References of "VanOosterwyck, Hans"
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See detailA hybrid bioregulatory model of angiogenesis during bone fracture healing
Peiffer, Veronique; Gerisch, Alf; Vandepitte, Dirk et al

in Biomechanics & Modeling in Mechanobiology (2011), 10(3), 383-395

Bone fracture healing is a complex process in which angiogenesis or the development of a blood vessel net work plays a crucial role. In this paper, a mathematicalmodel is presented that simulates the ... [more ▼]

Bone fracture healing is a complex process in which angiogenesis or the development of a blood vessel net work plays a crucial role. In this paper, a mathematicalmodel is presented that simulates the biological aspects of fracture healing including the formation of individual blood vessels. The model consists of partial differential equations, several of which describe the evolution in density of the most important cell types, growth factors, tissues and nutrients. The other equations determine the growth of blood vessels as a result of themovement of leading endothelial (tip) cells. Branching and anastomoses are accounted for in the model. The model is applied to a normal fracture healing case and subjected to a sensitivity analysis. The spatiotemporal evolution of soft tissues and bone, as well as the development of a blood vessel network are corroborated by comparison with experimental data. Moreover, this study shows that the proposed mathematical framework can be a useful tool in the research of impaired healing and the design of treatment strategies. [less ▲]

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See detailMathematical modelling of atrophic non-union and its treatment
Geris, Liesbet ULg; Vander Sloten, Jos; VanOosterwyck, Hans

in Proceedings of the International symposium on Biomechanics and Biology of Bone Healing (2008)

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See detailA mechanobioregulatory model for the study of bone fracture healing
Geris, Liesbet ULg; Gerisch, A.; Weiner, R. et al

in Proceedings of the European Conference on Mathematical and Theoretical Biology (2008)

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See detailMathematical modelling of bone regeneration during fracture healing
Geris, Liesbet ULg; VanderSloten@mech.kuleuven.be, Jos; VanOosterwyck, Hans

in proceedings of the OPTEC Topical Workshop on Parameter Estimation in Differential Equations (2008)

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See detailMathematical modeling of fracture healing: coupling between mechanics, angiogenesis and osteogenesis
Geris, Liesbet ULg; Vander Sloten, Jos; VanOosterwyck, Hans

in IFMBE Proceedings 22 (2008)

Both mechanical and biological factors play an important role in normal as well as impaired fracture healing. This study aims to provide a mathematical framework in which both regulatory mechanisms are ... [more ▼]

Both mechanical and biological factors play an important role in normal as well as impaired fracture healing. This study aims to provide a mathematical framework in which both regulatory mechanisms are included and angiogenesis is explicitly incorporated. To illustrate the added value of such a framework, a coupled mechanobioregulatory model was proposed. This model was based on a previously developed bioregulatory model [1], using a simple coupling between mechanics and biology whereby certain parameters of the bioregulatory model were made dependent on local mechanical stimuli. As a first example, in this study, the proliferation of osteoblasts and endothelial cells were made dependent on the local fluid flow [2]. Various loading situations, ranging from non-loading to overloading, were simulated. Simulations of adverse mechanical circumstances predicted the formation of avascular nonunions, a result that was corroborated by various experimental observations. This model allows testing various hypotheses concerning the nature of the mechanical stimulus influencing the healing process, as well as the most important cellular processes influenced by mechanical loading. It is one of the first models that provides an explicit coupling between mechanical and angiogenic factors. As both factors have been identified to play a key role in the occurrence of delayed and nonunions, the model allows to further explore their etiology and treatment. [less ▲]

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See detailThe influence of mechanical parameters on tissue differentiation and bone formation around immediately loaded implants in the bone chamber model
Vandamme, Katleen; Duyck, Joke; Geris, Liesbet ULg et al

in Computer Methods in Biomechanics & Biomedical Engineering (2005, September), 8(4), 275-276

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