References of "Vincke, G"
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See detailComparison between Pulmonary Resistance and Penh in Anaesthetised Rats with Tracheal Diameter Reduction and after Carbachol Inhalation
Kirschvink, N.; Vincke, G.; Onclinx, C. et al

in Journal of Pharmacological & Toxicological Methods (2005), 51(2, Mar-Apr), 123-128

Introduction: Single-chambered barometric whole-body plethysmography is frequently used as a noninvasive lung function test. However, the validity of the enhanced Pause (Penh), an index of airflow ... [more ▼]

Introduction: Single-chambered barometric whole-body plethysmography is frequently used as a noninvasive lung function test. However, the validity of the enhanced Pause (Penh), an index of airflow limitation, remains controversial. We compared Penh with pulmonary resistance (R(L)) to test whether Penh detects tracheal subobstruction and carbachol-induced airflow limitation in spontaneously breathing, anaesthetised rats. Methods: Fourteen male Sprague-Dawley rats underwent tracheal catheterisation, followed by measurements of R(L) and Penh. Six rats underwent tracheal subobstruction by the consecutive insertion into the lumen of the tracheal tube of two catheters of decreasing diameter. Eight rats received an inhaled saline challenge, followed by two noncumulative nebulizations of carbachol (1.25 mg/mL, 1 min). Results: In rats with tracheal calibre reductions, R(L) significantly increased at each reduction (0.218+/-0.052 vs. 0.417+/-0.058 vs. 0.820+/-0.258 cm H(2)O/mL s, p<0.05), whereas Penh only increased after the last reduction (1.88+/-0.25 vs. 2.47+/-0.26, p<0.05). Increases (Delta) of R(L) and Penh were not correlated. In comparison to postsaline values, carbachol induced a significant increase of Penh (1.93+/-0.44 vs. 4.05+/-1.45, p<0.005) and R(L) (0.137+/-0.04 vs. 0.284+/-0.084 cm H(2)O/mL.s, p<0.005). DeltaPenh and DeltaR(L) were significantly correlated (r=0.80, p<0.05). Discussion: This study showed, by comparing Penh with R(L), that single-chambered plethysmography measuring Penh allows to detect carbachol-induced airflow limitation in spontaneously breathing, anaesthetised Sprague-Dawley rats, but poorly detects an increase in R(L) due to tracheal calibre reductions. These findings suggest that Penh might be only be used as an index of airflow limitation under well-defined experimental conditions. [less ▲]

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See detailIncrease of MMP-2 and MMP-9 activity in bronchoalveolar lavage fluid of Ascaris suum sensitized cats and correlation with inflammatory and morphological variables
Kirshvink, N.; Delvaux, François ULg; Vincke, G. et al

in International Conference of the American Thoracic Society - Orlando - USA - Mai 2004 (2004, May)

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See detailCharakterisierung des bronchialen “remodellings” in einem Modell von felinem Asthma
Kirschvink, N.; Delvaux, François ULg; Vincke, G. et al

in 45. Kongress der Deutschen Gesellschaft für Pneumologie - Frankfurt - Allemangne - Mars 2004 (2004, March)

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See detailCharakteriseiring des bronchialen remodelligs in eimen model von felinem asthma
Kirschvink, Nathalie; Delvaux, Francois; Vincke, G. et al

Conference (2004)

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See detailCadmium-induced lung inflammation in rats is associated with an increase of matrix metalloproteinases-2 and -9 activity in broncho-alveolar lavage fluid
Vincke, G.; Kirschvink, Nathalie; Belleflamme, M. et al

in Pflügers Archiv : European Journal of Physiology (2004), 447

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See detailWhole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs
Halloy, D.; Kirschvink, Nathalie; Vincke, G. et al

in Veterinary Journal (2004), 168

The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the ... [more ▼]

The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the intensity of the pulmonary response to endotoxins. Penh was firstly recorded in non-sedated freeiy moving piglets exposed (1) to a nebulized acetylchoiine (Ach) pre-treated or not with cienbuterol, or (2) to endotoxin challenge. To measure Penh simultaneously with total pulmonary resistance (RL), dynamic compliance (cd1) and intrapleural pressure changes (MaxPpl), an oesophageal balloon catheter technique was used and the piglets were anaesthetised. The recordings were performed during (1) an intravenous metacholine (Mch) challenge and (2) in endotoxin-exposed animais. In freely moving animais, Ach induced a significant dose-dependent increase in Penh, which was significantly blocked by clenbuterol. Endotoxin instillation aiso resulted in a significant rise in Penh while the corresponding response measured under anaesthesia was signiflcantly and positively correlated with RL and MaxzPpi. Similar results were obtained during Mch challenge but the Penh was negatively correlated with Cd. We conclude that Penh could be used in freely moving piglets as a screening index for airway reactivity and pulmonary functional changes in cholinergic and endotoxin challenges [less ▲]

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See detailCadmium-induced oxidative stress and lung emphysema in rats
Kirschvink, Nathalie; Delvaux, F.; Vincke, G. et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2004), 71

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See detailMMP-2 and MMP-9 activity is increased in bronchoalveolar lavage fluid of asthmatic cats
Kirschvink, N.; Delvaux, François ULg; Leemans, J. et al

in Autumn Meeting, Belgian Society of Fundamental and Clinical physiology and Pharmacology - Liège - Belgique - novembre 2003 (2003, November)

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See detailIncreased hydrogen peroxide in breath condensate after aero-allergen challenge in ascaris-suum sensitived cats
Kirschvink, Nathalie; Delvaux, Francois; Leemans, Jerome et al

Conference (2003)

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See detailHydrogen peroxyde in breath condensate as marker of lower airway inflammation in an experimental model of feline asthma
Kirschvink, Nathalie; Malin, D.; Delvaux, Francois et al

Conference (2003)

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See detailEffect of polystyrene particles on lung mirovascular permeability in isolated perfused rabbit lungs : role of size and surface proporties
Hamoir, J.; Nemmar, A.; Halloy, D. et al

in Toxicology and Applied Pharmacology (2003), 190

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See detailEffect of bronchoalveolar lavage on lung function in healthy cats assessed by plethysmography
Kirschvink, N.; Vincke, G.; Marville, M. et al

in 20th Veterinary Comparative Respiratory Society - Boston, Massachussetts - USA - Octobre 2002 (2002, October)

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See detailFrequency dependence of Penh-index in healthy kittens
Kirschvink, N.; Vincke, G.; Marville, M. et al

in 20th Veterinary Comparative Respiratory Society - Boston, Massachussetts - USA - Octobre 2002 (2002)

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See detailRole of Substance P and Tachykinin Receptor Antagonists in Citric Acid-Induced Cough in Pigs
Moreaux, B.; Nemmar, A.; Vincke, G. et al

in European Journal of Pharmacology (2000), 408(3), 305-312

The purpose of this work was to investigate the role of tachykinins in cough induced by citric acid (0.8 M) in pigs. With this object, we have studied the effect of citric acid on substance P content in ... [more ▼]

The purpose of this work was to investigate the role of tachykinins in cough induced by citric acid (0.8 M) in pigs. With this object, we have studied the effect of citric acid on substance P content in the tracheo-bronchial tree and the effects of substance P and of tachykinin receptor antagonists on citric acid-induced cough. Citric acid exposure significantly increased substance P concentration in both broncho-alveolar and tracheal lavage fluids, while it decreased significantly the substance P content in tracheal mucosa. Substance P did not elicit cough, but significantly potentiated the citric acid-induced cough frequency. Tachykinin NK(1), NK(2) or NK(3) receptor antagonists, SR 140333 (nolpitantium), SR 48968 (saredutant) and SR 142801 (osanetant), respectively, significantly inhibited citric acid-induced cough. The same inhibitory effect of tachykinin receptor antagonists was observed, when substance P was nebulised before citric acid challenge. We conclude that citric acid induces in pigs a release of substance P in the tracheo-bronchial tree, which plays a sensitising role on the cough reflex. The involvement of tachykinin NK(1), NK(2), NK(3) receptors are also demonstrated in this reflex. [less ▲]

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