References of "Ackerman, Francine"
     in
Bookmark and Share    
Peer Reviewed
See detailDiversity of the Mechanisms of Resistance to Beta-Lactam Antibiotics
Frère, Jean-Marie ULg; Joris, Bernard ULg; Granier, B. et al

in Research in Microbiology (1991), 142(6, Jul-Aug), 705-10

The sensitivity of a bacterium to beta-lactam antibiotics depends upon the interplay between 3 independent factors: the sensitivity of the essential penicillin-binding enzyme(s), the quantity and ... [more ▼]

The sensitivity of a bacterium to beta-lactam antibiotics depends upon the interplay between 3 independent factors: the sensitivity of the essential penicillin-binding enzyme(s), the quantity and properties of the beta-lactamase(s) and the diffusion barrier that the outer-membrane of Gram-negative bacteria can represent. Those three factors can be modified by mutations or by the horizontal transfer of genes or portions of genes. [less ▲]

Detailed reference viewed: 41 (3 ULg)