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See detailIn Vitro Study of the Antioxidant Properties of Nimesulide and 4-Oh Nimesulide: Effects on Hrp- and Luminol-Dependent Chemiluminescence Produced by Human Chondrocytes
Zheng, S. X.; Mouithys-Mickalad, Ange ULg; Deby-Dupont, G. P. et al

in Osteoarthritis and Cartilage (2000), 8(6), 419-25

OBJECTIVES: Reactive oxygen species (ROS) are now recognized to play an important role in the pathogenesis of rheumatic diseases and constitute an interesting therapeutic target for drugs. This in vitro ... [more ▼]

OBJECTIVES: Reactive oxygen species (ROS) are now recognized to play an important role in the pathogenesis of rheumatic diseases and constitute an interesting therapeutic target for drugs. This in vitro study was designed to evaluate the antioxidant properties of nimesulide (NIM), a nonsteroidal antiinflammatory drug of the sulfonanilide class, and its main metabolite 4-OH nimesulide (4-OHNIM). METHODS: The scavenging effects of NIM and 4-OH NIM on hydroxyl radical ((.)OH) and superoxide anions (O(minusd)(2)) were investigated by electron spin resonance (ESR), using 5, 5-dimethylpyrroline-N-oxide (DMPO) as the spin trap agent. The quenching properties of these drugs on hypochlorite anion was studied by luminol enhanced chemiluminescence. Finally, the effects of NIM and 4-OHNIM on the reactive oxygen species production by human articular chondrocytes were recorded by HRP and luminol-enhanced chemiluminescence. RESULTS: By this method it has been demonstrated that NIM and 4-OHNIM, at concentrations ranging from 10 to 100 microM, are potent scavengers of(.)OH whereas only 4-OHNIM was capable to scavenge O(minusd)(2). Chemiluminescence generated by HOCl was also significantly and dose-dependently inhibited by both NIM and 4-OHNIM. Nevertheless, at each concentration tested, the inhibitory effect of 4-OHNIM was significantly more marked, even at the highest concentration (100 microM). Furthermore, when chondrocytes were pre-incubated for 48-96 h with NIM or 4-OHNIM, the luminol- and HRP-dependent CL produced by the cells was significantly inhibited in a dose-dependent manner. CONCLUSIONS: NIM and 4-OHNIM may protect cartilage against oxidative stress, not only by scavenging ROS but also by inhibiting their production by chondrocytes. [less ▲]

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See detailThe antioxidant properties of non stroidal anti-inflammatory drugs
Henrotin, Yves ULg; Mouithys-Mickalad, Ange ULg; Mathy-Hartert, M et al

in Osteoarthritis and Cartilage (2000), 8

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See detailIn vitro models for the study of cartilage damage and repair
Henrotin, Yves ULg; Labasse, A; Zheng, SX et al

in Rheumatology in Europe (1998), 27(S2), 7

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See detailL’INF gamma est un inhibiteur puissant de la synthèse d’IL-8 par les chondrocytes humains
Henrotin, Yves ULg; Zheng, SX; Deby, G et al

in Revue du Rhumatisme (1998), 11

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See detailEffets du monoxyde d’azote (NO) sur le métabolisme des chondrocytes
Henrotin, Yves ULg; Zheng, SX; Deby, G et al

in Revue du Rhumatisme (1998), 11

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See detailIFN gamma inhibits IL-8 production by IL-1bêta and TNFalpha stimulated human chondrocytes
Henrotin, Yves ULg; Zheng, SX; Deby, G et al

in Revue du Rhumatisme (English ed.) (1998), 11

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See detailNitric oxid (NO) down-regulates cytokines and PGE2 production by human chondrocytes
Henrotin, Yves ULg; Zheng, SX; Deby, G et al

in Revue du Rhumatisme (English ed.) (1998), 11

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See detailRegulatory role of nitric acid (NO) in chondrocyte responses to cytokines
Henrotin, Yves ULg; Zheng, SX; Deby, G et al

in BONE (1998), 23(S5), 344

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See detailS12911, a new divalent strontium salt stimulates cartilage matrix formation
Henrotin, Yves ULg; Labasse, A; Zheng, SX et al

in Revue du Rhumatisme (English ed.) (1996), 63

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See detailEffets d’un sel de strontium (S12911) sur le métabolisme des chondrocytes articulaires humains in vitro
Henrotin, Yves ULg; Labasse, A; Zheng, SX et al

in Revue du Rhumatisme (1996), 63

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See detailInterleukine 1 et métabolisme osseux
Reginster, Jean-Yves ULg; Zheng, SX

in Revue du Praticien (La) (1996), 46

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See detailEffects of three avocado/soybean unsaponifiable mixtures on human chondrocytes metabolism
Henrotin, Yves ULg; Labasse, A; Zheng, SX et al

in Arthritis and Rheumatism (1996), 39

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See detailIncrease in IL-1bêta, IL-6, and TNF-alpha production in postmenopausal osteoporosis
Zheng, SX; Geenen, Vincent ULg; Vrindts, Y et al

in Osteoporosis International (1996), 6(S1), 101

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See detail25-OH vitamin D levels in healthy ambulatory postmenopausal women
DEROISY, Rita ULg; Albert, Adelin ULg; Zheng, SX et al

in Osteoporosis International (1996), 6(S1), 119

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