers
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2016, May 27)

Detailed reference viewed: 14 (3 ULiège)
See detailSingle-Molecule Force spectroscopy on synthetic Foldamers
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2016, April 26)

Detailed reference viewed: 4 (0 ULiège)
See detailSingle-Molecule Force spectroscopy on synthetic helical Nanoarchitectures
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Conference (2016, March 16)

Detailed reference viewed: 4 (2 ULiège)
Peer Reviewed
See detailSingle-Molecule Force Spectroscopy on Synthetic Foldamers
Devaux, Floriane ULiege; Li, Xuesong; Ivan, Huc et al

Poster (2016, January)

Inspired by the many folded conformations of the molecular machineries responsible for chemical reactions and mechanical tasks in nature, such as enzyme catalysis and duplication in nucleic acids ... [more ▼]

Inspired by the many folded conformations of the molecular machineries responsible for chemical reactions and mechanical tasks in nature, such as enzyme catalysis and duplication in nucleic acids, chemists have been developing the syntheses of artificial folded molecular architectures, namely foldamers (Guichard and Huc, 2011). The investigation of these molecules using AFM-based Single Molecule Force Spectrosocopy (SMFS) allows the elucidation of both mechanochemical properties and conformational dynamics on the unimolecular scale in solution. The stepwise synthesis of aromatic oligoamide-based foldamers was designed (Jiang et al., 2003; Huc, 2004) to produce well-defined helically-folded molecular architectures. A poly(ethylene oxide) PEO tether was coupled to one end of the foldamer. This tether design enables the coupling with the AFM tip and increases the number of potentially accessible physicochemical parameters through SMFS experiments. SMFS pulling experiments on this system yielded specific and reproducible force-extension patterns characteristic of single foldamers. Those patterns were further analyzed to determine unfolding forces and dynamics as well as to propose mechanistics hypotheses of the unfolding process. Several helical foldamers presenting variable lengths were considered. Experiments in multiple solvents pointed out a variation in the foldamer stability, leading to different average forces values. This last study enabled us to modulate the intramolecular interactions responsible for the folding and to evaluate the mechanochemical properties of the helix. The force values measured for those foldamers are higher than those previously measured in natural biopolymers (Clausen-Schaumann et al., 2000; Janshoff et al., 2000), showing a high stability under a load and a propensity for the development of emergent properties. In addition, the increased stability of these aromatic oligoamide foldamers was confirmed by the observation of almost instantaneous reversibility of the unfolding under load. [less ▲]

Detailed reference viewed: 101 (3 ULiège)
See detailSMFS on Synthetic Helical Nanoarchitectures
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Scientific conference (2015, July 02)

Detailed reference viewed: 11 (3 ULiège)
See detailSingle-Molecule Force Spectroscopy on Synthetic Helical Nanoarchitectures
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2015, April 02)

Detailed reference viewed: 4 (2 ULiège)
See detailSingle-Molecule Force spectroscopy on synthetic helical Nanoarchitectures
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Conference (2015, March 20)

Detailed reference viewed: 7 (1 ULiège)
Full Text
Peer Reviewed
See detailSingle-Molecule Force Spectroscopy on Synthetic Helical Nanoarchitectures
Devaux, Floriane ULiege; Duwez, Anne-Sophie ULiege; Huc, Ivan et al

Poster (2015, February)

Foldamers are artificial folded molecular architectures inspired by the structures and functions of natural biopolymers. Folding is the process selected by nature to control the conformation of its ... [more ▼]

Foldamers are artificial folded molecular architectures inspired by the structures and functions of natural biopolymers. Folding is the process selected by nature to control the conformation of its molecular machinery to carry out chemical functions and mechanical tasks, such as en-zyme catalysis, duplication in nucleic acids, force generation,... During the last decade of research on foldamers [1], synthetic oligomers able to adopt well-defined and predictable folded conformations, such as helices, have been proposed. Recent progress has shown that stepwise chemical synthesis and molecular design based on aromatic oligoamide backbones enable to produce large helically folded molecular architectures. The shape and stiffness of the backbone, local conformational preferences, specific interactions between distant monomers in sequences, as well as the action of external parameters such as the solvent or the presence of ions, can be combine to induce folding tendency. A remarkable aspect of these architectures is that they can give rise to folded patterns that have no in natural counterparts biopolymer structures. For instance, helices whose diameter varies along the se-quence, helices possessing a handedness inversion centre, herringbone helices have been reported. The objective of the project is to synthesize various helical nanorchitectures based on an oli-goamide aromatic backbone and to obtain a detailed picture of their dynamical conformation in solution, as well as, their mechanochemical properties, by AFM-based single molecule force spectroscopy. It is worth mentioning that an important sub-objective of this project is to probe intramolecular interactions in small synthetic molecules with the AFM. Indeed, whereas single-molecule force spectroscopy on macromolecules (proteins and synthetic polymers) is widely exploited[2], implementing single-molecule force spectroscopy on small molecules, such as the foldamers proposed here, remains a major challenge[3]. [1] For a review, see G. Guichard and I. Huc, Chem. Commun. 2011, 47, 5933–5941. [2]E. M. Puchner, H. E.Gaub, Curr. Opin. Struct. Biol. 2009, 19, 605–614. [3]P. Lussis, A.-S. Duwez, Nature Nanotech. 2011, 6, 553-557 [less ▲]

Detailed reference viewed: 119 (3 ULiège)