References of "WITHOFS, Nadia"
     in
Bookmark and Share    
Full Text
See detailImaging myeloma and related monoclonal plasma cell disorders: Still room for standard radiography?
WITHOFS, Nadia ULg; Nanni, Cristina; Fanti, Stefano et al

in Clin.Translat.Imaging (in press)

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial ... [more ▼]

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial assessment of the disease. Although the radiological skeletal survey is the gold standard to detect bone osteolytic lesions, it may miss small bone lesions or lesions located in the spine or pelvis due to the superimposed images of soft tissues. These limitations propelled newer imaging techniques such as positron emission tomography combined with computed tomography (PET/CT) and magnetic resonance imaging (MRI) in the diagnosis of multiple myeloma. In addition, 18F-fluorodeoxyglucose PET/CT and MRI have prognostic value and can be used to monitor disease. This review discusses the additional value of PET/CT and MRI in the management of MM. [less ▲]

Detailed reference viewed: 32 (3 ULg)
Full Text
Peer Reviewed
See detail18F-FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas: Correlation with histopathology
WITHOFS, Nadia ULg; SIGNOLLE, NICOLAS; SOMJA, Joan ULg et al

in Journal of Nuclear Medicine (The) (2015)

Detailed reference viewed: 26 (0 ULg)
Full Text
Peer Reviewed
See detailImagerie de l'intégrine αvβ3 par PET/CT au 18F-FPRGD2
WITHOFS, Nadia ULg; HUSTINX, Roland ULg

in Revue Médicale de Liège (2014), 69(Synthèse 2014), 36-40

Detailed reference viewed: 29 (2 ULg)
Full Text
Peer Reviewed
See detailFDG PET/CT for rectal carcinoma radiotherapy treatment planning : Comparison of functional volume delineation algorithms and clinical challenges.
WITHOFS, Nadia ULg; BERNARD, Claire ULg; VAN DER REST, Catherine ULg et al

in Journal of Applied Clinical Medical Physics (2014), 15(5), 216-228

PET/CT imaging could improve delineation of rectal carcinoma gross tumor volume (GTV) and reduce interobserver variability. The objective of this work was to compare various functional volume delineation ... [more ▼]

PET/CT imaging could improve delineation of rectal carcinoma gross tumor volume (GTV) and reduce interobserver variability. The objective of this work was to compare various functional volume delineation algorythms. [less ▲]

Detailed reference viewed: 34 (16 ULg)
Full Text
Peer Reviewed
See detailUTILISATION DE L’IMAGERIE FONCTIONNELLE EN RADIOTHÉRAPIE
LALLEMAND, François ULg; LAKOSI, Ferenc ULg; HUSTINX, Roland ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 20-28

Les progrès technologiques réalisés par l’image- rie médicale l’ont placée au centre de la prise en charge des patients oncologiques, tant au niveau du diagnostic, du pro - nostic et du suivi que dans la ... [more ▼]

Les progrès technologiques réalisés par l’image- rie médicale l’ont placée au centre de la prise en charge des patients oncologiques, tant au niveau du diagnostic, du pro - nostic et du suivi que dans la prise en charge thérapeutique. En effet, l’imagerie représente, à l’heure actuelle, la pierre angulaire des traitements de radiothérapie. Les objectifs du radiothérapeute sont d’irradier le plus précisément possible la tumeur à dose curative, tout en évitant les organes sains. Pour y arriver, le radiothérapeute utilise de façon routinière l’imagerie anatomique (Scanner et IRM). Depuis quelques années, le développement des différentes imageries métabo - liques et fonctionnelles, comme l’imagerie par émission de positons (PET-CT) et la résonnance magnétique fonctionnelle, ouvrent de nouvelles possibilités thérapeutiques grâce aux informations qu’elles apportent sur la biologie des tumeurs. Cet article décrit, de manière non exhaustive, les différentes imageries anatomiques et métaboliques à la disposition du radiothérapeute. [less ▲]

Detailed reference viewed: 34 (4 ULg)
Full Text
Peer Reviewed
See detailImaging osteoarthritis using (18F)FPRGD2 PET/CT : observation and potential application.
WITHOFS, Nadia ULg; ALVAREZ MIEZENTSEVA, Victoria ULg; SIMONI, Paolo ULg et al

in Journal of Nuclear Medicine (The) (2013), 54(SUPPL), 250

Detailed reference viewed: 9 (3 ULg)
Full Text
Peer Reviewed
See detailBone mass of the calvarium
SIMONI, Paolo ULg; STULKO, Jennifer ULg; BEN MUSTAPHA, Selma ULg et al

in Skeletal Radiology (2013), 42

Detailed reference viewed: 32 (5 ULg)
Full Text
Peer Reviewed
See detail(18F)FPRGD2 PET/CT imaging of integrin αvβ3 in renal carcinomas : correlation with histopathology.
WITHOFS, Nadia ULg; SIGNOLLE, N.; NZARAMBA, EM. et al

in Journal of Nuclear Medicine (The) (2012), 53(SUPPL), 1647

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detailAcute intramural haematoma of the ascending aorta.
Govaerts, L.; WITHOFS, Nadia ULg; Durieux, R. et al

in European Journal of Nuclear Medicine and Molecular Imaging (2012), 39(8), 1368-9

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailImagerie des métastases osseuses du cancer du sein
WITHOFS, Nadia ULg; COLLIGNON, Joëlle ULg; HUSTINX, Roland ULg

in Revue Médicale de Liège (2011), 66(5-6), 291-298

Detailed reference viewed: 51 (6 ULg)
Full Text
Peer Reviewed
See detail18F-fluoride PET/CT for assessing bone involvement in prostate and breast cancers
Withofs, Nadia ULg; Grayet, Benjamin ULg; Tancredi, Tino ULg et al

in Nuclear Medicine Communications (2011), 32(3), 168-176

Detailed reference viewed: 65 (26 ULg)
Full Text
Peer Reviewed
See detailVers une radiothérapie chirurgicale :nécessité d’une radiothérapie guidée par l’imagerie
COUCKE, Philippe ULg; WITHOFS, Nadia ULg; JANSEN, Nicolas ULg et al

in Revue Médicale de Liège (2010), 65(supp 1), 17-22

résumé : L’évolution extrêmement rapide en robotique et en informatique a permis l’avènement de techniques telles que le CcyberKnife®, capables d’appliquer en radiothérapie des doses dites «ablatives» et ... [more ▼]

résumé : L’évolution extrêmement rapide en robotique et en informatique a permis l’avènement de techniques telles que le CcyberKnife®, capables d’appliquer en radiothérapie des doses dites «ablatives» et ceci avec une précision chirurgicale. Ce type de traitement ablatif n’est pas réellement concevable avec des techniques conventionnelles en radiothérapie et des changements <br />majeurs de paradigmes ont eu lieu, particulièrement dans la méthodologie de définition de la cible et des marges ainsi que dans la manière dont on fractionne le traitement. Ggrâce à ces changements, on est à même de proposer aux patients des traitements <br />qui représentent un doublement au niveau de l’efficacité <br />biologique. Ppour obtenir une couverture optimale au niveau de la cible, tout en évitant les structures saines avoisinantes, il est donc impératif d’obtenir la meilleure définition possible de la cible tant au niveau de la l’extension de la lésion qu’au niveau de son «contenu», c’est-à-dire les caractéristiques métaboliques et fonctionnelles. Lla révolution technologique en cours dans le monde de l’imagerie métabolique et fonctionnelle va permettre d’utiliser l’information numérisée pour individualiser les traitements <br />et les adapter aux caractéristiques mêmes de la lésion ainsi qu’à son évolution au décours du traitement. [less ▲]

Detailed reference viewed: 86 (8 ULg)
Full Text
Peer Reviewed
See detailContribution of positron emission tomography in pleural disease.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Larock, Marie-Paule ULg et al

in Revue des Maladies Respiratoires (2010), 27(8), 47-53

INTRODUCTION: Positron emission tomography (PET) now plays a clear role in oncology, especially in chest tumours. We discuss the value of metabolic imaging in characterising pleural pathology in the light ... [more ▼]

INTRODUCTION: Positron emission tomography (PET) now plays a clear role in oncology, especially in chest tumours. We discuss the value of metabolic imaging in characterising pleural pathology in the light of our own experience and review the literature. BACKGROUND: PET is particularly useful in characterising malignant pleural pathologies and is a factor of prognosis in mesothelioma. Metabolic imaging also provides clinical information for staging lung cancer, in researching the primary tumour in metastatic pleurisy and in monitoring chronic or recurrent pleural pathologies. CONCLUSIONS: PET should therefore be considered as a useful tool in the diagnosis of liquid or solid pleural pathologies. [less ▲]

Detailed reference viewed: 49 (3 ULg)
Full Text
Peer Reviewed
See detailPET imaging of tumor neovascularization in a transgenic mouse model with a novel 64Cu-DOTA-knottin peptide.
Nielsen, Carsten H; Kimura, Richard H; WITHOFS, Nadia ULg et al

in Cancer Research (2010), 70(22), 9022-30

Due to the high mortality of lung cancer, there is a critical need to develop diagnostic procedures enabling early detection of the disease while at a curable stage. Targeted molecular imaging builds on ... [more ▼]

Due to the high mortality of lung cancer, there is a critical need to develop diagnostic procedures enabling early detection of the disease while at a curable stage. Targeted molecular imaging builds on the positive attributes of positron emission tomography/computed tomography (PET/CT) to allow for a noninvasive detection and characterization of smaller lung nodules, thus increasing the chances of positive treatment outcome. In this study, we investigate the ability to characterize lung tumors that spontaneously arise in a transgenic mouse model. The tumors are first identified with small animal CT followed by characterization with the use of small animal PET with a novel 64Cu-1,4,7,10-tetra-azacylododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-knottin peptide that targets integrins upregulated during angiogenesis on the tumor associated neovasculature. The imaging results obtained with the knottin peptide are compared with standard 18F-fluorodeoxyglucose (FDG) PET small animal imaging. Lung nodules as small as 3 mm in diameter were successfully identified in the transgenic mice by small animal CT, and both 64Cu-DOTA-knottin 2.5F and FDG were able to differentiate lung nodules from the surrounding tissues. Uptake and retention of the 64Cu-DOTA-knottin 2.5F tracer in the lung tumors combined with a low background in the thorax resulted in a statistically higher tumor to background (normal lung) ratio compared with FDG (6.01+/-0.61 versus 4.36+/-0.68; P<0.05). Ex vivo biodistribution showed 64Cu-DOTA-knottin 2.5F to have a fast renal clearance combined with low nonspecific accumulation in the thorax. Collectively, these results show 64Cu-DOTA-knottin 2.5F to be a promising candidate for clinical translation for earlier detection and improved characterization of lung cancer. [less ▲]

Detailed reference viewed: 31 (3 ULg)
Full Text
See detailNuclear medicine imaging
Jerusalem, Guy ULg; Withofs, Nadia ULg

in Schmoll, Hans-Joachim; Van't Veer, Laura; Vermorken, Jan (Eds.) et al ESMO Handbook of Cancer Diagnosis and Treatment Evaluation (2009)

Detailed reference viewed: 12 (4 ULg)
Full Text
Peer Reviewed
See detailPET/CT for assessing bone involvement in prostate and breast cancer.
WITHOFS, Nadia ULg; GRAYET, Benjamin ULg; TANCREDI, T. et al

in Journal of Nuclear Medicine (The) (2008), 49(SUPPL), 21

Detailed reference viewed: 5 (0 ULg)