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See detailUn nouveau syndrome hémorragique inexpliqué chez le bovin- la Pancytopénie néonatale bovine
Theron, Léonard ULg; Galland, Bruno ULg; Vogin, Nathalie et al

Conference (2010, November 21)

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See detailUN NOUVEAU SYNDROME HÉMORRAGIQUE INEXPLIQUÉ CHEZ LE BOVIN – LA PANCYTOPÉNIE NÉONATALE BOVINE
Theron, Léonard ULg; Vogin, Nathalie; Moreaux, Emeline et al

in Antibiothérapies : Santé animale et santé publique (2010, May)

For several decades, the bovine was subject to various hemorrhagic syndromes which causes have historically been found. Since the mid-2000s, a new hemorrhagic syndrome seems to emerge with a significant ... [more ▼]

For several decades, the bovine was subject to various hemorrhagic syndromes which causes have historically been found. Since the mid-2000s, a new hemorrhagic syndrome seems to emerge with a significant epidemiological consistency, suggesting a common etiology, although unknown at present. The affected animals were calves of less than 30 days, of all races born to mothers without specific parity. We noticed a very sporadic disease (1/10.000) but lethal to 99%. The characteristic lesions are multifocal hemorrhages, hyperthermia, melena, we noted medullar aplasia systematically. These calves are vironegative for BTV, enzootic bovine leukosis and BVDV. No viral or bacterial agent could be isolated. It seems that most of these calves were born from dams vaccinated against BVDV. The track of an immune dysfunction is the most serious for the moment. [less ▲]

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See detailPancytopénie néonatale : nouveau syndrome hémorragique chez le bovin
Theron, Léonard ULg; Vogin, Nathalie; Moreau, Emeline et al

in Point Vétérinaire (2010), 41(Numéro spécial), 79-86

For 30 years, many haemorrhagic syndromes were observed in cattle. The recent observation in Europe of a new entity hemorrhagic highlights a consistent set of clinical cases in calves of all breeds under ... [more ▼]

For 30 years, many haemorrhagic syndromes were observed in cattle. The recent observation in Europe of a new entity hemorrhagic highlights a consistent set of clinical cases in calves of all breeds under 30 days of age, with pancytopenic haemorrhagic purpura. Calves are vironegative for BVD and BTV, most are seropositive for both viruses antibodies. No specific etiology has been highlighted, but it seems that the syndrome is linked to the ingestion of colostrum immunized against cells of the calf. The syndrome is sporadic, with a prevalence ranging between 1:10,000 and 1:100,000 cattle under one year of age, causing a lethality of 99%. The origin of the pancytopenia is a medullar aplasia. [less ▲]

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See detailDescribing an emerging disease: A case of thrombocytopenic syndrome of the newborn calf
Theron, Léonard ULg; Vogin, Nathalie; Bayrou, Calixte ULg et al

in Maillard, R.; Navetat, H. (Eds.) European buiatrics forum 2009 (2009, December 03)

Since the last 5 years, a specific hemorrhagic syndrome of unknown etiology was described in young calves. This disease has a low incidence but a very high mortality rate. No etiology has been found yet ... [more ▼]

Since the last 5 years, a specific hemorrhagic syndrome of unknown etiology was described in young calves. This disease has a low incidence but a very high mortality rate. No etiology has been found yet, though many labs have already gathered lots of cases around Europe. For example, more than 200 cases in 170 farms in Germany, 60 cases in 40 farms were described in Gent’s veterinary faculty in Belgium. In France and in the United Kingdom, several cases have been recorded yet, in multiple different locations. As far as we know, the disease concern young calves aging between 10 and 30 days, from different breeds. Most calves present a purpura on multiple sites on skin, gums, eye sclera and ears. Hematology indicates severe anemia, thrombocytopenia, neutropenia with or without leukopenia. Necropsy indicates multiple hemorrhages in serous membranes on every abdominal viscera. Alfort’s veterinary faculty has described acute necrotizing hepatitis on one case in France. Those calves are BVDV and BTV negative both on antigen tests. In Liege’s veterinary faculty one live case was examined, from a modern farm with 160 calvings, and less than 5% of calf mortality per year. The farm had 3 hemorrhagic fatal cases during July 2009, of very quick evolution. From those, 2 were autopsied and diagnosed BVDV negative. The 20 days old calf had hyperthermia in the morning, received oxytetracycline in the farm and began bleeding at noon. As many of the described cases, the calf presented mild depression with hyperthermia and tachypnoea. Skin and ear purpura, gum hematoma, melena, hematuria and hemoglobinuria were noticed. Hematology revealed a severe anemia with decreased hematocrite due to a profound thrombocytopenia (4.79*109/l). Leukocytes formula also shown neutropenia (0.10*109/l) and a monocytosis (1.32*109/l). It resulted in a mild leukopenia (3.59*109/l). We also noticed hypogammaglobulinemia (2.92 g/l and 6.8% of total protein). This calf received an immune-suppressive treatment with a high dose of dexamethasone (0.64mg/kg), and a cover antimicrobial therapy (Enrofloxacine). A good evolution of the symptoms on day 2 was observed. Leukocyte formula had a normal answer to dexamethasone concerning the lymphocytes and neutrophils population. On day 6, blood formula was already stabilized, with increasing hematocrite from 12% on day 3 to 15%. Thrombocytes count has also increased to 58.20*109/l; leukocytes count was also back to normal with normal formula. Flow cytometric measures on the lymphocytes subpopulations indicated a subnormal Gamma-Delta and Natural Killer population, and a high number of apoptotic cells 12 hours after sampling. This syndrome can be linked to idiopathic thrombocytopenia in human newborn both regarding symptomatology and treatment answer. Though this data helps in the understanding of this pathology, it concerns only one animal and needs to be confirmed through further experiment on live cases. [less ▲]

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