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See detailCHRONIC TOXIC HEPATITIS IN BEEF CALVES DUE TO MYCOTOXINS CONTAMINATION IN MIXED FEED
Theron, Léonard ULg; Callebaut, Alfons; Bayrou, Calixte ULg et al

in Zemljic, Borut; Podpecan, Ozbalt; Zmljic-Jokhadar, Spela (Eds.) Proceedings of the XV middle European Buiatric Congress (2015, June 10)

Mycotoxins intoxination is an emerging disorder in Belgium, due to evolution of cultural practices and harvesting weather conditions. These intoxinations are difficult to diagnose for the vet practioners ... [more ▼]

Mycotoxins intoxination is an emerging disorder in Belgium, due to evolution of cultural practices and harvesting weather conditions. These intoxinations are difficult to diagnose for the vet practioners, since unspecific clinical signs, and their impact on ruminant disorder remains controversial. Although legal concentrations have been established for mycotoxins in the EU, farm forages are most of the time not tested (EU 2006/576/EC). In January 2015, a 500 calvings cross-bred Belgian blue cattle herd (BVDV free) referred a second (the first was directly sent to the rendering-plant) unexplained fatal case of jaundice on a 2 months-old calf to the Clinic for Ruminants of the University of Liège for necropsy. In 2013, a case of jaundice due to a Salmonella dublin hepatocholecystitis had previously diagnosed in this farm (Ronzoni et al., 2014), but so far preventions measures were implemented. Necropsy revealed generalized icterus, mild bilirubinuria, splenomegaly, but no precise etiology. On February a second 2 month old calf with jaundice is referred, lethargic, normothermic with a mild diarrhea, Calf shown generalized jaundice, anemia, elevation of leukocytes (neutrophils, eosinophils and monocytes), TGO, bilirubinemia, total biliary acids and Globulins (alpha2). He had also diminished erythrocytes and albuminemia. Copraemia, leptospirosis serology, leademia, hemoculture and pancreatic enzymes were within normal ranges, ruling out classic causes of jaundice in calf. Abdomen ultrasonography revealed a mild hyperechogenicity of the liver but no gall bladder modifications. Symptomatic treatment was based on symptoms, with fluidotherapy and choleretics. A third calf was referred three days after in a worst clinical condition, with also a severely modified liver enzymes, but no anemia. Three days after, this calf died and a necropsy revealed petechiae and hemorrhages in the abomasum, congestive mucosae in the distal bowel, white depot in the kidney medulla, modified urine and splenomegaly. Bile bacteriology and leptospirosis PCR was negative and liver histopathology revealed a severe histopathological liver degeneration associated with a disruption of the parenchyma and marked hyperplasia of the bile ducts compatible with chronic metabolic disorder. Meanwhile, the anemic calf recovered from anemia without any treatment after 4 days and was discharged from the Clinic for Ruminants. Considering the weird clinical patterns of these jaundice cases, and the fact that only calves from 2 to 3 months were affected, a nutritional origin as etiology was suspected. To test it, eight clinically healthy two to three months-old calves, of two different pens were sampled. TGO, GLDH, GGT or biliary acids were either modified and the values tended to increase with the age of the calves. The water was analyzed for classic toxics, and cultured for total germ content and everything were within recommended values. The calves fed with a milk replacer (30 % milk powder), and a commercial calf starter until one month of age. Then, they were given a mixed feed (containing cereal mix, cocoa, beet pulp, soja, maize), made at the farm from primary product/byproducts bought from different sources. The mix was tested for mycotoxins presence and ranged from 0.8 to 1.5 ppm of Desoxynivalenone (DON), and 115-215 ppb of Zearalenone (ZEA). The principal source of DON was maize (3.1 to 6.2 ppm), as for ZEA (0.3-0.6 ppm), but several compounds contained small dose of DON (0.2-0.7 ppm) for Barley feed, Tanned soja. Cacao contained 2.7 to 5.9 ppb of Ochratoxine (OTA). Nutritionnal recommendations were immediately given with a change in the source of maize and an addition of clay and yeast at 40g/calf/day and hay. Since, any other hypothetic origin to this progressive hepatic intoxination was demostrated, and that the doses founded, even if barely legal in the mix, are not accounted for toxic in the EU regulation, we believe that the calves were chronically exposed to these toxins. However, some mycotoxins experts still claim that various clinical signs would be observed in ruminants, if the rumen is partially defaunated, like in our case with the lake of forage. We propose that monitoring of subclinical liver health could be a key to screen DON effects. [less ▲]

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See detailRational Development of an Attenuated Recombinant Cyprinid Herpesvirus 3 Vaccine Using Prokaryotic Mutagenesis and In Vivo Bioluminescent Imaging
Boutier, Maxime ULg; Ronsmans, Maygane ULg; Ouyang, Ping et al

in PLoS Pathogens (2015), 11(2), 1004690

Cyprinid herpesvirus 3 (CyHV 3) is causing severe economic losses worldwide in common and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass vaccination is needed. We ... [more ▼]

Cyprinid herpesvirus 3 (CyHV 3) is causing severe economic losses worldwide in common and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass vaccination is needed. We produced single deleted recombinants using prokaryotic mutagenesis. When producing a recombinant lacking open reading frame 134 (ORF134), we unexpectedly obtained a clone with additional deletion of ORF56 and ORF57. This triple deleted recombinant replicated efficiently in vitro and expressed an in vivo safety/efficacy profile compatible with use as an attenuated vaccine. To determine the role of the double ORF56-57 deletion in the phenotype and to improve further the quality of the vaccine candidate, a series of deleted recombinants was produced and tested in vivo. These experiments led to the selection of a double deleted recombinant lacking ORF56 and ORF57 as a vaccine candidate. The safety and efficacy of this strain were studied using an in vivo bioluminescent imaging system (IVIS), qPCR, and histopathological examination, which demonstrated that it enters fish via skin infection similar to the wild type strain. However, compared to the parental wild type strain, the vaccine candidate replicated at lower levels and spread less efficiently to secondary sites of infection. Transmission experiments allowing water contamination with or without additional physical contact between fish demonstrated that the vaccine candidate has a reduced ability to spread from vaccinated fish to naïve sentinel cohabitants. Finally, IVIS analyses demonstrated that the vaccine candidate induces a protective mucosal immune response at the portal of entry. Thus, the present study is the first to report the rational development of a recombinant attenuated vaccine against CyHV 3 for mass vaccination of carp. We also demonstrated the relevance of the CyHV 3 carp model for studying alloherpesvirus transmission and mucosal immunity in teleost skin. [less ▲]

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See detailPlantigrady due to a MRSI localized myopathy in a newborn Belgian blue calf
Genart, Marie; Evrard, Laurence ULg; Garcia de Fonseca, Rita et al

Scientific conference (2014, October 17)

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See detailHepatocholecystitis due to Salmonella Dublin in a crossbred calf
Ronzoni, Anna; Bayrou, Calixte ULg; Evrard, Laurence ULg et al

Scientific conference (2014, October 17)

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See detailProceedings of the 1st FARAH-Day Faculty of Veterinary Medicine (University of Liege - Belgium)
Bayrou, Calixte ULg; Cabaraux, Jean-François ULg; Delguste, Catherine ULg et al

Book published by Presses de la Faculté de Médecine vétérinaire de l’Université de Liège (2014)

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See detailNatural intrauterine infection with Schmallenberg virus in malformed newborn calves: pathology and distribution of viral RNA
Bayrou, Calixte ULg; Garigliany, Mutien-Marie ULg; Sarlet, Michaël ULg et al

in Emerging Infectious Diseases (2014), 20(8),

We comprehensively surveyed morphologic alterations in calves naturally infected in utero by Schmallenberg virus (SBV) and born deformed. SBV-specific RNA was distributed unevenly in different tissues ... [more ▼]

We comprehensively surveyed morphologic alterations in calves naturally infected in utero by Schmallenberg virus (SBV) and born deformed. SBV-specific RNA was distributed unevenly in different tissues. Implications for diagnosic procedures are highlighted. [less ▲]

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See detailPLANTIGRADY DUE TO A LOCALIZED MYOPATHY IN TWO NEWBORN BELGIAN BLUE CALVES
Genart, Marie; Evrard, Laurence ULg; Garcia da Fonseca et al

Poster (2014, June 26)

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See detailFirst report of a fatal autochthonous canine Angiostrongylus vasorum infection in Belgium
Jolly, Sandra ULg; Poncelet, Luc; Lempereur, Laetitia ULg et al

in Parasitology International (2014)

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See detailStéatite généralisée chez 3 chevaux adultes référés à l’université de Liège
Leroux, Aurélia ULg; Garcia da Fonseca, Rita; Bayrou, Calixte ULg et al

in Pratique Vétérinaire Equine (2014), 184

In horses, two forms of generalised steatitis have been described: one subcutaneous nodular form and one diffuse systemic form. Three cases of the second form are described in this paper. The clinical ... [more ▼]

In horses, two forms of generalised steatitis have been described: one subcutaneous nodular form and one diffuse systemic form. Three cases of the second form are described in this paper. The clinical signs included depression, anorexia, diarrhoea, abdominal pain, fever, subcutaneous oedema, tachycardia and tachypnea. Blood analyses showed anemia, neutrophilia, hypoalbuminemia, increased muscular enzymes activities, and low level of vitamine E concentration. Abdominal ultrasound demonstrated an irregular hyperechoic band of peritoneal fat tissue. Ante mortem diagnosis was achieved in 2 horses, one on the basis of rectal biopsies and one on the basis of biopsies of the nuchal ligament. Despite a corticoids therapy and vitamin E supplementation, the 3 horses died or were euthanized. Those cases confirm that, in horses, diagnosis of systemic diffuse generalised steatitis is difficult and that the prognosis is poor. [less ▲]

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See detailProceedings of the 3rd Scientific Meeting of the Faculty of Veterinary Medicine
Bayrou, Calixte ULg; Cabaraux, Jean-François ULg; Delguste, Catherine ULg et al

Book published by Presses de la Faculté de Médecine Vétérinaire (2013)

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See detailNo serologic evidence for emerging Schmallenberg virus infection in dogs (Canis domesticus)
Garigliany, Mutien-Marie ULg; Desmecht, Daniel ULg; Bayrou, Calixte ULg et al

in Vector Borne & Zoonotic Diseases (2013), 13(11), 1-4

Schmallenberg virus, a novel orthobunyavirus, is spreading among ruminants, especially sheep and cattle throughout Europe. To determine the risk for domestic dog infection, we conducted a survey among ... [more ▼]

Schmallenberg virus, a novel orthobunyavirus, is spreading among ruminants, especially sheep and cattle throughout Europe. To determine the risk for domestic dog infection, we conducted a survey among cases referred to the university Companion Animal Clinic to assess possible seroconversion. No evidence of transmission to dogs was detected. [less ▲]

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See detailHepatocholecystitis due to Salmonella Dublin in a crossbred calf
Ronzoni, Anna ULg; Bayrou, Calixte ULg; Evrard, Laurence ULg et al

Conference (2013, August 30)

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See detailHAEMATOLOGICAL PROFILES OF CALVES BELONGING TO HERDS WITH BOVINE NEONATAL PANCYTOPENIA HISTORY IN AND AROUND WALLONIA (BELGIUM).
Ronzoni, Anna ULg; Theron, Léonard ULg; Bayrou, Calixte ULg et al

in Buiatrissima, 8th ECBHM Symposium, 28-30 August 2013, Bern, Proceedings (2013, August)

The objective of the present study was to verify the hypothesis of subclinical BNP cases, by random sampling and haematological analysis in different herds with BNP history, in order to obtain a better ... [more ▼]

The objective of the present study was to verify the hypothesis of subclinical BNP cases, by random sampling and haematological analysis in different herds with BNP history, in order to obtain a better epidemiological picture of this disease. [less ▲]

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See detailBovine lymphotropic herpesvirus detected in Belgium
Garigliany, Mutien-Marie ULg; Bayrou, Calixte ULg; Cassart, Dominique ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2013), 172

The bovine lymphotropic herpesvirus was detected for the first time outside the US, Canada and UK in a cow with nonresponsive chronic metritis.

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See detailSchmallenberg virus circulation in Belgium in 2012
Bayrou, Calixte ULg; Garigliany, Mutien-Marie ULg; Cassart, Dominique ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2013), 172

Field and laboratory observations suggest that Schmallenberg virus was circulating in Belgium during the summer 2012 despite a very high herd immunity. Further studies will be conducted to determine ... [more ▼]

Field and laboratory observations suggest that Schmallenberg virus was circulating in Belgium during the summer 2012 despite a very high herd immunity. Further studies will be conducted to determine whether we are observing the last cases of this epizootic or if the above calves announce a transition to endemicity. [less ▲]

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See detailProceedings of the 2nd Scientific Meeting of the Faculty of Veterinary Medicine (University of Liège – Belgium)
Bayrou, Calixte ULg; Cabaraux, Jean-François ULg; Delguste, Catherine ULg et al

Book published by Presses de la Faculté de Médecine vétérinaire de l’Université de Liège (2012)

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See detailSchmallenberg virus in domestic cattle, Belgium, 2012
Garigliany, Mutien-Marie ULg; Bayrou, Calixte ULg; Kleijnen, Déborah ULg et al

in Emerging Infectious Diseases (2012), 18(9), 1512-1514

The Schmallenberg virus emerged in summer-fall 2011 in North-West Europe. Nine months later, 91% of adult cattle living about 250 km from the emergence location tested positive for IgGs targeting the new ... [more ▼]

The Schmallenberg virus emerged in summer-fall 2011 in North-West Europe. Nine months later, 91% of adult cattle living about 250 km from the emergence location tested positive for IgGs targeting the new virus nucleoprotein. Further, the risk of infection of the fetus in an immunologically naive herd is 28%. [less ▲]

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See detailSchmallenberg virus: a new Shamonda/Sathuperi-like virus on the rise in Europe
Garigliany, Mutien-Marie ULg; Bayrou, Calixte ULg; Kleijnen, Déborah ULg et al

in Antiviral Research (2012), 95

In the summer-fall of 2011, a nonspecific febrile syndrome characterized by hyperthermia, drop in milk production and watery diarrhea was reported in adult dairy cows from a series of farms located in ... [more ▼]

In the summer-fall of 2011, a nonspecific febrile syndrome characterized by hyperthermia, drop in milk production and watery diarrhea was reported in adult dairy cows from a series of farms located in North-West Europe. Further, in November 2011, an enzootic outbreak of abortion, stillbirth and birth at term of lambs, kids and calves with neurologic signs and/or head, spine or limb malformations emerged throughout several European countries. Both syndromes were associated with the presence in the blood (adults) or in the central nervous system (newborns) of the genome of a new Shamonda-like orthobunyavirus provisionally named Schmallenberg virus after the place where the first positive samples were collected. The clinical, pathological, virological and epidemiological facts that were made publicly available during the first 6 months after the emergence are presented here. Current knowledge of the epidemiology of the phylogenetically closest relatives of the newcomer (Shamonda, Aino and Akabane viruses) is not exhaustive enough to predict whether the current outbreak of Schmallenberg virus is the prelude to endemicity or to a 2 years long outbreak before the infection burns out when serologically naïve animals are no longer available. In the future, cyclic epizootic reemergences are a possibility too, either synchronized with a global decrease of herd immunity or due to antigenic variants escaping the immunity acquired against their predecessors. The latter hypothesis seems unlikely because of the wide array of biologic constraints acting on the genome of viruses whose life cycle requires transmission by a vector, which represses genetic drift. The remarkable stability of the Shamonda virus genome over the last forty years is reassuring in this regard. [less ▲]

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See detailSchmallenberg virus in calf born at term with porencephaly, Belgium
Garigliany, Mutien-Marie ULg; Hoffmann, Bernd; Dive, Marc et al

in Emerging Infectious Diseases (2012), 18(6), 1005-1006

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