Management of cases suffering from atypical myopathy:Interpretations of descriptive, epidemiological and pathophysiological findings. Part 2: Muscular, urinary, respiratory and hepatic care, and inflammatory/infectious status

in Equine Veterinary Education (in press)

Atypical myopathy is highly fatal, but about a quarter of affected horses survive. This highlights the need for provision of supportive treatment for these patients. This review is a practical guideline ... [more ▼]

Atypical myopathy is highly fatal, but about a quarter of affected horses survive. This highlights the need for provision of supportive treatment for these patients. This review is a practical guideline for equine practitioners and includes suggestions for close monitoring of involved organ systems and discusses options of supportive treatment based on current knowledge of the condition. Part 2 covers the muscular, urinary, respiratory and hepatic systems, and the general inflammatory/infectious status of the case. [less ▲]

OXPHOS protocols for the study of training and rare myopathies in horse skeletal muscle fibres

Conference (2012, December 05)

Physical Fitness and Mitochondrial Respiratory Capacity in Horse Skeletal Muscle

in PLoS ONE (2012), 7(4), 1-12

We applied high-resolution respirometry and multiple substrate-uncoupler-inhibitor titration protocols to study mitochondrial physiology in small (1.0–2.5 mg) permeabilized muscle fibres sampled from ... [more ▼]

We applied high-resolution respirometry and multiple substrate-uncoupler-inhibitor titration protocols to study mitochondrial physiology in small (1.0–2.5 mg) permeabilized muscle fibres sampled from triceps brachii of healthy horses. The present investigation on horse skeletal muscle has tested the methodology used to study mitochondrial function in muscle microbiopsies by high-resolution respirometry to define reference protocols for horses (from sampling procedure to data analysis). [less ▲]

What have the last outbreaks of atypical myopathy in Europe told us: new epidemiological evidence.

in Verwilghen, Denis; Van Galen, Gaby; Busoni, Valeria (Eds.) Belgian International Congress: Hippos 2012 (2012, February)

Atypical myopathy outbreaks are of an acute and unexpected nature and the information given in this review aims at helping equine practitioners in the recognition and handling of a suspected case in the ... [more ▼]

Atypical myopathy outbreaks are of an acute and unexpected nature and the information given in this review aims at helping equine practitioners in the recognition and handling of a suspected case in the event of AM outbreaks. So, this review (1) describes the diagnostic tools for AM, (2) reports prognostic criteria, and (3) lists preventive measures based on recent epidemiological surveys. [less ▲]

Systemisch-entzuendliche Reaktion beim Hochleistungssportpferd

Book published by Leipziger Blaue Hefte (2012)

European outbreaks of atypical myopathy in grazing horses (2006-2009): Determination of indicators for risk and prognostic factors

in Equine Veterinary Journal (2012), DOI: 10.1111/j.2042-3306.2012.00555.x

Appropriate management of atypical myopathy (AM) requires the establishment of an accurate diagnosis and prognosis. Furthermore, preventive measures to avoid AM need to be refined. The aims of the study ... [more ▼]

Appropriate management of atypical myopathy (AM) requires the establishment of an accurate diagnosis and prognosis. Furthermore, preventive measures to avoid AM need to be refined. The aims of the study were as follows: 1) to improve the diagnosis of AM; 2) to identify prognostic predictors; and 3) to refine recommended preventive measures based on indicators of risk factors. [less ▲]

The story of equine atypical myopathy: a review from the beginning to a possible end

in ISRN Veterinary Science (2012), 2012

Atypical myopathy (AM) is a frequently fatal seasonal pasture myopathy that emerges in Europe. Outbreaks are of an acute and unexpected nature and practitioners should be prepared to handle these ... [more ▼]

Atypical myopathy (AM) is a frequently fatal seasonal pasture myopathy that emerges in Europe. Outbreaks are of an acute and unexpected nature and practitioners should be prepared to handle these critically ill patients. This review retraces the history of AM and describes results of epidemiological investigations that were conducted to raise hypotheses concerning the etiology of this devastating disease as well as to be able to suggest potential preventive measures. Also, clinical studies have contributed to a better definition and recognition of the syndrome whereas, elucidation of the pathological process, identified as a multiple acyl-CoA dehydrogenase deficiency (MADD), was a great step forward improving medical management of AM and guiding the search for the etiological agent towards toxins that reproduce the identified defect. Treatment plans can be extrapolated from the described clinical signs and metabolic problems, but they remain limited to supportive care until the causative agent has been identified with certainty. Since treatment is still unsuccessfull in the majority of cases, the main emphasis is currently still on prevention. This review aims at being a practical support for equine clinicians dealing with AM and is based on discussion and comparison of the currently available scientific data. [less ▲]

assessment of acid base imbalances in horses suffering from atypical myopathy

in proceedings AAEP 2011 (2011, November 11)

How to diagnose atypical myopathy

in In proceedings: 50th British Equine Veterinary Association (BEVA) Congress (2011, September 08)

Exploratory survey on acid base derangements in horses suffering from atypical myopathy

in Proceedings BEVA 2011 (2011, September 08)