The effects of forodesine in murine and human multiple myeloma cells

in Advances in Hematology (2010)

Thymosin beta4 in multiple myeloma: friend or foe

in Annals of the New York Academy of Sciences (2010), 1194(1), 125-130

Antitumor and anti-angiogenic effects of aplidin in the 5T33MM model, syngeneic model of multiple myeloma

in British Journal of Cancer (2008), 98(12), 1966-74

Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients.

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2006), 20(10), 1870-9

Ac-SDKP: linking cardiac remodelling to haematological malignancies.

in Leukemia & Lymphoma (2006), 47(9), 1732-3

Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model

in American Journal of Pathology (2004), 165(3), 869-878

Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the pathogenesis of cancer. Multiple myeloma is ... [more ▼]

Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the pathogenesis of cancer. Multiple myeloma is a B-cell cancer characterized by the proliferation of malignant plasma cells in the bone marrow, increased angiogenesis, and the development of osteolytic bone disease. The role of MMPs in the development of multiple myeloma is poorly understood. Using SC-964, a potent inhibitor of several MMPs (MMP-2, -3, -8, -9, and -13), we investigated the role of MMPs in the 5T2MM murine model. Reverse transcriptase-polymerase chain reaction demonstrated the presence of mRNA for MMP-2, -8, -9, and -13 in 5T2MM-diseased bone marrow. Mice bearing 5T2MM cells were given access to food containing SC-964. The concentration of SC-964 measured in the plasma of mice after 11 days of treatment was able to inhibit MMP-9 activity in gelatin zymography. Treatment of 5T2MM-bearing mice resulted in a significant reduction in tumor burden, a significant decrease in angiogenesis, and partially protective effect against the development of osteolytic bone disease. The direct role of MMPs in these different processes was confirmed by in vitro experiments. All these results support the multifunctional role of MMPs in the development of multiple myeloma. [less ▲]