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See detailAdrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'etude des Tumeurs Endocrines database.
Gatta-Cherifi, B.; Chabre, O.; Murat, A. et al

in European Journal of Endocrinology (2012), 166(2), 269-279

Objective Limited data regarding adrenal involvement in multiple endocrine neoplasia type 1 (MEN1) is available. We describe the characteristics of MEN1-associated adrenal lesions in a large cohort to ... [more ▼]

Objective Limited data regarding adrenal involvement in multiple endocrine neoplasia type 1 (MEN1) is available. We describe the characteristics of MEN1-associated adrenal lesions in a large cohort to provide a rationale for their management. Methods Analysis of records from 715 MEN1 patients from a multicentre database between 1956 and 2008. Adrenal lesions were compared with those from a multicentre cohort of 144 patients with adrenal sporadic incidentalomas. Results Adrenal enlargement was reported in 20.4% (146/715) of patients. Adrenal tumours (>10 mm in size) accounted for 58.1% of these cases (10.1% of the whole patient cohort). Tumours were bilateral and >40 mm in size in 12.5 and 19.4% of cases respectively. Hormonal hypersecretion was restricted to patients with tumours and occurred in 15.3% of them. Compared with incidentalomas, MEN1-related tumours exhibited more cases of primary hyperaldosteronism, fewer pheochromocytomas and more adrenocortical carcinomas (ACCs; 13.8 vs 1.3%). Ten ACCs occurred in eight patients. Interestingly, ACCs occurred after several years of follow-up of small adrenal tumours in two of the eight affected patients. Nine of the ten ACCs were classified as stage I or II according to the European Network for the Study of Adrenal Tumors. No evident genotype/phenotype correlation was found for the occurrence of adrenal lesions, endocrine hypersecretion or ACC. Conclusions Adrenal pathology in MEN1 differs from that observed in sporadic incidentalomas. In the absence of relevant symptoms, endocrine biology can be restricted to patients with adrenal tumours and should focus on steroid secretion including the aldosterone-renin system. MEN1 is a high-risk condition for the occurrence of ACCs. It should be considered regardless of the size of the tumour. [less ▲]

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See detailMilli-arcsecond Astrophysics with VSI, the VLTI Spectro-imager in the ELT Era
Malbet, F.; Buscher, D.; Weigelt, G. et al

in Moorwood, Alan (Ed.) Science with the VLT in the ELT Era (2009)

Nowadays, compact sources relatively warm like surfaces of nearby stars, circumstellar environments of stars from early stages to the most evolved ones and surroundings of active galactic nuclei can be ... [more ▼]

Nowadays, compact sources relatively warm like surfaces of nearby stars, circumstellar environments of stars from early stages to the most evolved ones and surroundings of active galactic nuclei can be investigated at milli-arcsecond scales only with the VLT in its interferometric mode. We propose a spectro-imager, named VSI (VLTI spectro-imager), which is capable to probe these sources both over spatial and spectral scales in the near-infrared domain. This instrument will provide information complementary to what is obtained at the same time with ALMA at different wavelengths and the extreme large telescopes. [less ▲]

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See detailVSI: the VLTI spectro-imager
Malbet, F.; Buscher, D.; Weigelt, G. et al

in Schöller, Markus; Danchi, William; Delplancke, Françoise (Eds.) Optical and Infrared Interferometry (2008, July 01)

The VLTI Spectro Imager (VSI) was proposed as a second-generation instrument of the Very Large Telescope Interferometer providing the ESO community with spectrally-resolved, near-infrared images at ... [more ▼]

The VLTI Spectro Imager (VSI) was proposed as a second-generation instrument of the Very Large Telescope Interferometer providing the ESO community with spectrally-resolved, near-infrared images at angular resolutions down to 1.1 milliarcsecond and spectral resolutions up to R = 12000. Targets as faint as K = 13 will be imaged without requiring a brighter nearby reference object; fainter targets can be accessed if a suitable reference is available. The unique combination of high-dynamic-range imaging at high angular resolution and high spectral resolution enables a scientific program which serves a broad user community and at the same time provides the opportunity for breakthroughs in many areas of astrophysics. The high level specifications of the instrument are derived from a detailed science case based on the capability to obtain, for the first time, milliarcsecond-resolution images of a wide range of targets including: probing the initial conditions for planet formation in the AU-scale environments of young stars; imaging convective cells and other phenomena on the surfaces of stars; mapping the chemical and physical environments of evolved stars, stellar remnants, and stellar winds; and disentangling the central regions of active galactic nuclei and supermassive black holes. VSI will provide these new capabilities using technologies which have been extensively tested in the past and VSI requires little in terms of new infrastructure on the VLTI. At the same time, VSI will be able to make maximum use of new infrastructure as it becomes available; for example, by combining 4, 6 and eventually 8 telescopes, enabling rapid imaging through the measurement of up to 28 visibilities in every wavelength channel within a few minutes. The current studies are focused on a 4-telescope version with an upgrade to a 6-telescope one. The instrument contains its own fringe tracker and tip-tilt control in order to reduce the constraints on the VLTI infrastructure and maximize the scientific return. [less ▲]

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See detailSystem overview of the VLTI Spectro-Imager
Jocou, L.; Berger, J.-P.; Malbet, F. et al

in Schöller, Markus; Danchi, William; Delplancke, Françoise (Eds.) Optical and Infrared Interferometry (2008, July 01)

The VLTI Spectro Imager project aims to perform imaging with a temporal resolution of 1 night and with a maximum angular resolution of 1 milliarcsecond, making best use of the Very Large Telescope ... [more ▼]

The VLTI Spectro Imager project aims to perform imaging with a temporal resolution of 1 night and with a maximum angular resolution of 1 milliarcsecond, making best use of the Very Large Telescope Interferometer capabilities. To fulfill the scientific goals (see Garcia et. al.), the system requirements are: a) combining 4 to 6 beams; b) working in spectral bands J, H and K; c) spectral resolution from R= 100 to 12000; and d) internal fringe tracking on-axis, or off-axis when associated to the PRIMA dual-beam facility. The concept of VSI consists on 6 sub-systems: a common path distributing the light between the fringe tracker and the scientific instrument, the fringe tracker ensuring the co-phasing of the array, the scientific instrument delivering the interferometric observables and a calibration tool providing sources for internal alignment and interferometric calibrations. The two remaining sub-systems are the control system and the observation support software dedicated to the reduction of the interferometric data. This paper presents the global concept of VSI science path including the common path, the scientific instrument and the calibration tool. The scientific combination using a set of integrated optics multi-way beam combiners to provide high-stability visibility and closure phase measurements are also described. Finally we will address the performance budget of the global VSI instrument. The fringe tracker and scientific spectrograph will be shortly described. [less ▲]

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See detailLong-term prognosis of congestive heart failure in patients with acromegaly
Bihan, H.; Valdes Socin, Hernan Gonzalo ULg; Levasseur, S. et al

in The 85th Annual Meeting of the Endocrine Society - Abstract book (2003)

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