References of "Vanderkerken, Karin"
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See detailMithramycin Exerts an Anti-Myeloma Effect and Displays Anti-Angiogenic Effects through Up-Regulation of Anti-Angiogenic Factors.
Otjacques, Eléonore ULg; Binsfeld, Marilène ULg; Rocks, Natacha ULg et al

in PLoS ONE (2013), 8(5), 62818

Mithramycin (MTM), a cytotoxic compound, is currently being investigated for its anti-angiogenic activity that seems to be mediated through an inhibition of the transcription factor SP1. In this study we ... [more ▼]

Mithramycin (MTM), a cytotoxic compound, is currently being investigated for its anti-angiogenic activity that seems to be mediated through an inhibition of the transcription factor SP1. In this study we evaluated its anti-myeloma effects in the syngenic 5TGM1 model in vitro as well as in vivo. In vitro, MTM inhibited DNA synthesis of 5TGM1 cells with an IC50 of 400 nM and induced an arrest in cell cycle progression at the G1/S transition point. Western-blot revealed an up-regulation of p53, p21 and p27 and an inhibition of c-Myc, while SP1 remained unaffected. In rat aortic ring assays, a strong anti-angiogenic effect was seen, which could be explained by a decrease of VEGF production and an up-regulation of anti-angiogenic proteins such as IP10 after MTM treatment. The administration of MTM to mice injected with 5TGM1 decreased 5TGM1 cell invasion into bone marrow and myeloma neovascularisation. These data suggest that MTM displays anti-myeloma and anti-angiogenic effects that are not mediated by an inhibition of SP1 but rather through c-Myc inhibition and p53 activation. [less ▲]

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See detailThe effects of forodesine in murine and human multiple myeloma cells
Bieghs, Liesbeth; Caers, Jo ULg; De Bruyne, Elke et al

in Advances in Hematology (2010)

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See detailThymosin Beta 4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma
Caers, Jo ULg; Hose, Dirk; Kuijpers, Ine et al

in Haematologica (2010), 95(1), 163-167

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See detailThymosin beta4 in multiple myeloma: friend or foe
Caers, Jo ULg; Otjacques, Eléonore ULg; Hose, Dirk et al

in Annals of the New York Academy of Sciences (2010), 1194(1), 125-130

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See detailDecreased Thymosin Beta 4 Expression Results in Poor Prognosis and Decreased Survival in Multiple Myeloma
CAERS, Jo ULg; Hose, Dirk; Kuipers, Ine et al

Poster (2008)

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See detailUnraveling the biology of MM disease: cancer stem cells, acquired intracellular changes and interactions with the surrounding micro-environment.
Caers, Jo ULg; Van Valckenborgh, Els; Menu, Eline et al

in Bulletin du Cancer (2008), 95(3), 301-13

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See detailAntitumor and anti-angiogenic effects of aplidin in the 5T33MM model, syngeneic model of multiple myeloma
Caers, Jo ULg; De Raeve, Hendrik; Lepage, Doreen et al

in British Journal of Cancer (2008), 98(12), 1966-74

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See detailMultiple Myeloma, an update on diagnosis and treatment.
Caers, Jo ULg; Vande Broek, Isabelle; De Raeve, Hendrik et al

in European Journal of Haematology (2008), 81(5), 329-343

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See detailNeighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells
Caers, Jo ULg; Deleu, Sara; Belaid, Zakia ULg et al

in Leukemia (2007), 21(7), 1580-1584

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See detailNeighboring adipocytes participate in the bone marrow micro-environment of multiple myeloma cells
CAERS, Jo ULg; DeLeu, Sarah; Belaid, Zakia et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2007), 21(7), 1580-4

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See detailDe bijdrage van muismodellen bij studies naar multipel myeloom
Vanderkerken, Karin; Van Valckenborgh, Els; Menu, Eline et al

in Nederlands Tijdschrift voor Hematologie (2007), 4(4), 193-143

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See detailEndothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients.
De Bruyne, Elke; Andersen, T. L.; De Raeve, Hendrik et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2006), 20(10), 1870-9

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