References of "Albert, Adelin"
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See detailSepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study
LAYIOS, Nathalie ULiege; Delierneux, Céline ULiege; Hego, Alexandre ULiege et al

in Intensive Care Medicine Experimental (2017), 5(1), 32

Background: Platelets have been involved in both surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with ... [more ▼]

Background: Platelets have been involved in both surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to sepsis in critical illness remains unknown. The aim of this work was to identify platelet markers that could predict sepsis occurrence in critically ill injured patients. Results: This single-center, prospective, observational, 7-month study was based on a cohort of 99 non-infected adult patients admitted to ICUs for elective cardiac surgery, trauma, acute brain injury and post-operative prolonged ventilation and followed up during ICU stay. Clinical characteristics and severity score (SOFA) were recorded on admission. Platelet activation markers, including fibrinogen binding to platelets, platelet membrane P-selectin expression, plasma soluble CD40L, and platelet-leukocytes aggregates were assayed by flow cytometry at admission and 48h later, and also at the time of sepsis diagnosis (Sepsis-3 criteria) and 7 days later for sepsis patients. Hospitalization data and outcomes were also recorded. Of the 99 patients, 19 developed sepsis after a median time of 5 days. SOFA at admission was higher; their levels of fibrinogen binding to platelets (platelet-Fg) and of D-dimers were significantly increased compared to the other patients. Levels 48h after ICU admission were no longer significant. Platelet-Fg % was an independent predictor of sepsis (P = 0.030). By ROC curve analysis cutoff points for SOFA (AUC=0.85) and Platelet-Fg (AUC=0.75) were 8 and 50%, respectively. The prior risk of sepsis (19%) increased to 50% when SOFA was above 8, to 46% when Platelet-Fg was above 50%, and to 87% when both SOFA and Platelet-Fg were above their cutoff values. By contrast, when the two parameters were below their cutoffs, the risk of sepsis was negligible (3.8%). Patients with sepsis had longer ICU and hospital stays and higher death rate. Conclusion: In addition to SOFA, platelet-bound fibrinogen levels assayed by flow cytometry within 24h of ICU admission help identifying critically ill patients at risk of developing sepsis. [less ▲]

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See detailDoes Oxidative Stress Play a Role in Altered Characteristics of Diabetic Bone? A Systematic Review
Bacevic, Miljana ULiege; Brkovic, Bozidar; Albert, Adelin ULiege et al

in Calcified Tissue International (2017)

Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms ... [more ▼]

Diabetes mellitus (DM) has been associated with increased bone fracture rates, impaired bone regeneration, delayed bone healing, and depressed osteogenesis. However, the plausible pathogenic mechanisms remain incompletely understood. The aim of the present systematic review was to investigate whether oxidative stress (OS) plays a role in altered characteristics of diabetic bone under in vivo conditions. An electronic search of the MEDLINE (via PubMed) and Embase databases was performed. In vivo animal studies involving DM and providing information regarding assessment of OS markers combined with analyses of bone histology/histomorphometry parameters were selected. A descriptive analysis of selected articles was performed. Ten studies were included in the present review. Both bone formation and bone resorption parameters were significantly decreased in the diabetic groups of animals compared to the healthy groups. This finding was consistent regardless of different animal/bone models employed or different evaluation periods. A statistically significant increase in systemic and/or local OS status was also emphasised in the diabetic groups in comparison to the healthy ones. Markers of OS were associated with histological and/or histomorphometric parameters, including decreased trabecular bone and osteoid volumes, suppressed bone formation, defective bone mineralisation, and reduced osteoclastic activity, in diabetic animals. Additionally, insulin and antioxidative treatment proved to be efficient in reversing the deleterious effects of high glucose and associated OS. The present findings support the hypotheses that OS in the diabetic condition contributes at least partially to defective bone features, and that antioxidative supplementation can be a valuable adjunctive strategy in treating diabetic bone disease, accelerating bone healing, and improving osteointegration. [less ▲]

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See detailL’exploration des perceptions relatives à l’excès de poids pour mieux comprendre les difficultés dans la prise en charge de l’obésité : une étude populationnelle exploratoire
Crutze, Céline ULiege; Pétré, Benoît ULiege; Dardenne, Nadia ULiege et al

in Revue d'Epidémiologie et de Santé Publique = Epidemiology and Public Health (2017), 65(3), 209-219

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See detailStability-based validation of dietary patterns obtained by cluster analysis
Sauvageot, Nicolas ULiege; Schritz, Anna; Alkerwi, Ala'a et al

in Nutrition Journal (2017), 16(3),

Abstract Background Cluster analysis is a data-driven method used to create clusters of individuals sharing similar dietary habits. However, this method requires specific choices from the user which have ... [more ▼]

Abstract Background Cluster analysis is a data-driven method used to create clusters of individuals sharing similar dietary habits. However, this method requires specific choices from the user which have an influence on the results. Therefore, there is a need of an objective methodology helping researchers in their decisions during cluster analysis. The objective of this study was to use such a methodology based on stability of clustering solutions to select the most appropriate clustering method and number of clusters for describing dietary patterns in the NESCAV study (Nutrition, Environment and Cardiovascular Health), a large population-based cross-sectional study in the Greater Region (N = 2298). Methods Clustering solutions were obtained with K-means, K-medians and Ward’s method and a number of clusters varying from 2 to 6. Their stability was assessed with three indices: adjusted Rand index, Cramer’s V and misclassification rate. Results The most stable solution was obtained with K-means method and a number of clusters equal to 3. The “Convenient” cluster characterized by the consumption of convenient foods was the most prevalent with 46% of the population having this dietary behaviour. In addition, a “Prudent” and a “Non-Prudent” patterns associated respectively with healthy and non-healthy dietary habits were adopted by 25% and 29% of the population. The “Convenient” and “Non-Prudent” clusters were associated with higher cardiovascular risk whereas the “Prudent” pattern was associated with a decreased cardiovascular risk. Associations with others factors showed that the choice of a specific dietary pattern is part of a wider lifestyle profile. Conclusion This study is of interest for both researchers and public health professionals. From a methodological standpoint, we showed that using stability of clustering solutions could help researchers in their choices. From a public health perspective, this study showed the need of targeted health promotion campaigns describing the benefits of healthy dietary patterns. [less ▲]

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See detailScreening for the metabolic syndrome in subjects with migraine
Streel, Sylvie ULiege; Donneau, Anne-Françoise ULiege; Dardenne, Nadia ULiege et al

in Cephalalgia : An International Journal of Headache (2017)

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See detailFDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer.
LOVINFOSSE, Pierre ULiege; POLUS, Marc ULiege; VAN DAELE, Daniel ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2017)

PURPOSE: The aim of this study was to investigate the prognostic value of baseline 18F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC ... [more ▼]

PURPOSE: The aim of this study was to investigate the prognostic value of baseline 18F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC underwent 18F-FDG PET/CT before treatment. Maximum and mean standard uptake values (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), histogram-intensity features, as well as 11 local and regional textural features, were evaluated. The relationships of clinical, pathological and PET-derived metabolic parameters with disease-specific survival (DSS), disease-free survival (DFS) and overall survival (OS) were assessed by Cox regression analysis. Logistic regression was used to predict the pathological response by the Dworak tumor regression grade (TRG) in the 66 patients treated with neoadjuvant chemoradiotherapy (nCRT). RESULTS: The median follow-up of patients was 41 months. Seventeen patients (19.7%) had recurrent disease and 18 (20.9 %) died, either due to cancer progression (n = 10) or from another cause while in complete remission (n = 8). DSS was 95% at 1 year, 93% at 2 years and 87% at 4 years. Weight loss, surgery and the texture parameter coarseness were significantly associated with DSS in multivariate analyses. DFS was 94 % at 1 year, 86 % at 2 years and 79 % at 4 years. From a multivariate standpoint, tumoral differentiation and the texture parameters homogeneity and coarseness were significantly associated with DFS. OS was 93% at 1 year, 87% at 2 years and 79% after 4 years. cT, surgery, SUVmean, dissimilarity and contrast from the neighborhood intensity-difference matrix (contrastNGTDM) were significantly and independently associated with OS. Finally, RAS-mutational status (KRAS and NRAS mutations) and TLG were significant predictors of pathological response to nCRT (TRG 3-4). CONCLUSION: Textural analysis of baseline 18F-FDG PET/CT provides strong independent predictors of survival in patients with LARC, with better predictive power than intensity- and volume-based parameters. The utility of such features, especially coarseness, should be confirmed by larger clinical studies before considering their potential integration into decisional algorithms aimed at personalized medicine. [less ▲]

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See detailDo evoked potentials contribute to the functional follow-up and clinical prognosis of multiple sclerosis?
GIFFROY, Xavier ULiege; MAES, Nathalie ULiege; Albert, Adelin ULiege et al

in Acta Neurologica Belgica (2017)

The clinical variability and complexity of multiple sclerosis (MS) challenges the individual clinical course prognostication. This study aimed to find out whether multimodal evoked potentials (EP ... [more ▼]

The clinical variability and complexity of multiple sclerosis (MS) challenges the individual clinical course prognostication. This study aimed to find out whether multimodal evoked potentials (EP) correlate with the motor components of multiple sclerosis functional composite (MSFCm) and predict clinically relevant motor functional deterioration. One hundred MS patients were assessed at baseline (T0) and about 7.5 years later (T1), with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) and the MSFCm, including the 9 Hole Peg Test and the Timed 25 Foot Walk (T25FW). The Spearman correlation coefficient (rS) was used to evaluate the cross-sectional and longitudinal relationship between EP Z scores and clinical findings. The predictive value of baseline electrophysiological data for clinical worsening (EDSS, 9-HPT, T25FW, MSFCm) during follow-up was assessed by logistic regression analysis. Unlike longitudinal correlations, cross-sectional correlations between EP Z scores and clinical outcomes were all significant and ranged between 0.22 and 0.67 (p\0.05). The global EP Z score was systematically predictive of EDSS and MSFCm worsening over time (all p\0.05). EP latency was a better predictor than amplitude, although weaker than latency and amplitude aggregation in the global EP Z score. The study demonstrates that EP numerical scores can be used for motor function monitoring and outcome prediction in patients with MS. [less ▲]

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See detailUse of finite mixture models in dietary patterns analysis.
Sauvageot, Nicolas ULiege; Schritz, Anna; Leite, Sonia et al

Scientific conference (2016, September 29)

Background In recent years, the dietary pattern approach has been used extensively to describe overall eating profiles in populations. In the literature, dietary patterns are often computed by cluster ... [more ▼]

Background In recent years, the dietary pattern approach has been used extensively to describe overall eating profiles in populations. In the literature, dietary patterns are often computed by cluster analysis and principal component analysis (PCA). However, PCA does not create distinct groups of individuals with different dietary habits; moreover the choice of the clustering method and of the number of clusters in cluster analysis remains difficult. On the other hand, finite mixture models (FMM) do not have those limitations and have many other advantages. However, they have been rarely used in dietary pattern analysis. Objective The objective of this study was to use FMM to compute dietary patterns based on data from the NESCaV survey (Nutrition, Environment and Cardiovascular Health), a large population-based study carried out between 2007 and 2011among the Greater Region population (N=2298 subjects). Methods A 134-food frequency questionnaire was used to assess dietary intakes. The most appropriate parameterization of the covariance matrix and number of clusters was chosen on the basis of the Bayesian information criterion (BIC). Results Four dietary patterns were determined. A ”non-prudent” and a “prudent” patterns were characterized respectively by non-healthy and healthy food choices. A “breakfast/low alcohol” pattern was characterized by high intakes of food items usually consumed at breakfast. Finally, a “vegetables/dairy products/low carbohydrate” pattern was characterized by low intakes of carbohydrates but high intakes of vegetables, pulses, fruits, animal protein and fat mostly from dairy products. The “non-prudent” pattern was the most prevalent with 34% of the population assigned to this cluster. The “prudent”, “breakfast/low alcohol” and “vegetables/dairy products/low carbohydrate” patterns accounted respectively for 25%, 29% and 19% of the population, respectively. Women, older people and non-smokers followed the “prudent” and “breakfast/low alcohol”, whereas the “non-prudent” and “vegetables/dairy products/low carbohydrate” were more adopted by men and smokers. In addition, the “non-prudent” pattern was associated with higher cardiovascular risk. Conclusion FMM should be considered more often as they do not have limitations encountered with other methods and are not restrictive on cluster geometry. Moreover, this study highlights the need for targeted health promotion campaigns focussing on the benefits of healthy dietary patterns. [less ▲]

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See detailComparaison de deux méthodes statistiques explorant la relation entre régimes alimentaires et risques cardiovasculaires.
Sauvageot, Nicolas ULiege; Leite, Sonia; Donneau, Anne-Françoise ULiege et al

Poster (2016, September)

Introduction L’analyse en composantes principales (ACP) et la régression à rangs réduits (RRR) sont deux méthodes de réduction de dimension permettant de construire des variables reflétant des régimes ... [more ▼]

Introduction L’analyse en composantes principales (ACP) et la régression à rangs réduits (RRR) sont deux méthodes de réduction de dimension permettant de construire des variables reflétant des régimes alimentaires. Les régimes alimentaires obtenus par ACP sont associés aux habitudes alimentaires de la population étudiée tandis que ceux obtenus par RRR sont associés à des indicateurs d’intérêt. L’objectif de cette étude est de comparer les deux approches quant aux régimes alimentaires obtenus et à leurs associations avec les facteurs de risques cardiovasculaires (FRCV). Méthodologie Les données proviennent de l’étude interrégionale et transversale nutrition, environnement et santé cardiovasculaire (NESCAV) ayant pour but de décrire la santé cardiovasculaire de la grande région (Luxembourg, Lorraine et Wallonie). Les apports alimentaires ont été mesurés à l’aide d’un questionnaire de fréquence alimentaire et 2298 individus ont été retenus pour cette analyse. Les indicateurs d’intérêt retenus pour l’approche RRR sont les FRCV usuels (obésité, hypertension, diabète, dyslipidémie). Résultats Nous avons trouvé que les régimes alimentaires consommés par la population et ceux associés au FRCV étaient similaires. Les régimes riches en fruits, fruits secs et oléagineux, légumes, huile d’olive, graisse riche en oméga 6, thé, et ceux pauvres en aliments frits, viandes, charcuteries, soda, plats préparés, bières étaient associés à une diminution des FRCV. Les autres régimes caractérisés par des apports élevés en aliments frits, viandes, abats, bières, vins, apéritifs et liqueurs et de faibles apports en céréales, sucres et soda étaient associés à une augmentation des FRCV. Conclusions L’utilisation des deux méthodes est utile pour obtenir des informations permettant d’élaborer de nouvelles recommandations alimentaires. Les régimes alimentaires identifiés dans cette étude sont à la fois associés aux habitudes alimentaires de la population et aux FRCV. [less ▲]

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See detailAssociation of Empirically Derived Dietary Patterns with Cardiovascular Risk Factors: A Comparison of PCA and RRR Methods
Sauvageot, Nicolas ULiege; Leite, sonia; Alkerwi, Ala'a et al

in PLoS ONE (2016), 11(8),

Abstract Introduction Principal component analysis is used to determine dietary behaviors of a population whereas reduced rank regression is used to construct disease-related dietary patterns. This study ... [more ▼]

Abstract Introduction Principal component analysis is used to determine dietary behaviors of a population whereas reduced rank regression is used to construct disease-related dietary patterns. This study aimed to compare both types of DP and theirs associations with cardiovascular risk factors (CVRF). Materiel and Methods Data were derived from the cross sectional NESCAV (Nutrition, Environment and Cardiovascular Health) study, aiming to describe the cardiovascular health of the Greater region’s population (Grand duchy of Luxembourg, Wallonia (Belgium), Lorraine (France)). 2298 individuals were included for this study and dietary intake was assessed using a 134-item food frequency questionnaire. Results We found that CVRF-related patterns also reflect eating behaviours of the population. Comparing concordant food groups between both dietary pattern methods, a diet high in fruits, oleaginous and dried fruits, vegetables, olive oil, fats rich in omega 6 and tea and low in fried foods, lean and fatty meat, processed meat, ready meal, soft drink and beer was associated with lower prevalence of CVRF. In the opposite, a pattern characterized by high intakes of fried foods, meat, offal, beer, wine and aperitifs and spirits, and low intakes of cereals, sugar and sweets and soft drinks was associated with higher prevalence of CVRF. Conclusion In sum, we found that a “Prudent” and “Animal protein and alcohol” patterns were both associated with CVRF and behaviourally meaningful. Moreover, the relationships of those dietary patterns with lifestyle characteristics support the theory that food choices are part of a larger pattern of healthy lifestyle. [less ▲]

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See detailMultimodal evoked potentials for functional quantification and prognosis in multiple sclerosis
GIFFROY, Xavier ULiege; MAES, Nathalie ULiege; Albert, Adelin ULiege et al

in BMC Neurology (2016)

Functional biomarkers able to identify multiple sclerosis (MS) patients at high risk of fast disability progression are lacking. The aim of this study was to evaluate the ability of multimodal (upper and ... [more ▼]

Functional biomarkers able to identify multiple sclerosis (MS) patients at high risk of fast disability progression are lacking. The aim of this study was to evaluate the ability of multimodal (upper and lower limbs motor, visual, lower limbs somatosensory) evoked potentials (EP) to monitor disease course and identify patients exposed to unfavourable evolution. One hundred MS patients were assessed with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) at baseline (T0) and about 6 years later (T1). The Spearman correlation (rS) was used to evaluate the relationship between conventional EP scores and clinical findings. Multiple (logistic) regression analysis estimated the predictive value of baseline electrophysiological data for three clinical outcomes: EDSS, annual EDSS progression, and the risk of EDSS worsening. In contrast to longitudinal correlations, cross-sectional correlations between the different EP scores and EDSS were all significant (0.33 ≤ rS < 0.67, p < 0.001). Baseline global EP score and EDSS were highly significant predictors (p < 0.0001) of EDSS progression 6 years later. The aseline global EP score was found to be an independent predictor of the EDSS annual progression rate (p < 0.001), and of the risk of disability progression over time (p < 0.005). Based on a ROC curve determination, we defined a Global EP Score cut off point (17/30) to identify patients at high risk of disability progression illustrated by a positive predictive value of 70 %. This study provides a proof of the concept that electrophysiology could be added to MRI and used as another complementary prognostic tool in MS patients. [less ▲]

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See detailThree-dimensional analysis of craniofacial bones and soft tissues in obstructive sleep apnea using cone beam computed tomography
BRUWIER, Annick ULiege; Poirrier, Robert ULiege; Albert, Adelin ULiege et al

in International Orthodontics (2016), 14

A total of 154 adult patients with sleep complaints underwent a polysomnography and a craniofacial cone beam computed tomography (CBCT). OSA was defined as an apnea and hypopnea index (AHI) or an oxygen ... [more ▼]

A total of 154 adult patients with sleep complaints underwent a polysomnography and a craniofacial cone beam computed tomography (CBCT). OSA was defined as an apnea and hypopnea index (AHI) or an oxygen desaturation index (ODI) + or = 10. Soft tissues and craniofacial bones volumes were prospectively measured by CBCT and collected blindly from sleep polysomnography. Among the study patients, 127 (83%) suffered from OSA and 27 (17%) did not. OSA patients demonstrated a narrower maxillo-palatine core volume (11.7 + or - 3.2 vs 14.6 + or - 4.9 cm3) even when adjusting for age, gender, height, neck circumference and body mass index. These upper airway measures provide a comprehensive analysis of bony structures and soft tissues, which can be involved in OSA. [less ▲]

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See detailKnowledge, attitudes and clinical practice of blood products prescribers in Niamey.
Mayaki, Z.; Kabo, R.; Moutschen, Michel ULiege et al

in Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine (2016), 23(2), 78-85

AIM OF THE STUDY: The lack of traceability and monitoring of blood donors and transfused patients constitute a barrier to the most basic rules of haemovigilance and overall good transfusion practices ... [more ▼]

AIM OF THE STUDY: The lack of traceability and monitoring of blood donors and transfused patients constitute a barrier to the most basic rules of haemovigilance and overall good transfusion practices. This study draws up an inventory of knowledge, attitudes and clinical practice of blood prescribers in Niamey. MATERIALS AND METHODS: A questionnaire was administered to 180 prescribers of blood products in Niamey in 2011. Questions were related to basic informations on blood transfusion and clinical use of blood. Analyses were performed using SAS 9.3 version. RESULTS: The sample consisted of 180 respondents from several professional categories: 51 physicians (28.33%), 10 medical students (5.56%), 84 nurses (46.67%), 15 anaesthesiologist assistant (8.33%) and 20 midwives (11.11%). Among these, 22.2% received training in blood transfusion safety. Half of the respondents (50.8%) got between 50 and 75% of correct answers, 45.8% got less than 50% correct while 3.35% scored more than 75% correct answers. The overall quality of responses was higher among physicians compared to other prescribers (P<0.0001); among respondents who received training in transfusion safety (P<0.0001); and among males (P=0.0306). For some items, subjects with more experience scored the best. CONCLUSION: The level of knowledge is still inadequate. More training in transfusion practices is necessary for prescribers of blood products. Accompanying measures to improve transfusion practice must be considered or strengthened through assessments, knowledge update/upgrade (regular, ongoing training) and establishment of active and motivated hospital transfusion committees. [less ▲]

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See detailQuality of documentation on antibiotic therapy in medical records: evaluation of combined interventions in a teaching hospital by repeated point prevalence survey.
VERCHEVAL, Christelle ULiege; GILLET, Manon ULiege; MAES, Nathalie ULiege et al

in European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology (2016), 35(9), 14951500

This study aimed to improve the quality of documentation on antibiotic therapy in the computerized medical records of inpatients. A prospective, uncontrolled, interrupted time series (ITS) study was ... [more ▼]

This study aimed to improve the quality of documentation on antibiotic therapy in the computerized medical records of inpatients. A prospective, uncontrolled, interrupted time series (ITS) study was conducted by repeated point prevalence survey (PPS) to audit the quality of documentation on antibiotic therapy in the medical records before and after a combined intervention strategy (implementation of guidelines, distribution of educational materials, educational outreach visits, group educational interactive sessions) from the antimicrobial stewardship team (AST) in the academic teaching hospital (CHU) of Liege, Belgium. The primary outcome measure was the documentation rate on three quality indicators in the computerized medical records: (1) indication for treatment, (2) antibiotics prescribed, and (3) duration or review date. Segmented regression analysis was used to analyze the ITS. The medical records of 2306 patients receiving antibiotics for an infection (1177 in the pre-intervention period and 1129 in the post-intervention period) were analyzed. A significant increase in mean percentages in the post-intervention period was observed as compared with the pre-intervention period for the three quality indicators (indication documented 83.4 +/- 10.4 % vs. 90.3 +/- 6.6 %, p = 0.0013; antibiotics documented 87.9 +/- 9.0 % vs. 95.6 +/- 5.1 %, p < 0.0001; and duration or review date documented 31.9 +/- 15.4 % vs. 67.7 +/- 15.2 %, p < 0.0001). The study demonstrated the successful implementation of a combined intervention strategy from the AST. This strategy was associated with significant changes in the documentation rate in the computerized medical records for the three quality indicators. [less ▲]

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See detailBody image discrepancy and subjective norm as mediators and moderators of the relationship between body mass index and quality of life
Pétré, Benoît ULiege; Scheen, André ULiege; ziegler, olivier et al

in Patient Preference and Adherence (2016), 10

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