References of "Vandamme, K"
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See detailNumerical simulation of bone regeneration in a bone chamber.
Geris, Liesbet ULg; Vandamme, K.; Naert, I. et al

in Journal of Dental Research (2009), 88(2), 158-63

While mathematical models are able to capture essential aspects of biological processes like fracture healing and distraction osteogenesis, their predictive capacity in peri-implant osteogenesis remains ... [more ▼]

While mathematical models are able to capture essential aspects of biological processes like fracture healing and distraction osteogenesis, their predictive capacity in peri-implant osteogenesis remains uninvestigated. We tested the hypothesis that a mechano-regulatory model has the potential to predict bone regeneration around implants. In an in vivo bone chamber set-up allowing for controlled implant loading (up to 90 microm axial displacement), bone tissue formation was simulated and compared qualitatively and quantitatively with histology. Furthermore, the model was applied to simulate excessive loading conditions. Corresponding to literature data, implant displacement magnitudes larger than 90 microm predicted the formation of fibrous tissue encapsulation of the implant. In contradiction to findings in orthopedic implant osseointegration, implant displacement frequencies higher than 1 Hz did not favor the formation of peri-implant bone in the chamber. Additional bone chamber experiments are needed to test these numerical predictions. [less ▲]

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See detailA coupled mechanobioregulatory model for the simulation of peri-implant bone formation in an in vivo bone chamber
Geris, Liesbet ULg; Vandamme, K.; Duyck, J. et al

in Proceedings of the second thematic workshop of the European Society of Biomechanics on Finite Element modelling in Biomechanis and Mechanobiology (2007, August)

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See detailInfluence of immediate loading and implant design on bone formation
Vandamme, K.; Naert, Ignace; Geris, Liesbet ULg et al

in Proceedings of the 85th General Session & Exhibition of the IADR (2007)

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See detailThe effect of mechanical loading on peri-implant osteogenesis
Vandamme, K.; Naert, Ignace; Geris, Liesbet ULg et al

in proceedings of the 17th annual meeting of the Dutch society for calcium and bone metabolism (2007)

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See detailBone Formation around Immediately Loaded Implants: a Bone Chamber Model
Vandamme, K.; Naert, Ignace; Geris, Liesbet ULg et al

in Proceedings of the 84th General Session & Exhibition of the IADR (2006)

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See detailThe influence of micro-motion on the tissue differentiation around immediately loaded cylindrical turned titanium implants.
Duyck, Joke; Vandamme, K.; Geris, Liesbet ULg et al

in Archives of Oral Biology (2006), 51(1), 1-9

OBJECTIVE: The aim of this study was to evaluate the effect of various degrees of implant displacement on the tissue differentiation around immediately loaded cylindrical turned titanium implants. DESIGN ... [more ▼]

OBJECTIVE: The aim of this study was to evaluate the effect of various degrees of implant displacement on the tissue differentiation around immediately loaded cylindrical turned titanium implants. DESIGN: The experiments were conducted in repeated sampling bone chambers placed in the tibia of 10 rabbits. Tissues could grow into the bone chambers via perforations. Due to its double structure, tissues inside the chamber could be harvested leaving the chamber intact. This allowed several experiments within the same animal. The chambers contained a cylindrical turned titanium implant that was loaded in a well-controlled manner. In each of the 10 chambers, four experiments were conducted with the following test conditions: immediate implant loading by inducing 0 (control), 30, 60 and 90 microm implant displacement, 800 cycles per day at a frequency of 1 Hz, twice a week during a period of 6 weeks. Histological and histomorphometrical analyses were performed on methylmethacrylate histological sections. An ANOVA was conducted on the dataset. RESULTS: The total tissue volume was significantly lowest in the unloaded control condition. The bone volume fraction on the other hand, was significantly larger in the unloaded and 90 microm implant displacement, compared to the 30 microm implant displacement. Bone density increased with increasing micro-motion with significantly higher values for the 60 microm- and 90 microm-test conditions compared to the unloaded situation. The chance to have bone-to-implant contact decreased in case of micro-motion at the tissues-implant interface. CONCLUSION: The magnitude of implant displacement had a statistically significant effect on the tissue differentiation around immediately loaded cylindrical turned titanium implants. Implant micro-motion had a detrimental effect on the bone-to-implant contact in an immediate loading regimen. [less ▲]

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