Theoretical discrepancy between cage size and efficient tibial tuberosity advancement in dogs treated for cranial cruciate ligament rupture

in Veterinary and Comparative Orthopaedics and Traumatology (2011), 24

Finite element simulation of canine humeral condylar fractures

Conference (2011, July 04)

Humeral condylar fractures are common in dogs. Different types of fractures (lateral, medial, bicondylar) may occur, depending on the age of the dog and the position of its elbow during the impact. The ... [more ▼]

Humeral condylar fractures are common in dogs. Different types of fractures (lateral, medial, bicondylar) may occur, depending on the age of the dog and the position of its elbow during the impact. The goal of this work is to understand the effects of bone posture and skeletal development on canine humeral fractures by means of the finite element method. Four distinct finite element simulations were performed, corresponding to an immature and a mature dog elbow, respectively in extension and flexion. To create the finite element models, subject-specific finite element meshes were extracted from the CT-data. Appropriate material properties were used for cortical bone, trabecular bone and cartilage. The modified Mohr-Coulomb failure criterion was implemented to take account for strength asymmetry. Lateral humeral fractures are obtained for both the young and adult dog elbow, in extension and flexion. This is in agreement with clinical observations, in which lateral condylar fractures are most common. [less ▲]

Relationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO(2), and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint.

in Osteoarthritis and Cartilage (2011), 19(11), 1323-9

OBJECTIVE: To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these ... [more ▼]

OBJECTIVE: To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these levels relate to arthroscopic findings of inflammation and degeneration. MATERIALS AND METHODS: Venous blood and synovial fluid samples were collected from 63 horses presented for arthroscopic removal of osteochondral fragments in the tarsocrural joint. Prior to removal of the osteochondral fragment, an exploration of the joint was performed and an inflammatory and degenerative score was determined. The blood and synovial levels of Coll2-1, Coll2-1NO(2) and MPO were also measured. The effects of the arthroscopic evaluation (inflammatory and degenerative classes) on the blood and synovial markers were evaluated using a linear model (GLM procedure), and correlations between biochemical markers in the blood and synovial fluid and the arthroscopic evaluation (inflammatory and degenerative classes) were established (Pearson's correlations). RESULTS: Significantly higher levels of Coll2-1 were detected in synovial fluid of higher degenerative classes. There was a significant correlation between the degenerative score and the synovial levels of Coll2-1 (r=0.27). According to the logistic regression model, there was a significant effect of the degenerative class on synovial levels of Coll2-1. CONCLUSIONS: Coll2-1 correlates well with the degenerative state of tarsocrural joints as evaluated by arthroscopy. This marker can therefore be classified as a burden-of-disease marker in the assessment of joint disease in horses. [less ▲]

Mechanical testing of a modified stabilisation method for tibial tuberosity advancement

in Veterinary and Comparative Orthopaedics and Traumatology (2010)

Traumatic partial elbow luxation in a dog

in Journal of Small Animal Practice (2008)

MG-63 Osteoblast culture on P culture on PLA– based copolymers for bone tissue engineering applications

Poster (2007)

Physical injury or pathological changes such as removal of a tumor can result in large bone defects, preventing the recovery of its original function. Autogenous bone grafting, which is the most common ... [more ▼]

Physical injury or pathological changes such as removal of a tumor can result in large bone defects, preventing the recovery of its original function. Autogenous bone grafting, which is the most common technique for bone defect repairing, is associated with serious limitations, e.g. limited supply and donor site morbidity. Since a few years bone tissue engineering by degradable biomaterials has been shown as a very promising avenue for providing bone substitutes. Among these materials, bioresorbable synthetic polymers such as poly(ethylene oxide) (PEO), poly(vinyl alcohol) (PVA), poly(acrylic acid) (PAA) and poly(lactic acid) (PLA) are very appealing because their chemistry and properties are controllable and reproducible. Cellular activity and proliferation of osteosarcoma cell lines (MG-63) on films were determined by the tetrazolium salt MTT assay and by phase contrast/fluorescence microscope observations. The cytotoxicity of the materials was found to be low or negligible. Cells viability variations were observed on the surface of the films. Long-term cell culture and degradability of PLA-PEOpolymer film was investigated by optical microscopy (Giemsa staining) and environmental scanning electron microscopy (ESEM). Hydrolysis of the PLLA ester linkages led to slow film degradation. After 113 days, optical microscope observations revealed the presence of large cracks on the surface, and even breaks of small polymer fragments, while MG-63 proliferation was still very important, showing a tissue-like aspect, with extracellular matrix (ECM) deposition. These results show that PLA-PEO copolymers are very interesting bioresorbable materials for long-term bone tissue engineering applications. [less ▲]

Health status of dogs referred to the consultation of clinical nutrition at the faculty of Liège

in Coenen, M.; Vervuert, I. (Eds.) Proceedings of the 11th ESVCN Congress (2007)

Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs

in American Journal of Veterinary Research (2006), 67(5), 901-908

OBJECTIVE: To compare the urodynamic and morphologic effects of the administration of estriol alone and in combination with phenylpropanolamine on the lower portion of the urogenital tract in female dogs ... [more ▼]

OBJECTIVE: To compare the urodynamic and morphologic effects of the administration of estriol alone and in combination with phenylpropanolamine on the lower portion of the urogenital tract in female dogs. ANIMALS: 3 sexually intact and 3 spayed female Beagles without urinary incontinence. PROCEDURE: Dogs received estriol (2 mg, PO) once daily for 7 days followed by estriol (2 mg, PO) and phenylpropanolamine (1.5 mg/kg, PO) once daily for 7 days. Urethral pressure profilometry, diuresis cystometry, and vaginourethrography were performed before treatment (day 0) and at days 7 and 14. The maximum urethral pressure (MUP) and closure pressure (MUCP), urethral functional and anatomic profile lengths, integrated pressure (IP), plateau, distance before MUP, maximum meatus pressure, threshold pressure, threshold volume, compliance, urethral length, and vaginal length and width were measured. RESULTS: Before treatment, no urodynamic differences were observed between the 2 groups; however, vaginal length and width were significantly shorter in spayed dogs. Compared with day 0 values, estriol treatment significantly increased MUP, MUCP, and IP values at day 7, but at day 14, this effect decreased despite phenylpropanolamine administration. No morphologic changes from baseline were detected after either treatment in any dog. CONCLUSIONS AND CLINICAL RELEVANCE: Data suggest that estriol mainly acts on the urethral sphincter mechanism by increasing urethral resistance in sexually intact and spayed female dogs without urinary incontinence. Administration of estriol and phenylpropanolamine did not increase the urethral resistance more than estriol alone. The urodynamic effects of estriol in female dogs with urinary incontinence remain to be elucidated [less ▲]

Texture characterisation of ultramacroporous materials using x-ray microtomography: application to alumina foams and deer antlers

Conference (2005, September)

Use of autogenous fascia lata graft for perineal herniorrhaphy in dogs

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (2005), 34(4, JUL-AUG), 405-413

Objective-To evaluate the effectiveness of a herniorrhaphy technique, using an autogenous fascia lata graft (FLG) for perineal hernia (PH) repair in dogs. Study Design-Prospective clinical study. Animals ... [more ▼]

Objective-To evaluate the effectiveness of a herniorrhaphy technique, using an autogenous fascia lata graft (FLG) for perineal hernia (PH) repair in dogs. Study Design-Prospective clinical study. Animals-Twelve dogs with PH. Method-PHs were repaired with FLG harvested from the dog's ipsilateral thigh and sutured directly into the perineal defect. Correction of associated conditions, and castration were performed. Surgical time, pain, inflammation, pattern of defecation, lameness, hospitalization time, postoperative complications, and owner satisfaction were recorded. Histopathologic examination was performed in 1 dog euthanatized 10 months after repair. Results-Hernia did not recur (mean follow-up, 5.8 months). Lameness was the most frequent minor complication, and was resolved within a few days. Transient rectal prolapse occurred in 2 dogs with bilateral PH. The mean (+/- SD) hospitalization was 1.8 +/- 0.9 days, and the surgical time was 76.5 +/- 9.8 minutes. Histopathologic examination in 1 dog revealed perfect integration of FLG into adjacent tissues without substantial tissue reaction. Conclusions-FLG reconstruction of PH is a simple, effective method of treatment. Clinical Relevance-FLG can be used without major complications for primary repair of PH, as an augmentation procedure when the internal obturator muscle is thin or friable, or when herniation has recurred after another repair technique. (c) Copyright 2005 by The American College of Veterinary Surgeons. [less ▲]