References of "Vandeputte, Sébastien"
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See detailECONOMIC IMPACT OF USING AN ANTIVIRAL IN THE CONTROL OF A FOOT-AND-MOUTH DISEASE EPIZOOTIC IN SOUTHERN BELGIUM
Dal Pozzo, Fabiana ULg; Humblet, Marie-France ULg; Vandeputte, Sébastien ULg et al

Poster (2013, October)

Foot-and-mouth disease virus (FMDV) is a highly contagious pathogen of cloven-hoofed mammals and one of the biggest concerns for veterinary authorities. The control measures to be applied in case of an ... [more ▼]

Foot-and-mouth disease virus (FMDV) is a highly contagious pathogen of cloven-hoofed mammals and one of the biggest concerns for veterinary authorities. The control measures to be applied in case of an outbreak vary in function of the disease-free or disease-enzootic status. Vaccination depends on the prior identification of the involved viral serotype and subtype, it confers an immunity limited to 6 months and it requires between 4 to 7 days to trigger the immune response (i.e. immunity-gap). The use of anti-FMD drugs has been discussed as an alternative or supplementary method to be used in previously FMD-free countries/zones. Such an antiviral treatment could protect against the viral dissemination to fill the gap between vaccination and the rise of a protective immunity. Apart from broad spectrum antiviral agents, such as ribavirin, specific anti-FMDV molecules have been identified in vitro, but none of them has been used in clinical studies involving ruminants or pigs. Next to the anti-FMDV activity, the absence of toxicity and the withdrawal period influencing the food safety, the cost of the treatment would be another important parameter influencing the potential use of an antiviral agent in the control of a FMD outbreak. The aim of this study was to assess the economic impact of using an antiviral in the control of a FMD epizootic in southern Belgium (Walloon Region). This work was based on the results of previous investigations concerning the epidemiological and economic data of a FMD outbreak in Southern Belgium. In the considered scenario, the epizootic was caused by the introduction of an infected cow (during the incubation time) in a beef cattle farm during winter. During the two weeks between the brood cow introduction and the official declaration of the outbreak, animal movements occurred between other beef cattle farms. The economic effects of the epidemic were evaluated taking into account the air-borne transmission of FMDV, the occurrence of animal movements (two scenarios were considered, with a minimum of 2 and a maximum of 17 movements), the presence of bovine and small ruminant farms, as well as pig farms in the protection and surveillance zones around the initial and secondary outbreaks. The wild fauna was not involved in the epidemic. In order to integrate in the above scenario the application of an antiviral agent in the control of the disease, it was assumed that the efficacy of the anti-FMDV drug was proven by reducing viral excretion in infected animals as well as by preventing the infection in animals at risk. Two hypothetical prices were used to introduce in the model the costs related to the administration of the antiviral drug (5€ and 10€ per dose). Furthermore, different strategies of control could be envisaged, such as the administration of the drug to both domestic ruminants and pigs, or depending on the epidemiological role of these species in the FMD transmission and their density in the territory, the administration of the drug to only one of them. Other scenarios could be characterized by the use of the antiviral in the control of the epizootic within the protection and surveillance zones or in only one of them. The costs associated with the use of antivirals in the different proposed scenarios are compared to the costs and socio-economic losses associated with the FMD outbreak and the implementation of control measures. [less ▲]

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See detailMultidisciplinary and Evidence-based Method for Prioritizing Diseases of Food-producing Animals and Zoonoses
Humblet, Marie-France ULg; Vandeputte, Sébastien ULg; Albert, Adelin ULg et al

in Emerging Infectious Diseases (2012), 18(4),

To prioritize 100 animal diseases and zoonoses in Europe, we used a multicriteria decision-making procedure based on opinions of experts and evidence-based data. Forty international experts performed ... [more ▼]

To prioritize 100 animal diseases and zoonoses in Europe, we used a multicriteria decision-making procedure based on opinions of experts and evidence-based data. Forty international experts performed intracategory and intercategory weighting of 57 prioritization criteria. Two methods (deterministic with mean of each weight and probabilistic with distribution functions of weights by using Monte Carlo simulation) were used to calculate a score for each disease. Consecutive ranking was established. Few differences were observed between each method. Compared with previous prioritization methods, our procedure is evidence based, includes a range of fields and criteria while considering uncertainty, and will be useful for analyzing diseases that affect public health [less ▲]

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See detailInstruments de gestion économique des crises sanitaires touchant les animaux de production en Europe
Vandeputte, Sébastien ULg; Humblet, Marie-France ULg; Fecher-Bourgeois, Fabienne ULg et al

in Revue Scientifique et Technique / Office International des Epizooties = Revista Cientifica y Tecnica / Officina Internacional de Epizootias = Scientific and Technical Review / International Office of Epizootics (2011), 30(3), 683-701

The importance of animal health crises has considerably increased over the last few years. When a crisis occurs, farmers can receive financial support through various public, private and mixed ... [more ▼]

The importance of animal health crises has considerably increased over the last few years. When a crisis occurs, farmers can receive financial support through various public, private and mixed compensation schemes. Economic losses resulting from diseases may be direct and indirect. If a disease is covered by European Union regulations then countries have a legal obligation to partly compensate farmers for direct losses, either directly through the national budget, or through a specific fund. The European Veterinary Fund also cofinances these losses. Only a few countries provide compensation for indirect losses. The private insurance sector also provides protection against some direct and indirect losses but the risks covered are variable. To encourage farmers to subscribe to this kind of insurance, some public authorities provide subsidies to help pay the premium. Insurance companies do not generally cover the risks linked to contagious diseases, but some companies do extend cover to include this type of risk. Several alternatives, such as mutual funds, are available to improve risk coverage. There is a lack of harmonisation among the various compensation schemes of different countries. Public authorities cannot provide full compensation, but mutual funds and private insurance companies are alternatives that should be further investigated and their use should be extended to other countries. A classification of diseases would harmonise the situation at the European level. [less ▲]

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See detailSigns of neurotoxicity in a Belgian Blue herd after ingestion of moulded silage
Guyot, Hugues ULg; Sandersen, Charlotte ULg; Brihoum, Mounir ULg et al

in Cattle Practice (2011), 19(1), 57-60

After ingestion of moulded beet pulp silage, cases of cerebro-cortical necrosis (CCN) and mortalities were observed in a dual purpose Belgian Blue (BB) herd. Contamination with Paecilomyces spp., a mould ... [more ▼]

After ingestion of moulded beet pulp silage, cases of cerebro-cortical necrosis (CCN) and mortalities were observed in a dual purpose Belgian Blue (BB) herd. Contamination with Paecilomyces spp., a mould that produces byssochlamic acid, malformins and patulin, was proven. Twenty-five days after progressive introduction of beet pulp silage into the ration, most of the animals showed diminished appetite, excessive salivation and decreased milk production. Some of them showed anorexia, head pressing and blindness while 4 animals died within 1 week after onset of neurological symptoms. The survivors had been treated successfully with thiamine and recovered completely within five days. Once the beet pulp silage had been identified as causative agent, it was removed from the animals’ ration and no more clinical cases were observed. Silage was obviously moulded and analysis revealed the presence of 1.6 million CFU Paecilomyces spp./g of silage. Although no further investigation was undertaken to identify the mycotoxins, intoxication with patulin was suspected, since other mycotoxins produced by these species are less toxic. Although it has not been described that CCN can be induced by ingestion of Paecilomyces spp., it seems that there is a close relation between ingestion of Paecilomyces-contaminated silage and clinical signs observed in this herd. [less ▲]

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See detailComparison of Four Refractometers for the Investigation of the passive transfer in Beef Calves
Vandeputte, Sébastien ULg; Detilleux, Johann ULg; Rollin, Frédéric ULg

in Journal of Veterinary Internal Medicine (2011), 25

Background: Failure of passive transfer (FPT) in beef calves can be detected by refractometry. Nevertheless, different models of refractometers are available, and few studies compare them for the ... [more ▼]

Background: Failure of passive transfer (FPT) in beef calves can be detected by refractometry. Nevertheless, different models of refractometers are available, and few studies compare them for the detection of FPT. Objectives: To compare the accuracy of 4 different refractometers for measuring serum total protein concentrations in comparison with results obtained by the biuret method and, based on the serum IgG threshold of 1,600 mg/mL, to determine, for each refractometer, the optimal serum protein concentration’s lowest threshold for successful passive transfer. Animals: One hundred and eight healthy beef calves, 3–8 days of age. Methods: Observational study. The concentrations of serum total proteins were determined with 4 different models of refractometers and compared with the biuret method by a Bland–Altman statistical method. The optimal serum protein concentration’s lowest threshold for successful passive transfer was determined for each refractometer by receiver operating characteristic (ROC) analysis. In addition, the serum immunoglobulin G (IgG) concentration was compared with the serum gamma-glutamyl transferase (c-GT) activity and with the total immunoglobulin concentration. Results: The refractometric measurements were highly correlated with those obtained by the biuret method. Serum total protein concentration threshold values of 56, 58, 54, and 56 g/L were found respectively for the Atago, Atago ATC, Wolf ATC, and digital ATC refractometers. Immunoglobulins were highly correlated with IgG, whereas Gamma-GT only reflected colostrum uptake by the calf. Conclusions and Clinical Importance: All refractometers could be used for the assessment of passive transfer using their individual serum protein concentration threshold. [less ▲]

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See detailEvaluation of a Bovine Concentrated Lactoserum for Preventing Neonatal Diarrhoea in Belgian Blue Calves
Vandeputte, Sébastien ULg; Rollin, Frédéric ULg; Guyot, Hugues ULg et al

in Open Veterinary Science Journal (The) (2010), 4

The purpose of this study was to evaluate, under field conditions, the efficacy of an european registered bovine concentrated lactoserum (Locatim) in 3 farms with neonatal diarrhoea in calves. A total of ... [more ▼]

The purpose of this study was to evaluate, under field conditions, the efficacy of an european registered bovine concentrated lactoserum (Locatim) in 3 farms with neonatal diarrhoea in calves. A total of 117 healthy Belgian Blue (BB) calves were allocated in 2 groups. Two thirds of the calves received Locatim orally immediately after birth and maternal colostrum one hour later (treated group), while control calves only received maternal colostrum. Every day during 14 days, mental status, faeces consistency, suckling reflex and hydration status of each calf were monitored. Individual blood samples were assessed for passive transfer and specific Escherichia coli antibodies against strains F5, CS31A, F17 and F41. Faecal samples from diarrheic and non diarrheic calves were analysed for rotavirus, bovine coronavirus, Cryptosporidium parvum and Escherichia coli F5. Locatim had no significant effect on the onset, duration and incidence of diarrhoea. The mean serum IgG concentration of 23.1 ± 7.8 mg/ml indicates a good IgG transfer. Only the CS31A strain titer was significantly higher in the treated group. The major identified causative agent of diarrhoea was C. parvum. In conclusion, Locatim only has a slight effect when IgG transfer is optimal, but could be justified when specific antibodies lacking in colostrum are needed [less ▲]

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See detailNutritional markers course after oral supplementation with different forms of iodine in Holstein non-lactating cows
Guyot, Hugues ULg; VanParijs, Sandrine; Uyttenhoef, Aude et al

Poster (2009)

Iodine (I) deficiency is commonly reported in cattle around the world and is often associated with clinical or sub-clinical diseases. As most of clinical signs are not pathognomonic, diagnosis has to be ... [more ▼]

Iodine (I) deficiency is commonly reported in cattle around the world and is often associated with clinical or sub-clinical diseases. As most of clinical signs are not pathognomonic, diagnosis has to be confirmed by biochemical analyses such as plasmatic inorganic iodine (PII) or urinary I. Different oral mineral forms of I are available in Europe for cattle. The aim of the study was to compare the kinetic of I in blood and urine in non-lactating cows, following oral administration of different forms of I. Five groups of 6 non-lactating cows (aged 6 ± 2 years, weight 604 ± 89 kg), receiving the same ration (11 kg dry matter) and housed in the same conditions (tied-stall and straw) underwent a double-blinded trial during 2 months. Excepting in Group A (Control), all cows received a daily oral supplementation of I equal to 5 ppm, in the form of Ca(IO3)2 (Group B), KI (Group C), organic form of I 1 (Group D) and organic form of I 2 (Group E). Formulas of the organic forms of I are not public and coverable by patent. Supplementation was stopped at T45. Blood and urine samples were taken at T0, T15, T30 and T60. Thyroxine (T4) was measured at T0, T30 and T60 while PII and urinary I were measured at the 4 times of the trial. Student-t test and multiple comparisons of means (mix crossed model) were used to compare I and T4 concentrations between groups and times. All characteristics about the cows and I levels in blood or urine were not significantly different at T0 (p>0.1). There was no significant difference (p>0.1) between groups B, C, D, E at the different times of the trial. PII and urinary I in Group A were significantly lower than in other groups (p<0.01) at T15 and T30. Highest concentrations of I (PII up to 242 ± 30 µg/L and urinary I up to 2326 ± 439 µg/L) were reached at T15 for groups B, D and E. At T60, PII (19 ± 4 µg/L) and urinary I (110 ± 29 µg/L) of all groups reached the basal level. A good correlation was found between PII and urinary I (r² = 0.77). No significant differences were found about T4 (67 ± 10 nmol/L) in all groups and times (p>0.1). PII and urinary I are good markers to assess I nutritional status. No difference was found between either inorganic or organic forms of I, nor between them. Concerning the mineral forms of I, Ca(IO3)2 might be preferably used because of its higher stability in the mineral complexes. [less ▲]

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See detailSerum cardiac troponin I concentrations as a diagnostic aid of pericarditis in cattle
Guyot, Hugues ULg; Sartelet, Arnaud ULg; Leidinger, K. et al

Poster (2008, July 10)

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See detailWhole blood viscosity and viscoelasticity in healthy dairy cows
Sandersen, Charlotte ULg; Dringenberg, B.; Vandeputte, Sébastien ULg et al

Poster (2008, July 10)

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See detailHighly effective SNP-based association mapping and management of recessive defects in livestock.
Charlier, Carole ULg; Coppieters, Wouter ULg; Rollin, Frédéric ULg et al

in Nature Genetics (2008), 40(4), 449-54

The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal ... [more ▼]

The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes and mutations that cause inherited defects. We report the fine-scale mapping of five recessive disorders in cattle and the molecular basis for three of these: congenital muscular dystony (CMD) types 1 and 2 in Belgian Blue cattle and ichthyosis fetalis in Italian Chianina cattle. Identification of these causative mutations has an immediate translation into breeding practice, allowing marker assisted selection against the defects through avoidance of at-risk matings. [less ▲]

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See detailManagement of hyperlactataemia in bovine medicine
Vandeputte, Sébastien ULg

in Point Vétérinaire (2007), 38(280), 47-51

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See detailCongenital muscular dystonia (CMD): a new congenital pathology in Belgian Blue calves
Vandeputte, Sébastien ULg; Brihoum, Mounir ULg; Hubin, Xavier et al

Conference (2006, October 15)

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See detailCombined spastic paresis of both gastrocnemius and femoral quadriceps muscles in Belgian blue calves
Janda, Jozef; Uyttenhoef, Aude; Vandeputte, Sébastien ULg et al

Conference (2006)

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See detailTools to assess iodine deficiency in calves born from deficient and non deficient dams
Guyot, Hugues ULg; Uyttenhoef, Aude; Lebreton, Pascal et al

Poster (2006)

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See detailEmergence of bovine Ehrlichiosis in Belgium
Guyot, Hugues ULg; Vandeputte, Sébastien ULg; Sandersen, Charlotte ULg et al

Conference (2005)

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