References of "Votion, Dominique"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailLes nouveaux outils de diagnostic et de pronostic de la myopathie atypique
Habyarimana, Jean ULg; BOEMER, François ULg; Amory, Hélène ULg et al

in Proceeding de la 41ème Journée de la Recherche équine (2015)

In equines, ingestion of hypoglycin A, a toxin produced in the seeds (samaras) of sycamore maple (Acer pseudoplatanus) tree alters the energetic metabolism of muscle cells and results in atypical myopathy ... [more ▼]

In equines, ingestion of hypoglycin A, a toxin produced in the seeds (samaras) of sycamore maple (Acer pseudoplatanus) tree alters the energetic metabolism of muscle cells and results in atypical myopathy (AM). This alterations leads to a characteristic biochemical profile of acylcarnitines (AC) that enables to confirm the diagnosis of AM. This study aims at validating a methodology for the dosage of hypoglycin A in vegetal extracts but also in blood. In addition, the biochemical profile in AC has been determined in AM cases (5 survivors and 13 deceased) and in 5 horses suffering from exercise-induced myopathy. The AC profiles of these horses have been compared to the one of healthy horses (n = 35). This study showed that hypoglycin A was present in seeds and spring seedlings of sycamore and also in blood of AM cases horses. In addition, the establishment of AC profile contributes to the diagnostic and helps to assess the prognosis of AM cases. [less ▲]

Detailed reference viewed: 13 (4 ULg)
Full Text
See detailProceedings of the 1st FARAH-Day Faculty of Veterinary Medicine (University of Liege - Belgium)
Bayrou, Calixte ULg; Cabaraux, Jean-François ULg; Delguste, Catherine ULg et al

Book published by Presses de la Faculté de Médecine vétérinaire de l’Université de Liège (2014)

Detailed reference viewed: 20 (5 ULg)
Full Text
Peer Reviewed
See detailEtiologie de la myopathie atypique : conditions de toxicité de l’agent causal – étude préliminaire
Patarin; van Galen, Gaby; Dopagne, Claude ULg et al

in 40ème journée de la recherche équine (2014, March 18)

Recently it has been shown that atypical myopathy in Europe results from hypoglycin A ingestion, a toxin produced in the seeds (samares) of some trees of the genus Acer. Grasslands of 12 cases of atypical ... [more ▼]

Recently it has been shown that atypical myopathy in Europe results from hypoglycin A ingestion, a toxin produced in the seeds (samares) of some trees of the genus Acer. Grasslands of 12 cases of atypical myopathy for whom the toxic metabolite of hypoglycin A was found in the blood were visited by two experienced botanists in order to establish the list of the different species of trees found in or around these pastures. For all visited pastures, horses had the opportunity to ingest samaras from various maple species. The sycamore maple (Acer pseudoplatanus) was the only common tree in all pastures visited (n = 12 /12). Other trees with samaras were also found near or around the pastures. Since June 2013, a study is conducted to define the conditions of toxicity of several species of trees via the sampling, at regular intervals, of samaras and leaves. The study of the seasonal evolution of the toxicity of these trees in relation to weather conditions and specific biotopes will aim [less ▲]

Detailed reference viewed: 205 (26 ULg)
Full Text
See detailMyopathie atypique : la recherche continue
Votion, Dominique ULg

in Pratique Vétérinaire Equine (2014), 46(182), 22-24

Detailed reference viewed: 17 (3 ULg)
Full Text
See detailEditorial : La myopathie atypique.
Votion, Dominique ULg

in Pratique Vétérinaire Equine (2014), 46(182), 5

Detailed reference viewed: 13 (4 ULg)
Full Text
See detailGestion des cas, traitement et prévention chez les compagnons de pâture lors de myopathie atypique
van Galen, Gaby; Votion, Dominique ULg

in Pratique Vétérinaire Equine (2014), 46(182), 16-21

Detailed reference viewed: 45 (23 ULg)
Full Text
See detailMyopathie atypique : épidémiologie des cas européen. Pratique vétérinaire équine
Patarin, Florence; van Galen, Gaby; Pitel, Christel et al

in Pratique Vétérinaire Equine (2014), 46(182), 12-14

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailDistribution des cas européens de myopathie atypique de 2003 à 2013 : maladie endémique ou émergente Pratique vétérinaire équine
Patarin, Florence; Pitel, Christel; Votion, Dominique ULg

in Pratique Vétérinaire Equine (2014), 46(182), 6-10

Detailed reference viewed: 5 (0 ULg)
Full Text
See detailMetabolic responses to exercise and training
Votion, Dominique ULg

in Hinchcliff K.W; Kaneps A.J.; Geor R.J. (Eds.) Equine Sport Medicine and Surgery (2014)

This chapter reviews the whole-body and muscular metabolic responses and also describes the effects of training adaptation on these processes.

Detailed reference viewed: 31 (13 ULg)
Full Text
See detailÉtiopathogénie de la myopathie atypique et gestion raisonnée des cas
Votion, Dominique ULg; Patarin, Florence; Cerri, Simona ULg et al

in In Proceedings: Journée AVEF (Association des Vétérinaires Equins Français) (2013, December)

Atypical myopathy is an acute intoxication resulting from the ingestion of a toxin contained in the seeds of some trees of the genus Acer (i.e. « maple trees »). The causes of the emergence of the disease ... [more ▼]

Atypical myopathy is an acute intoxication resulting from the ingestion of a toxin contained in the seeds of some trees of the genus Acer (i.e. « maple trees »). The causes of the emergence of the disease due to trees naturalized for many decades remain undetermined. Currently, there is no cure for atypical myopathy but symptomatic treatment may be revisited on the basis of knowledge of the aetio-pathogenesis of the disease. This paper compiles recommendations following a discussion on treatment of atypical myopathy held in October 2013 at the University of Liege (Belgium) to provide emergency treatment distinguishing clinical management (1) at hospital, (2) in the field and (3) preventive measures to protect pasture companions. [less ▲]

Detailed reference viewed: 88 (24 ULg)
Full Text
See detailProceedings of the 3rd Scientific Meeting of the Faculty of Veterinary Medicine
Bayrou, Calixte ULg; Cabaraux, Jean-François ULg; Delguste, Catherine ULg et al

Book published by Presses de la Faculté de Médecine Vétérinaire (2013)

Detailed reference viewed: 54 (23 ULg)
Full Text
See detailManaging acute myopathies
Votion, Dominique ULg

in In proceedings: 51th British Equine Veterinary Association (BEVA) Congress (2013, September)

Detailed reference viewed: 32 (9 ULg)
Full Text
See detailAtypical myopathy: epidemiology and aetiopathogenesis
Votion, Dominique ULg

in In proceedings: 51th British Equine Veterinary Association (BEVA) Congress (2013, September)

Detailed reference viewed: 78 (7 ULg)
Full Text
Peer Reviewed
See detailThe challenge of understanding myopathies in horses using permeabilized muscle cells
Votion, Dominique ULg; Mouithys-Mickalad, Ange ULg; Ceusters, Justine ULg et al

in In proceedings 9th Conference on Mitochondrial Physiology (2013, September)

Detailed reference viewed: 47 (19 ULg)
Full Text
See detailPrédiction des performances sportives et détection précoce des myopathies par respirométrie à haute résolution
Votion, Dominique ULg; Serteyn, Didier ULg

in cheval athlète, stress oxydant & inflammation (2013, June 07)

Detailed reference viewed: 47 (20 ULg)
Full Text
Peer Reviewed
See detailIdentification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy
Votion, Dominique ULg; van Galen, G; Sweetan et al

in Equine Veterinary Journal (2013)

Detailed reference viewed: 167 (32 ULg)
Full Text
Peer Reviewed
See detailManagement of cases suffering from atypical myopathy: Interpretations of descriptive, epidemiological and pathophysiological findings. Part 2: Muscular, urinary, respiratory and hepatic care, and inflammatory/ infectious status
Van Galen, Gaby ULg; Votion, Dominique ULg

in Equine Veterinary Education (2013), 25(6), 308-314

Atypical myopathy is highly fatal, but about a quarter of affected horses survive. This highlights the need for provision of supportive treatment for these patients. This review is a practical guideline ... [more ▼]

Atypical myopathy is highly fatal, but about a quarter of affected horses survive. This highlights the need for provision of supportive treatment for these patients. This review is a practical guideline for equine practitioners and includes suggestions for close monitoring of involved organ systems and discusses options of supportive treatment based on current knowledge of the condition. Part 2 covers the muscular, urinary, respiratory and hepatic systems, and the general inflammatory/infectious status of the case. [less ▲]

Detailed reference viewed: 282 (40 ULg)
Full Text
Peer Reviewed
See detailTraditional and quantitative assessment of acid-base and shock variables in horses with atypical myopathy
van Galen, G; Cerri, Simona ULg; Porter, S et al

in Journal of Veterinary Internal Medicine (2013), 27(1), 186-193

BACKGROUND: Descriptions of acid-base disturbances in atypical myopathy (AM) are limited. OBJECTIVES: Describe and compare traditional and quantitative acid-base abnormalities and cardiovascular shock ... [more ▼]

BACKGROUND: Descriptions of acid-base disturbances in atypical myopathy (AM) are limited. OBJECTIVES: Describe and compare traditional and quantitative acid-base abnormalities and cardiovascular shock status in horses with AM at admission. ANIMALS: 34 horses with AM, 15 healthy controls. METHODS: Retrospective case-control study. Records were searched for shock variables (packed cell volume [PCV], blood urea nitrogen [BUN], heart and respiratory rate) and acid-base variables (venous blood gas analysis, electrolytes, total protein, lactate) on admission. Base excess (BE) of free water (BEfw), chloride (BEcl), total protein (BEtp), and unidentified anions (BEua), anion gap (AG), measured strong ion difference (SIDm), and concentration of total nonvolatile weak acids ([Atot]) were calculated. Acid-base classifications, using simplified strong ion model and traditional approach, and shock grades were assigned. A 2-sample Wilcoxon rank-sum test and Bonferroni correction compared variables in AM cases versus control horses. Significance was P < .05/16 for acid-base and P < .05/5 for shock variables. RESULTS: Tachycardia, tachypnea, and normal to increased PCV and BUN were common in AM cases. Respiratory, metabolic acid-base alterations, or both were mainly caused by respiratory alkalosis, lactic acidosis, and SIDm alkalosis, alone or in combination. Evaluated variables (except pH, potassium concentration, total protein, and related calculations) were significantly different (P < .001) between AM cases and control horses. The strong ion model provided a more accurate assessment than the traditional approach and identified mixed derangements. CONCLUSIONS AND CLINICAL IMPORTANCE: Acid-base derangements should be evaluated in horses with AM and this preferably with the strong ion model. [less ▲]

Detailed reference viewed: 30 (9 ULg)
Full Text
Peer Reviewed
See detailAltered mitochondrial oxidative phosphorylation capacity in horses suffering from polysaccharide storage myopathy
Tosi, Irène ULg; Art, Tatiana ULg; Cassart, Dominique ULg et al

Poster (2013)

Introduction: Exertional rhabdomyolyses are a common cause of exercise intolerance in the equine athlete, and Polysaccharide Storage Myopathy (PSSM) is a widely described muscular pathology. It is ... [more ▼]

Introduction: Exertional rhabdomyolyses are a common cause of exercise intolerance in the equine athlete, and Polysaccharide Storage Myopathy (PSSM) is a widely described muscular pathology. It is characterized by an accumulation of abnormal glycogen in myofibers due to a genetic defect in the skeletal muscle glycogen synthase (GYS1) enzyme. We hypothesized that the energetic production through the oxidative phosphorylation (OXPHOS) in muscular mitochondria might be impaired in type-1 PSSM-affected horses. Material and Methods: Eight horses with a history of exertional rhabdomyolysis were tested for the GYS1 mutation. Muscle biopsies were collected and used for histological analysis and high resolution respirometry (HRR). HRR values from 3 groups of horses (PSSM-positive horses, horses with a history of myopathy but negative to PSSM and healthy controls) were compared using a linear mixed model to take into account repeated (2-3 times) measurements made for each horse. Results: In four horses histology revealed an accumulation of abnormal glycogen in myofibers. A severe depression of the maximal OXPHOS capacity was observed by HRR in all horses with exertional rhabodmyolysis, with lower values in PSSM-positive cases. Conclusions: Our study shows a severe decreased OXPHOS capacity in PSSM-affected horses. PSSM is considered primarily a defect in glycogen synthesis but altered OXPHOS might play a central role in its pathogenesis. [less ▲]

Detailed reference viewed: 57 (10 ULg)
Full Text
Peer Reviewed
See detailManagement of cases suffering from atypical myopathy:Interpretations of descriptive, epidemiological and pathophysiological findings. Part 1: First aid, cardiovascular, nutritional and digestive care
Van Galen, Gaby ULg; Votion, Dominique ULg

in Equine Veterinary Education (2013), 25(5), 264-270

Atypical myopathy is highly fatal, but about a quarter of affected horses survive. This highlights the need for provision of supportive treatment for these cases. This review is a practical guideline for ... [more ▼]

Atypical myopathy is highly fatal, but about a quarter of affected horses survive. This highlights the need for provision of supportive treatment for these cases. This review is a practical guideline for equine practitioners and includes suggestions for close monitoring of involved organ systems and discusses options of supportive treatment based on current knowledge of the condition. [less ▲]

Detailed reference viewed: 266 (20 ULg)