References of "Vindevogel, Henri"
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See detailFractionation of the reference inoculum of epizootic rabbit enteropathy in discontinuous sucrose gradient identifies aetiological agents in high density fractions
Szalo, Ioan Mihai ULg; Lassence, Cédric ULg; Licois, Dominique et al

in Veterinary Journal (2007), 173(3), 652-657

Epizootic rabbit enteropathy (ERE) is a major cause of economic loss in intensive rabbit production. Since its first recognition in 1997, much work has been done to determine the pathogenic mechanisms of ... [more ▼]

Epizootic rabbit enteropathy (ERE) is a major cause of economic loss in intensive rabbit production. Since its first recognition in 1997, much work has been done to determine the pathogenic mechanisms of the disease and to identify the aetiological agent(s). Unfortunately, the quest for aetiology has only met with limited success despite the ability to reproduce the syndrome by inoculation of intestinal contents from field cases. These intestinal inocula contain a huge number of microorganisms which could all be involved in the aetiology of ERE. To decrease the number of putative agents, the French reference inoculum TEC3 was fractionated on a discontinuous sucrose gradient so that seven fractions (supernatant, 10%, 20%, 30%, 40%, 50% and pellet) were obtained. Specific-pathogen-free rabbits were inoculated with three out of these seven fractions (supernatant, 30%, and pellet). The objectives were: (1) to characterise the seven fractions by bacteriological examination; (2) to verify whether the aetiological agent was present in the fractions by inoculation of rabbits; (3) to assign the aetiological agent of ERE to a morphological group of pathogens; (4) to identify a fraction which could replace the reference inoculum TEC3 in applications such as cell cultures or egg inoculation. The results strongly suggest that ERE is a bacterial disease and does not have a viral or parasitic aetiology. (C) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailExperimentally induced epizootic rabbit enteropathy: Clinical, histopathological, ultrastructural, bacteriological and haematological findings
Dewrée, Roxane; Meulemans, L.; Lassence, Cédric ULg et al

in World Rabbit Science (2007), 15(2, APR-JUN), 91-102

Epizootic rabbit enteropathy is an emerging disease that has appeared in French intensive enclosed rabbit farms since the beginning of 1997. Common clinical signs are mild watery diarrhoea with ... [more ▼]

Epizootic rabbit enteropathy is an emerging disease that has appeared in French intensive enclosed rabbit farms since the beginning of 1997. Common clinical signs are mild watery diarrhoea with considerable distension of the abdomen. At necropsy, a significant dilation of the stomach and small intestine without gross evidence of acute or chronic enteric lesions (inflammation or congestion) was observed. The purpose of this study was to describe the anatomopathologic changes concerning the small intestine and those concerning the blood profile, in experimentally infected rabbits. In a first part of the experiment, thirty animals were inoculated with a reference inoculum and five were kept as controls for clinical signs examination and histopathological study. In a second part, 17 out of the inoculated rabbits and the 5 controls animals were randomly assigned to blood testing. Microscopic lesions were studied in sections from the different parts of the small intestine (duodenum, jejunum and ileum) by light microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The histological findings revealed only limited inflammation in inoculated animals. Major villous changes were atrophy, fusion, destruction and loss of epithelial cells. In inoculated rabbits, the congestion and dilation of blood vessels of jejunal lamina propria were significantly higher than in control animals (P<0.005). There was significantly more (P<0.05) apoptosis of cells of the jejunal epithelium in inoculated rabbits than in control animals. Infiltration of polymorphonuclear neutrophiles was observed into the jejunal or ileal tunica muscularis. SEM performed on the intestinal tract of 15 inoculated rabbits revealed blankets and globular particles of mucus associated with numerous bacteria on jejunum and ileum villi. This was; not observed in the intestinal tract of control rabbits. Bacteria were found adhering to the epithelial surface and inside intestinal epithelial cells in a few animals by TEM and by light microscopy after Warthin-Starry staining. None of the bacteria isolated from the intestinal mixed contents and cultivated on usual media, are commonly known as rabbit's pathogens. Regarding the haernatological profile, neutrophil counts significantly increased (P<0.05) and lymphocyte counts significantly decreased (P<0.01), in inoculated rabbits compared to those of the control group. [less ▲]

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See detailIncreasing incidence of megabacteriosis in canaries (Serinus canarius domesticus)
Marlier, Didier ULg; Leroy, Cécile ULg; Sturbois, M. et al

in Veterinary Journal (2006), 172(3), 549-552

A total of 312 post-mortem examinations of 178 canaries (Serinus canarius domesticus), 40 parakeets (Melopsittacus undulatus, Nymphicus hollandicus) and 94 parrots (Amazona aestiva, Psitaccus erithacus ... [more ▼]

A total of 312 post-mortem examinations of 178 canaries (Serinus canarius domesticus), 40 parakeets (Melopsittacus undulatus, Nymphicus hollandicus) and 94 parrots (Amazona aestiva, Psitaccus erithacus) were conducted at the Birds and Rabbits Service of the University of Liege, Belgium. After a detailed gross examination, tissue samples were collected for virological and/or bacteriological and/or parasitological examination to complete the diagnosis. In all cases, a microscopic examination of the proventricular mucus layer was undertaken for the detection of the anamorphic ascomycetous yeast Macrorhabdus ornithogaster, which causes the non-zoonotic but important disease in cage birds known as megabacteriosis. At the time of death, megabacteriosis was diagnosed respectively in 28% of canaries and 22.5% of budgerigars (P value for Fisher's exact test = 0.5576), but was not diagnosed in parrots (P value for Fisher's exact test < 0.0001). The incidence of megabacteriosis significantly increases along the years (P value for chi(2) test < 0.0001, Cramer's coefficient = 0.3405). The most common gross lesions seen at necropsy of the 59 megabacteriosis cases was proventricular dilatation (86.1%). All the birds diagnosed as typical megabacteriosis cases were free of Salmonella spp. infections and of any parasitic infections. Four megabacteriosis cases (three canaries, one parakeet) were not included in statistical analysis as salmonellosis, pseudotuberculosis, coccidiosis and chlamydophilosis were diagnosed concomitantly in these birds. With the exception of megabacteriosis, the most frequent causes of death were protozoan (coccidiosis, lankesterellosis) infections (18.4%) and salmonellosis (17.1%) in canaries, and psittacosis (31.5%) and viral hepatitis (26.3%) in parakeets. In parrots, the most common causes of death were psittacosis (28.6%) and aspergillosis (28.5%). (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailViral infections in pigeons
Marlier, Didier ULg; Vindevogel, Henri ULg

in Veterinary Journal (2006), 172(1), 40-51

This review provides a current update on the major viral diseases of the domestic pigeon (Columba livia domestica), based on scientific reports and clinical experience. Paramyxovirus 1, adenovirus ... [more ▼]

This review provides a current update on the major viral diseases of the domestic pigeon (Columba livia domestica), based on scientific reports and clinical experience. Paramyxovirus 1, adenovirus, rotavirus, herpesvirus 1, poxvirus and circovirus infections are described according to common clinical signs and target tissues. Since pigeons are sometimes treated as if they were poultry, the review also summarises the common viral infections of poultry for which pigeons are considered resistant. It is hoped that the review will provide a useful reference for veterinarians and others and offer advice on the diagnosis, treatment and prevention of the major infectious diseases of pigeons. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailInfectious agents associated with epizootic rabbit enteropathy: Isolation and attempts to reproduce the syndrome
Marlier, Didier ULg; Dewrée, Roxane; Lassence, Cédric ULg et al

in Veterinary Journal (2006), 172(3), 493-500

Epizootic rabbit enteropathy (ERE), a highly lethal (30-80% mortality) disease of broiler rabbits aged 6-14 weeks, first appeared in 1997 in French intensive enclosed rabbitries and is of unknown ... [more ▼]

Epizootic rabbit enteropathy (ERE), a highly lethal (30-80% mortality) disease of broiler rabbits aged 6-14 weeks, first appeared in 1997 in French intensive enclosed rabbitries and is of unknown aetiology. Bacteriological, virological and parasitical examination of the intestinal contents of rabbits that had died either in spontaneous field cases or after experimental reproduction of ERE, were undertaken in an attempt to identify infectious agents that may play a role in the disease. Two bacterial strains, Clostridium perfringens and non-enteropathogenic Escherichia coli, were repeatedly isolated at high faecal counts from naturally infected animals. In field cases, a correlation between typical gross lesions of epizootic enteropathy and the presence of the alpha toxin of Cl. perfringens was observed (P < 0.0001; Chi-squared test). Although attempts to reproduce the disease by inoculation with different pools of cultivable bacterial strains failed, the disease was successfully reproduced by inoculation with one French and two Belgian samples of caecal contents. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailNew data on the transmission of pigeon circovirus
Duchatel, Jean-Pierre ULg; Todd, Danny; Curry, J. et al

in Veterinary Record : Journal of the British Veterinary Association (2005), 157

Nineteen racing pigeons aged from one to five years were examined postmortem. PCR tests showed that the spleens of 16 of them were positive for pigeon circovirus, the livers of six were positive, and ... [more ▼]

Nineteen racing pigeons aged from one to five years were examined postmortem. PCR tests showed that the spleens of 16 of them were positive for pigeon circovirus, the livers of six were positive, and blood from one of them was positive for the virus. Five of 44 embryos in embryonated eggs collected from three lofts were positive by PCR, but swabs taken from the crops of 64 adult birds which were feeding one- to 10-day-old squabs in these three lofts were negative for the viral DNA. [less ▲]

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See detailEuropean College of Rabbit Medicine and Surgery?
Vindevogel, Henri ULg; Marlier, Didier ULg

in Veterinary Record : Journal of the British Veterinary Association (2004), 154(13), 412-412

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See detailRisk evaluation of the transmission of the avian influenza virus to humans
Saegerman, Claude ULg; Meulemans, G.; Van Reeth, K. et al

in Annales de Médecine Vétérinaire (2004), 148(2), 65-77

Since mid-december 2003, an epizootic of highly pathogenic avian influenza (type A, sub-type H5N1) occurs in eastern and south-eastern Asia. This epizootic is historically unprecedented in its virulence ... [more ▼]

Since mid-december 2003, an epizootic of highly pathogenic avian influenza (type A, sub-type H5N1) occurs in eastern and south-eastern Asia. This epizootic is historically unprecedented in its virulence, geographical spread, and economic consequences for the agricultural sector. Implications for human health were registered in Vietnam and in Thailand. This paper summarizes the current knowledge about the risk evaluation of the transmission of avian influenza virus to humans. The current asian epizootic has highlighted the key role of global health information systems and also the need for exhaustive notification of human and animal cases. It reinforces the concept of veterinary public health. [less ▲]

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See detailL'Entéropathie Epizootique du Lapin (EEL) : un bilan provisoire des résultats après 20 mois de recherches
Marlier, Didier ULg; Dewrée, Roxane; Licois, Dominique et al

in Proceedings of the 10èmes Journées de la Recherche Cunicole (2003, November 20)

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See detailL'Entéropathie Epizootique du Lapin (EEL) : étude du rôle des infections par clostridium perfringens dans l’étio-pathogénie de ce syndrome
Dewrée, Roxane; Licois, Dominique; Coudert, Pierre et al

in Proceedings of the 10èmes Journées de la Recherche Cunicole (2003, November 20)

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See detailEssais de reproduction expérimentale de l'entéropathie épizootique du lapin (EEL) avec des inoculums originaires de Belgique et des Pays-Bas et avec des souches bactériennes isolées de ces inoculums ainsi que de TEC2 et TEC3 (inoculums INRA)
Licois, Dominique; Dewrée, Roxane; Coudert, Pierre et al

in Proceedings of the 10èmes Journées de la Recherche Cunicole (2003, November 20)

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See detailA review of the major causes of digestive disorders in the European rabbit
Marlier, Didier ULg; Dewrée, Roxane; Delleur, V. et al

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 385-392

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state ... [more ▼]

Digestive diseases frequently occur in rabbitries, inducing high mortality rates and huge economic losses. The major causes of these pathological conditions are described in this review. The current state of knowledge on two diseases of unknown origin, the so called Rabbit Epizootic Enteropathy and Mucoid Enteropathy is also presented. [less ▲]

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See detailCross-Sectional Study of the Association between Pathological Conditions and Myxoma-Virus Seroprevalence in Intensive Rabbit Farms in Europe
Marlier, Didier ULg; Herbots, J.; Detilleux, Johann ULg et al

in Preventive Veterinary Medicine (2001), 48(1), 55-64

Myxomatosis is a major viral disease of the European rabbit (Oryctolagus cuniculus). Two forms of the disease (nodular and amyxomatous) exist. The clinical diagnosis of the nodular form is easily ... [more ▼]

Myxomatosis is a major viral disease of the European rabbit (Oryctolagus cuniculus). Two forms of the disease (nodular and amyxomatous) exist. The clinical diagnosis of the nodular form is easily performed on the basis of typical skin lesions whereas that of amyxomatous forms must be based on virus isolation or detection of specific antibodies to myxoma virus (MV). The seroprevalence of MV was studied between March 1998 and February 1999 in 16 farms from three European countries considered free of myxomatosis on the basis of the absence of typical clinical signs. MV antibodies were detected by enzyme-linked immunosorbent assay (ELISA) (sensitivity 100%, specificity 90%) in all 16 farms; the seroprevalences corrected for test inaccuracy (95% confidence interval) were 55+/-7.7% and 37+/-6.1% for does and broilers, respectively. The association between herd sizes, types of rabbitries, and presence of recurrent respiratory or digestive troubles and seroprevalence of MV antibodies was tested in logistic multiple regressions. In all models, the seroprevalence of MV antibodies was significantly higher in herds (does and broilers) with recurrent respiratory or digestive troubles than in herds without these problems. The seroprevalence was also higher in herds (does and broilers) where animals were housed totally or partially in outdoors rabbitries than in totally enclosed rabbitries. The effect of herd sizes on the presence of MV antibodies was the same in does and broilers; intermediate sizes were at lower risk than the smaller and larger ones. [less ▲]

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See detailDuck plague: a permanent threat for domestic and wild anatids
Marlier, Didier ULg; Jaumin, F.; Delleur, V. et al

in Annales de Médecine Vétérinaire (2001), 145(5, NOV-DEC), 287-291

Duck plague: a permanent threat for domestic and wild anatids. Duck plague, also named duck virus enteritis is a disease of ducks, geese and swans of all ages. The authors present a review of the current ... [more ▼]

Duck plague: a permanent threat for domestic and wild anatids. Duck plague, also named duck virus enteritis is a disease of ducks, geese and swans of all ages. The authors present a review of the current knowledge about this viral infection. [less ▲]

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See detailRecommended methods for euthanasia
Marlier, Didier ULg; Verstegen, John; Serteyn, Didier ULg et al

Scientific conference (2000)

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See detailStudy of the Virulence of Five Strains of Amyxomatous Myxoma Virus in Crossbred New Zealand White/Californian Conventional Rabbits, with Evidence of Long-Term Testicular Infection in Recovered Animals
Marlier, Didier ULg; Mainil, Jacques ULg; Sulon, Joseph ULg et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 101-13

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by ... [more ▼]

The virulence of five amyxomatous myxoma virus (MV) strains, the clinical and pathogenetic effects of which had been studied previously in specific pathogen-free (SPF) rabbits, was determined by inoculation of five groups of 10 crossbred New Zealand White/Californian conventional rabbits. A much more acute myxomatosis syndrome was produced in conventional rabbits than that reproduced previously in SPF animals. However, the main clinical signs were of the respiratory type. The MV strains MYX 254/95 and 801 appeared very virulent, killing all the inoculated animals. The strains MYX 217/95, MYX 555/94 and Saint Benoist were somewhat attenuated, killing only seven, six and six rabbits, respectively. Extensive lung lesions due to supervening bacterial infections were observed in 36 of the 39 rabbits that died. Lethality was found to be a better estimate of virulence than mean survival time. By 98 days after viral inoculation, all the surviving animals had completely recovered. At that time, they were immunosuppressed by treatment with adrenocorticotrophic hormone (ACTH) for 10 days to determine whether they still harboured the virus. After the ACTH treatment, eight of the 11 surviving rabbits showed clinical signs that resembled amyxomatous myxomatosis. All the virological examinations performed on naso-conjunctival exudate, on mononuclear cells, on eyelids and on ovaries remained negative but infectious virus was isolated from the testes of three of six surviving male rabbits. [less ▲]

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See detailInfectious Agents Associated with Rabbit Pneumonia: Isolation of Amyxomatous Myxoma Virus Strains
Marlier, Didier ULg; Mainil, Jacques ULg; Linden, Annick ULg et al

in Veterinary Journal (2000), 159(2), 171-8

Sixty-six rabbits, with no history of vaccination against myxomatosis and which had died of pulmonary lesions, were submitted for virological and serological tests for Myxoma virus (MV) infection and for ... [more ▼]

Sixty-six rabbits, with no history of vaccination against myxomatosis and which had died of pulmonary lesions, were submitted for virological and serological tests for Myxoma virus (MV) infection and for bacteriological examinations. At post mortem, the diagnoses based on observed lesions were as follows: acute haemorrhagic pneumonia (38%); acute suppurative bronchopneumonia (35%); and fibrinohaemorrhagic bronchopneumonia with fibrinous pleuritis (27%). MV was isolated from 10% of the rabbits, mainly from those with acute haemorrhagic pneumonia. Serological evidence of MV infection was demonstrated in 44% of rabbits. Pathogenic bacteria species isolated from lungs were Pasteurella (spp. and multocida), Escherichia coli, Bordetella bronchiseptica and Pseudomonas aeruginosa, respectively, from 41, 11, 7 and 6% of samples. No relationship could be established between the presence of specific antibodies to MV and the observed pulmonary lesions or the results of the bacteriological examinations. A significant trend was established between the severity of the lesions and the results of the bacteriological examinations. [less ▲]

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See detailDescription de cas de chondrodystrophie dans trois exploitations de poulets label
Korsak, Nicolas; Marlier, Didier ULg; Mathieu, F. et al

in Annales de Médecine Vétérinaire (2000), 144(6), 415-420

The present paper describes chondrodystrophy (perosis) in three poultry units producing labelled chickens. An unilateral deviation of a hind leg along with a tumefaction of the tarsal joint appeared in 4 ... [more ▼]

The present paper describes chondrodystrophy (perosis) in three poultry units producing labelled chickens. An unilateral deviation of a hind leg along with a tumefaction of the tarsal joint appeared in 4-day- to 4-week-old birds; 5 to 50% of the animals were affected. The growth rate was reduced and cachexia was also observed. There were also breast blisters. Chemical analyses were carried out on the poultry feed in two of the units. The manganese content was below the requirements at about 35 mg/kg; in one unit, the ionic balance (Na+K-Cl) was insufficient along with a too narrow Ca/P. The insufficient supply in manganese was corrected by the addition of manganese sulfate in water at a rate of 120 g/litre of water. Manganese sulfate was also added in the feedstuff at a rate of 120 g/ton. [less ▲]

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See detailThe Efficacy of Two Vaccination Schemes against Experimental Infection with a Virulent Amyxomatous or a Virulent Nodular Myxoma Virus Strain
Marlier, Didier ULg; Mainil, Jacques ULg; Boucraut-Baralon, C. et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 115-22

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An ... [more ▼]

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An experiment was designed to compare two vaccination schemes for their ability to protect rabbits against challenge with either a virulent amyxomatous MV strain or a virulent nodular MV strain. Apart from a difference in the cutaneous expression of the disease, the two challenge strains resembled each other in respect of mortality rate, naso-conjunctival shedding of virus, and tissue infection. Vaccination with SFV alone failed to prevent clinical signs, naso-conjunctival shedding or tissue infection. Vaccination with SFV followed by a booster inoculation with SG33 protected rabbits against the development of clinical signs and significantly reduced both viral shedding in naso-conjunctival exudates and viral infection of eyelids, lungs and testes; virus was, however, isolated from testes of some surviving animals. [less ▲]

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