References of "de LA BRASSINNE, Michel"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailHistological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: an approach of vascular development chronology in psoriasis
Henno, Audrey ULg; Blacher, Silvia ULg; Lambert, Charles ULg et al

in Journal of Dermatological Science (2010), 57(3), 162-169

Background Dysregulation of angiogenesis and lymphangiogenesis could participate in psoriasis pathogenesis. Analysis of nascent psoriasis lesions should help at identifying early vascular anomalies ... [more ▼]

Background Dysregulation of angiogenesis and lymphangiogenesis could participate in psoriasis pathogenesis. Analysis of nascent psoriasis lesions should help at identifying early vascular anomalies. Objective To analyse vascular development, angiogenesis and lymphangiogenesis markers expression in uninvolved skin in psoriatic patients (N), early psoriasis lesions or pinpoints (PP) and psoriasis plaques (PSO). Methods Skin biopsies were taken in 17 patients in N and in PSO and/or PP. The mRNA steady-state level of angiogenesis and lymphangiogenesis markers was measured by RT-PCR. Immunohistochemistry was performed for von Willebrand factor, podoplanin, Ki-67 and VEGFR3. Blood (BV) and lymphatic (LV) vessels expansion was measured by computer-assisted morphometry. Results Clinical and epidermal aspects indicated that PP are intermediate between N and PSO. While total BV area was already increased in PP similarly to PSO as compared to N, LV area in PP was intermediate between N and PSO. Mean LV size was identical in N and PP and increased in PSO, mean BV size in PP being intermediate between N and PSO. VEGF-A 189 variant was increased in PP as compared to N and PSO. As compared to N, angiogenesis markers (VEGF-A isoforms, PlGF, VEGFR2, NRP-1), VEGF-C and NRP-2 were similarly increased in PP and PSO. Keratin 16 and the lymphangiogenesis markers (VEGFR3, prox-1) were intermediate in PP. Conclusion These data suggest that the expansion of lymphatic vessels occurs after blood vascular development in psoriasis. Expansion of BV in PP could be followed by vessel enlargement during progression to PSO, in parallel with a decreased VEGF-A 189/VEGF-A 121 balance in plaques [less ▲]

Detailed reference viewed: 61 (6 ULg)
See detailKératoses actiniques sous la loupe.
PIERARD, Gérald ULg; BASSET-SEGUIN, N.; HENGGE, U. et al

Book published by Publ. Artoos (2009)

Actinic keratoses are common lesions caused by the cumulative action of the sun’s rays on the skin of predisposed individuals. They generally develop in seniors, but they may be earlier in those who have ... [more ▼]

Actinic keratoses are common lesions caused by the cumulative action of the sun’s rays on the skin of predisposed individuals. They generally develop in seniors, but they may be earlier in those who have an occupational activity outside or who spend a lot of spare time under the sun. The depletion of the ozone layer might also be involved. [less ▲]

Detailed reference viewed: 35 (5 ULg)
See detailActinic keartosis under scrutiny: 20 questions and answers
PIERARD, Gérald ULg; BASSET-SEGUIN, N.; HENGGE, U. et al

Book published by Artoos (2009)

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailScedosporium apiospermum septicemia following a wedge excision of an ingrown toenail.
Vanhooteghem, Olivier ULg; Gillard, Patricia ULg; Dezfoulian, Bita ULg et al

in International Journal of Dermatology (2009), 48(10), 1137-1139

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailLes allergies aux plantes d'intérieur
Wauters, Odile ULg; Dezfoulian, Bita ULg; Failla, Valérie ULg et al

in Revue Médicale de Liège (2009)

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailAltered expression of angiogenesis and lymphangiogenesis markers in the uninvolved skin of plaque-type psoriasis
Henno, Audrey ULg; Blacher, Silvia ULg; Lambert, Charles ULg et al

in British Journal of Dermatology (2009), 160(3), 581-90

Background Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the ... [more ▼]

Background Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder in the mechanisms regulating skin angiogenesis and lymphangiogenesis could participate in the pathogenesis of the disease. Objectives To quantify differences in the expression of angiogenesis and lymphangiogenesis growth factors, receptors, coreceptors as well as their antagonists in the uninvolved skin of patients with psoriasis compared with the skin of nonpsoriatic volunteers. Methods Skin biopsies were collected from the involved skin of 13 patients with untreated plaque-type psoriasis, from their nonlesional skin at distance from the lesions and from the skin of 16 healthy volunteers. The mRNA steady-state level of keratins 10, 14 and 16, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), vimentin, collagen I and IV, proliferating cell nuclear antigen, the various splice variants of vascular endothelial growth factor, VEGF-A, VEGF-C and VEGF-D, their receptors VEGFR1, VEGFR2 and VEGFR3, neuropilin (NRP)-1 and its soluble forms, NRP-2, semaphorin 3A and prox-1, was measured by reverse transcription–polymerase chain reaction. Immunohistochemistry was performed for Ki-67, von Willebrand factor and D2-40. Blood and lymphatic vessel density, area and distance from epidermis were estimated by morphological analysis coupled to an original computer-assisted method of quantification. Results Skin from healthy volunteers and nonlesional skin from patients with psoriasis displayed similar histological, morphometric and proliferative features. However, a significant overexpression of VEGFR3, the VEGF-A isoform VEGF121, soluble 12 NRP-1 and GAPDH was observed in the nonlesional psoriatic skin as compared with that of normal volunteers. Conclusions These data point to significant differences in the blood and lymphatic vascular transcriptome between the clinically normal-appearing skin of patients with psoriasis and the skin of volunteers without psoriasis. [less ▲]

Detailed reference viewed: 122 (54 ULg)
Full Text
Peer Reviewed
See detailCosmetic surgery for congenital nail deformities
Richert, Bertrand ULg; Choffray, Alexandre ULg; de LA BRASSINNE, Michel ULg

in Journal of Cosmetic Dermatology (2008), 7

Only a few nail dystrophies may be improved by surgery: malalignment of the big toenail, racquet thumbs, trapezoidal nails, and vertical implantation of the nail on the fifth toe. Knowledge of the ... [more ▼]

Only a few nail dystrophies may be improved by surgery: malalignment of the big toenail, racquet thumbs, trapezoidal nails, and vertical implantation of the nail on the fifth toe. Knowledge of the surgical management of these deformities may allow a nice cosmetic outcome if performed by skilled surgeons. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detailLe systeme vasculaire lymphatique: etats des connaissances et implications dermatologiques potentielles.
Henno, Audrey ULg; Lapiere, ChM; Nusgens, Betty ULg et al

in Annales de Dermatologie et de Vénéréologie (2008), 135(10), 704-9

Detailed reference viewed: 97 (9 ULg)
Full Text
Peer Reviewed
See detailLe traitement biologique des maladies inflammatoires à médiation immune. Le cas de la dermatologie et de la rhumatologie
Von Frenckell, Christian ULg; Henno, Audrey ULg; de LA BRASSINNE, Michel ULg et al

in Revue Médicale de Liège (2007), 62(Spec No), 55-62

The pathophysiology and the treatment of diseases with clinical presentation so different as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis vulgaris have been ... [more ▼]

The pathophysiology and the treatment of diseases with clinical presentation so different as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis vulgaris have been revolutionized by the discovery of common pro-inflammatory effector mechanisms involving TNF-alpha and by the use of targeted therapies, the anti-TNF-alpha antibodies. In the past 10 years, our experience has helped several hundreds of patients who were treated with novel drugs, years before they became routinely available. In parallel tools of metrology were developped that can now be applied to the routine patient. Lastly, clinical research on these new drugs has also generated derived research works allowing the university hospital to satisfactorilly fullfil its specific missions. [less ▲]

Detailed reference viewed: 216 (6 ULg)
Full Text
See detailUn ongle d'inclusion: une complication de la cure chirurgicale d'ongle incarne selon la technique de Zadik
Vanhooteghem, Olivier ULg; Henrijean, A.; André, Jean-François ULg et al

in Annales de Dermatologie et de Vénéréologie (2006), 133(12), 1009-10

Detailed reference viewed: 39 (1 ULg)
Full Text
Peer Reviewed
See detailLa comparaison des taux de sensibilisation IgE-dépendante aux moisissures, aux dermatophytes et aux levures dans les maladies allergiques générales et les dermatoses inflammatoires
Dezfoulian, Bita ULg; de LA BRASSINNE, Michel ULg

in Revue Française d'Allergologie et d'Immunologie Clinique (2006), 46

We aimed to determine IgE-dependant skin sensitization rates to moulds, dermatophytes and yeasts in patients with typical allergic diseases in comparison to those with inflammatory dermatitis seen over ... [more ▼]

We aimed to determine IgE-dependant skin sensitization rates to moulds, dermatophytes and yeasts in patients with typical allergic diseases in comparison to those with inflammatory dermatitis seen over the course of one year. Skin prick tests were done in 267 patients (172 women and 95 men; median age 38 years, range 25–50 years). We allocated them into 8 groups: 64 with head and neck atopic dermatitis; 11 with seborrheic dermatitis; 52 with eczema and not atopic dermatitis other than on the head and neck; 64 with rhinitis, conjunctivitis and asthma; 28 with urticaria; 10 with food allergy; and 12 healthy controls. Skin tests were done with the following aqueous standardized commercial extracts: Alternaria, Penicillium, Aspergillus, Cladosporium, Mucor, Trichophyton, Epidermophyton, Candida albicans, Malassezia and Saccharomyces cerevisiæ. Globally, positive skin test reactions occurred most frequently with the yeast extracts, less to the dermatophytes and even less to the moulds. The results were homogenous among members of each group. The relevance of our tests was reinforced by the fact that the moulds that gave positive skin tests most frequently were those most often isolated in the Belgian environment. In patients with atopic dermatitis of the head and neck, positive tests were most frequent with four moulds and three yeasts; compared to this group, positive tests were less frequent in patients with atopic dermatitis localized to other sites. In inflammatory dermatitis of the head and neck, the study of immediate hypersensitivity to yeasts seems to be important. [less ▲]

Detailed reference viewed: 52 (0 ULg)
Full Text
Peer Reviewed
See detailPsoriasis et arthrite psoriasique
Henno, Audrey ULg; Rausin, Annick ULg; Malaise, Michel ULg et al

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 334-340

Psoriasis is a frequent multifactorial chronic skin disease that can lead to a decreased quality of life. Some patients also present arthritis. Those two complex inflammatory diseases share some of their ... [more ▼]

Psoriasis is a frequent multifactorial chronic skin disease that can lead to a decreased quality of life. Some patients also present arthritis. Those two complex inflammatory diseases share some of their characteristics, but several clinical manifestations can be distinguished in each of them. In addition to classical medications (constituted of topical treatments, methotrexate, ciclosporin and retinoids for cutaneous psoriasis and non steroidal anti-inflammatory drugs or methotrexate for psoriatic arthritis), they are the target of a new generation of therapies: the biologics. [less ▲]

Detailed reference viewed: 67 (2 ULg)
Full Text
Peer Reviewed
See detailLe lichen sclereux vulvaire
Gillard, Patricia ULg; Vanhooteghem, Olivier ULg; Richert, Bertrand ULg et al

in Revue Médicale de Liège (2005), 60(7-8), 656-660

Vulvar lichen sclerosus is a frequent mucocutaneous disease especially affecting 50 to 60 year-old women but with a possible onset at very young age. Symptoms are most disabling including pruritus and ... [more ▼]

Vulvar lichen sclerosus is a frequent mucocutaneous disease especially affecting 50 to 60 year-old women but with a possible onset at very young age. Symptoms are most disabling including pruritus and dyspareunia. Vulvar mucosa gradually becomes more white and atrophied. Degeneration into epidermoid carcinoma is possible. Treatment only consists of topical corticosteroids. [less ▲]

Detailed reference viewed: 162 (4 ULg)
Full Text
See detailCheloide et cicatrice hypertrophique
Mostinckx, S.; Vanhooteghem, Olivier ULg; Richert, Bertrand ULg et al

in Annales de Dermatologie et de Vénéréologie (2005), 132(4), 384-7

Detailed reference viewed: 59 (12 ULg)
Full Text
Peer Reviewed
See detailComment je traite ... les varicosités par sclérothérapie
Mostinckx, S.; Dezfoulian, Bita ULg; Richert, Bertrand ULg et al

in Revue Médicale de Liège (2005), 60(2), 77-80

Sclerotherapy is a technique for the treatment of varicosities, vascular ectasia, and sometimes, leg varicose veins. This method is aesthetic and in some cases therapeutics and uses sclerosing agents ... [more ▼]

Sclerotherapy is a technique for the treatment of varicosities, vascular ectasia, and sometimes, leg varicose veins. This method is aesthetic and in some cases therapeutics and uses sclerosing agents, electrocoagulation and exceptionally LASER. These relatively simple methods are safe and efficient if they are applied with a rigorous procedure by well trained physicians. [less ▲]

Detailed reference viewed: 25 (0 ULg)
Full Text
Peer Reviewed
See detailÉtude comparative des « prick » et « patch » tests aux moisissures, aux dermatophytes et aux levures dans la dermatite atopique de la tête et du cou, la dermatite séborrhéique et le sébopsoriasis
Dezfoulian, Bita ULg; de LA BRASSINNE, Michel ULg

in Revue Française d'Allergologie et d'Immunologie Clinique (2005), 45

Aim of the study. – The capacity of fungi to induce eczema in head and neck dermatitis has already been studied. Malassezia has often been implicated in two other dermatitis of the cephalic region ... [more ▼]

Aim of the study. – The capacity of fungi to induce eczema in head and neck dermatitis has already been studied. Malassezia has often been implicated in two other dermatitis of the cephalic region (seborrhoeic dermatitis and sebopsoriasis).We have explored the cellular and IgE dependant reactions to different groups of fungi in these three dermatitis using “patch” and “prick” tests. Tested allergens were: Alternaria, Penicillium, Aspergillus, Cladosporium, Trichophyton, Epidermophyton, Candida albicans, Malassezia, Saccharomyces cerevisiae. Material and methods. – Seventy persons including 42 females (60%) and 28 males (40%) aged 40 years old in average were distributed in four groups: Head and neck dermatitis (24 patients), seborrheic dermatitis of the face (21 patients) and sebopsoriasis of the face (10 patients) compared to 15 controls without these dermatoses. Results and conclusions. – Globally, in “prick” and “patch” tests, yeasts had the highest number of positivity comparing to the two other groups. Malassezia was the leader in “prick tests”. In “patch tests”, the global results showed a positivity rate, which was clearly lower than those in “prick tests”. Detailed analysis of the results revealed that in the head and neck dermatitis the highest number of positive “patch tests” for all of these allergens is found. For the three other groups, no significant difference for these two techniques for any of these allergens has been detected. [less ▲]

Detailed reference viewed: 45 (2 ULg)
Full Text
Peer Reviewed
See detailHyperkeratotic nail discoid lupus erythernatosus evolving towards systemic lupus erythematosus: therapeutic difficulties
Richert, Bertrand ULg; André, J.; Bourguignon, R. et al

in Journal of the European Academy of Dermatology & Venereology (2004), 18(6), 728-730

Nail changes occur in about 25% of systemic lupus erythematosus (SLE) cases. Onycholysis has been reported as the most frequent abnormality in SLE. Nailbed hyperkeratosis may be observed in both SLE and ... [more ▼]

Nail changes occur in about 25% of systemic lupus erythematosus (SLE) cases. Onycholysis has been reported as the most frequent abnormality in SLE. Nailbed hyperkeratosis may be observed in both SLE and discoid lupus erythematosus (DLE). Involvement of the nail apparatus in DLE is extremely uncommon and never restricted to it. We report on a patient in whom the clinical features on the proximal nailfold were similar to those observed on the skin of a patient with typical DLE. This has, to the best of our knowledge, not yet been reported. The patient also exhibited a very distinctive prominent subungual hyperkeratosis. Interestingly, the patient developed biological alterations suggesting a systematization of the disease. Only a combination of systemic corticoids, retinoids and antimalarials was able to achieve nail improvement and this partial resistance to therapy may be explained by the very unusual subungual hyperkeratosis. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailPeriungual lipoma: About three cases
Richert, Bertrand ULg; André, J.; Choffray, Alexandre ULg et al

in Journal of the American Academy of Dermatology (2004), 51(2 Suppl), 91-93

Lipomas are one of the most common benign soft tissue tumors. The usual development sites are the neck, the torso, and the legs. Lipomas of the nail unit are extremely rare. Only five cases have been ... [more ▼]

Lipomas are one of the most common benign soft tissue tumors. The usual development sites are the neck, the torso, and the legs. Lipomas of the nail unit are extremely rare. Only five cases have been reported tip to now. four in subungual locations and one in the lateral nail fold. We report three cases of peri-Lingual lipomas, one on the digit and two on the toes. Two of them exhibited the histological features of perisudoral lipomas. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailLes xanthomes
de Schaetzen, V.; Richert, Bertrand ULg; de LA BRASSINNE, Michel ULg

in Revue Médicale de Liège (2004), 59(1), 46-50

Xanthomas are cutaneous lesions due to a local accumulation of spumous cells in the dermal tissue or the tendons. Histologically, they are characterized by the presence of histiocytes, fibroblasts ... [more ▼]

Xanthomas are cutaneous lesions due to a local accumulation of spumous cells in the dermal tissue or the tendons. Histologically, they are characterized by the presence of histiocytes, fibroblasts, macrophages and Touton cells full of lipids. Xanthomas may be found on any part of the body and are usually yellow-orange in color. They may or may not be associated to hyperlipoproteinemia which may be genetic or secondary. A blood test and a complete physical examination are necessary in case such a lesion is discovered. When there is no hyperlipemia some types of xanthomas may be associated to rare diseases. Xanthomas are classified according to their clinical features. [less ▲]

Detailed reference viewed: 24 (4 ULg)
Full Text
Peer Reviewed
See detailUne bouche en or
Dezfoulian, Bita ULg; Henno, Audrey ULg; Jason, Françoise ULg et al

in Revue Française d'Allergologie et d'Immunologie Clinique (2004), 44

Contact dermatitis to gold has rarely been reported. This precious metal is generally considered as inert, insoluble and resistant to corrosion. Nevertheless, gold salts have a strong potential for ... [more ▼]

Contact dermatitis to gold has rarely been reported. This precious metal is generally considered as inert, insoluble and resistant to corrosion. Nevertheless, gold salts have a strong potential for sensitization. This condition can occur after contact with gold jewellery and dental alloys, after systemic therapy with gold salts and after occupational contact. The lesions may be expressed as contact dermatitis on the face, ear, neck and/or fingers, and as lichen planus and/or lichenoid stomatitis. The dermatitis is usually not very irritating and the lesions are rarely persistent. Diagnosis is based on the clinical history and examination, on the nature of the exposure sources, and on the results of patch tests with gold sodium thiosulfate (GSTS) at 0.5% in petrolatum. The patch test is read on days 2 and 3 and again after 1 and 3 weeks. Allergen avoidance can be expensive and tiresome, and improvement is not guaranteed.We report the case of a female patient who came to us complaining of burning in her mouth. She had polymetallism and lichenoid lesions facing gold tooth crowns. Patch tests were positive to GSTS at 72 h and at 1 week. Replacement of the gold crowns led to total disappearance of her symptoms within 1 year. Local factors, including humidity, temperature, acid pH, abrasion and contact with substance such as amino acids, bring about the liberation of the sensitizing metallic salts, which may be enhanced by galvanic corrosion secondary to the polymetallism. [less ▲]

Detailed reference viewed: 30 (0 ULg)