References of "Brihoum, Mounir"
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See detailSigns of neurotoxicity in a Belgian Blue herd after ingestion of moulded silage
Guyot, Hugues ULg; Sandersen, Charlotte ULg; Brihoum, Mounir ULg et al

in Cattle Practice (2011), 19(1), 57-60

After ingestion of moulded beet pulp silage, cases of cerebro-cortical necrosis (CCN) and mortalities were observed in a dual purpose Belgian Blue (BB) herd. Contamination with Paecilomyces spp., a mould ... [more ▼]

After ingestion of moulded beet pulp silage, cases of cerebro-cortical necrosis (CCN) and mortalities were observed in a dual purpose Belgian Blue (BB) herd. Contamination with Paecilomyces spp., a mould that produces byssochlamic acid, malformins and patulin, was proven. Twenty-five days after progressive introduction of beet pulp silage into the ration, most of the animals showed diminished appetite, excessive salivation and decreased milk production. Some of them showed anorexia, head pressing and blindness while 4 animals died within 1 week after onset of neurological symptoms. The survivors had been treated successfully with thiamine and recovered completely within five days. Once the beet pulp silage had been identified as causative agent, it was removed from the animals’ ration and no more clinical cases were observed. Silage was obviously moulded and analysis revealed the presence of 1.6 million CFU Paecilomyces spp./g of silage. Although no further investigation was undertaken to identify the mycotoxins, intoxication with patulin was suspected, since other mycotoxins produced by these species are less toxic. Although it has not been described that CCN can be induced by ingestion of Paecilomyces spp., it seems that there is a close relation between ingestion of Paecilomyces-contaminated silage and clinical signs observed in this herd. [less ▲]

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See detailClinical evaluation of cardiac effects of experimental doxycycline overdosing in healthy calves
Brihoum, Mounir ULg; Rollin, Frédéric ULg; Desmecht, Daniel ULg et al

in Biomedcentral Veterinary Research (2011), 7

Background Cardiac morphologic and functional changes consistent with cardiomyopathy have been reported in field cases of calves with accidental doxycycline overdosing. The purpose of this study was to ... [more ▼]

Background Cardiac morphologic and functional changes consistent with cardiomyopathy have been reported in field cases of calves with accidental doxycycline overdosing. The purpose of this study was to evaluate clinically the cardiac effects of an experimentally-induced doxycycline overdosing in healthy calves. Twelve 2 months-old healthy Belgian Blue calves were studied. Six of them (group 1) received the normal dose (5 mg/kg, BID) and the six others (group 2) received five times the normal dose (25 mg/kg, BID) of oral doxycycline for five consecutive days (D1 to D5). Each calf was clinically examined daily. Measurement of serum AST, CK, Iso-CKs and LDH activities and an echocardiographic examination were performed before (D0) and one day after (D6) the last doxycycline administration. An ECG tracing was recorded at D0, D4, and D6. Results In both groups, no clinical, blood, echocardiographic or electrocardiographic changes suggestive of a cardiomyopathy were observed. Only a decreased appetite was observed in the calves of the group 2 between D3 and D6. Conclusions This trial failed to reproduce cardiac changes reported in accidental doxycycline-poisoning in calves, suggesting that high doses of doxycycline may not be the only etiologic factor of the cardiomyopathy reported in the field cases. [less ▲]

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See detailDescriptive study of 32 cases of doxycycline-overdosed calves.
Brihoum, Mounir ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Journal of Veterinary Internal Medicine (2010), 24(5), 1203-10

BACKGROUND: Reports of doxycycline-induced toxicity are limited despite common use of this antibiotic to treat infectious respiratory disorders in calves. OBJECTIVE: To describe previously unreported ... [more ▼]

BACKGROUND: Reports of doxycycline-induced toxicity are limited despite common use of this antibiotic to treat infectious respiratory disorders in calves. OBJECTIVE: To describe previously unreported kidney lesions and diagnostic test results in doxycycline-overdosed calves and to compare these results with other findings reported previously. ANIMALS: Thirty-two calves that presented with adverse effects after receiving high doses of doxycycline as a treatment for mild respiratory disorders. METHOD: Retrospective review of medical records. RESULTS: Clinical examination identified mainly lethargy, dyspnea, cough, tongue paresia or paralysis associated with dysphagia and sialorrhea, tachycardia, tachypnea, and signs of myopathy. Blood analysis indicated increases in creatine kinase, lactate dehydrogenase, aspartate aminotransferase, and sorbitol dehydrogenase activities and increased serum creatinine and urea concentrations. ECG recordings and Doppler echocardiography examination identified ventricular premature beats and a decrease in left ventricular global and systolic function, respectively. Necropsy and histopathology disclosed necrosis of the myocardium, tongue, and some striated muscles, acute renal tubular necrosis, and fatty degeneration or congestion of the liver. CONCLUSIONS: Most of these findings corroborate previous observations made in doxycycline-overdosed calves, and further suggest myocardial and striated muscular toxicity as well as renal toxicity in doxycycline-overdosed calves. [less ▲]

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See detailLes cardiomyopathies dans l’espèce bovine
Brihoum, Mounir ULg; Rollin, Frédéric ULg; Amory, Hélène ULg

in Annales de Médecine Vétérinaire (2009), 153(3), 156-163

Cardiomyopathies in cattle are disorders that are sometimes encountered by rural practitioner. They usually lead to cardiac dysfunction, heart failure, arrhythmias and even sudden death. Most of ... [more ▼]

Cardiomyopathies in cattle are disorders that are sometimes encountered by rural practitioner. They usually lead to cardiac dysfunction, heart failure, arrhythmias and even sudden death. Most of cardiomyopathies in cattle are of hereditary, nutritional or toxic origin. Bovine cardiomyopathies may involve only one animal as they may affect several animals of the farm and can cause considerable economic losses either in treatment costs, decrease of zootechnical performances or in mortality. The etiological variability of cardiomyopathies as well as non-specificity of clinical signs often complicate the diagnostic approach of the practitioner. In this paper, a literature review on cardiomyopathies that may occur in cattle is proposed. Their different aetiologies and clinical aspects as well as diagnostic means in affected cattle are discussed [less ▲]

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See detailCongenital muscular dystonia (CMD): a new congenital pathology in Belgian Blue calves
Vandeputte, Sébastien ULg; Brihoum, Mounir ULg; Hubin, Xavier et al

Conference (2006, October 15)

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See detailCombined spastic paresis of both gastrocnemius and femoral quadriceps muscles in Belgian blue calves
Janda, Jozef; Uyttenhoef, Aude; Vandeputte, Sébastien ULg et al

Conference (2006)

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See detailCase report : A suspicion of cortico-cerebral necrosis in a Belgian Blue herd after ingestion of moulded silage
Guyot, Hugues ULg; Sandersen, Charlotte ULg; Aliaoui, Hamani et al

Poster (2004)

After ingestion of moulded beet pulp silage, cases of cortico-cerebral necrosis (CCN) and mortalities have been observed in a Belgian Blue (BB) herd. Contamination with Paecilomyces spp., a mould that ... [more ▼]

After ingestion of moulded beet pulp silage, cases of cortico-cerebral necrosis (CCN) and mortalities have been observed in a Belgian Blue (BB) herd. Contamination with Paecilomyces spp., a mould that produces byssochlamic acid, malformins and patulin, has been proven. Among these toxins, patulin is known to have cancerogenic, immunosuppressive and tremorgenic effects, but also acts on the respiratory and digestive systems. Twenty-five days after progressive introduction of beet pulp silage into the ration of a dual purpose BB herd, most of the animals showed diminished appetite, salivation and decreased milk production. All 35 cows were reluctant to consume the beet pulp silage, but continued to eat grass silage voluntarily. Seven of them showed anorexia and nervous symptoms, like head pressing and blindness. Four animals died within 1 week after onset of neurological symptoms. No necropsy has been performed, since legislation does not allow post-mortem examination of the central nervous system in the field. The three survivors had been treated successfully with thiamine (10 mg/kg, IV, TID) and recovered completely within five days. After the beet pulp silage had been identified as causative agent, it had been removed from the animals’ ration and no more clinical case has been observed. Four weeks later, the same beet pulp silage has been reintroduced into the animals’ ration and provoked again diminished appetite, salivation and a decrease in milk production in most of the animals. Clinical signs were also suggesting lead poisoning but any contact with lead containing material could have been excluded. Silage was obviously moulded and analysis revealed the presence of 1.6 million CFU Paecilomyces spp./g of silage. Although no further investigation has been made to identify the mycotoxins, an intoxication with patulin has been suspected, since other mycotoxins produced by these species are less toxic. Although it has not been described that CCN can be induced by ingestion of Paecilomyces spp., it seems that there is a close relation between ingestion of Paecilomyces-contaminated silage and observed clinical signs in this herd. [less ▲]

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See detailEpisode de dyspnée consécutive à une intoxication par l’ergot dans une exploitation laitière
Brihoum, Mounir ULg; Desmecht, Daniel ULg; Bony, S. et al

in Annales de Médecine Vétérinaire (2003), 147(5), 353-358

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These ... [more ▼]

A chronic consumption (3.5 months) of ergot (Claviceps purpurea) contaminated triticale in dairy cows resulted in dyspnea, mainly expiratory, consistent with interstitial pneumonia and emphysema. These troubles can be compared to many observations done in humans after long lasting treatments with ergot derivatives [less ▲]

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